{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229HkrTv4dH3HI\\\\\\\\\\\\\\\/eTTIQ0zT1cj24RnRFvkuUFQ2OVnucc0hx74I+diyhUcuhQ4ZUXXsRTzpsdTOLTjDN4yTeDy2cdHfUfQhao9iKTdjblw8UZcSM1vqyY36QGLuEi9773d3fGsmtv9hykrZDBc0DWHIqXOi6heiDu9r5PPYJzCi1RpRH9U6reyNTLcCA2P4GnA\\\\\\\\\\\\\\\/jl3+O3PXytaD0JGIR+sye\\\\\\\\\\\\\\\/zGG06m1OBCOcjfL++tVsi5l3OkSAWe68wwBB5z4IXGZtdcczaLRrCiA4\\\\\\\\\\\\\\\/BVgBYY+XsPzla+VSuVqlbt\\\\\\\\\\\\\\\/z0ZTJUkgDzHEdvSLF6784M8dkY+kl8TgpXIRPeG5uGoBSCJxpOGc5HOq7g7dtIF9b8wdLcMfMknB8rEiNnH9GKa\\\\\\\\\\\\\\\/oQrN8igczmMqzVqRwzQx9N9b5PPPD+y7lJL57RcBXNhTXfTS2Q+OBvXITUFmopIpEwzwuaRMrMVqG2w5rC0NSuIBUUR7pjxC3m47h2ydxXxVrMJPjiLQT+Vuu\\\\\\\\\\\\\\\/Y18SQErl8tBKuR\\\\\\\\\\\\\\\/I6q2kbB7q7usRSJrGWQAJUIheEijkSSaiL9KeDBFcqCssnPXYmde16j46ous4gaoMYDDJVymvEEySKCk3d\\\\\\\\\\\\\\\/WoYODLe9JWLP8ymvcPxxcOHQ4Kov9ic\\\\\\\\\\\\\\\/Avaw1ulQf+Vhc3t9LpHZjeNh2Vz6p7dDbC8UkEclRoMWtQEdQbqmh1rGIsUO6vn0jiAF4dgndnKQ9v2Zy8lAtdkrxIbKru1sXtoLGYm\\\\\\\\\\\\\\\/HPS60nRTAJHam2q85m8PIOrF9PY7d0xpsGEttkbMrGthIVGGn7gF5D37NRKkrz0PkhoCqY2FCfS2lNcJTNCxXgXCxUPt3k9kkB6frBlNEktOgeEOON5\\\\\\\\\\\\\\\/JhWk+xSHXHAZZ0cdvSiK7anYC2\\\\\\\\\\\\\\\/jsXeGACe5Wf5a6Y\\\\\\\\\\\\\\\/wTV\\\\\\\\\\\\\\\/BwIb6ZfyVtxFYub9zXg51THHn5vaV7yvQ8m8gIqgxNlfXm\\\\\\\\\\\\\\\/uqp5Htpp3M54DHhYqtskkNDVtKMrBA4XDAjqgeVZpc\\\\\\\\\\\\\\\/rxgtY6b5Y7PfKweK9WXo3sq\\\\\\\\\\\\\\\/vVM1sgQSNDTVKYOuJt2HPrKuqYwjd9l6h3dJOZ7kKu4ktIyar\\\\\\\\\\\\\\\/TX2yfhK7ZPeotoNdB6tZpr47zHtT5QdnNUXHeq7mHiHwFeOuYTMta53nFePpwPlLDo1XiKzWPQIMTZKzN\\\\\\\\\\\\\\\/tQSuI6E\\\\\\\\\\\\\\\/xWPaQmOn0Bct3ArLz3dDJVpaoPcjPutU8VTfK1eSPFnpwWZBiojNu4dukT+bIHeggH5Q+e3na\\\\\\\\\\\\\\\/kkkwEj6ebBKnzjNwNcJh+N0g4JdIh0ky4X49nWz08BgK81UxvQ8QIS1gg3m8\\\\\\\\\\\\\\\/bWDPlIbi7Ae3G11LYINOKv+isskCBJdC3euwIwiu+IgnMEVirOPusTkTwr+olcMpVJ\\\\\\\\\\\\\\\/blW9aQExlRnslZz43UCAs\\\\\\\\\\\\\\\/4MiBJ8MHOMCTLu2I6THunT4GXBOiUdSotivRfXgChaChsRR0OkU8n0YZ9umaAxvm47YYZIFGYK6rx1E7S2Cm0PGHRhuKDkdNHWF1QfrHotie8R0Bxi+vTAQRYIy