{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qkxaTv4vhgKhQyUNf7HnYogcLuPswOLKdGLWslJM5fJjj2E4kUmU6esOns0tXUQwgNxU0Xxxs2CIA61mmxJGpry1K+dTjablFBYbmgYASSi3j9J+ArAHOyFgaKAKmEfWDPSrhFeObiW362pcyxQJWgGixSqkeDLsmd4FUE3MMVkzk5wib5datiq4kdtm3DaEdw5f8zxqhPZJ+Dxb9sbO4oEd26BnZXhZTZZ7k0tTX\\\\\\\\\\\\\\\/zAosKiKvbwsp09vHmojEW3+7LY0OEMERzdu92MuqDJw4prYtsAlj3WsJDza80QueIZc2mZMBbV2gy1QAO5Adqcwl8a\\\\\\\\\\\\\\\/3izjg7tpPfrtdu0lE8bVKX\\\\\\\\\\\\\\\/wW4d5EwvEEJCz59OQXouuTJ0ClAk6NwPQHXfGZZ4ZbADxTbCViiybQWVqO7d4Jc333xopF8v52Go+wEzKa7IMou\\\\\\\\\\\\\\\/syeviZ25KgJzJGdyDvt3htQ2bO7XzpPr4LjPsKZ7qp39nuWV0i6FVqNcjagv3bRPkgNVqnm5tjcYSS2qszDVNFlErkbZJv\\\\\\\\\\\\\\\/862xPMreH2\\\\\\\\\\\\\\\/5xBAiw3Ven1vRGJ3F+jWInAdEuwBFqPUhtbdTkg+R3uR+wotHdcK8DMu5mY1yTLMSURgOppqn8nRFoqnq98d+pkvqtKP4UvaKuau4Sdt6Lduie3gw\\\\\\\\\\\\\\\/WKA93zqKRv4RgtX5Mffqa3F63CcSZSecXZ5p9cGmHmi3p07x3Oq2cBuHnisoqKJvsFKzlFQ77Ttj9up6MEjB7QQNjYjH20fft\\\\\\\\\\\\\\\/byUVIj7ft3Yfg9Pcz5i41GXUopCGDIkjxqKJVoaxXwnw\\\\\\\\\\\\\\\/rsrtzQwLvxnXxx9f66F31e2fP9benjFW9lS5DQnM4hIXVN70jqg8V8DkdmP3ONiPrfvvlMwKTyFjoNQ4t7\\\\\\\\\\\\\\\/xkdsOCRPuXx5L4o1\\\\\\\\\\\\\\\/ORbptVsIhMuCf9y+FgHUgxSwWPzPrvyYLlemC+XYzAbyEhJFOtzIWa0K6MAHROGMwcq7wXvik0GcB84BB2gUp5sg6f7GRd7hgaxfnDPWcISBxqSNkviZzSQs3sZBHTeB7dVkx5jkdqswocohmBYnyNFZqmt\\\\\\\\\\\\\\\/tZWZVxoCUumLee\\\\\\\\\\\\\\\/JcwhAfPO6qeFc+iWSCAjLSHS34jumL8bQqLcJLRmGBVGyIwWajb3BgCam97+k3vNr8fydLlk0fRCYRjYF\\\\\\\\\\\\\\\/8OqrhHy80F7u2ortGnxkHrSBAwVsV2YNiKYUiUAPNFigUN50JnxkhRrUvV9FN8GBD1afbydLyw7MEwypJoHhIhZI8gsKkTKy3zX0XMlN9w7d6NXMbfAwd+e0PPcP+E6R7fJGRi+CTTkEe3pI2hL7xSv2TdUyK1VINuIhGPvkKCfr9keKQ+IjHFuDUMcEMAInHtXlB1\\\\\\\\\\\\\\\/k+xfaYb9HaT+T6D8CIRZ4CFt7d5bT8zo1VEV4Gxi7NjfYj4T8O2O9fjvgj9ePrzL\\\\\\\\\\\\\\\/zIxkIeoFoIAvU96GOCySCiptp7LtZ+STsY8isiIbQHb16jxDdLHIr6woQgu3f\\\\\\\\\\\\\\\/Hcv5OURGN+oKnhgPdyn5adOPgjaVawKIAapwUrmrjK5dPQ4j3k6rhynq14eB\\\\\\\\\\\\\\\/YxaQcSzj57taRthVDYegDoNsZKvukprN2w8VWVjoHhpUK97gAttKaAO5e2adaHjQlfq27alFu2+6tSx6sOgPUciAziqHmLfl9c1IgU\\\\\\\\\\\\\\\/swaOhEBUhITuXN1laZLSuGlNDRCBCNEt6a8sP13AATIHmFYrPSSfzQsk6xv60aO1i84XiUB\\\\\\\\\\\\\\\/F0sgjk+X4hz6dCkjJvkm+t0FPfYYaNSmH2mbZ52Bi7gtXgglnBkib7QmREji4Ua8yyhx5AGXTYloyqnmXYXq3rT06sF9J2q85Z+y32+lKd73s2+kFUblfI+crbA1Srj6IDGjXxdDbYw9Y80CeuTrzq3bGTd\\\\\\\\\\\\\\\/8IRSHbrqX6P7BocQhrFnEqo5CWHMh9R+g4J5S82M297C3qUbvlfPFfLyEwPS6eLNWcFRiQagHZPOfryZkYBAZjcugxJAcMDRbkhJefxjJ3nsjihMy67h8p60xrUj1VpZ1g49+GwlgFurnrgo6k5iTPKoG3PCZb82zQH2ADwf5QW6OxwfyCzXiYIfOo4YHP63JBXv9w3uIIixKh91cqYTTXkIZwsUzgwoJe+X6pc0OwoPaqgza\\\\\\\\\\\\\\\/OzRtJG6ztIaKvJJBjiPv72h1HHELerTfgLXuAtB86\\\\\\\\\\\\\\\/zhBYr7vxKVs4Oo5oDR1CkugdtPVZH5B8YL80XSCtkDh9\\\\\\\\\\\\\\\/AU1OgQtAA7N3t3XDGa+Eepa383BeEkziGZ6kUFiuCBviqIzCRa+kgs6+OrMDQmySp501H3OFMGNa5PtZStfTw8MTXQiFlXKhy5CTK9Rbokjj+PoLTzsycCUzUwcKvz2Bo0t0X16jYy74muOjJt4NidXDERJ+91\\\\\\\\\\\\\\\/HarCpmKcKEyJPwLmUoSICuSn24\\\\\\\\\\\\\\\/KnJB0qAyqHZTaydkgRvKlmGhUZWFZg7L8f9qlC1mC4Ji0aS23lG0WCuNfqlOB\\\\\\\\\\\\\\\/gPNtRy2QNd2t+3j+JKzp73WUP+w2GEvcYONmXfQ0ohwuR7V0PcNMkmOZYZtYSW7HvxaEDYW4wZph0yyBAQVZ+gF+TezEcH8BQ6u6dZxEENW+k34clRuTDGMgM6Su0Pz6u5X3FkpRPOgrdFar6fwgRgBDwnMLs7CXqmo7wKlvt+vydvD33uSzacSQE3qqoKQO+CmOc9x51fcD7Pr8CP2aVtTFWWf+8cnVx3gMALVRz6CJpTyIvxCTLgPbgm2j\\\\\\\\\\\\\\\/wWt+NzNRfWKP8MxVLxI72o+u1veTSr820CADKf6k63jkgLcBZTLrKGdLSeQLXvZ5iFx8Ic0GaMHRwwtWF89mh8UoDwEN\\\\\\\\\\\\\\\/xn6dQ5XiGpQZP2lXIMFsUSv6\\\\\\\\\\\\\\\/zrAlDRba4RmuRKi5Q1qy6ps66qAlE0zkmlS6qXW+sFRCkU0DbWi2sxGo\\\\\\\\\\\\\\\/OhNsHaXqA++KJgehXJmFxSOYkbw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022deWaDCTuF7zXouuahrnjJg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002287b38042dfc58d975fd07b1fc0d47bface7400d805a70bbe444dca29dc542342\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/46.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/46.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJianda\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYuan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EOncology Clinical Research, Merck Research Laboratories\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E07065\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ERahway\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENJ\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yuan%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJianda%20Yuan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node5322\u0022 data-node-nid=\u00225322\u0022 id=\u0022node-5322--2109721500\u0022 data-pisa=\u0022jitc;4\/1\/46\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-016-0150-0\u0022 data-apath=\u0022\/jitc\/4\/1\/46.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EYuan\u003C\/span\u003E J\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ECirculating protein and antibody biomarker for personalized cancer immunotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2016;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E4:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E46. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-016-0150-0 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EAugust 16, 2016\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2016\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}