{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RuZDwmxkli+rCfDVGBvO3h6kCMRb2tNquHeeEUZrVGBrTrdGhIUnj6GH0D8ECvquBDUkpHHoZCTtJa+XpBVHJEcu96DHJZQtbbJ0P1TISlV40QrFaZLRRLL48U4irG\\\\\\\\\\\\\\\/QPZOxLNkbGRJuNhws9LiI\\\\\\\\\\\\\\\/hhc9Xt2iSAnGBe0cJ0WEOarewFMSbYZ3qakV\\\\\\\\\\\\\\\/Ao+IVDO8wopou7GEeS22B7jHbOXe+iSt199tDAQ3Vttcp3PxtgwOkJOfnR57mVPp2Xsxw5gcTenbwnEoHj8\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/jucIOJz0nhP9PoUC5M9O6WZvFZlbK9+a+iPMLJDH4BZsVgNP77poyDjfSqiug6gBme5fLb\\\\\\\\\\\\\\\/znTlKNo1pec0hM591gAA5uCuY9STVPKOFPWhkagC4kH1yuc0EmTqn4BVy4SPJlT3GE3vARz6iSKq4YEyB43GlhO0O7rPwP8xaP\\\\\\\\\\\\\\\/AL648zPjjD6dfSHxxME9PwG\\\\\\\\\\\\\\\/14\\\\\\\\\\\\\\\/87BOkZnfkeTc5aJr3q4RFCkl4HMH5F8Jw54CmgJL22xqnRPpX6QhmyFzBWCrr\\\\\\\\\\\\\\\/sH6dWtC5fT1fSuwFg9UDMDpW0h5dDp24qZJRD+VBFRftJYilORbrVQNGSbg1wvY0euSZ0n\\\\\\\\\\\\\\\/TFe69I9SBk06U6Bc2hDioTMTfXMatVFQS0cHZrZwK\\\\\\\\\\\\\\\/V187jG\\\\\\\\\\\\\\\/huC2EzN3vBckgIwtolZ7x+c+wdAOEB1w1ySYF1NcmYYpVNoFTOzLwvGLKzAdH3n0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/N2YiwkfLySVs6fkEnE1pmsCgFfgGL7SlWNcFcL5SkWbfbfS3nHK1Jm9B4pZZgmZngoDzznGIjd1hOBEVHpULUWbu5ENAXjsrBHwaCYupgR9IJhujT6ehUx7qmB7i7bBz0WcI5\\\\\\\\\\\\\\\/7GR83DEbKCGy5PWZCd\\\\\\\\\\\\\\\/YF0pK17aAPZm7kYIxej892DssRnPvJg5kNf+IZlW64M\\\\\\\\\\\\\\\/PNKIyQy9WdBgNamYf\\\\\\\\\\\\\\\/+EIx9eMgata8vDPGjXABUQTRELGCoNHbFaYDEfJcuMLbAE0abw9Sv7mnDTx0jXmmUBuQ09oRKUq\\\\\\\\\\\\\\\/zjkIpiKGDf9cNS9iVi2BwP4AYIux3ClA5kKnFuY37HGgotWGPwj3hZGY8a2WkOQVa+wuOmrKKyybmMzDL+BmZwGYV8JSLk1NYjE4tN\\\\\\\\\\\\\\\/sMWx+B6nCDAtdgNxn9eIkZjlhIrwjAWxBYwIOAlsKTA9dOwq5\\\\\\\\\\\\\\\/0BQZtswAlO6qc5o8Em+cNTnP8u6fu2dAmcQhxUdFcTdVAqm+Ij04GoKmL\\\\\\\\\\\\\\\/iQn+FSl9YqoZNWfalwWGZLzYRxWExYiCzPKl0NIwpYT9Wz3dMjwTDA5TgdoizgK6NxpN9+oHx\\\\\\\\\\\\\\\/PBp9pjHuNZQZ2ZZqOu5DVc7yKGHtGPbQYTat+5KizqKcfq4S4IUauhV8COL2ZcxaqLAqm7Jex5rHcLC\\\\\\\\\\\\\\\/YzW0wIqFo++iJpIf9Yadsvsx+0ymTaxvJuj7XSdEpilpRfqRX6CBtFmqRgQ39RpU7QOGXw+G5+XDwedGRFXXg21ZSPb3fyAbjLEOhmqDFYi02iKk6Tu+gNMW767x15J06VRCFB4Ac\\\\\\\\\\\\\\\/Rvk3kQZ6TSryPPOmCfZ88d2\\\\\\\\\\\\\\\/8TbH7wZedxqve1I3PFP2oUDbpdxs5pyJ9TacI9jp\\\\\\\\\\\\\\\/nV6Y4VwCTdqP23iJuMFgE6TAz9eFT9K3UnYCwEyJZ62xn5Yeh0qQ9rYV7GRozRd8PtxXO266a5vnAaKCsbc6ZhPVR9ogSAjpFP8PQqKmqMRxowgdLALzkguiBzTo6x7rVYzhi4TOq2hnbrVffJxyCyhntzPUYL5Bg2JCvxB72e26owBRXv6Glyz1U7A8P0aZjslHvoj8HwzzMTlk8dskVX7SsLUXZwMIzCUd3lta4OKjbKltKvadvLgRYv5YglzHV0db29Twf0L0J4u48NrEVrqhKYN4DGo36btuHoRlR\\\\\\\\\\\\\\\/6GzSSOMPLELWhpySkregc5r2xVuVnIShUmd9G1EOs3LVzKIdhp1dxP9u9V4wAFVGez3z6FV0CJv3dc59RVF6xVSmTZW8QulwHMACwmDyvr+KgXZcaopJEQsvtlrYc1\\\\\\\\\\\\\\\/pLmrrzMhqvZu4YFjlcLNLiqTHePEUT2nyI6898Jgz\\\\\\\\\\\\\\\/NSV0MTJcLTn9dk9WkBUmdecXye9ctJaD5XSR0tKOF\\\\\\\\\\\\\\\/6hbUR\\\\\\\\\\\\\\\/gUqfzRC5hbxUrNYAf4qGvUqAJ5\\\\\\\\\\\\\\\/737ujMnryHOQcYa7K6\\\\\\\\\\\\\\\/DVFIhc0J7Zfs6qXVdRd9+vf86vCKDpklsXCBngTCOCyqS+QFUCP\\\\\\\\\\\\\\\/UVzGpEQtuDJGO3kh6anLKEM4q5AkHV0Atkb6GUGBckscnfS9MF5g3D9wuHVzG7WtgG2Ws6+G\\\\\\\\\\\\\\\/rO+6EUFOsOAQyVhr+sP6fsuZ4j3xaB9RX1YbO8awFhD+StvyI74\\\\\\\\\\\\\\\/FRsY4YOGXX3Wzt8D+2XY\\\\\\\\\\\\\\\/95OaLFTiowXtJOWjRG\\\\\\\\\\\\\\\/Ac95m2+PrrHjU7aRHpDUKUIDiM0\\\\\\\\\\\\\\\/T\\\\\\\\\\\\\\\/DlAYzet6mXC6PIJKZTGJ4T3fKimxVjwmFCyw83CNcWfhhMwIUc1RjQTEF01okrMpHslKSlo75QHxOBZqczZzMBQ+3xk24Dudc\\\\\\\\\\\\\\\/MhqjmrE5d4KZZia4VTr+WRAhXkoFB0m62L38dF1ZGrWA5ayLwfNYmweghnbGZPPBLf7C1ab8PlGBX8xpneq+oUdbQPZbRDkLX6EKEFXv0ZSEWPqf2urLakdaY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QS5I+ZzEh2YiXWccvN0k6w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022708add75de29412282ec5d78920d1be49e592f817c3793652942e73ffe7af442\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/175.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/175.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0611-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0611-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0611-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}