30\\\\\\\\\\\\\\\/eLTJl+3Tx4GuxQ\\\\\\\\\\\\\\\/HBDNRqJhxJXqGQ32jgmA3H\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+kv6WvI9nWMtpCU2ym+cQWIY\\\\\\\\\\\\\\\/dzKk+3UFOfsLW8zAbqYhdZe+7UtcVxsEIIj8EJeKW+73+KSS34IQq91JHea7HE498mqoXiSdIPNCAJzOwWMeUGMNXhi8fgwcgtwXTDnCHGQdJh+q8t5jatxokoIIuEjel5pXauacU56HCQmpV2l+5Vh35WejtUX\\\\\\\\\\\\\\\/AgZuhXpJ1EzrsNiI8yGZB21fJiFGtDClXK4w6nPUyy19YlH80jh7ZjW2DSO\\\\\\\\\\\\\\\/Ktzjy3SVTHOnjpFWKjfZBHJsMzELMXoAnvrvDO2ISv3oMaj6RkZkcDWf4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+RSYXSbMHxGNygaDrh5B+pnUnRmpv46aJ\\\\\\\\\\\\\\\/8TBd1gk49OA4mobhoX1ony9dZaZ3F5mme3NjB40Y9x9fGTi0YXYT9w3EEScnjy7rl9BBRbd8xXNgp5eWY0Wo8nQMY1Q\\\\\\\\\\\\\\\/M4Q7kPhWaUn4pnC1H++GQNHOkgGZbqO+p++CUpycwxaKYnng1vlTmUNjocubkAKf4eskGniX1fnbgDF6Udvno96ndoeAI8yFUfT8EswwsJSSqpc2Zk8Gq6Y3pfo4ZUfb9ALFHrmIgovz2jJEE99VMpo\\\\\\\\\\\\\\\/TIZwvD0yl2JzrmM4yUJ6Ftzuvt+1120g+TKB6pEoUxznQC7oS8GGXYdJCmNuFyGdZElfgnSABbDme4DYCXAswBCwVptfG\\\\\\\\\\\\\\\/36zZxI0uFAHm5q8N1E1j9llwQQllDtOPpPKrVxEE6jqYbc4kP0VhGMe0DQTva+A8iBYE5k130g6gN\\\\\\\\\\\\\\\/L7bP44K+EL8A2gRQa2wsujBhxlM2huLeAHAuG3cJgzMEyqibUymdO6S91KQhD\\\\\\\\\\\\\\\/WJUVIu4nXRqtEP5bP+F8TE1GRRLfoKoeZXMSNCGbpSyTRoEFYuOB37OMX8IzresgWECXQ7muh+SkJQjlM4BUvljPHN0Trm8nTVxRzX0ifcEzB\\\\\\\\\\\\\\\/xCM2wdStCK7rS2Sa6aeOuZJHAA4rx2vH65ATFryR0+vK7C33FTMg2BG+ziDL0phPJRA7eZmBisqjbDTrLCzfZNdLsjr+lssiJrl06uh+t0LmpEn6Qf+hetANOflLpC3A\\\\\\\\\\\\\\\/ttE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cMqwq6X+jTMYszQxSrUwvg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224522d96f4c72bb2e0b53fdbdd2bb7baa6858cc3a9e41c1b6d293e9a79b12885c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/10.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/10.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0485-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0485-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0485-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}