{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224rvNR5wd6j9Aq\\\\\\\\\\\\\\\/KGMtaN7elhwPH+j7Q+qoAMTtieb1rCZ47N5kNo35TwsOqlBeHk01Qks16KVZ8QAqKxIg4q5bBM7ZNpXVxE7yQp6vL8rToX1X5b6jLbvV\\\\\\\\\\\\\\\/Jk36CVVbOSmtRTiO1WzfVF11E+qUTHUQ4xlCjm7MmKHOl04qejz8ToqbN8eKVqUr7a8amIQULkeeDANGL53DRR80qzJy7VTRbrXcNNVzt97YmnKi5hAOi61mM3KtZTaDEnTkWwEKL8rFA7OMjdVBsUplsQejp+dPphHRtoiic3z0dk38oB9vygKbe1Wg8adfrbICDUpPzuqtSgdfLpEZo5F5JQllYPop5Z+NF4yskReCH7+X8m5Gscn\\\\\\\\\\\\\\\/lzi9f5VCmtJ8xX+aoXIZ6UpeqMkn9T06Zj3WXl+PogsrnsZ\\\\\\\\\\\\\\\/h0rHT10fyd30iog+Q8F1jtR54QfjCpssz4j+K0VzIyNIlXl3WBCGCehqcgHe2qLdLmMaSyPQBHtOvD7G6re9Mbux1oX1balWhGU4\\\\\\\\\\\\\\\/L8F2avDavHiO6IGaQubgQ6iV88sQtDI1uYrI75vic73YnJ\\\\\\\\\\\\\\\/AkD+uurT\\\\\\\\\\\\\\\/p2TzPgRovbOg9xb1IWA799NYkMCWfz\\\\\\\\\\\\\\\/D8nn\\\\\\\\\\\\\\\/9kh2djlW3mVRKcI3B46Lb0GIRjWlK9UWrNA3PZapmqsMsrtkAxRWRRdWskbjG9YZuD+EQqij9rObOiI+TENASrOl17LHCmHbHMnwpfUZs9GRgg4t\\\\\\\\\\\\\\\/lKtB6ZItV4OYL2Cig60w9tjJMUdkCTSRHZplck10PI+b39r+HOj7ZDyovzGE9HGpgHCCf3TOvu1Y4ECT0S7C+H8Cu1NYCBSMJBefiNwJktLn0kGKWfBtPdAgaapwvFZNtqWL05IAxLM\\\\\\\\\\\\\\\/1xZQJSeG5uDzVrafuxSlGYz\\\\\\\\\\\\\\\/fOWpm1dEpE9+Z5qO7yyiEcWILEMAvcpgutYVDvELQSeB+bgGXqZBzAxwyL9Z+TxQmnq3IyWZHAzkNImaWsKU2EYe9FVGTF+LF80649N0RU6kyDjSYf4mwLqfE84A66386FRxIB63uLk6vO2Ye8eiP+qcS4Z7gJocuoElEuK4T8E+4+BBQo5SXELRxbE35x1MLTALE1pvhXRTun8fNlJrns5Dgoz3DST\\\\\\\\\\\\\\\/IAUZqV6qh1kB77BNTdt7eyFiwQ\\\\\\\\\\\\\\\/7ls\\\\\\\\\\\\\\\/Fdj6RKqmT5m2ytCIdn7M61an4JbG9wLQsxlhKeW01beykRWgKPAIS9Kle1TCGQOCkBc+1C4uClEu\\\\\\\\\\\\\\\/OtVKMGdkbho4WmgDYNciNLn5VxjL\\\\\\\\\\\\\\\/qFXcscD1zzZ\\\\\\\\\\\\\\\/ADVyrSzFYG0Ozi2ZI0mkasCnyVfLfTeUUw6BNSc1QTn92ntgjAnaq7LMYqN4o1svD6PYgYOKdpwenZWnUU6WdkvGsrwohDE3sUlpCk1dr7pJqvC3nzy5CzO8ZnlUACzK9rFIpC2\\\\\\\\\\\\\\\/sq6A+1UUneb\\\\\\\\\\\\\\\/anch9\\\\\\\\\\\\\\\/Ra5r5U9oDJx+6xa6xEmvY9pEIRN+YRIDr+1saS6z2yMUJ7ohgi4YYnJl2X8toFm7KiS91YD0FZWYPJj3iS8yJcgxF