{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022L97tajZgMvyHa0fPVKHdifcYen2NYYHL3DvLCj1erFD0bHG4w7+nTn4lVcpLXnpp6dk91fNoZItowJWt7ze0Y8nUbMcu5tLlBWylxX6qtJlvz9vfizd5O2xXyw+3P3u9UfNCrk3rSwEtjNoNXIHoSKLchNwy5dC1hrfZWdUuJ3h5ajFGQXdMq5EtxtUaNfbEyKyt9sVGzNwFcQXEYvG2uBdobsh5\\\\\\\\\\\\\\\/e2RuxVyCB+0yMM4JCsO4oaf1wU8MqtX6r5hYBnvVGcdK8bJQ5Hjvd374VbBai21h7D4uuKIYyir5zE5Ucvwgad\\\\\\\\\\\\\\\/KzZeh+CTW2YMiO75xzvf1wNPtfbx6AGNg2jxK7HlD4AHnKjiiqmTrEXn03BD4C76fcRnONuxCI7Plk6DU8YlA2ni0qZ3cPYRUB06YIGzxqc1ny\\\\\\\\\\\\\\\/sXHK3L\\\\\\\\\\\\\\\/Gtj25VhYa\\\\\\\\\\\\\\\/snfEY\\\\\\\\\\\\\\\/ufJyl1c\\\\\\\\\\\\\\\/lviUEfKUWQ8JNe8IgJi5vQxqTlqh0qflbi4JR6qPVS7cJMTCqIYEmcN7co1ZhQdTawu9WRk62v0IDtEzfvNqgYl9HWKzlvTGjSw9bVRvXeirPGIq68+ztgC8WrkuO32EBssNHwe\\\\\\\\\\\\\\\/MGM14VsNjknJXodWd5COAvYu3A0zv1d5PN5IzS5SGWXm\\\\\\\\\\\\\\\/BGztSw8PtITs\\\\\\\\\\\\\\\/iIJNfgOpuk7fcQb\\\\\\\\\\\\\\\/vvH\\\\\\\\\\\\\\\/DjfI9K5azXtjiLB6wg8ML+7WqMeBxpLUayQtSXlLsJsbyJ9jevcofNmbgv9SDzJhoJup3q\\\\\\\\\\\\\\\/9+YGsLswxsEobCaxzed4willrs9cGfPoA2EGi4KtUJ15yIjxTjEfeiFhiM33G4Pfj+aaNqiTJVglz+6rjKsaRZICfB2Yc+e09FxLJFA4tqJDAAQqlq9q\\\\\\\\\\\\\\\/lLuWrc\\\\\\\\\\\\\\\/4hUkkx+7qSg4FzichF2hEjpjE4h1m2Bfj0AFpGFZHYw3Z5hEwk\\\\\\\\\\\\\\\/9H9oIaq2ubKB5ou8WZH57AeV1+5ZrXnMFOQA3Qx2ulOeUqQ75an2xQW84\\\\\\\\\\\\\\\/9YohfUASZiv3Ox+px6mI9PvzAac\\\\\\\\\\\\\\\/nY8AM0lzrMLd9asulMndS47Tq5BwEJvHwvNWdFWj2rpenfBtQ4CaDKkDrqjF5\\\\\\\\\\\\\\\/wlrrx1cPbmRyBYhFeXcnDISSaLnHDqBCIc7EKwtBBWYGA2J99Xfv5qrhI0ggCIXqqsmW\\\\\\\\\\\\\\\/gB\\\\\\\\\\\\\\\/Ax7oDjwrdedPZ9JrxiJB6wvgfkXMllw4LTpkKQ9FpKSRUjhYGpls6daUomGzwbqCbRkQTyBiZEmvSTY6F9PpBqBadwLAPVzPk8tor8E71SxFY8iB9V7VekielPC9ZcEiQ6HBQtWzANE1wmQxPXB7UBu21YvFdpZy04Amt8XaeUCDIeKKIFOyEOKzTZP2auew+L3rzR2wIXfI8bQ4FLthQlEM+t+9EJCN81PaobbNRQvj7TPKMBwQ\\\\\\\\\\\\\\\/gJU+YCWR+CEefK0Ws39++sjAckJjA2\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/haUQOW7gIFEnNnH3WIUEzqRrxqap2MZagJPZaBlzGJqud24Dqfg\\\\\\\\\\\\\\\/8CYI9uobgg+Y+u0t4cGX7Iso