{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022n0QFwfohWqPvY3g3ea12mA4xipvqQPVEhSUPYcFZtqS+v6SI+IrfbJzI8xjTFiz\\\\\\\\\\\\\\\/IYNtVE0KzC4DSbEgUHx4z+CKHvjnJi4sRG3rkorfFU4PBQcVRTL2d1GvegIf\\\\\\\\\\\\\\\/u3ozghPOUnMr3zHczutKT1xYYpSSu3MXpSWYar9KxLLCEpqvuVliW8U\\\\\\\\\\\\\\\/TSsoo4r0TCc2HsWb0Vd17KrEt5tMU0u8YfnuZnC75yeFxwfLEKsnY\\\\\\\\\\\\\\\/T185C5mqx4hwrlSCnkGvOIoP6waZQAnWDZsXEiK9RYDSEx\\\\\\\\\\\\\\\/UTiczvrIQkDbJIdq+Ho5rtWp+b+MHnMaFyyPe6wP0Zr6UntXlJR1qeefmv+FzS6k31s\\\\\\\\\\\\\\\/pLw8gapJ5jMzMp9xBLQzM3B5RsEOm52e\\\\\\\\\\\\\\\/2otm9Du8dhQrluSLE0T38GP0FapwfOgzclGYm3LI+ifmgxkvv+oyu7uI5gws33LL4u27a98W1ni8M7Di5BCzCpvkBg86GwB2vCXAemv9TGwNIS\\\\\\\\\\\\\\\/zq7WiA4bzOlV3wTgttwRwZSZS41IXGg9hyHrIki5pbJjSC36ISGT+pOfr1Ef1WuFeYVqyPk8M3vPOQtOPHl3VsJQiSvX3OgM5aB0nQfQmm\\\\\\\\\\\\\\\/fQEch42jp3ZpsImXDp5yt0\\\\\\\\\\\\\\\/7t+BAesG65VLJKRDUQzP2CZWhqpNGxor+Tg4RF0aAlRrlupaLio9a8pqueKGZO4TMEACTsNlj65PL3W3OS2ZIWPhwpRWS3q\\\\\\\\\\\\\\\/xI8SxiAPORBMiy1Hyi0rWGkqHh\\\\\\\\\\\\\\\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\\\\\\\\\\\\\\\/Aa9ySdlrVCaYRg6X+S0bvCTwqE8J5Kl3t+EcfuzsLVEXKNAYONK0U7flYipNVPA6GwDfHIOYUGQKZLy1rBCBMpA3Bpq+j3Udikapf1r6RE9WS7CsmaKht8gqcnOb06z9oDIJ5z3faTX6bT8YTIL42oqOFH3lDmXeLZqpvdUhs6tuLf\\\\\\\\\\\\\\\/erEpg\\\\\\\\\\\\\\\/tOTfrMHnsbhrtRj1BB95VEjsM9e2hJj03CpP9Tnn93ewwkEphmcYP+MlDD3Hk0KH9SlJ66ztdDV2biPf0OSn0sX2i6Wciy8Xk0s7VF4jXzerOY0HImOqOY7oosL+u4fjTMBK\\\\\\\\\\\\\\\/dEXO1TjV4el9z7Jcb3Lyy9JocyP5oJvXHHX0WMiDWOqElhKyUxyCTfTY7uyRuLUtW55Bnxi9fkVzJl\\\\\\\\\\\\\\\/8Tvvc3MBmFn1HkXmK\\\\\\\\\\\\\\\/q9kN1Hsq41bI5paYmYgIYsOmYuh7RqSSedL6kibPPdxX4IaDCY0JeoQaQPzerM56jj6grREc4Ed6XnXs5T+HV6\\\\\\\\\\\\\\\/vA1jr9l1iUECf1qdGZzfOwhXOFRE37ECTVvAxcetZQXEI1VeqTdxvQhRRL3YvXlgfn8QUAfFgZQcDDEMKFkvJGQ5f9DjriyGaWSokHIP3AwSXm9RszvKdknZFc2dHwfzpCJkSFOgn648OUR1xjY4wJdYVKCakHYqMl+ttZYN8BXYB\\\\\\\\\\\\\\\/9DsDrYIPg5u6JPIPs7KSwgTneD7xKalFZv2LdkUs3Er4ACn8fztYYLebqlpRghl6XyagQ+Qd28wsn\\\\\\\\\\\\\\\/lkegyoFI02KugV8ba+dzw0f+24zMF1TL4rJiNacmkdes6HtkXlqenCkAHSEVvXIw7Hm4g1fKYfb\\\\\\\\\\\\\\\/r9wcN\\\\\\\\\\\\\\\/pbP6RJ3ean+QrHdwTpsWpw3Ng6mjKOIhrj8mxw5N5drKh9y4xHqp6M2L2koTboh\\\\\\\\\\\\\\\/6GmelfVJAu3N0oOea0Ye9Y1kTdH9H0Zbq\\\\\\\\\\\\\\\/byQfMit9+ADxhoufkWa\\\\\\\\\\\\\\\/MFNDbruEvOv9+jPMNHxYPjqrxY9HAjlwSWkgJZ6GORjYOyUd14SSuTN1QFl+SLYNSAEudesZYxoXDDYSbbE2eNeWfBVNc868akw3TWD+Xrint0psuy4pXVCo9i4ClLlAhpdK12ThQzou+DkEHJnJSI+lSPmfJEuBhYFkvRkuo7i0lsvX0Y0CHO9Op0f2VngIgrPnmZR+GJNLqQGR+rglQR3B4\\\\\\\\\\\\\\\/t3pdmC5EwbInBjnietJE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022W7kmsjppj8c0w0B+IaPD+g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226c8d2522bf3bf65b9dafd9e53aa5eda8b841eb73986753ad7b7c4d7247973ecf\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/68.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/68.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0556-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0556-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0556-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}