{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PwTZxjFIxmpIU2mOejJAylvVIg8XbujjYTr8QJSK3qdQ1+ny6DKm0FJRTGrl8R0otjNIVkvmQUxkaqYnVFce2X1rHG1H0hY5l+DMi2YO0jMtiWBSP7LGsBxPg4fJzpeVTY3nqopj0tS+E4Iba4aFMSeptlFNBZrEE6o4uLd5lRXogHheusXGfa3mTKl+8o5c\\\\\\\\\\\\\\\/f0FIh080CGiKx9VwTEBr1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0BqYCJBNWICBlPJu4OgVd6LarEJusysavtmi81zVXCxPJyqnZbXOOAqF+H6gXzPwF017D9ZcY\\\\\\\\\\\\\\\/zKjH\\\\\\\\\\\\\\\/O2VXuHisf7kiy7PwEuryCZybFTXsAjoEv8KBTAPgL+krVAxZRt5Q31ouDM6T9cl5snUkQFv1A6Tv5gNeQCr5ZC\\\\\\\\\\\\\\\/hySaVv72\\\\\\\\\\\\\\\/7HB1U5FKsShTPS8IdHy3j7UuimfTbPNMTZ27qWgCYPA0bzBmjcoaSOK9HTqxdvkB+y86R8QmKyeSzf9oQ6KLEHdJ\\\\\\\\\\\\\\\/zygK7LAWZ8DiewCfWmVOWpEgMDn1CbVw5wDdX5elHKJsgdo\\\\\\\\\\\\\\\/tI6OzLP4VsbHd0Ha0u\\\\\\\\\\\\\\\/NqjaXXJAG\\\\\\\\\\\\\\\/dDJadHvwPHGLvD7HPRqgBzewk0e6gxZ7TYpIZx4HCR7D6+QVbmym7qeVsdHgQyD47zY8o0njFG8OVYjT2wzvHORQ0iel9b3i6y5bi6KzrbWIvRr2xep7\\\\\\\\\\\\\\\/FQsnA2\\\\\\\\\\\\\\\/OX1oNfjDkoF3tQwLR3R++xiw7EdyGJHHsvY81QL4tYTmsnS7WXOtt1UXptSOUyjeqrLk25zIRgjRrJz9hJWQKKSsWQBxISap627AA40HA\\\\\\\\\\\\\\\/5PRSpMO61D0T8\\\\\\\\\\\\\\\/4NPCiHUmH7AZn07B9raQOF5s9NCPq7vZOdIshy4f41V7WnPBwPI1CWrdPz28\\\\\\\\\\\\\\\/Lfp8s7KwYOsVTdqYWlnYk1TEDDHn0wDdLkaUVb8B0D2q6Cv8VWzPu6fYn2qm9cdfyCUQXvYytr3\\\\\\\\\\\\\\\/UclYdV+8zEFVw+6aUoea2CZ8d3EXZsJFPtRpYQkJK3lgC1iZtAr9ZJJKQq+isrUGrLVmpCaBSfE\\\\\\\\\\\\\\\/cq9A0V17cbTpxm\\\\\\\\\\\\\\\/eH5HRHX\\\\\\\\\\\\\\\/dqvGM8+iO+ms\\\\\\\\\\\\\\\/r6EK4B60FZBbhyqoCIVgvo\\\\\\\\\\\\\\\/27ppyxsO\\\\\\\\\\\\\\\/UpwHfnptO1CVwt7DbI\\\\\\\\\\\\\\\/Ukcm6lK0BKLN9kI5CB4chyonScIP+GQxtB9XDTW+WPZafQ8\\\\\\\\\\\\\\\/KkYr90o18+l3mb\\\\\\\\\\\\\\\/K4Jqds6MzlUKx7cpJf3+Z7BPUgGp1RJnA95CWb\\\\\\\\\\\\\\\/gcL9buAiRejsPhr4wEZyIxZbUXh8JGptFsDZgfQlHudJXyPHV02xAlH6XcuJo+\\\\\\\\\\\\\\\/Gg3DDHhakV8G6flA1wHXQ2RYJCr+TqgbPqYiYADi32Y0n4y+AK7rDAS+u++UCGniM+Pg4Bj6ov9FuD6YHzjalPVu8YsSBfh9t\\\\\\\\\\\\\\\/9dmSRCtZISjDsf\\\\\\\\\\\\\\\/aCM3+8m0nsQwJEN5hQppj1sIgjPlH36xr2151NQxS7fHz2hF7LyVQCPpiW8K+f6WySQzrVYBmEtXJzpv4qYaGMTaAZqn4o7Zr\\\\\\\\\\\\\\\/pKW0snPIaECr7jg\\\\\\\\\\\\\\\/0Gl4SaQEI52Xbtoz901+yxXPhSBPGSSsQpAc3ZE96pLZspEDsBZzx3J4KSy9785Knu5wq+UVLIReRQ8qlam8c5Uu6WoPHpuFkyyxn1eS+a1P7LYIiLHA4H7KXKTPIclpze5NMRz8DSQOolYxbeLhnYM+60FYXZmKV4lDIcw5+iqmWXigiL8edqsnQmNUXFurv\\\\\\\\\\\\\\\/n7LLiPO4hlqgSsL8901bkYdeutaGuzjYGyRxvp9\\\\\\\\\\\\\\\/NYvVDsVRCpGv9wTTGl1FFG0vGK45c9nM7HnZg2fKPVWQVaGUaDyeuBUlxOyoAI6+7MGy+q9i\\\\\\\\\\\\\\\/gubPc4QFPHS4IIqd812jWH7LpXRarCRsWUt3HZHCCzjIr\\\\\\\\\\\\\\\/fR0bhRC7AnIkEw7SBue87WiSuWOacc9iZCyYAYK4z2IAsnFWKbOe8b5dhCXz8MDKMzj3QcHcMRgZuSHwTHyZopDGRSTWMXBNX+kz3FWk9DCD38r95tkT\\\\\\\\\\\\\\\/FTE53vTQb209iC0dqp4zT+goYaNArlsai6S\\\\\\\\\\\\\\\/Apu87ia3g7IEvFr+PtL4vO4Ze5P48r03JNFkZxXSfGjLICzTkL\\\\\\\\\\\\\\\/FYX2BOicDylsXwlVRbuRByi\\\\\\\\\\\\\\\/Pw5qZL4dfWrSLhHNSiehOFdYbgR0IzeCma4NcGBca\\\\\\\\\\\\\\\/24Ey3j1dHKM5j\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/t3SLWNEEc9gH\\\\\\\\\\\\\\\/txJd8R4Tw2xKWipb3+X5XzJ9DYbFQ2odX2f0\\\\\\\\\\\\\\\/KaySA+daY5EJPU0icP5omwNtYA6HGXUydZz9A2pyMhGneH4Lgp\\\\\\\\\\\\\\\/jlmimpLmwVO7FKYrcE0ybmbR0n7Dm0gJB\\\\\\\\\\\\\\\/vzhBXxKa\\\\\\\\\\\\\\\/xorfaGO43K2aqVZqVHqLIs8PHMTJCy8scW0JyE9KvvLnL1ySywRi7mNrpFu6OeQzbH5MW5GiDed1YCbtTNle6Z4vfSWv1AW5jN1q71Ur6VrVJctUNPMsdEuLFI9S5eq8NCf9aH0hF5zE6wHN3Uh6CNudEg3Ym5rby6R0TXM2bpsTDmEqS1z1cD6Tj63cZ8u0hO7RKFehmk\\\\\\\\\\\\\\\/IGR9CScmjKXnGY7WOMEJYxobHOuWwjFhN3vjEfEsylGbJBot2Bkvk33AVbYD6nJjHvT71BTKu9Rm32\\\\\\\\\\\\\\\/JgXOFE758GCVE6w176ScXXNtd+OmCOlEVYdID8wwUnhQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223O4u1z3NSXUKgVLaEiRr9w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fae5b9ac56ed6146ba0661d2546f4f586866d43033051b91bd4644a7a8696972\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/239.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/239.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0717-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0717-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0717-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}