{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wUEvSkCtZkgL6NSWwZI5rE79hLGgwQtCFtkwV6duU4hz+uhBxK2KZYyM6CY81wW25+WA0IU9tsUiZ8IRqa+FZ6D3c4JzcuVxDRUDvluN9OlO10mDKfkCm71nO0lGDstr0coLUhnhZFi8TgtTO1UeelOIqIuH\\\\\\\\\\\\\\\/K6qBqTIYuyOk2VMDGoU9eBTt0CL5Wj1qBIzdreWQ1txMPBq+V2ao6ytbfqwsQLsFO2WAYbgUS+K2xJDMec4OgozPo+5+5oPeThoKyLe2qRXkh5M6xG9qeFaCp6pSszLHj2U2Y8\\\\\\\\\\\\\\\/XNKPT4os5xVebwURtVOX4QypeuyPrJ7FlPA+UFyklhLC4FwW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/hE55POmxaA4Zo6xfHnhNfgI1bXtFdlUIG1d+QHuaAE5DGnqlsDC5WREEujdagVL6vTMZuYAaZ2Kvae9CxflYbsQI1U\\\\\\\\\\\\\\\/Y2WAzwicq1cjmKFPbCBzSiFEHokmLIt1vtdJd\\\\\\\\\\\\\\\/KxWcsQ1LXS8BTwvJyhcjnAFGBBGwDpWkpfvc909AGIjLyr0MIALg6aTfH+8t4uo7ky8aQ+1CqiMKB0farL5m+nQL5ioXhXyQdwtYfH1c6WyWH9VhbeNSwkEvEOG1lNCKqJUIDY+lM9jse5Nenzj\\\\\\\\\\\\\\\/Oi9+dbrK3lTP8T98EZwXx8\\\\\\\\\\\\\\\/khjPY2lmKBp7MIiWuacKH3n8mKPaFOFUZ0Z\\\\\\\\\\\\\\\/BfnnFm07pRvzvJtsvw9CtE56PKNBNyAJ3MWlf9n+d5zmBG9ym5uB5hegqy+VvoIIV+4hlXmsaMcbhK+rRNANe2bwD\\\\\\\\\\\\\\\/kQMDjgMQQKb0ecv+KrrLP3U7s+Z0Fu9eczyxW0YsqD3ct2tpvk8ItaETK4zTHJsf9mtDjAm4PLO8KCcEQ0QeVFjdQEEGumss7dPdn+8djkQMFQSS8m\\\\\\\\\\\\\\\/508JMhXbh6gc9p+ZtaT1nl3mmL8pB\\\\\\\\\\\\\\\/pa2dPtZGFCQalyEYDuvP32s6xcJkvsEsvgleDOzJi7+nDziRXw57mWluu4\\\\\\\\\\\\\\\/D7MyZQpnA+5sGMf+Q7vxocRNNsp0wozGfi\\\\\\\\\\\\\\\/wFGddjuYYBgWTjQYtDDhZVD07PHkh9Z\\\\\\\\\\\\\\\/Sk0a3SXyShjCX5RGOEX0hhwCLdW1Lc2\\\\\\\\\\\\\\\/gGngMSbvprRPpyMd5YpDTFgTS8n8EE52OR0+aFCnXSAIIdcF2dgHstl0wwM0XZCcgLxjHJCkR+qzOTEZTuk6AQFH0KmgxUuYXRpOtLb4HzU3jUAW+PlB3UHB0fRffgZuV8rXxUgWH0FL+g0z9Kz0Rm5h5+JbDuIgGiobD2yh4WXjMBSOrEfpmr6D+kfJ\\\\\\\\\\\\\\\/HVgJlxs\\\\\\\\\\\\\\\/7Yk01sTsdPA5uivmrcI4lXhIreEL8wpD+tYe\\\\\\\\\\\\\\\/CoI1JSowO76I2O+V9tU51F\\\\\\\\\\\\\\\/vcHzZruSCj6j3FJpc+NyeVGvM1l7Jd6yoWL6SCnmY51g34+8gJ8rIigP6UmsEfjuZofJ4sGc7vIvyx6zr3FmUtpvEpkfhOGQcb2i44ErvgfeMxJr0gCqTc1SO3FxIkQHGLl8oOtGwvS2kUqa6z650kgGpxAMT9lpma7JDEPBUmYI44y1srjNG\\\\\\\\\\\\\\\/sGC8MPnhKd3IO\\\\\\\\\\\\\\\/meCdfUQX\\\\\\\\\\\\\\\/KWeBwSrCxmrQQNltaOgopvYTwS9Rlhxeb7IPJkF60Xh8T4JbC20K5OZrLVT4PRGZmGqRdrQxlGnpwlnH3hIkn3MWI\\\\\\\\\\\\\\\/DIqWncdLwXYqbEPMFOwd\\\\\\\\\\\\\\\/nM1hLwzrExhBnnzmLjDBGv47Mw76X+PaGFoubJXKUM0CDkjsF\\\\\\\\\\\\\\\/NUZHKkrwuvLsII4mKDA0W\\\\\\\\\\\\\\\/cowzny3LCPlLfW9DwhlmfdL3g2Vl0YsHC07n1LzCoweASrsvwPnTiHjTddzmjxo9\\\\\\\\\\\\\\\/d66DFDCWElyZEv1GhrCY7mVTFlSrNnI8MaYsRx01JRc2wW9TjjG\\\\\\\\\\\\\\\/h8KP\\\\\\\\\\\\\\\/pQKqo\\\\\\\\\\\\\\\/WqfO7rfFPNfsEHXM1hGBfi41pSfgBQuGoNffhG\\\\\\\\\\\\\\\/kSvAPlW9S3vurP9tmoTN\\\\\\\\\\\\\\\/koEpVRjvYfo\\\\\\\\\\\\\\\/BapidI9qAq6JFOnBRAv2sKbVmW4Uzedb6s6KoV8DCRSmtI+5EChvtWOuzXDluJ6hIChkmDfJjklr0Nlh1Bo73KQTWlVg2E\\\\\\\\\\\\\\\/k1gU10twZ8XQRrKgp\\\\\\\\\\\\\\\/ohGwFxcaUqZAXoxfe21HaGTEst1ASneSs6n0xtnJgggfedQ27Bak7hr5t6t3sihiIiMetOrI\\\\\\\\\\\\\\\/dCC6QmDw8uBa8Jj8gDr5rB7UdE+lmtQ56qjnAP4Bk+\\\\\\\\\\\\\\\/0O77\\\\\\\\\\\\\\\/a6w1uPmqxAwgGunVkgnmpdTeBkUCZTK9k+nDYnSRHN4n7W9EMciBw\\\\\\\\\\