{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229YXkjGyDTfY8koBtLVz67waZEWr\\\\\\\\\\\\\\\/aia+XjwNmT01T+vXVwXlvonI4VrIW3bcEXbNwebyVBl7SZXOs9IN\\\\\\\\\\\\\\\/aB+8GgZ7UqfocU8m4d8VJ7VI6UcNJzi8iHjx\\\\\\\\\\\\\\\/ciN8DBSPj8DmVsfg8qvkVo8Ihq\\\\\\\\\\\\\\\/EHzL24\\\\\\\\\\\\\\\/8zKdaizGW8bj3RWeUzN047gVUWAke72UXVOwZAU3eBQCgTRt5ZNJ\\\\\\\\\\\\\\\/fd0TYJa\\\\\\\\\\\\\\\/8AHzJMMOvxIdZXqrn6A+c\\\\\\\\\\\\\\\/b5CGdvpPhenYuNWwLZKjmRMY04u0qfydXoxX91+TRcQbWq\\\\\\\\\\\\\\\/SSTloQS8YxuWdme7n0AiWAB4lTQ9UE\\\\\\\\\\\\\\\/NdUtEh8x65RIOoT9pLAajHZuPRkT1whBMW7QshdmhpN9kojEm7Rr5nIzNd9bu9WxtNjxcLKDzHPY8VABwLJcW15CfZTTKHwx1fXyr0RP45lw3pDqlFkFjnpm4ZMng3Eudg1xIPHuI\\\\\\\\\\\\\\\/Vslg2pkK74gqAYETG5EJdpMDu0SwL1V93ZLRZOUhUk18Oz\\\\\\\\\\\\\\\/hRRZMuIR9cfKHguKGfDLaIp9+2LuVN+AfK0Q3pYC\\\\\\\\\\\\\\\/VZthyoJnohABYJLphjMLXIeobvPU0FFvVq6P7oxSWXwXx00R6CKvoLHRAW904bsUq7przzr25ZjwPmkOdRxdl2XceS46VEGIh96draVEn1cHEHfTQRGmS9bo30NwYNr7+whRdhYJ576iUw\\\\\\\\\\\\\\\/GQBN6T\\\\\\\\\\\\\\\/Kl0ngPsoUUuxigdOkLjzaxKzDATAE3bm4ZZ7bskPR6NOdSQHODrJ+i3liRYiWBH9vZw9y\\\\\\\\\\\\\\\/lhL5Th+sCXbc7uBMYY3IJtmkhn3\\\\\\\\\\\\\\\/CBRlq8tukQL6qoXWQMjVksRmpEPIM7CWEOcRkgxQTU7Rbv06H+dMRkHlRNJBr\\\\\\\\\\\\\\\/yoMq6200PtTRhjs+qPPyHvj+byZqzmy4VNuYhgFPmPAEgAjzF3Y17j9pF32R9CYTVhMJf1TW7c5+DwbeRtGau6tFdSJ5l0UIC9G930E826SD1g8RGOdYFtRMDRKXEdftwkPsxeFnAUThvfC8cHi15nJEfgaWZk7QPtj04TLu5T8hjhoVZMQRgZBuG6TZLv5bqCAJfWd7\\\\\\\\\\\\\\\/T1\\\\\\\\\\\\\\\/KP\\\\\\\\\\\\\\\/xDdVmOSda2zM6UkDs7uHUvn1D7mVXI7r3iZk\\\\\\\\\\\\\\\/ufp6lI7HT5npcX1baYgc6nB4yOFl5U0tCEtMoqacxwdmURUkYz0NzIx1cgS6l290Egv5PlpvAiWyafW3bFGiVYyOkgOzQfCCQL\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/tylWn7nv6DJLyhKn5N8Z4aw01F7NWx8JjC+Y\\\\\\\\\\\\\\\/aPPCYBgRspNxFb9JQGAP7EFbDdxY\\\\\\\\\\\\\\\/vmw8s7orPQRSoSsFQa4EiE9zrjTAvbL7P0HkWy1WcuRR3mn1ZqIU57jX6kg9l6zOd\\\\\\\\\\\\\\\/LxKfDNieDGpyNkSNACnLvvDuX8d0luQJTilTLr2k+DEgUIrIomeu1FQ7p0XDcW90h5d9Sjyy3Z9PiO1a7O6R0qMkcbu9kCWBa4kCQaLsDxfJYC9qGjGFhc5lDnSNhycV\\\\\\\\\\\\\\\/+5pfwtrEiz5Rtp2+xjurZQQBhrkLrXAAwv+ND520+VrLUU+\\\\\\\\\\\\\\\/5NVRvbFXpj1n3EyoC8xrHKYjdwVK7n79MDJ\\\\\\\\\\\\\\\/XbN8ni40PIlJGKUl8sVUYd8os1ajP2IelQUhZu2EaupLXGLUF8ReiLEnMsmRUtWQ2p1M1q4IU+NkT5ETGtno0nf5EfGTgCD8eE3cl7rZxL\\\\\\\\\\\\\\\/EUkrKgDQHH5rlX2o4Qu6hggJ8bM9pOuppn3QuHSmKH\\\\\\\\\\\\\\\/6gqTaKjJrimskGUEwWrjfkjw4MLxK7MG\\\\\\\\\\\\\\\/FR+ClfZoxwsQ3hwr2p9L7qOU6O7YfqZZnf8WKh1FT8NJk7QpxGVIWcCzS8WwdtYRtM44AbTJ5fRFrvGEvGyOU4QNca4JHhf2h0eFNHq2Jcxmkv7OuVzZ\\\\\\\\\\\\\\\/0xbLmL++yazyoVPcq5ufDPqKMahpvCdTHK6fnZCq1IDOEuVqxe+q5Cf1oNNYNRT5rMwaof4CayQR1rDmfJBUHCWVhLgCIYSSQ\\\\\\\\\\\\\\\/E\\\\\\\\\\\\\\\/+krR+19qPo\\\\\\\\\\\\\\\/IKVb0x\\\\\\\\\\\\\\\/XGg\\\\\\\\\\\\\\\/cLTzPlUBY94+agqjoXsjLBSV94xbmjwFBl8gLjwIakcUseDUfX9gSlpVyl5X90MAAy7\\\\\\\\\\\\\\\/rC3HcGLP5+IQWz+4tR75GOcjaPhdCWd9JH7r\\\\\\\\\\\\\\\/17eYolQY+Q14YjJoaCCt62CvS0PgHj4uDPsNEn1tJes+WBdvxZ01uC+J20f7Kjn3hIuTEgHVAENKTzwI+zZRqG\\\\\\\\\\\\\\\/8WCGHf3VzzqqjB0tt6YncFTlSZDkRnL5eeigjWdrAjVyfsQPRraBmpCjGKbTpSazMNLmdeKhAu2RMP3lFP8wHh0JQ10Qb4IQ27NURoXDAC\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/hYauQY9+nayzP6pjfajC+d+fnROwSvtE2Ux40WhKCyv\\\\\\\\\\\\\\\/pMvsUy0eZ9dAswAuCw9nUtUMqkLTrc93N78DYMjSZ1kqzIEqlBxJlntPPEJQ35RSAad2q5sV4uUlAFlO4DUGR8SG8WVKVhG6+KbgV9MPKQVKhWSjCO3+SzH0rWObF2\\\\\\\\\\\\\\\/xBMGYE5giXKACicevGufxZPDo3FOR37Jk1kRydxA9+J\\\\\\\\\\\\\\\/2eCZDHgo9\\\\\\\\\\\\\\\/+MSn2dnjC9GdHtv2ZbwV+PTFFRxJo4x2ES3Hv\\\\\\\\\\\\\\\/SFcIwjvepEbb8YGsZGxuuUQHACiFiFHRC46F4Z4lFyTMdSr\\\\\\\\\\\\\\\/ttQdI0+\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/4YdNmfmzvvo8uuaynyjrl4Aa9nWeBwfPMvR+7AdAf0OqZJk+W0ti2weEctIhFBO9nOPJfj45k4+djAtJWrP2z+xUWHTX8J8aEVT7yDKso0dzFK9xMg9fleF0Z0BoelcfB7eP\\\\\\\\\\\\\\\/CHJnBJQxKbusUOlFiT22s2ILHBEXv\\\\\\\\\\\\\\\/o5x7cjPWXhP7RTzRE7dOGH8a\\\\\\\\\\\\\\\/TWGm83HOYbchs6bVL78OGR87D3XjzX56765VH3VVAd2lD396LSUFQiCcpDABPLE3lu5bHV8K2cxTclIViKhu2epdds6YeqkwlBC7l1StswATRdL6tblaqQEWO93PHcuMh5sQ==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022qvk2Rgn5McLcmmSsbkjrQg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c43ebb2ee3fb41f828b3ea028dc541fb8abb92d456d1245cb638a6a4c8169b8d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/2\\\/e008210.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/2\\\/e008210.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShogo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETakei\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Gastroenterological Surgery\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYokohama City University Graduate School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EYokohama\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0003-0614-8383\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Takei%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShogo%20Takei%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYosuke\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETanaka\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDivision of Cellular Signaling\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_13543\u0022 data-hwp-id=\u0022institution-6\u0022\u003ENational Cancer Center Research Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETokyo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tanaka%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYosuke%20Tanaka%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYi-Tzu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELin\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDivision of Cancer