{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022040U2Dpc1MjbrtA93s1lCJxdq4S7ij2xuyv2gV1gM5HtZYdFPWP3fBuUfEHO8Ajg42EBGxeUw9toCNX1gVt+bTCkeUX0eBSKKVEFVLqxvzjNAEk97g7qgm\\\\\\\\\\\\\\\/i\\\\\\\\\\\\\\\/YpY6osc3yhSbnk1Re6aSQk4QSN+VLMj7Ssi688yZh2V39jUFhksw1fLc+5VFNNZXe0cAZDxuK4lcq1smmaTb803kcTmlUVUg+a9KRbBl5eD402BUVZ+CsxqOpwfVgB8DXV8FU7RfNRwKrb9CqCwe3GSMXGDHEgvyQTtejONoG64u32MC5bhK+uHDffmlS5L+\\\\\\\\\\\\\\\/1Yi2+w5Ng9A20fp95JNQozyM7FSciz3fxrc50KrfW43cAOPGVdLWtHG67vMuEHkR48fQO2HfX0zkUejFDkZjIyDOiieh9Tkwy6wdhAUsN+gINmLJV1BQDwgcJouAiNtdo1Aohgy5AGME3PwFjFXaF5LBH2EGqpXxvE8PH3ByW2mfHPYhT7gJOY\\\\\\\\\\\\\\\/VILa7dwy8Kl7qMTyE0IYe3y05Mop14CSKS5nlhDnxQlmAsRoyb4PUtaCimPVq+EqTcjopU+Qke42Ft9O76FWHGxzhjd1wE+P43o1lH2PSHCmrJsvNvLM+R2CnWaOxlKuGYBTLEAaQ+Ov9BDhx4zwrwXwe5bBNlH2TJuqxiFPAWaAVgQ2Blc80mHZ+W5o0i7z5xdmItiGXdQO9HU13M6LNw5ccKJxYgKLDXFLoKG93\\\\\\\\\\\\\\\/qYbykN4\\\\\\\\\\\\\\\/8tAqGS9KgmROg89tfjx1o4n0WpXIiIBUmXy8CZBClj42QJVOwGR9db4LE\\\\\\\\\\\\\\\/JEOVPbzlhvo5q8Fh6ndqQerLN+mQJwwMK8I5U+Uo9pH+NVagp7k5kEobG80WcL31jC06C0gPfvLGlg0M3bc32mBHd4ckE7BWr+JnR15BvYBaUm+b8wmUP8yzu+kGfCWD8OuRucqOpVSTKhfIOWUFf26zFpywz9UZjw8vx8B7poSB2F7CsBuDDX9XJ7W8YqQUfpOIdljtixZKKJFkWEXq3rTnXr07+0mjQL08b1rymNJ\\\\\\\\\\\\\\\/U2IMR1qJRvo2HdAvOE7m7dAePVrIYauHmAS\\\\\\\\\\\\\\\/Tcuw+7GgW8FWnXlLq4qTmKQ7\\\\\\\\\\\\\\\/Hyzkdx6rjX+MnGI2sKp6ke7IPGrHx6vsShc+F0CCkRux07tiyOYbbsunYMZmybnaMVSkEnFpOvq2Z7mVGrkQInkwgmkydSSgcuckYHxHqzpaNWq6W6fijoERDxLgJEUOubjU9JHS8X5Cg4zoPOuh5gYrLz7O1RfVnRvJPHHU4iMUBraSp5ka1QWD3lwvYmc0hwVWpge5Rl3\\\\\\\\\\\\\\\/ma15MIMzIeJjmXa14pzKzO5k9mtVNMH6QsvfDsbhfphJeu4PCnH+wSANUnjGvIaKktLp3c8lUrav\\\\\\\\\\\\\\\/jIBw\\\\\\\\\\\\\\\/NE0xRdGejSsC\\\\\\\\\\\\\\\/yhkWXZlLR4CPRnjmyM00H6CoiM0SpTpO6hnrO8qkExPsPYiLEbATXJOlqyzLJ3OWVr+7S2aY9hajCkjKe9R\\\\\\\\\\\\\\\/tAblxBIggo5n7hFI\\\\\\\\\\\\\\\/UQW5w1OLZ5SjHbI72S0ahLbw6AHGwsbmOcCT+0zYQPRGe4rSf+Hlldwi+fe\\\\\\\\\\\\\\\/k4F5rHreZ168Uwlj5gGqeUT154qcU16KgcP6RuQY8O7Yzog9FXqJ1afeCe3cMjDX1eHU3khcN58gXMxBj+TRlxKDylbsRVcW+XL06xBquXRWJ1IvRmkiPUNswx1RT8ClZr909YBq69oW19\\\\\\\\\\\\\\\/dMc9CLokhj2k9A6q7XxNQcP269Ugq+m+Z2KtBgQChG2sUFInJXshmoeR7fjlpt9cAuSVg1KXHh4+hJ4+KSAugl1jEQyQBFeaEKGFdgmE7teYwYy8TG9cm0w4tsdMU9RfiK83lrG2Qh9Oc2Th7Tj+lWCVoKN2o+PzXUDjecU+H5hsrDxqNkPpwC6NEyPLjzGWkF89Vw\\\\\\\\\\\\\\\/DPqCzcYMea83gwOTv4ny9uNFUk+Ka1lqMmFGEd+m+zVAtlp8Ca\\\\\\\\\\\\\\\/g2aVBrgq1CNDBCAzcdHRLsTn\\\\\\\\\\\\\\\/T6R14njEUrp\\\\\\\\\\\\\\\/+vXT5VCVAFhlePhp4rZzAH1yasbkfjBExmsP8xUBFoLCl56FT+sC+NQ3qelbDyq6BI4vQjxVK1VIpcHUGp2af2t6q5X1r0eR+kdOU0YOhAGRTLP4GvjhmpjFNoCZxTeunMutOEQ5ldSduqHe85lgA7AcHmlISvcIuL2PkhGZvpUwH5ftEEsYVTswU0Fx+sv0lQSYaYJLS3aDsB0SASbsPaTBte8xY7rCTzjUJdRDlNdZh681U+oc20ghDK1q5QYdgNv9KnEdJ\\\\\\\\\\\\\\\/e6yfN2cCm5wn8XqYzt\\\\\\\\\\\\\\\/VBzZqsA0ieR70gBXo7H8R5pXzxiBNpM\\\\\\\\\\\\\\\/eh4QMaYeTPdEC8LCwk4u1ErH8yevGVmiKtpTBdImAA3YP8lFAc85UjcFKG9hpMshbIeGuidUZyZHp6TTRT09DXR4L\\\\\\\\\\\\\\\/my4F0AINun9ZIyfgCYhk\\\\\\\\\\\\\\\/ONB6qxbg\\\\\\\\\\\\\\\/5gKXuZVhZ6wFGB43jVPfIS8dN0h+kMeKPaSxJpzlMD3ZLwADCmAiFoaYFR5oreShoQkR\\\\\\\\\\\\\\\/pfyq8TQmuFwyVGzQkH2X5dLt3tO\\\\\\\\\\\\\\\/k\\\\\\\\\\\\\\\/dlLUlhhMSOpFMDWzKG+ImVqzyxjJMvRY\\\\\\\\\\\\\\\/MbtVT3QBVmlYtR65yLTlLyfo\\\\\\\\\\\\\\\/JNQVGBJmqqMnO00ZvuaUOJXVDa193TehRZEFNFPUMpC94M5l9dQUpCOrNSNJJum\\\\\\\\\\\\\\\/qMUD3shqST1Ac2or\\\\\\\\\\\\\\\/Bee7aplSLrehlCz8PjSO1Z5+hmsk4oSqUlVbIdpCxKdMNLH3QcTRJ7m75JqPj7fqCJ+tp3+SGX\\\\\\\\\\\\\\\/8H4jbxVrQzHW81D\\\\\\\\\\\\\\\/IxKnD9Bi50eFk7XbQmwjOtO9r8PI7WT7AgYZThtFctHdEIUFFWulJlVmIeTIkwHiwNPB9ezz1Rq9OZGgkTQMtSLK61tILQvPS6rRCif0hwHYOvP4+TLlgP8rTdIe4\\\\\\\\\\\\\\\/f6MWgefT9dmsFB3jXzZHq6s4jA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BKlj8pttCYZC+jJu6lX+oA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002252559f4816e8f510ac73bb2cc33d7d1fe30d7c6203c905e98c72b4f554553029\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/120.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/120.