{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LbjQllUNDm72USob26aK1lOchxBjBH2Lz1TWha8N2yCBosqW2R40Opp\\\\\\\\\\\\\\\/lA0eCr5omPU1430JrZ7grFH2PEMX005hkdMrBUZ7ItoWFARUQGU4DMTtDsY4OyUxv72tYkhTdgKEN1kVsmxFlQWgMn+xixLe4o0w2JM5kNuMHcjZgk1AMtz2mYFS+v37odYUhN7p+905Xh5\\\\\\\\\\\\\\\/woQ7BnfwOaLAV0lB0HPpzFTAua87Zofi\\\\\\\\\\\\\\\/2ojXR9WatfVzHPnsSbzwuqbOdzDhnvJQQuICXIvXOQfiiGXsxHUmE8zTfub1LVK50pAnxQk7Y51SbnzM15c19lJgMc3NkKOVL\\\\\\\\\\\\\\\/dIy1r05PZmreXJLgdiSPIrWnrX39BriH0Jwymfh1oaUMK5f4B0JjkCRNTCQ\\\\\\\\\\\\\\\/6T+X6TyKvXM3s7ZT8Bozg5SD8uGueL8bZeJ36vy863g8cFsDRYCBTZ2IEpKII2IkFc0TJDpiLFUyb\\\\\\\\\\\\\\\/ifHDBcxk6R9j4tpMG5O6Ty59vx88u\\\\\\\\\\\\\\\/cC140fe0ybFXqP4uU9RYthPX4egd5E9vHzgv1lj\\\\\\\\\\\\\\\/zLVMFPuZIjr5+WJOQBtcxwhL8dK5jGwozSj67DXZER8AkhzmJspJz5+qcpxe4O3EWSSR\\\\\\\\\\\\\\\/e6o00sS8DYLYq9WS7mInF3L3Dfj3QuTT89pAD+TmFeAu98fkScLutofjnsbRYuNiYinyTyKoJ2erJtvt9YdVE\\\\\\\\\\\\\\\/UUhsw1RZv8nxzxI5KYJKh6+qGvSU6gUwr3heGdOmPXf9DDmnlOfBs783AzOhB6qegzZAOQUscwlcqqzkKYQEE7MEF2W1QEt7XBz4t\\\\\\\\\\\\\\\/3YdimxrbCcHm6C1VixBnW6wvSldvfmh\\\\\\\\\\\\\\\/s7eC9+Q9+pQWppQN+p+Nq0C8sQ\\\\\\\\\\\\\\\/lHIMm3MrGdimb53Gs5DykICvQ2wWN4nl84PW8oCtTLGDpUtv7FDUSdMUJK\\\\\\\\\\\\\\\/UMBgQiKm3v5NEaB55QimEswZegRT\\\\\\\\\\\\\\\/gQluyySeOpAc4YCZuKKDtrtIiw+bCBOFMqIOWK8XdCejwP6yMMoNS+Iy76zMZALpd0YfVFfdaX+qfD4KBqcrwjl2EJONCj5otq0FC1kBYUI+KcMC2joZRI5InFrG7oan74XyHWF337orYSXBGbBh7Sp471P9odE9mpMcu34ykJAK1ug+kyKcbkfjzl7xeXl\\\\\\\\\\\\\\\/aV5aqt6ExW4+H+Qful2ZWw8w87BN3uJKrTY4kfZtVCeIYTBDzyi5YDTGWCGWfix58bP1w4eBkM1IlDan47Me0shPmigqpzoVmWAZzIRU\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/2Qb1D5J\\\\\\\\\\\\\\\/ncIqxiuPXUvnuIOki2oSB5MX2WMlr04\\\\\\\\\\\\\\\/4dE9Ungbi2gSI502c4w6GsogCcsfzkHvsl8rvYvxIiHkfnVwofHcOznUW4n\\\\\\\\\\\\\\\/Vp+GeCZZw6FWfCsFiabLIo6+sBRR\\\\\\\\\\\\\\\/x\\\\\\\\\\\\\\\/rDjEZSyTswU0B4bPVL7AWFVHmvDHSeVRoRzbX8A5FB0MM2vOZyild41A9VKvR+mfQIUcbhV\\\\\\\\\\\\\\\/BbabM9Z17KoQpEykllazPuBxILPkgsfxKMc8g7pWqXv86yIvtEiV4mKILX2\\\\\\\\\\\\\\\/Fsw5i5jRjLE54h3NYxSCUy6oBm9Na\