{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00226atbgALcMZRMCdP88K1cf1HPNi9KEWlnWny9kOpDbomiDRI+KvMYU\\\\\\\\\\\\\\\/DcpDnzLpm6bN0W03tMKJFqbVtFXFtzkj8zef0KC2RYCNteoJXv7M5JESzu\\\\\\\\\\\\\\\/EntW22KABVOKg\\\\\\\\\\\\\\\/NmwOCpYleeXwHjolgSRsQjsx1T36F0PWY6BSaayNk02vAMRIJwRgxaobiw5Y317WTj6PpCeM1wGXoWn\\\\\\\\\\\\\\\/N1JKKWtNR\\\\\\\\\\\\\\\/MAPRjfUzQCh2THKvUK19TwaUBymLRZZ8GCG8zdKqFRSdGWysGfsCdj2RBeCrp5tQF2IZmJJ21JAbI06Nz6WuSSilrvpEn6eAdBCylK5lh9Nxzo8F3UFpiQtINKV3j+qe5+EHOhAWrbE3+perk7UgkWSY7a+W0mfpXv0ExG5NqGezDVCxZSkZN4LGltghOqj2+VKtoXnQwUKu9jUGmHo\\\\\\\\\\\\\\\/po\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/l\\\\\\\\\\\\\\\/U9+mJ1FdFAjV1wrBcZNbAGq6ENzw+5cHqTjh1NYRQJ\\\\\\\\\\\\\\\/0BifaFIXmPG1J6YVmJnJ7B+cuPJASRs6638cKbzT7ETvNb1EHx+M3a0Ht5+BqZJgJDvt+fEL1ughxVzyq9cgAm52omElppt6lZQdLfdfz8U6wmq3lM\\\\\\\\\\\\\\\/vxvwy9F2VctzRvKJ4Lxar9dIiCL0lBl3Tc2QwHYO\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/VcojnqnS2ioa3c+ga36lrfRPKNC\\\\\\\\\\\\\\\/J38h87tSFTdk9YhycxNJnc+i78fJdN2FQ0LcMVIpizFa8SOEevr0x+xSKGE9LK6cz2mduzskmfzsZqDErn6JwcrXGWAwG7MYdpOJw0AWyN2nHEs9Oig\\\\\\\\\\\\\\\/qgEFq+gXULfCRuQSvlD6AlMqNHMrznxbj8koCGsBlrVUkXog19iO1lKXNV7d9rm9N6dkH8eeRWXPdkSWoi5Au3aVYiZ5gEdzZV2bqw55cNO0TTuybG8RFUZl6SFmsWvbeywp037gY72tl+4Li1MFcsriA6fnN76FAIw37y49Pqx\\\\\\\\\\\\\\\/BufUzAfxWmDKEqXy1d2bE+0Ab9ygv7DD8Iwm0+AaCnwjMgMqMqQ2TimMmUOHryg4fv7p7rBaV87bAxQ+\\\\\\\\\\\\\\\/TWK3gxxyhMFnituGUfxN2NFCa5+sAErtZYohU\\\\\\\\\\\\\\\/MYReWuDLGBW7c9GHMVTZT0dXmdoQ3r1vi6AuX\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/dXX1OOWGb6OBD696www6jnoj+GauPvTvEQaBcmAwUa6FCk6vto9jUyomLDXbmwWepWF2y9c\\\\\\\\\\\\\\\/SQZMcnbPuMHNDVl0yyVe+tuY5kpdmFSKggxpneZRO2v1SvUys4X2HVX54MmSIBoRJc1YpIg\\\\\\\\\\\\\\\/JUXN7VPP7wggry+Kn6L4FE+6sz+OD7\\\\\\\\\\\\\\\/V2G1AbT1lX5hwga27PBp1Ng4nkOwgRLVFaaDDnq8\\\\\\\\\\\\\\\/bWC9r56IJoV2pwC4JA2NvJkXtAt5wnYMt3cm2P2Te9lAvzC3wnahD1j0KMSzZhr6gJHhyYgwIvb8nc4FMCufU\\\\\\\\\\\\\\\/2ChpxB9RY9IixGwOwddU7D\\\\\\\\\\\\\\\/4Nh4XIcqgayCbOAOsnTcc\\\\\\\\\\\\\\\/8D1qkkD4i\\\\\\\\\\\\\\\/Sq9jGUWBAfVXwGdGwOhlp6HL1Nbwi6dk4e+2c1ncFWldRxGiHC1ZuvvUsHnzvy414yspdAq0IosLN8TRntVUoXmBS3Q8ZsMMksH17Mq5+0L+zw23M\\\\\\\\\\\\\\\/8yvbmG7W1Bys7VG2F9NceAd\\\\\\\\\\\\\\\/8wJuURYlKYMIojlXogk+4P6Av1iHH6FcQjPBQERO45P7Pr\\\\\\\\\\\\\\\/yOlFlD\\\\\\\\\\\\\\\/QgsqxXt+Z1ViwUPfziYXS2XvPKMt40kOLHPCKSyGLuvyzOVvM0EMLRipnsvVBmhtXWj\\\\\\\\\\\\\\\/kCJ+xM7QLIf\\\\\\\\\\\\\\\/E6ppC9XcBtrMeZYgZnRtjKlx4DQZ+Kvb3AD93iin78Zb26IZIONmAc4qTWzba6yNtK07Lg1Jj+gsVpX1uBPruG9KqFYMXakgYYAbJQtl\\\\\\\\\\\\\\\/BEyfjqvZZ8xqIpq7X9AM7K1NM3YE6P0DyoURckJ\\\\\\\\\\\\\\\/iEaaUrTzHhjuNTh\\\\\\\\\\\\\\\/4s0+NlKB7rs\\\\\\\\\\\\\\\/GZeRS3a50rm9izPzXVABF8laXYE9h179p6qo8U+LeQn++fT+UQ+oNV4Jyq28KtsvGnKue8rqauby3KgJ3\\\\\\\\\\\\\\\/AuaOqZ7WoskUsi+JvnaKTcBu63cOvqlJMAFz0H2C48D6etrWRLHm41RWggWo4lPuGlo4SIEt1+EmPyHdRLvcTs9V4oe3kNQ4NuOWHK\\\\\\\\\\\\\\\/EnNCVx8O7lqXETaga9TADIPJ41yKYNtNaxcqZEe8aWuwgCfTSVyVRtDfAFgfV5QKVw86tHf3XFO25tZAetjqB38UvpTDiaeT9NKxJsWntsSKJbKhM03NBFScSvYUkk2aopCpPk1kH22AtmDHvUp+HI+dMQAKTvzND2uERFIxyOOZYB9bT7ydvhiVvaZt2mgbiSILwrEsESujGfMh68rXgHRMx+o59wRvC4ij5m4eOx2WQZ+ro9Y8tMCqf2Ya1K+NNOMhdouhoRfzE1ayNl\\\\\\\\\\\\\\\/EUSxrm1nDKkGnFyvekmp\\\\\\\\\\\\\\\/PY0bZ81Z2zPZBr0I4h+qo3UAaZjkvHScjaZdiF2igAY+tWi6XYOvTBB\\\\\\\\\\\\\\\/qacRz0zjAQCaCIp3acQac4XyTgzbU6vne2l\\\\\\\\\\\\\\\/oruCPfUKgmNnHo9qXvaWt1WE1s4j9fhY03LRs3jFcEKXKlBcq3fENz6nnYlwxjse\\\\\\\\\\\\\\\/WKcGcb2\\\\\\\\\\\\\\\/fZt2\\\\\\\\\\\\\\\/FsMr9cQDySPc0pDcL7M0BZX+SdoQkoSipfIuBhYfGj4+kcgR5WIGKe+I8tzKFll25vnf8FyhmvQBy\\\\\\\\\\\\\\\/1cATT9WAYv\\\\\\\\\\\\\\\/nDg14lazxaEoj9OWvoDhYaeuZROaMPaHsODdqmfe4GSA0GG8fp\\\\\\\\\\\\\\\/U9xgapvjnw9A3nawZ+4zY0\\\\\\\\\\\\\\\/w7WJFh8UjPmSZzWdxUXbONsIta6xg\\\\\\\\\\\\\\\/kbyVqYvF+obeSHlNurFwTo3MYr0455V1S+U\\\\\\\\\\\\\\\/RXK62zzaz7KjZ704K3R8kRZnuPBigOwigMZMWUU62lCVPweWrQe9Z4Aq3OC3\\\\\\\\\\\\\\\/EkFDtNUfL1X4jPOaEhJzFUuelXLKBQlRR0RQMZ5DggQ3fIkA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002218BvZAtiftXhJsTerhidag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022012fb1f9ae8c5eb120b4dd9483b89ce1025b9caae3f7be2bab82393f148da1e7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/5\\\/e008689.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/5\\\/e008689.