{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iRjKvBsRRQAgO7dSjE5q7n2ceC8b2z\\\\\\\\\\\\\\\/Sdj6Aovq9x6mec\\\\\\\\\\\\\\\/PWAr1cc4TOHi49xuOY+0ZsgNwl0jOI6VW9ySQivGwFqavPlRgwyXKRTxhQ95T9hreySj84LReGZSd5vwd8hI8Iyiv62UT50cNC9qCoDzGv3MK3OziWBtIJk1D\\\\\\\\\\\\\\\/gXv1X7SCxr3Y942qC6jknn8qXrntEEl2lgELrV93xH3wP4+Tcu6iYssc5NU1Fa+ZLA4Yjj4Bfkt2hF7BQ+zAq0UC\\\\\\\\\\\\\\\/0ffWFQ+zdWjjCA6TBqji\\\\\\\\\\\\\\\/Vuz\\\\\\\\\\\\\\\/pSFoU5Yfl7S\\\\\\\\\\\\\\\/iUnerIrx6BweBHb86VEUAkNFgMFvJN+vfClcjisqOd0k7b3FcoWyQHaNQyD0rOpbEq6FbrnWzoAX7jkJEpAnmA14405ybHkQF5L+5iJo+nyS+mdwzug\\\\\\\\\\\\\\\/WRfDnps2OlJJmUnpwNWTuYNQb+W9U+8\\\\\\\\\\\\\\\/uS7U0naHuL7umnxrISFtngQK4dYNDU\\\\\\\\\\\\\\\/nFjOPk0Kh1NTbp5u3xyAoGKF4B6H6t3nX0LMZEP\\\\\\\\\\\\\\\/RIeZT6uvati8O1gLLnGPFCjD4PJelghsUls9QOOvec90O1ncgCXwnW8UupODsXGbFmIaCi+KZMXTwxqNxVmOIzz9C\\\\\\\\\\\\\\\/+cUwQq7bG3gajPYwnXZL4JpoAQbRCtBY6KbNRO8QucVXa7ry2mtkGIWBIgAknw2QZCd6pFRypYBFc+gfdPhP8vZIMlTenzy7zF1Ge2yJ3LcSfeLkqAtcz\\\\\\\\\\\\\\\/b8bv76ekA3\\\\\\\\\\\\\\\/1QKIE33ArNAC+6v1TolMz0c2aD3GH1yVNPHi35jIX1xGEeM\\\\\\\\\\\\\\\/R8RkuhhMuY5gkqk7xFiPXRaVLY063Q8\\\\\\\\\\\\\\\/1aOry9WGdMfSOESyKhu+fNpydYO1oLqIIBN6OeXnFReCCQw3KoS\\\\\\\\\\\\\\\/6b\\\\\\\\\\\\\\\/EZR6psRUUmhcGbwFypLCak0vDjs\\\\\\\\\\\\\\\/+BDHArK7r59FqOiV8A1VDndaTXXhu5UQOXtFadw+8hRSaHAwdXG3udsPedPSO4r\\\\\\\\\\\\\\\/gt2sY6+ee8AYrMAxrjXnsvEbFiulWIxcQcxlh9e\\\\\\\\\\\\\\\/LQ+yLjHMk3dU0cfnN3odqjrSFI2W1fZJCXBMrw7Nsb2V97mJ8TOizLCXmy+wxEl16RL0ZIzloYZvMjkZ+ucROAMpqx6ZOuucXuqGcTJ5voBo9hAmC4\\\\\\\\\\\\\\\/fxzgqxXJm1EpSp8EXST1BU2G6w1m6NgK+zURjGSlGRG42HR1k729QA6TR2hukvYHC42146ofVQfKDCp0OhgHWVY7q1wrDebD\\\\\\\\\\\\\\\/DLqUTU2YCm5RTe7g8glo+1RWahNbui6M32Tanek\\\\\\\\\\\\\\\/Fw4i0GhHLFloBNatyEmc6sowasa3VYUC+X\\\\\\\\\\\\\\\/as9wWbsWyU1Ta3CW26z5S2PhYho6lQhHXhMEOyYwag9\\\\\\\\\\\\\\\/wy+AJdbGQUpmQNskQSZEHYJGaWWU2DuA7vTfewYmNRJqJHcWCHJVA3TjLM\\\\\\\\\\\\\\\/B3vcM\\\\\\\\\\\\\\\/qI0oPrNGj80fJMuQmvhCGZnArvsFGTo2qXoz3FHjmN6+tBztZZ+eh6jvC9LRDH8