Immunology, Exploratory Oncology Research and Clinical Trial Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-8\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lin%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYi-Tzu%20Lin%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShohei\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKoyama\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDivision of Cancer Immunology, Exploratory Oncology Research and Clinical Trial Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-8\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-6897-9417\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Koyama%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShohei%20Koyama%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShota\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFukuoka\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-9\u0022\u003EDepartment of Gastroenterology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-10\u0022\u003ECancer Institute Hospital of the Japanese Foundation for Cancer Research\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETokyo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Fukuoka%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShota%20Fukuoka%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHiroki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHara\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-11\u0022\u003EDepartment of Gastroenterology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_46619\u0022 data-hwp-id=\u0022institution-12\u0022\u003ESaitama Cancer Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKitaadachi-gun\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hara%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHiroki%20Hara%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYoshiaki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENakamura\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Nakamura%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYoshiaki%20Nakamura%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYasutoshi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKuboki\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kuboki%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYasutoshi%20Kuboki%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDaisuke\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKotani\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kotani%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADaisuke%20Kotani%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ETakashi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKojima\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kojima%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ATakashi%20Kojima%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHideaki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBando\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bando%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHideaki%20Bando%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESaori\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMishima\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mishima%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASaori%20Mishima%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EToshihide\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EUeno\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDivision of Cellular Signaling\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_13543\u0022 data-hwp-id=\u0022institution-6\u0022\u003ENational Cancer Center Research Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETokyo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ueno%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AToshihide%20Ueno%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShinya\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKojima\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDivision of Cellular Signaling\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_13543\u0022 data-hwp-id=\u0022institution-6\u0022\u003ENational Cancer Center Research Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETokyo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kojima%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShinya%20Kojima%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMasashi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWakabayashi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-13\u0022\u003EBiostatistics Division, Center for Research Administration and Support\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-14\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EChiba\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wakabayashi%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMasashi%20Wakabayashi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENaoya\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESakamoto\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-15\u0022\u003EDepartment of Pathology and Clinical Laboratories\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-16\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EChiba\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sakamoto%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANaoya%20Sakamoto%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMotohiro\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKojima\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-15\u0022\u003EDepartment of Pathology and Clinical Laboratories\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-16\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EChiba\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kojima%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMotohiro%20Kojima%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ETakeshi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKuwata\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-15\u0022\u003EDepartment of Pathology and Clinical Laboratories\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-16\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EChiba\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-17\u0022\u003EDepartment of Genetic Medicine and Services\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-18\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EChiba\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kuwata%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ATakeshi%20Kuwata%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ETakayuki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYoshino\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yoshino%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ATakayuki%20Yoshino%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHiroyoshi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENishikawa\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDivision of Cancer Immunology, Exploratory Oncology Research and Clinical Trial Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-8\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-19\u0022\u003EDepartment of Immunology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-20\u0022\u003ENagoya University Graduate School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENagoya\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-6563-9807\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Nishikawa%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHiroyoshi%20Nishikawa%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHiroyuki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMano\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDivision of Cellular Signaling\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_13543\u0022 data-hwp-id=\u0022institution-6\u0022\u003ENational Cancer Center Research Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETokyo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mano%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHiroyuki%20Mano%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EItaru\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EEndo\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment of Gastroenterological Surgery\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYokohama City University Graduate School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EYokohama\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Endo%20I\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AItaru%20Endo%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKohei\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EShitara\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-19\u0022\u003EDepartment of Immunology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-20\u0022\u003ENagoya University Graduate School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENagoya\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-5196-3630\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Shitara%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKohei%20Shitara%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAkihito\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKawazoe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Gastroenterology and Gastrointestinal Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_26351\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Center-Hospital East\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EKashiwa\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EJapan\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kawazoe%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAkihito%20Kawazoe%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node52201\u0022 data-node-nid=\u002252201\u0022 id=\u0022node-52201--21241572411\u0022 data-pisa=\u0022jitc;12\/2\/e008210\u0022 data-pisa-master=\u0022jitc;jitc-2023-008210\u0022 data-apath=\u0022\/jitc\/12\/2\/e008210.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ETakei\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ETanaka\u003C\/span\u003E Y\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELin\u003C\/span\u003E Y\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EMultiomic molecular characterization of the response to combination immunotherapy in MSS\/pMMR metastatic colorectal cancer\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2024;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E12:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee008210. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-008210 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 08, 2024\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222024-02-09\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}