{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022D0pp0yGUOEwp8mdPE9hyGno+oKRhdjH+pk9wuHKwOhHOMzmVlHEfYSGB6O+q6\\\\\\\\\\\\\\\/jNLKNAb2GangIM\\\\\\\\\\\\\\\/zpCQESxPjqvCiZUF\\\\\\\\\\\\\\\/wEe+NOc\\\\\\\\\\\\\\\/1Is6vUrhXLAgETGELtto9ttvhnTptsvEIt94T8Ipw9\\\\\\\\\\\\\\\/vlsUbxuvJH\\\\\\\\\\\\\\\/CfOl7lR6R4d\\\\\\\\\\\\\\\/kJ7Dcqsy86OPGu9n9p6rPsmHnWCJczVOtPVrzOCtKmQe2Plc39+M2otlz94+KAnpBORP2AzXwjFM\\\\\\\\\\\\\\\/BCdivIToQx+7dT9YaFR\\\\\\\\\\\\\\\/kmKbdhXIW2GyhSyEKcR7HsIob4WDhos+mWCpj82ERp0gzybadSoNPwKY+tIt0wrR5cjGPsG\\\\\\\\\\\\\\\/ctPjgHTBdgmC1Zz3ro9XhmlFgD\\\\\\\\\\\\\\\/ILrJJccwBi35S06tEA3znbcobPvRVXELsESZJcddUwquZwKItDzNBeI2gL5rh4FriPGjXnlEwXeIVqJtYC60aVHVhuDO9Wt1fMlITDHCzI5+ENoPJBhBojFuI4jEaFI7dCrFj5DeFWN+XsDJIHFwirv9UeeQNeiV\\\\\\\\\\\\\\\/rCSYEslVgnR5REe7JC\\\\\\\\\\\\\\\/gPzKbLj4BquheY086RCMCEc+zvcqtx6VcYJhxaSUICBfmT2MwqA1us\\\\\\\\\\\\\\\/CPoIzS5E1q3i9xpU\\\\\\\\\\\\\\\/XBgzAQEjqzh161pquVPT3aQJHqOjgNsSf0f9nTbt4MWXH31HM31n6fmxgE7+H6HxVTwAvR0WBvJNhQJKH914iiaha4PtBUOf6\\\\\\\\\\\\\\\/fe3QVUcsyq9qDklMaYv6w2JaLIKaZjkC4KKO+Gk2ouWrK2p\\\\\\\\\\\\\\\/bJRFz72uJxGLiCN+UXg2kg7inKSoBgfJ\\\\\\\\\\\\\\\/EEQ+8koRDsEIlEGRoJME+CSLg5mquZbvmzBATFBh0EKII\\\\\\\\\\\\\\\/hyQ27uNcj8NreGZOfignehjwZKfo7r+KUnaH\\\\\\\\\\\\\\\/NguAFHg4e5\\\\\\\\\\\\\\\/+Q\\\\\\\\\\\\\\\/aDi38tD0RCDgJE\\\\\\\\\\\\\\\/M0SuU2YuUqW2M62HmksiCAyI9947QRtsEDDzyk5JiDH+iF73fUd+yigEPS6Ny0htmEygICaOpnS+SmAEUz8txNNRSFJVD6STAPjVyT8zWzLPiQ9YJYpgt0FcY2KtALNTCw4TI347DbWanA1i2Zx1Mlo5qUOeQidkUaMuMnjo+RNsJegh\\\\\\\\\\\\\\\/2r750vTJxe9apoTrKPLeKlchCzLvkKTBzt5kx07mm9OdJxyF23gyX9DoDkSM09F4LVK0D0dYjeEiyJtduAIDYXtp\\\\\\\\\\\\\\\/+5tePFgM8VTzXww6bRnk\\\\\\\\\\\\\\\/+LAwHbozzpdkZ36biGbEYaFPhxVd17qDoDReNSTp0FX5tN4nIDjCBj3bRDC0+5OFjlZDs8IgSKgHVRXMqnrHzWqbHXlfPM63uTAhwSpi9dKS+DVaLrLpg7dXqDmvCTX2tBpWeQ2G8ml7R+9VFj1fjYy2WkMQAz5RSa6gYYzE\\\\\\\\\\\\\\\/XRAux+DNPsRLEixb3Qm0xhxquTlKLWK0ym8df138+7ZpKrCBP8YPg0Ed7oEq32p35ZKa6tezGokwFaYmLS0s6u70XNZBKfkgMlIc7qVaG3QKSyXR+6AOhD21zg1xJnBmPFaRm743hT5\\\\\\\\\\\\\\\/5CpqKUIf4xXA3Tc+rXY4VSnjUpY4+fXk2wed90R+W6PbQaM5AP1nIhtt0uqTGk4Spo6RelwUzWpw1IT9tShk0WzpTIHYmtvL8oQUeangGu7Cok\\\\\\\\\\\\\\\/DXHSMXyw\\\\\\\\\\\\\\\/Yb+3o7JvaOCydbYQFJUzHMXx20gJcf6VoS6oqEYmQe9JsWQwXJI32K5FS8aF7LRmrDDtuAIMrbXKwURZzK2QxEDVPNAGeKXwr0oDvvGQNgWoqQsPC623GFJDdt2a362tYq0p3lXak6DoHJjiHq\\\\\\\\\\\\\\\/sOICuQgQ72jxt3T3bvrGM025ySLSANyxlinecpbE7q9noVQwOCQgbo\\\\\\\\\\\\\\\/P7OwtGtu3w0\\\\\\\\\\\\\\\/dKmRtAdcQnpHD15ZkP+JY2prIrT+omJU8GP0LfhafGd11pRBWzxU+\\\\\\\\\\\\\\\/VGdtInsorWAu7gNv1T6sgT8lcrZShw7Kj3W2XsYtXO5vp\\\\\\\\\\\\\\\/LTqlBt9+CHM13loHgc+hPKkhyaqtPGW\\\\\\\\\\\\\\\/p+sEZMsZ\\\\\\\\\\\\\\\/CnOCU1FaG1GYALWIdLTMqhMe\\\\\\\\\\\\\\\/I80U74NkbhNuMzYCJQOT6U0jzWMMmjICLSs9TfWXF0H5DbvjBHSHjyFOtShmLK3UK6yMDIeAB2uujm9cTSr\\\\\\\\\\\\\\\/UpMn5RfHyu+WyJBxrwVSiyGyb2QUltZMxZkVJT\\\\\\\\\\\\\\\/axPQFf4TML\\\\\\\\\\\\\\\/R5O+d0VZELdutVsZ1ZSXJhvZSgjp8RtqQJnFZvwgk9\\\\\\\\\\\\\\\/jMh4hbXwlaGcuBaAiaDXWIpPcLmpgChtIMto0hBnazYxf1CYyqdtIYi3qFUtbRxQUSbCEQd9KFBhNItDHEi0uPGegh7PTl2tlzq5WaJt8coFrI4kLGYPv0s66e3GUEdqxgfS1ZIBSTtEhs96I0+2y17YtRT8s1T0HOJxN8rwIVu\\\\\\\\\\\\\\\/A6LMQ456r6zvVgrL1H8rcMcR1MHBH1K7y9F3dwGrxf2eRw0rLj4OFPPjaaTpxRw5n1gM5p9rAjOl10spmWzWJRTIee4N1r\\\\\\\\\\\\\\\/ICmWD7K6xtC0+lSrRTEED8m7sTVjDbLVlZsbOyRjKR\\\\\\\\\\\\\\\/S0vBVVNxaBGVSWvHRFpIY30lq1yusDTAFbojk04a5srF92H66ydhC1xjtNpxWfcH\\\\\\\\\\\\\\\/ZOhPmccfPD1EGEZ7fhADE2zcxXlZ6rY8MW85F6VAcJRp5CADUsx7RqFLH76PHLiFKnkKDv\\\\\\\\\\\\\\\/a+ie\\\\\\\\\\\\\\\/Ie6MZB8C23+QBlmRAgA4D63OOEIsUVNCGDiBepV60Ip6x4GNgWF6yTTEpwaCdoziptkLRF5bE78teNyQnCDQScWhlddNEkQnA1vdtZI94WCmqxcP+\\\\\\\\\\\\\\\/zttSdMb4tk1Dmnc3CMr1YW9z7CgPHS6cLiC7qjVVl5JO1O4+79eznLr3hlr+iRuhPskQIO0+Nx+FKm8VgVB+CJwSP1kyhdDXAnbldEn9bs53I9gqFoQZxtVsvQAZxu6WrEAYLSOdneRoXOBEd693UpbqvXk8g==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022A\\\\\\\\\\\\\\\/W3tH0iKJW98SbbrfwcTw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002244f7804496a22fd56103fea57b585eb5cd3c599d1a3e245b0290e64f33f5a4c2\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EChristopher R\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EShaler\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Shaler%20CR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AChristopher%20R%20Shaler%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESabin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDhakal\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Brookline, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dhakal%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASabin%20Dhakal%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYeon Sook\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChoi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Choi%20YS\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYeon%20Sook%20Choi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMelissa\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMyint\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Myint%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMelissa%20Myint%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPathricia V\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETilstam\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tilstam%20PV\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APathricia%20V%20Tilstam%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMonika\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPradhan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Pradhan%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMonika%20Pradhan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAesha\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EUpadhyay\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Upadhyay%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAesha%20Upadhyay%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDaniela\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMaiz\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Maiz%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADaniela%20Maiz%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJeremy\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFung\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Fung%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJeremy%20Fung%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJeffrey\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELauer\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lauer%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJeffrey%20Lauer%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJingzang Tao\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMiu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Miu%20JT\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJingzang%20Tao%20Miu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECarlos\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESanmarco\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sanmarco%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACarlos%20Sanmarco%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EErik\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHett\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hett%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AErik%20Hett%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFrancesco\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMarincola\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Half Moon Bay, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Marincola%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFrancesco%20Marincola%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVolker\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHerrmann\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nSonata Therapeutics, Watertown, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Herrmann%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVolker%20Herrmann%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node51304\u0022 data-node-nid=\u002251304\u0022 id=\u0022node-51304--2223913382\u0022 data-pisa=\u0022jitc;11\/Suppl_2\/A1851\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1403-B\u0022 data-apath=\u0022\/jitc\/11\/Suppl_2\/A1851.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EShaler\u003C\/span\u003E CR\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EDhakal\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EChoi\u003C\/span\u003E YS\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1403-B\u0026acirc;\u0026#128;\u0026#133;Sonata\u0026acirc;\u0026#128;\u0026#153;s proprietary intrinsic antigen release technology (iART) drives in situ generation of potent anti-tumor immunity across warm and cold tumor models\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1403-B \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EDecember 18, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-24\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}