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMichael J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EOverman\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastrointestinal Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_4002\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Texas MD Anderson Cancer Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EHouston\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ETexas\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-5377-135X\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Overman%20MJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMichael%20J%20Overman%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFabio\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGelsomino\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Oncology and Hematology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_208968\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity Hospital Modena\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EModena\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Gelsomino%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFabio%20Gelsomino%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMassimo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAglietta\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_18524\u0022 data-hwp-id=\u0022institution-6\u0022\u003EIstituto di Candiolo, FPO IRCCS\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ECandiolo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Aglietta%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMassimo%20Aglietta%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMark\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWong\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_200123\u0022 data-hwp-id=\u0022institution-8\u0022\u003EWestmead Hospital The Crown Princess Mary Cancer Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESydney\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENew South Wales\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EAustralia\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wong%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMark%20Wong%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMaria Luisa\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELimon Miron\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_16885\u0022 data-hwp-id=\u0022institution-9\u0022\u003EHospital Universitario Virgen del Rocio\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESevilla\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EAndaluc\u0026Atilde;\u0026shy;a\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESpain\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Limon%20Miron%20ML\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMaria%20Luisa%20Limon%20Miron%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGregory\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELeonard\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-10\u0022\u003EMedical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-11\u0022\u003EUniversity College Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EGalway\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EIreland\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Leonard%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGregory%20Leonard%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPilar\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGarc\u0026Atilde;\u0026shy;a-Alfonso\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-12\u0022\u003EMedical Oncology Service\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_16483\u0022 data-hwp-id=\u0022institution-13\u0022\u003EHospital General Universitario Gregorio Mara\u0026Atilde;\u0026plusmn;\u0026Atilde;\u0026sup3;n\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMadrid\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESpain\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Garc%C3%ADa-Alfonso%20P\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APilar%20Garc%C3%ADa-Alfonso%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAndrew G\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHill\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-14\u0022\u003ETasman Oncology Research, Ltd\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESouthport\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EQueensland\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EAustralia\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hill%20AG\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAndrew%20G%20Hill%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAntonio\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECubillo Gracian\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_221921\u0022 data-hwp-id=\u0022institution-15\u0022\u003EHospital Universitario HM Sanchinarro, Centro Integral Oncol\u0026Atilde;\u0026sup3;gico Clara Campal HM CIOCC\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMadrid\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESpain\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cubillo%20Gracian%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAntonio%20Cubillo%20Gracian%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEric\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EVan