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/gbr1dwX+bjjeQlglnvzelELBkKs3+a\\\\\\\\\\\\\\\/hza2vHhm9NrKcFHarNEts7+UUUhjZpZ2kfHhCpSP6AoQyNnM4yk9LM2aS24iM5CIKxPNjAOu4ovfHY9noD4a1ugOhlXVesP87NAqzRmEWPYRHZjmoxrX0Us3oV4HNaffeW8GkqMj\\\\\\\\\\\\\\\/wMKGY5Tmn8OPbm6eUWA3N97GVOxe0f7osxN2DCv\\\\\\\\\\\\\\\/mXXoY3Te41kmDVDkQ3vOZWmeOzMlbxoXvYUBVM0v1XjLaj\\\\\\\\\\\\\\\/KIC\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/k8Xn+8AxnR0+0tTjoYBRgLSJuiS9AM6vYd6vdfxc8u4Yw4bNbRNHEoYhnCqAiZNXH5zTYWEA9odJ7LdV8MJsUtieZmyFzoG8nljXb+DS1nZPZ76ILSAMFJaiyPCmJe5jG33JB8qQl1+jN+U0YefFIR3hAbnUJDKS0awhmECjQ9Xf9dK6cvqCQK2sgyRXDx5tu4ulC3igIgPwPYCpY1T\\\\\\\\\\\\\\\/kNBvNcZoXUE5gB5oWjF\\\\\\\\\\\\\\\/FEe+cdHspVT8DNV+v2hQrtErmfvjGtkKpkHdloB+AWJvS+b+nBb0+iqkfV00cwYQo0FswQhncOLPKG4z+pdu4ZJmDTEJSgrpygnWM6ZlaS88nJcuh7Aw+KLvkhxMOdwBxRTYoGBMpzCj\\\\\\\\\\\\\\\/7UMVoVNEqhQ4yZcjkYNOExk9oCpMn\\\\\\\\\\\\\\\/JHgMezqAG\\\\\\\\\\\\\\\/lWrsRYkChjzn+NpJ8G\\\\\\\\\\\\\\\/Mrnb\\\\\\\\\\\\\\\/+tz7c3QJ8+Wk+nuSjrjIwQWuxj3jsp5yj1zcAMFooMRCIfmwZFKe\\\\\\\\\\\\\\\/AAFdWGPMcLju0mtEQ+HY9FOrB5DsjM3qeUw8drOZHmCapJqiig\\\\\\\\\\\\\\\/tQQtoMPJ+UBQd\\\\\\\\\\\\\\\/KU5Emvm+TCZjpPXv5qExQbrGvOe4CMB4N4+te0qsrHZPcu6kA6QZ3R\\\\\\\\\\\\\\\/4GyMRYn0ONXtEtQj9\\\\\\\\\\\\\\\/lgIokbphqJO+qCO3EyrMQD49SBriEHFZQgX5YyDo0uM5ABjTTyussLQYa+l9qKfdJdgzy4hn9\\\\\\\\\\\\\\\/3Qm3P61WRSjylvbRF7yI1RyIu2p2B\\\\\\\\\\\\\\\/fi3j1ctxgG91SnN\\\\\\\\\\\\\\\/6nWRcXz0OMFftAuuAoIQamo+4xezDtpheA4j4Wx5klmFOOz8cVqfQFtvnKg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022O\\\\\\\\\\\\\\\/wasuxwicZ+mgEpWnWn4Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002272ca7a65be1f8dc198c0e80a6d45f30dde351dead3d37b90911c357990783793\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/201.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/201.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0668-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0668-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0668-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}