\\\\\/8RQwa35eO5Dwxzn51Ma7L8HClCclfErcpjxeco0pb\\\\\\\\\\\\\\\/R+nb9LK95ANjq9mVa5Q+LECMuu1T86tt+FeKwb84GsEDV1PYYvPXU3yTWY\\\\\\\\\\\\\\\/pkhPG+QPfSnRDsrwe2MNBDp2VKcqa0iRobre+lcemJFZ3COsnaw7eWwqUlpRwZd5IGLT3rabetiTwiQElaH5wLAuDSsIXCmdyrY3BZPsBqDTGzpujDYNjNlW7q8hYy9qwJNN\\\\\\\\\\\\\\\/H7p6Xpto1MYPb3oVOztAob+nS1xO2zM9k\\\\\\\\\\\\\\\/uceWcFkdueYDYRVmIC\\\\\\\\\\\\\\\/oNcCBB6pGrhL49DjVORNNPFa9YoyrG+31cwmac9A0lOauk6ovQY2axIhNyWoEq31RdzOwSXsQ\\\\\\\\\\\\\\\/bPtk5nCw4GJNgk5m9YJsfQj0h1UdBia6OTr17X2DikzkccNzfPuE6Bddmq4H4UXbaFgP8mTId+fyQ7jjNSP8trJywaCvR78OS7OJ4iBFRde27U6AB4uQoOTW\\\\\\\\\\\\\\\/GBFRE+um2tRc1kFLieqCWgIzOcE\\\\\\\\\\\\\\\/QzZH4ewsYYieVb2eSFf0CIWWkbFJ1HZ96VNqBGqXe6AF4wozVXdnLrj7URMHhKF+RqOUXpWAVUTtjFb6+kvHwvvJ6h1jl6MHrvKGlDRtO1YmTz\\\\\\\\\\\\\\\/YURKnSgWhI1YrVxFsZk86XZXDZErTDTjKqGNMiagKH58LfOQeWnsZaNJnLDi6MbDDADkMRSw6vc1Q==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022l\\\\\\\\\\\\\\\/VZUXfyq5Pq1n1hDzy6aQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ff0e804b56ba1b5eaec9ba9550dfaa70f15672d0cd173974894d9ec69ac720e9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/157.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/157.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESaman\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMaleki Vareki\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Oncology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Western Ontario\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EON\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CA\u0022\u003ECanada\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-3\u0022\u003ECancer Research Laboratory Program\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003ELawson Health Research Institute\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EOntario\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022CA\u0022\u003ECanada\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Maleki%20Vareki%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASaman%20Maleki%20Vareki%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node8133\u0022 data-node-nid=\u00228133\u0022 id=\u0022node-8133--2692104545\u0022 data-pisa=\u0022jitc;6\/1\/157\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-018-0479-7\u0022 data-apath=\u0022\/jitc\/6\/1\/157.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EMaleki Vareki\u003C\/span\u003E S\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EHigh and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2018;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E6:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E157. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-018-0479-7 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 10, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; The Author(s).\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}