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data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-4\u0022\u003ENew address: Immune Insight Ltd, Biohub\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EAlderley Park\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECheshire\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cumberbatch%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMarie%20Cumberbatch%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMargaret\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EVeldman-Jones\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EAstraZeneca Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECambridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Veldman-Jones%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMargaret%20Veldman-Jones%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShaun E.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGrosskurth\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-3\u0022\u003EAstraZeneca Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E35 Gatehouse Lane\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EWaltham\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-5\u0022\u003ENew address: Abbvie Inc\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E1 North Waukegan Road\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E60064\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENorth Chicago\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIL\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Grosskurth%20SE\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShaun%20E.%20Grosskurth%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVasu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESah\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-3\u0022\u003EAstraZeneca Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E35 Gatehouse Lane\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EWaltham\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sah%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVasu%20Sah%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlwin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchuller\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-3\u0022\u003EAstraZeneca Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E35 Gatehouse Lane\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EWaltham\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schuller%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlwin%20Schuller%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECorrine\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EReimer\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan 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class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESimon J.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDovedi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EMedImmune Ltd, Granta Park\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECambridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dovedi%20SJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASimon%20J.%20Dovedi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPaul D.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESmith\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EAstraZeneca Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECambridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Smith%20PD\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APaul%20D.%20Smith%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERoss\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EStewart\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EMedImmune Ltd, Granta Park\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECambridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Stewart%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARoss%20Stewart%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERobert W.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWilkinson\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EMedImmune Ltd, Granta Park\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECambridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wilkinson%20RW\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARobert%20W.%20Wilkinson%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node5528\u0022 data-node-nid=\u00225528\u0022 id=\u0022node-5528--2318210634\u0022 data-pisa=\u0022jitc;5\/1\/63\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-017-0268-8\u0022 data-apath=\u0022\/jitc\/5\/1\/63.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EPoon\u003C\/span\u003E E\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EMullins\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EWatkins\u003C\/span\u003E A\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EThe MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2017;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume 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