qYF3c38iQ+hznxWnP08m93i3QYeNmzNFr71fT3ECItU3k6zrDtp1y72kfGj5naowTBevvm1uR6ytlhS\\\\\\\\\\\\\\\/i5Eb8\\\\\\\\\\\\\\\/aouQLXJbY4CeYPhmCT0OV1u6oK37tFsc5antSggmjMU6grF4nA5TCfgIgH2uKtD04wfFg5bOA82lThonSjJT2UFkCcPTiQF2HE0uBetai8UCzQqJ3W7ngf9Wi6M1kLxOuULOwydDni6FMSAEkrMv8jJFUTj7i8Wnd7Dmtb+2FZzNkhN7i+mRpIeJDrhtazkWoTnHYkTjt5qKrtyklKp8C1tl8cb1MBnas\\\\\\\\\\\\\\\/sL5vgbzL2cl7maILvlsDa7+R2NKW0D9\\\\\\\\\\\\\\\/IP9\\\\\\\\\\\\\\\/xFbB0idh6KFHjkvXYZdyM\\\\\\\\\\\\\\\/5bKRpbExIBoK\\\\\\\\\\\\\\\/ljz3esdMLE7LJzOfxKOVGn7xQZAao05FIxRdkivg+WARKrVIEvzTL0xMUptasNZsfziIUAhhJWDv0ctqFa17GseNHh4ffTMh4Z4aP48isVJOEdw43nQyurEFkGXWjJ2ydkuAkJ36\\\\\\\\\\\\\\\/0mcUyBNXzhE5LThPEbSwIg4yrYu+4UkImuJKZh5VFr+wojn6tD3KvGs1N1NlVtk90K5RGdiASbvl9MitzZZMYWHt9uJjepNWDplJEWXlIGt\\\\\\\\\\\\\\\/yFQRBbrlFtcNmEckwiw5\\\\\\\\\\\\\\\/Ls3mDsdiOUrbAEHQnf6AybasiwFXtD9aiAgWiWhviqKAaTd4MATFcGhH8xcrJgt6cpklQ2WoxGQ6pYY\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/JuGpWcZCRlUtnVTb1fnMD53qgunx13BjymAihAKcFZkbcBIrHMM5MvhUJF2y6YcZtm9xdyP2xt1DLeId5CLnUbW63lpAy2GL6zfJP2dCyAFUMS+IyQs2uM9kpQwM7pvOgEq\\\\\\\\\\\\\\\/igEezdVcHaw3bhfniiadw65eOKgeC\\\\\\\\\\\\\\\/mNQT83JfAoYHOkmwqPINDOnOdyH+eTsd7+TDHmlpMBOItt4szqkJGumlTA9RNrKAmmsTPXiS09L3tO8zF6sTsWQso0vYOUFNSSxQP0hp1gysC5SK23K3dsGmdp5hfgvCMjqVy+RpWSsZWP8iTnCYMjDfQdQduDtbafbRMf1ecO9MpA6SfrQQkfW9cezXJhndtCFdpD5yikd9\\\\\\\\\\\\\\\/j9YXF1KjtW6QhY3epF4Od7DHYM3vSBSZGfR4POKcHsEybeVw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ATD3QE8DuckS5kyt0qktCA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228f3eafc6f9eede74698e6b4c0c250caa92243e30f4eeef3c30717f45d35a8e60\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/104.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/104.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0576-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0576-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0576-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}