02OwZrYFwziFO9TkT9HyS5BGCONA7NT8pfVvdO+uavVVBIwL3ziGov9zmmdYBPrOOGYVBTGXACAQbPF08BX9zKWQp2vgI6UNjuLfmNEwm82wrc+vw2WG7PKnGflXEdb+6xEFBUktsZQi908MRr9fDb2RRgg+lJ4PPcBfihX4hhyn+cBEx8qf2lFOEQxOrtLrh21CjaFEVoFmw8QHPD4AVZaBLMvdA1tSvH3w\\\\\\\\\\\\\\\/qu6i9+u6rlDi7hRmpFjNQjky4UShHlJTlqgAc2rMezhXfTd5qb7JvrOO5ZRjOaK\\\\\\\\\\\\\\\/05MLYjhMaKaP1mDgEHfkR1F\\\\\\\\\\\\\\\/TIeeeSQ29cuZiE0EwW0h3lsAE844Rch2ieark2MTM7Ij9\\\\\\\\\\\\\\\/jCLG7NtPUfbibyCLM1Zxmi7kDAOZpUB6CtT1PwwyDnA5lASltoNOP\\\\\\\\\\\\\\\/EH5R\\\\\\\\\\\\\\\/2mEsYrXo4Tt8cvtDO3H0AwiXQYZZQtXQ7B4LLS0rnrwWrNPpI4E8X62+A+mgMgPAd795ocDutYAWA36LC3al1HBWyQiC3lAROMI929hdcc46WabzPV\\\\\\\\\\\\\\\/JymvShgz4lhBlpC1NmQUbrsolEcUTY4mJsKSp0Pa2IYswZbv0K5+drGCW18CW61xR5EZt44zpg3\\\\\\\\\\\\\\\/MzbQj6hR1yvXeiHaR29XQFzttEkiO4d2wsnTKNiHMZCQ25gnjD+0X8oYhebrH863WjValICtIVWnP2X5+saxVQ0kj1\\\\\\\\\\\\\\\/bWxOJ4qG0Iqzr2X7DtEPVC+cMg3F4XzOHq85m8S8Zbv20vS+96buqrLRrX58l\\\\\\\\\\\\\\\/RrHYLtzNJZGpOhXSy2RvADe80HGTRXbizgPDXnYp+Qbzn+vSgoYbSZKinG7vTQX27dMYiVVjb\\\\\\\\\\\\\\\/JkLI4jFpmVZTm6Icc3wdIjOHgKMg12n4tiJtL4KdUq93noKPND13+TMoZrC6wd1QcbQAF8Ak37X+IG\\\\\\\\\\\\\\\/kS5N5f1uUqZVHNo3dK\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/wkyYptp0yNsf1w3V7URqbhHQukHwr+jle0AHo+7ZMBa+cwjkzuPh5M0mo9S1HFU7hRxqlxjrA+eQnCze7BgoPUGu9T7Eu5HN2l8b8BTC3MTBfXRo3RE8ztSM2P6tsU0RcHqfQb7MKwKTsjNvIVCEZ\\\\\\\\\\\\\\\/VAfFf64cZVc\\\\\\\\\\\\\\\/+5oFbr6YBMFkbVfn\\\\\\\\\\\\\\\/Jc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022sRc9a8wa5oPrX6+mzfH9Eg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222a8011066027f4a5773e94112dce538d5f5f8c141dd6d8a11274432eaf332af9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/19.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/19.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0505-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0505-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0505-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}