Cutsem\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-16\u0022\u003EDepartment of Digestive Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_74883\u0022 data-hwp-id=\u0022institution-17\u0022\u003EKU Leuven University Hospitals Leuven Gasthuisberg Campus\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELeuven\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EBelgium\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Van%20Cutsem%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEric%20Van%20Cutsem%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBassel\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EEl-Rayes\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-18\u0022\u003EDepartment of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_23034\u0022 data-hwp-id=\u0022institution-19\u0022\u003EEmory University Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EAtlanta\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EGeorgia\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=El-Rayes%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABassel%20El-Rayes%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EStephen M\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMcCraith\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-20\u0022\u003EDepartment of Translational Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_480678\u0022 data-hwp-id=\u0022institution-21\u0022\u003EBristol Myers Squibb Co\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPrinceton\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENew Jersey\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=McCraith%20SM\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AStephen%20M%20McCraith%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBeilei\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-20\u0022\u003EDepartment of Translational Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_480678\u0022 data-hwp-id=\u0022institution-21\u0022\u003EBristol Myers Squibb Co\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPrinceton\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENew Jersey\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=He%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABeilei%20He%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMing\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELei\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-22\u0022\u003EGlobal Biostatistics and Data Science\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_480678\u0022 data-hwp-id=\u0022institution-23\u0022\u003EBristol Myers Squibb Co\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPrinceton\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENew Jersey\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lei%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMing%20Lei%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESara\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELonardi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-24\u0022\u003EDepartment of Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-25\u0022\u003EVeneto Institute of Oncology IOV-IRCSS\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPadova\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-7593-8138\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Lonardi%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASara%20Lonardi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node53998\u0022 data-node-nid=\u002253998\u0022 id=\u0022node-53998--2201438164\u0022 data-pisa=\u0022jitc;12\/5\/e008689\u0022 data-pisa-master=\u0022jitc;jitc-2023-008689\u0022 data-apath=\u0022\/jitc\/12\/5\/e008689.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EOverman\u003C\/span\u003E MJ\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EGelsomino\u003C\/span\u003E F\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EAglietta\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ENivolumab plus relatlimab in patients with previously treated microsatellite instability-high\/mismatch repair-deficient metastatic colorectal cancer: the phase II CheckMate 142 study\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2024;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E12:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee008689. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-008689 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EMay 31, 2024\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222024-05-31\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}