{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KNzmRglpH9dc7MWtKV8HWQpOh1MK8S41j6+pajTNx++HXUtKSgWnrIKBueFN2\\\\\\\\\\\\\\\/+tHNycAlS0YXXQJaP8M9tVgk5\\\\\\\\\\\\\\\/T9fNGTaJC\\\\\\\\\\\\\\\/VxTM5C6S2CRfZEOX+mtgVG5dNFB5i3vjKOaFSw6xvlG3MymmXMGDOGFKjCeOLlTrp18ZxOSDU05E3sxFqbQ48ayFL0iKVZ3Ra\\\\\\\\\\\\\\\/T22HpdZGP0bEUP82DLVV31aOkGqxH2CnAkHyl3MnC0Wx6UVV9rvDuc6Bws+FlsoCtws741y9TUNCUL8yIn33mCyenD\\\\\\\\\\\\\\\/a6bnjOSQh6c547b1f97RSpMME3qHM1ptxEolMUjkT7EYWI2y5eDTiezKAr8MRrESiExLq8Xusd74KIGzZG3Y\\\\\\\\\\\\\\\/14JbyFvjjXngHu4YxtWwGUC2F0oV6ErrANEffkHsPwRUHVtfbcyFEc9rhq3\\\\\\\\\\\\\\\/6F6rWCeYh4tk9wkisAEMNOGCSbYSbgNeu8tcCc39knKNci0iyfZdNxUPsz53W7ak1Z5atdwHn1aE8vbIoemAHoVAXpwi+sNA0aymS8Lns5pLP6aEKW12fWuRIMscbU6T+btFHc+o8nbphgAtjN9DDTztXwJt2gGVucYYYmicGQ10AQpMenw2RMo+0odxWzn7Xnw64MbBVKoAAxBymRSAWGwD6849l7p2gw4Sm8Wo\\\\\\\\\\\\\\\/G9DftqFaCICP7GPasUn5\\\\\\\\\\\\\\\/ahBOB1s2nekrYU8CUVq4movpn64mmS4HIFd1\\\\\\\\\\\\\\\/jFXyHYg0UXQNLK39UT\\\\\\\\\\\\\\\/y4hOXARGFesVWMHW3oRwwPh5WGcC\\\\\\\\\\\\\\\/e4zGn+tFSGlYUGUOhblicNvE+XroEZKlM667EQH5DL8yF74vaOQawRn1WtJMEQjCeDLiXASr6MXX0TQY2em+ZY1Ad+r3WfrtV6fLNBGHxtnjk14ZK3fztf3uU\\\\\\\\\\\\\\\/FJICRObMjx4b6he\\\\\\\\\\\\\\\/fRVO3n+wP0Dy3VvXIT6myYnq5RnJr9b1RrA9bTEp8nGIzLWQhobvByJtlIuVTlHy0U4kbHIBjJlUUNnOxOiTC\\\\\\\\\\\\\\\/08vOBWoSwlc0p6EphShUrXqP5HL\\\\\\\\\\\\\\\/GVRcc2cXyniBAOaIreJP2JWFhhSt9ENXqCEcFWGHF4cZJTJsi2ndTpHFHYdqZioTQ+IVEGsJIumjw75\\\\\\\\\\\\\\\/LXxczLhG4hc2RLYxKaps\\\\\\\\\\\\\\\/5qKqtybC8hwkv\\\\\\\\\\\\\\\/stQNkMhRUrypSZhvOE37OF\\\\\\\\\\\\\\\/UpQRgUtx4Xq3mb5RT\\\\\\\\\\\\\\\/586\\\\\\\\\\\\\\\/y002Cn50OWJbU0qG3NjhS8TDoMN\\\\\\\\\\\\\\\/NsESggvPvzjfjQHZjG0VystqpNfgBfZMOXwW+uWjRtBjc8hEv6NMkWQjHbrn1\\\\\\\\\\\\\\\/omtrGrlzYofJqJCLhIxnxgfDbT4C5rjYDZ8O0ooO1hZ\\\\\\\\\\\\\\\/wLwsh2DQYxH+A3BfupxR\\\\\\\\\\\\\\\/sAcVegYdA4D5bXx\\\\\\\\\\\\\\\/6mzFc4RLQcik8F92lqlefbHCqCpbt+wjdEGIbn+L8UuN1ealI\\\\\\\\\\\\\\\/tAtXGmBV9VIifVG\\\\\\\\\\\\\\\/kjQzolB76mDfOME77EQeqK0ULdmCTYN\\\\\\\\\\\\\\\/0oFIQPYaZpe1H1QV1oO64l9GNj2RLSdbb6S0jma7EywI3RkDOe3FIYvzVHJDILTZLiP7pt5pNdGM0if14YP5\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/1EMvA3VFt+33y8ueVQLkigLSvkNO\\\\\\\\\\\\\\\/jnSM7dCpW0jtKCvfFmd37HOu+mypgdWEKdBXMXZQEfAWwPwLOSEMuCmkTix7\\\\\\\\\\\\\\\/o5bhKl7oeQKy399jMmjeHQqDC0\\\\\\\\\\\\\\\/UxsxSVq24XaR\\\\\\\\\\\\\\\/HtGf7r1cBH1oeD0Zd\\\\\\\\\\\\\\\/TfOzwuvqlxQZVhyumDjMaZJySjKnZrFs2XEYIV7UBQ7JjTaCiYbpzZgjV8gJe91r91e+8WyTZDkfGPNlZVzAdovUvabtwK1xP+AOj4SyzdbA1sJynciTe5wCn7VKLwW8Oc0AOqq2a93Wk1tt0a+aDFbcdDENb1Kc4d+AZTtmI3rpiq6DzN1OXI914V26XDWHT5k8apZvkE8GrooY4zEvmkprzIsp7JlFPGX134cC+cMBVSKNhjX0WGk4ae12qLJ\\\\\\\\\\\\\\\/DDmrpYvGOJOofqSlaBI8VSUHz2JVNeMXnqFkL83QFkIJJTPVtnWIubHJrLUZmV2AqwSL7S2GHdH\\\\\\\\\\\\\\\/5Sepb2MJWSrUksHIHj3cN6pQ4AKlKE42YShf9hYQhGEFVcnU483kRTUwazenErbeKpVk\\\\\\\\\\\\\\\/wgKbHe9sjyYIMvO3iIJu1sQRahM\\\\\\\\\\\\\\\/K5pR+OUdk1kK+oSmMdQfW7t2Zf6orL0rxqgi4R56mNdId5m5eU3+26Bmu56eIMqkZkrOdvHCv+RtO0LCnIjbYFYI4SJ5JO9uO2hlAhdPQcub+Kz2LzQtqlpD\\\\\\\\\\\\\\\/qNaHLCbyBjTpYT3k7W4zwlNqrPjv\\\\\\\\\\\\\\\/7OLe9XD5rnvqberrjsUXIY2nxzSZDoi53l3dSo\\\\\\\\\\\\\\\/a9wnyQKVZxfj8lacTvgsVeWyQRtt+SYzEMAJeZ\\\\\\\\\\\\\\\/We4embGG1LpY96g69FsxCfn4a\\\\\\\\\\\\\\\/+dx1P7DYzeW6ZpvJ4vnYm2XAb2L85q4BeFVaXjB9qdVR5oyjmAr3nR7rmItcijO0rucgg7JliqPl7of8OtXGZe7EYT2ZdJ\\\\\\\\\\\\\\\/FRjTcxr445AN9Z3CYMXweTBcCsagnCCptl4N9R0z2xokNmzsuNp400hBjQtp0sQu6Yc2I8v7cE1qk410kF8jWOdtd1zjXxiEZu+CVUiIsvjuMrr7UTZO00kvxyddep6XpcMOQuTgiWikQ4PYgAcL0kgS0\\\\\\\\\\\\\\\/+Pk7AYYt4Jq8OwFE5kfZQtK+MlzeMsHu7n3fS7UQT5tWzGToHMfOpRCTJ4GFPmnXJTmKUfUSJwKv9z25suYcpcGJGT3CQhCThL0kIJzqXbBZTFX8Y5UBbig8mPPP87Qdtwd4beiTWJyxOFqdoPZYV1l7\\\\\\\\\\\\\\\/pYbEOZORC35DHN6XoiC7pOBK9u9owbJxAvGcy4scyvtqy+qE1i54h90DFwx0bFPlKkf67DX7DrYsvHggEC8jImzIjt1NzuKkhUUTkSWPwNnhQGNRft7flZNibgPLlzPnUaA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022vwh8jweEALQgSGA3EkWiHw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022faa7fb5ec2a6a8ff2e631b39871e71e475a8e1e09a543c046d39cfdf127b645b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/57.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/57.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFabienne\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHermitte\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EHalioDx\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMarseille\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022FR\u0022\u003EFrance\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-4813-8741\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Hermitte%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFabienne%20Hermitte%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node5343\u0022 data-node-nid=\u00225343\u0022 id=\u0022node-5343--21579879419\u0022 data-pisa=\u0022jitc;4\/1\/57\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-016-0161-x\u0022 data-apath=\u0022\/jitc\/4\/1\/57.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHermitte\u003C\/span\u003E F\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EBiomarkers immune monitoring technology primer: Immunoscore\u0026Acirc;\u0026reg; Colon\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2016;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E4:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E57. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-016-0161-x \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ESeptember 20, 2016\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2016\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}