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYixin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhou\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of VIP region\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhou%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYixin%20Zhou%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZuan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELin\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Clinical Research\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-6\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lin%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZuan%20Lin%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXuanye\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-8\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E651 Dongfeng East Road\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E510060\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXuanye%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EChen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-9\u0022\u003EDepartment of Radiotherapy\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-10\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chen%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AChen%20Chen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHongyun\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhao\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Clinical Research\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-6\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhao%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHongyun%20Zhao%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShaodong\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHong\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-8\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E651 Dongfeng East Road\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E510060\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-5632-6857\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Hong%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShaodong%20Hong%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EState Key Laboratory of Oncology in South China\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECollaborative Innovation Center for Cancer Medicine\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-8\u0022\u003ESun Yat-sen University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E651 Dongfeng East Road\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E510060\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGuangzhou\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CN\u0022\u003EChina\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALi%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node9244\u0022 data-node-nid=\u00229244\u0022 id=\u0022node-9244--21333906875\u0022 data-pisa=\u0022jitc;7\/1\/120\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-019-0600-6\u0022 data-apath=\u0022\/jitc\/7\/1\/120.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZhou\u003C\/span\u003E Y\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELin\u003C\/span\u003E Z\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E X\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EFirst-line treatment for patients with advanced non-small cell lung carcinoma and high PD-L1 expression: pembrolizumab or pembrolizumab plus chemotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2019;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E7:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E120. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-019-0600-6 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EJanuary 08, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; The Author(s).\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}