4sacbsXpqJyIrGOaUUQB78K4VKcEhjCB0YM8FYAKU6xymNw\\\\\\\\\\\\\\\/WKYZzDDcLF\\\\\\\\\\\\\\\/gR062oBQpi2LIYmYt9yQlOLygT3cM01ANW+OlZhFOuOxtxUyv6LOyMBBleROmkVjJC1DHr9E9UWJ\\\\\\\\\\\\\\\/o9ccFCjyNMd2uVvDKOrYq3EWioKP04DcfQWCXJeZ+hpBke9m17yCXKI+dArM0XX7YlM3f2BV25xPUKNva+824ctS3B7DJ3vRcZ0Y9dEK+NmbGn1uNjmBXul\\\\\\\\\\\\\\\/jN6SMDoGX\\\\\\\\\\\\\\\/05KCclUix658JDVYQjE82PhdwP377G1d1qwnHS0PcM4vwcAwXeGAlehCyWiSSvXL20EOoeLPoHwp1dpNAXXgCyIXWgj3p2IKK5WR3zeJkiaRwflAzcJ34EFOragxBarxSAMpvVzqkJzkGW2xRx8m1zmwNwjqJthCYPcZO8f0B7M8LkFS00I+CVXx4bpHDrXG5scknoj9GkLFRIM1RxUEuEpJUwOd\\\\\\\\\\\\\\\/GALQIlixq44zqWvqgfKNRLQwVDBaQDaYWslm\\\\\\\\\\\\\\\/z+lCCbM1l4iv\\\\\\\\\\\\\\\/3UrdJGi7FzOnij6tUhSjdTPSlW5X9HGNnAN68nrD9a7FP1p6b2xmTz8VBwJDNpXV6V0h1b+SEfoktfGwSPcPJmPrsi3UOYdSQjq0R5O6xxSWyzSiLFRbleQTFBgfei46dgjIgNNeSgwai291zVS36\\\\\\\\\\\\\\\/nvhFVmoi5OV5B8hHU70r3rUmDjuBjJn6tQH+gVJCZl40JPNYagyKzGWw06CteBb3y8hchsrTCiU+B07zhJwkEB+ae\\\\\\\\\\\\\\\/ObU+gk5b6WImTnlWNTZKdKm1R\\\\\\\\\\\\\\\/epmENzKBaEhgBqFZJkU0uSNxR+EJN2C+jOL9M5AhS2ctZVkzJtNGY8vcKT7pAr2Dfwd4TaQpBgdVQC0nmJaC9uOQggQaC70YNNWGF9TMAjq1FavC3SP3K1Wo6np7VwMUtpQoNFznBAHmGnfNcmaXY8EoSV7u5qee6FWDkOJwk89y7sJ6rpCyGNMjjBt6HKUOYeyMqTYXnQ93aDLhtdEBN1\\\\\\\\\\\\\\\/lA\\\\\\\\\\\\\\\/vdo3IIE\\\\\\\\\\\\\\\/Ik+zoOnUj13YmlhssZwWJoorLBeYUBiJ+NBqQx0v62K\\\\\\\\\\\\\\\/pnasKFpyqsSss5TAER22tuihpWBBY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00222OGsU2o7l1cjOIlRw1t6og==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002236951ad2ada11f962e4e96d8bc75094d69ad0dcf2ef5dd1e61ec5bb4323451a3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/30.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/30.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0508-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0508-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0508-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}