{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022SzSAeROarK7zyRmJFqh1EwBK+v8WFxYO5snGBK+Du3D6I\\\\\\\\\\\\\\\/41sl\\\\\\\\\\\\\\\/lQ2DOmU0ybuG8MBn5pkeFd6dXhmUdJcg3AmbpjVED7wM2Zbj9FagUyTKPVLaXSdjzV3AA3dH6DLeXIOLwVzCZEESNYE5gzojpyDorrZU7dbQ18VuVZB7wbK0D2UV3+n7rTYBPG8KfyOJPKUWe1ehI59npJU3BT9nFPTa\\\\\\\\\\\\\\\/9nRZ8p4nCy0siUaeRgmHT8CaiDoY8musoLSVCoWtgo+N0ggqlbxgI0U5NW6o\\\\\\\\\\\\\\\/xCKtqyZLzopgTkOEmBmklwNGwmnn0upZO6ejDxo8qnVKQBzFF65RzwRbxKVsdVCPU8k1OYTff+rLeCcm0AQ1\\\\\\\\\\\\\\\/gXZJYUNpFK90dyMUTjaOLL\\\\\\\\\\\\\\\/em2D9DHSUbKRSann8AGllsYgVnQbgI4Uz7RBR5aLJIhb9WlFGjF7u6yeslfdmvUamv9ibBx5Qgp5R5iLv3X6fnyuCaFATqjb9wg9GW+AkYIP5ginzyjP9IwqNgnFWmwUs8asdywHO3UseEciAVpNdqFe2EQlpZ8ol2sVjQct9HJn2A+hWyKq1a1klhE91Bf1nhPA4IU+Un6bXaNhuKqkixTK6UjctlXZmrgQ3aoNnrNQv7sDFYveBjsoLX2fYaMLzKsgj7ul3y62cQ8Wl5bvwvZyIiVo7gLnZQ7Np5vCBIxz8RlPGRvvo0A2oLJ3QrB+tIh3+RZ578kVHevdAcXKTiCDF41IhciHf2LBUipDX9eXAARNexk2kLlXat9izFkE1cDwPGEAGjqrTfCAl\\\\\\\\\\\\\\\/QKuTPirwQa\\\\\\\\\\\\\\\/2ROC7s0XITjQ5fScs96yotwGzVFFkJ62aFEL6UHB0pQV8Y9WhzDeuSr\\\\\\\\\\\\\\\/fEkMkoTCe3+0alELcSsZm8\\\\\\\\\\\\\\\/tUwRV3F3uzpW2eldlZ3PDA7i5xRm9ORLzwfMne\\\\\\\\\\\\\\\/P8jdT6AsK6xcWPGHkTF4H9HeTP\\\\\\\\\\\\\\\/nH6Q+\\\\\\\\\\\\\\\/8elYNjjCLgbP9wt0A5LW8A01VRD2n65PlJY+Qn8zs\\\\\\\\\\\\\\\/Jg6RB2hncO3LMqxn9rgv8HuO13RZgRa9eJ2av7BtEV1VkP8he+Ir9\\\\\\\\\\\\\\\/U+GTPYEYfwrvj7836avHAfxAMqirOfMdbI1zQluBgYGZ\\\\\\\\\\\\\\\/CKqaVLByUrZEgoyqej9ZInEU6eQ0qgwbZ5+\\\\\\\\\\\\\\\/xqDpousYin6v+cPyeATdY3ppJ260tlbstEwbSh9K2sI0SWUV4cd6QfNYDiVISRAiqkJJbWWKM4Ik9pz4YcjzvCmbQntkRWEYxAm3elcN\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/scBiJbDk55kRXcBT53qNMcMH4wqaE1ZhUDzhP0nljZ7heD2DwvvUxy4npPaOcwZjDtXl9O1ep8F+7ns6iYFaXpwP+6K6ITccxmyXDtlrJ2IE+qlTB7Z0uvujwjzYPsBIxZJh9x5Dt3896hzSZMePpPIpVCTMZbpeOai3BIntTQODWpzcbxY1XQzHPNj\\\\\\\\\\\\\\\/IsUANPsKj26LeAlvnYRBFXeb46eoumet4Zss3uH1HmxhddrGalPliVNT5k29lsMaLGpvfwcQPMzHGXmMXamKMSZ0UxhY4JgH04BTtBN2NVdfh8GL4+rs3jBJhNVrHb0XY6DhTcI9CKQZGyDxaVweU\\\\\\\\\\\\\\\/X7viec6ytBhubJsTjVSGjij6i0kkVpEHAexmkUSAyb+yZzp8cvSQupF6tij\\\\\\\\\\\\\\\/LLRQztJk5gf9FI+6eQ\\\\\\\\\\\\\\\/0+4x4JlNM6fxiJMe9PgMUEn0g+LhnkQF78C7ymi21d906JmjaowbBTDBXUAjVZc4CNAOBWUgLIRI07YiXIqpr03KN\\\\\\\\\\\\\\\/VkAnFk7yEOfxrsIBHIdMRgAYR7zjI\\\\\\\\\\\\\\\/AxEK1UFrepPLAm386AgxEg6Lozihpl89qFwfTb\\\\\\\\\\\\\\\/603mSu5CeoNo\\\\\\\\\\\\\\\/sUaN5fhAV12OQj3gpAxGLOUxutC4Z3v4rjz795VvePMPFi1AzqU2Fagte0ydT2Orc23uTh6XaZm5zmX7z0t1MJRaLYlqMb01SS8Jcc6IqAsBMlMc3l6pp0hbYU3WW+17UPafBP4ZxGYJ+9gMmKfZZpgAOtgEyLQUTon30UE\\\\\\\\\\\\\\\/5Y64FteMDs6UQjGi7ZnLBKn\\\\\\\\\\\\\\\/3OL9AWVkbXMGDUh9otWoWl+3ta66LyKOxRl99\\\\\\\\\\\\\\\/AAD7PX1ZWyxTUmch0hZRxMWCvE2DJtW+O7+rgbvYnxPb6Tilb\\\\\\\\\\\\\\\/BjsiqoRjB9A3xJ0ZhGXgAa4Ja3rCwkfEEMXQUn9e3NRHG7ZVdirMqommxB7C58H6Nl3FjEsUNmdrTkYgRbC5N4qweHNs6\\\\\\\\\\\\\\\/51lQ9m5ndwbvuHTRSk2JRn52BAmDbnIFsYOoehWHiu34vOFqPtNM\\\\\\\\\\\\\\\/CbIzB9xx5SFU3UM0WIw8XDSDnJo6s8UUt6uBl+YEOGKFT7ed1nm2JMv\\\\\\\\\\\\\\\/1oHuMi6pvmINKWOgFxFcYkugAEsu8bs0TvAo3YSH+zm9VB8uj8MFlAA3NyJU2scU7m08TUFErmHEAb+d1cwLjIWOnoqHTNEZoajKagxABHC3YlB9nKg3p5EWHCIAY4kxXMclIKXpas0Cm0Z\\\\\\\\\\\\\\\/VYX7TZKMLXgKmUe\\\\\\\\\\\\\\\/aUMke1cKJ47Fw8oDHVjbLVC23TaZd6MjcmK3vGyKu2YXZA7VsfVvUXgXUFYfeSmXe5O01ibudptTqhHMFGuk0SerlO+m4IC7EMwae3XiUkXTGCQgFtQQXSpgnpdfU1MBfjdBazz4pQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NvnGizKKCol3p4o+3aVTEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b3bb70ed5738abfbfd936068c08035f088da86313deebb524b07b2e9462b3cfd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/76.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/76.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0560-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0560-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0560-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}