{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022EJBl0o5FMXVi5A+ECkc76Gy7Xh6gla3s1nUCkuE50GPvZ5iSHsHfPeZO\\\\\\\\\\\\\\\/vVsNaLroOOJRUcqo5II8NJT9fc\\\\\\\\\\\\\\\/DYb7n4vLU5DWLJqGat2hk+odILmwJ0b+SmbeQfENKc3H34l4eA8WiI4C7f62yjOD5KdIeK69lQGxWeoYFPiA4pXSFqDU5AlFoTOaa6lwz+HoTY9sXfMUQWM\\\\\\\\\\\\\\\/0tNiKk9q+z2rSVo6dEAiCO2OO\\\\\\\\\\\\\\\/tb4N0JY3bIehIhLER5HEnVoSu+3\\\\\\\\\\\\\\\/gPokPFXjvnPqYnSAXO5PanVYA2udiEkw\\\\\\\\\\\\\\\/YDqO0154mJ4nk\\\\\\\\\\\\\\\/65hosStOy3oaXF2cfjkjsXktMf3PQxVQ3xZOCKD\\\\\\\\\\\\\\\/M6edsbhqGIezkwYU7k6fWUGqkINFsTHW\\\\\\\\\\\\\\\/1+Lq1dXPb46FpwX8U5i\\\\\\\\\\\\\\\/XUYy09yKrn3QHewfUbynhgdKX8mKYlUUurjIeaWT\\\\\\\\\\\\\\\/RArgOdW0gI1MqdeB9k9gg2c21lErq\\\\\\\\\\\\\\\/anSkW4reg3env491BoCpuKdCgDfP7myudnWvxjhTipVXjxWgG2LRs1lVTXxhOaUriyVapXq6VrxIX3ccp2iqZ+gEWLZybQRDgxw+kNZOaxswfLR5JjLl004\\\\\\\\\\\\\\\/2lKfY8tYxRRdZmfWbBZ04\\\\\\\\\\\\\\\/G1TS58m6Km+53J3Z1JE\\\\\\\\\\\\\\\/XqpebELe5oNG2MS2Y5pfM69g2YqjMlDkOS+sbwKmxegFSlM4jg2LC3zbTf1vQ7JbnoYWbzsCJrVJYVKlt\\\\\\\\\\\\\\\/qTU5HjYeI9Bn8oTZjkq0LMBcn4+01DYD9PVaNRcgpJlOJnxe+uURCiX2+ElV1qVZKj+QNi\\\\\\\\\\\\\\\/AcEbJkT+QJqF8ZyZSVbYriT7+QluxGBY\\\\\\\\\\\\\\\/QB2pjz\\\\\\\\\\\\\\\/XvkH+QhAHV6ixZkn7T+lucQP812us1mjS\\\\\\\\\\\\\\\/7jioihmHEGF\\\\\\\\\\\\\\\/dFQ6kmLIO7zqpjzBTyB4a27YHmtyZcDNyidQ1gO3ex23aZsRMw+I\\\\\\\\\\\\\\\/+EKB9izgnzmJzyuvVvGPHUGOcttm2nhyjJFpfcMyLoafCegIt6nyvnhhzlB1IHGW617G5XVoLmpjVR4XUWI5ALibBQckxig6uo66tdhbg+bwWuhrGwXLJAqB9s0lqhFdHjSGE9j13FKro4pmFkvZM6\\\\\\\\\\\\\\\/tZduRm1R+jDbOU6XGatCKl2X3lLVn+xXFFD31oRei4ue1DFl0klSyeEpVfSpqzxysrsV1FYgpBmJ8i6h9IjMrBzB4fSWC9nSZt1MHgNyLYfIvvboaTyYliGjUYQKbF1gXTEa3HU0ae0w5v\\\\\\\\\\\\\\\/l3fynmPf+WfvQqYe0d8VmJqCC3cEpKuv4S+pNj33UNx1I+W9Nc1I8rhiuJfWW+ZWwjRd361Wdj2lIhbGHaMr0534zN2jPHLPMfPhChJdsZqTpkaOlGSoM\\\\\\\\\\\\\\\/mYMrMqSQeS2JqQ6fkmgNZau9a8Av39slLxdwAoN8X5Gfkr4PGzZQw8KhzmBW4Ul8HE8R2rHRSyKNJ2v12Z0bCT5q43W9FlvoKlzHx6uauhayKtBnYli7cRwaRz21XsIbS8IwqciGv+XXuaF9xadk+n3IoumRM0qWLrkf35F+XsmuaqphyJV7hZ\\\\\\\\\\\\\\\/apJMc2yyvOSVRaaI8YCR2Axp3KNNul8hJ5cu0r6hFH\\\\\\\\\\\\\\\/WCz4F35\\\\\\\\\\\\\\\/Ku7XkPWsZSFJR6Br2ebzFNYped1dEcGjvnp2i6m39sp6\\\\\\\\\\\\\\\/KVvk38\\\\\\\\\\\\\\\/6d85mg6LwdlI1W2BxxHI4poSJmYxYRmQOh7GRx8UnN+Gjqza92xoiE1tOErn1hu8Jv7YEENtUA4A4wqSGAPpk0Iem21Klq1\\\\\\\\\\\\\\\/nI7wNwIWPXwPx+flgkZUhe9fyYI\\\\\\\\\\\\\\\/bZNcQNBGmHAvDI9BpCb+QoNS99XGcI+oo+Pu32ZKsieX\\\\\\\\\\\\\\\/1mZvvKRbNxrzGtkyBTRZ2SfQ1Ch+pm8qEvgU2s+eLkkUxpLf0FYPNK\\\\\\\\\\\\\\\/rzXeuYY5dLr7X4kp2PIHsGJuHvr2kStA8WFRSU4ldvvkm7fEyT4\\\\\\\\\\\\\\\/A3pgp5QWlyKEmd7fM97eg9nRtTdGv+Aq8iMARkETNFNdyc\\\\\\\\\\\\\\\/VHHyaeBzA2EHfuhW8f53TDW1X+gjL0\\\\\\\\\\\\\\\/daRSr7ICKdZly8AhQCITeONZvCeCLYhFgmuMSr9t3HHVy79vaXkkF8WT1gvRdIbnLOfvLXwmA8MPe0yw6\\\\\\\\\\\\\\\/oHaReuNcfJe\\\\\\\\\\\\\\\/eHWC8gyATOuNxirA6yMs0YcTE526wbGTaxCR2E12ujV4VGQpZ5sqHiyxArr36K+KExIJyYby4o6S\\\\\\\\\\\\\\\/Wav1mA16hnznN\\\\\\\\\\\\\\\/pIWsSPY86JvdHuD\\\\\\\\\\\\\\\/d4CJCmuYHUwstWwJl\\\\\\\\\\\\\\\/Nm2HKbHevuUZs9XgWnThatJFx+J\\\\\\\\\\\\\\\/Z337auz33s7KT1lfDX6BLF7AEcqRQBI3yeac0uCIrz7CoPjb+DMLETYuXeHbNTbTYhWNGrZ5VvERLBtukxJNDw\\\\\\\\\\\\\\\/c5Z1Ph8ZrTJtPdmgjdQkM1E4nWSZepvqwKUPliB0I5NShgTCPdA8gKHzKDkzX+Btwu0+kfMi+06Gv8L7m5rij6YxtuqTzwv7khZxEl+dq46kTgG0ZcdTm3hi0Dw7qBYe19ARM5vX9uA6VXI9uHEOELrzBZ2+sSIvjIp4C3b8P0inR4Bv45ADraOwMIeMaqrQK29gmED3yKFpLaTSlzRvzZowriEtrP2gzr7ILvet\\\\\\\\\\\\\\\/JcL49RvOCDRRkFRpgYEQsjCpukIeaul8JVuD07tEqWDLeDz7rVxsS66SK+hB8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BS5v2E1qJ0VuyJNq6wc51A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b8c0e599e343f79821af9d2a5cfba9ed0e14ffb6d61b7217522af50e006e607a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/12.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/12.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0459-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0459-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0459-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}