{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022E2tjKOemcRTHHbCsblEvm9Yp9B6fF8qqtW+b8EkXbjPTMWMODuFEBVJ7OHZxIIfWRjlQMZLM2XTNJDLVfTVNjMZE6r5LqelG76tGcJbap8RtBQN9SfW9D4Muox7EAG6kvypJ35Dg3L\\\\\\\\\\\\\\\/qsTzhgJgjeZOQ95othOVFwzXejGmN4WchHhYvvgiYWXkCGz6qWTV1fPGL+dq2w72W1shyu4UujtrSU7zraDMCYbgZWun00HNgsvN9WKNAWCVsQC1jmRXQvPZoXVyJQdo6mhU\\\\\\\\\\\\\\\/9WWRCtH1fJ3Nwxijr4ImOgEBmD7RhGiJXM4jLg3m6gpzA34NW+U4wDnck9iVYEZHpUIfYKlY2xBAI1CZr38fnrNnRJ6epWP1XrJm2zT9ZrJ2yN8gupyRNodyjVtf7cUmQdbefsHrjsjWeB+HFyTCnQuizdZ2saXEMQSEZTBlDqR\\\\\\\\\\\\\\\/CfQAIKAFXNBixZmEOR09dQ8lu3WfDXyOxOEG7u5qo3gAFHFMcdkuihe3CGhRKLk4Cl4sICDKnz49BT6iDCZ6QGmYHkte4Jr\\\\\\\\\\\\\\\/4wx\\\\\\\\\\\\\\\/8DNKBpskZNh0ikIpFW0qtC76VY8W1RCuG0v5NbP9s9kxWeXis2Qr6GrhzJes1ziG9jVwfQBDxrcfIY\\\\\\\\\\\\\\\/ZTQDazpKaW7LsS1I\\\\\\\\\\\\\\\/gunmBtBrmMnsns15ZJq7Bb45hYeTJh7Mi+DMKz6q6Hv52N1eiYeF\\\\\\\\\\\\\\\/tLN4CyWMDy9\\\\\\\\\\\\\\\/IOuV7y0nE81uWT4+Hztt3BDKuOFJaSDgT2kQRkKDHiCMcjsFGaasVdVeQgQ3cSSGfQAdfCenF7rubhblbs6Om4GaKchAYYYfw4ZMll8fUHSvJyfhEZBAcdXthN9I+3KbQtarlPsCssjMDpd+aLU1hhLC5FCndfykcV5bGeXJoMrODtZuQj55Uu7kU0fAyhmR8nYmxVjW8DDneE3impqXrN1pUQ8zut\\\\\\\\\\\\\\\/FJ2CJwSpatpLPgXyOrDeSZA6c3bf8VrgoCwFv2DYuDn4vlncmU55xc5FLxHdqF0zZoDQ+JWhWsWHv6sc0Jt15YUncpa6BEBPEBkkFvS4ETlYIQ\\\\\\\\\\\\\\\/q3He2O1r1s5av8DZLyL2PHKUKVktip1IM1esKz2fc25xttB9LLSg6hFYByZLyJsBvviT40J5g2yt\\\\\\\\\\\\\\\/XE5rdtb+AocJmeRPISQFDnZQggctqQ2dDd5VilMrlAPCDAcuRJhydh48o6Bs9jEOD8aWT3RZ\\\\\\\\\\\\\\\/UuAxw6+rC1+lr8QC5XWij7z8isTHXCLZJ2zLcvWcbwm97pAbxf0wrMAsPTpb4Bnk1EIFpVQS+RyaiPha328ZybyC5ZLjCnLd8aL1OFwYHVMEGnB1KLNczHP26VQzLfLr\\\\\\\\\\\\\\\/HuZTwT7xNGGQR81bHmRpqC8kTB6+DZLjGbzdj3ghCNVSO0j6oJaAbNMYef1FXHvbdCsmU2HlwiaSguyuCpciQEmK755kC8xBNfaGd7my2yyhQRrxJ3caUuCNnHvcnCX+Ip8qHjCXyW6FiKLcvcHbzux6BYX\\\\\\\\\\\\\\\/AI82\\\\\\\\\\\\\\\/DpAJ8MP67ssXKfX5DXCUSwKs6zyYwAZYOD8gSI0sWJIMR\\\\\\\\\\\\\\\/+n4H1DoAMhk2Lpr3\\\\\\\\\\\\\\\/O82cbDXLIFU8nSiS7\\\\\\\\\\\\\\\/vOFboi3\\\\\\\\\\\\\\\/LZBGM718GeSc3rcM22VqwA17zhsRC4fTEQ5JGlZu6ZoWvs1nynTDup+Fu\\\\\\\\\\\\\\\/0hJjQ0uZaVyWBRoe3c29jGefd1WIxGSzpvQ1M3WkIV2sBYUNIZLLkoBjOIsnzXfoz8jxCLGO0cfy1azerFYMA7anZRAalvOYImeO6dt8GIJPhiWifZTshDh4OrtrZFZ+\\\\\\\\\\\\\\\/Ei+FB2ua55BXT+\\\\\\\\\\\\\\\/sMSVIIsrPpvuCwXvNXcGe3mER8H3dMgyOMTLxrfcV2MlT9SblSomfAnBLjQnS+5+o2DVgBfK3QSI50YoAxUoQCjoea3uWxM0B6WN2Oph5rhP1qym25RmJjj0dUobyWxRV8rgtcVqCJC9eV1c5OicmgQEqT86u2a7tIDiJ8EUYfGssNbvWhtu1UN9tYXb\\\\\\\\\\\\\\\/Yyf09OINGpk8EAdANxV4cOuxuroay8xQ4AIfeK+rz+AQpec62VerzsD4bW6rvfrU2hNGirvM8788IkVuu2UUNYpia8HnZ95BqdIyWmbmtzlR1zWOCb9c+F1WUHZoFVKQur+bEjqFXN1bILH9yW2esN9rlL8uC0xxuQ4PRIS26+wh5ZdlK1LoW9fOIZtTf1lFE9AHai5YcEXH4GiTYv2lA3ebXN5c6NWvL3CCTvotA6LSwXuwS0C2Nn4GjScQZr9wBPQAyMO06TYh6v\\\\\\\\\\\\\\\/lMX+lKE1TJetpmxdSQyq2OaVtl34NEHd5etaZEx60Woyxuuiz6Bq9cT+\\\\\\\\\\\\\\\/3PEaDjAmp4zo\\\\\\\\\\\\\\\/399qUeKnU\\\\\\\\\\\\\\\/7vfDEe0UGtFm\\\\\\\\\\\\\\\/bASW3wHnZiXVHf5CFolin1ETGzN6aQ0eL8KAhKgHYMIPqSWJgQd9PMVt5qKBM6ngYx5g5lN+X+UDQNiYwXWhRg\\\\\\\\\\\\\\\/jjSdjVHXsSTqok5Ah65T8I5ZmptrWkVo6ru+OAFdpNbbjktY2K3hWws711fUS264WqHNECC0BAc8Vb0iluFEDsQ3LrAvhP7ugubWvNmC180kPruzU1oYWXMqthRK61CTKOOsf2rE5NMI\\\\\\\\\\\\\\\/S245yMWlKqXNOh5HZvhGuVyyuq6S42Lm\\\\\\\\\\\\\\\/CxPWs0rgNfnCkm0LBD+YjHHrcJTNg0arHjX6I0V\\\\\\\\\\\\\\\/U6rkVsgyf3hpVD+9WGCGE679BGGCLVt+dlQDk1Ssy1OfMiOX8B10Xdi+wlxBvbvO835MTyXQiRKXeNRLh2Hl0w42Pz7A4Ue6QRLISijYGvGp70OFTrxnyiDdi01H5twmqTAqH1elvSGFWdz2eAvEJqFq0MItBUT+fILmuiPjcLZeOEAZ+j7eT+Jk2SxmNAyBDOnns9jbgxTaU2Kvi7Sjt+xxOAW40g3NNgUzUWD4t7ICH6A272k1D1c2rXryAgNRg9AyTCFbwtekSKbpg+nzYg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022KPbZBCwCi0iL547RUnF2Xw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221d4bd0aa7f7ce19bee85d5fa827051f7897c4e3760da77cb88daa0fd205be961\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/18.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/18.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELaura Rosa\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBrunet\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EImmodulon Therapeutics Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EStockley Park 6-9 The Square\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003EUB11 1FW\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EUxbridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Brunet%20LR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALaura%20Rosa%20Brunet%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESamuel\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELaBrie\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EMyriad RBM\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E3300 Duval Road\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E78759\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EAustin\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ETX\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=LaBrie%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASamuel%20LaBrie%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EThorsten\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHagemann\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EImmodulon Therapeutics Ltd\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003EStockley Park 6-9 The Square\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003EUB11 1FW\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EUxbridge\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022GB\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hagemann%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AThorsten%20Hagemann%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node5276\u0022 data-node-nid=\u00225276\u0022 id=\u0022node-5276--2293517253\u0022 data-pisa=\u0022jitc;4\/1\/18\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-016-0122-4\u0022 data-apath=\u0022\/jitc\/4\/1\/18.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EBrunet\u003C\/span\u003E LR\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELaBrie\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHagemann\u003C\/span\u003E T\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EImmune monitoring technology primer: immunoprofiling of antigen-stimulated blood\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2016;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E4:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E18. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-016-0122-4 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 15, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2016\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}