{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RM6VsHA5R6TInNdWpWporf7gd14AiZEKTU9V1bAYDyf15HKaSEma\\\\\\\\\\\\\\\/CJZktdXSo8jkqypZ83vG7iuX99yAHzfTf3U86FXvEEskm5iHlQ+086XZZBNQm7\\\\\\\\\\\\\\\/ylCk0ZH4k+JbLor\\\\\\\\\\\\\\\/6AJKqnMn2Wc2h62Uoahp4Mek\\\\\\\\\\\\\\\/6XYxC4kiczlRpYtHfYHaJFYOxckB7feAqF\\\\\\\\\\\\\\\/TxFKwfebCiHOV2mzYmpgDfV5WU8W0O55RayIEVfmSo9hmq6NlvEWpTNmKPbewdo6Yb1+eLy46CDaPXOwn0IkcIlKqKXbLYfdtK6bJZ2Bsk93V+UK83wD9uFQ\\\\\\\\\\\\\\\/kU884lWionMSmJSnNwmzSGAJ7fTp8LoD8hjOFpdgn4k8m+Z1MYEu2+hAJLfIB649XNDGTN1zSDACng\\\\\\\\\\\\\\\/v2EjyUMEsLmaTvRcRzUUsYWAlVOwgYVM\\\\\\\\\\\\\\\/SbH1S14cZoHsRVHEyQ7E\\\\\\\\\\\\\\\/bBJJeS\\\\\\\\\\\\\\\/dJaeYWLuaUzkllOAOLI2\\\\\\\\\\\\\\\/tWzs7ZeK1UmhfFa+ppQ7+gdq10g7yzjyyVGKsznENBHucu1SI+hu5+Ln0q+0fcWQjohM8kV7aLjQmk6AdzVZw13xlZCh8Q4\\\\\\\\\\\\\\\/cinF6Wr7k\\\\\\\\\\\\\\\/IfBqmsV7NdXYyF1BWOXshK+D4QGfABOEeo3Ws+VFNEqErMJu3HNX5faegMu+M9k2zC6bosISsnXh2w62uBdAl8BiT\\\\\\\\\\\\\\\/VpSTV8nRBiNhbBuGuuR+iF68NuwUKy2JBOJHLYTVS4IXJhdg2fDI9hAhgsdBSjzUhP6hgDDSDzXXtrZQLJwfEXDQ\\\\\\\\\\\\\\\/hugNZDbWvqTX8fZ6QI26sEVQEdmYIZKg049zL4dgHFi0Of3pUIBYURku38hiKxRObheIgW1jhkXN\\\\\\\\\\\\\\\/FwwEUxbFQn9VFKW7KmtCqu4t6m5L9CX5eKq7SegLlkyW\\\\\\\\\\\\\\\/f+KJppNAswuRZd2vvIoAIlFDhkhC1jpy9gwDvqqNCNxmR5tFDo8D5RXgX+LmLRRhb4eJPoDK2xALWzyEz3b\\\\\\\\\\\\\\\/sG5oSqTxHkcDgJMV4MCGcbChO80rNsxi6GHDM4EbmXVrV6ulYj9D+Bbvdg4dJx0Vyq05WVui9J++Q7EQzH1\\\\\\\\\\\\\\\/9Kv7QTgAMSdJkoG9Qwq40fWAszivVUDIoxxWyXa9GWiUZkXSpBOyakFpu0Md4FeBvW5n5MtSfRENJoWHvWi1skzznr1O3aw6viWO2FdnuhI\\\\\\\\\\\\\\\/xkk7\\\\\\\\\\\\\\\/dc7uWrw7sgx\\\\\\\\\\\\\\\/LTUFYLRnB8xwM3v7bqqmi2rTSLjUjlAazMM1WmVXk3\\\\\\\\\\\\\\\/QCu91y7PCVFbDfUKdSn+jnl7qVee7lXNG\\\\\\\\\\\\\\\/570MtPqvipE1HZN8qQxsIeGtwUx053fAPpsJcumHhpez2XMVf0IhDsKEKFbDtUgIM9nXXP\\\\\\\\\\\\\\\/IEP4Zc1T2mlzVaFqGVQ9W+AEs2z3zsGicuWzY1XioUX\\\\\\\\\\\\\\\/+j5ePhSjnyoekO5L6+XvHNeNPOc+HSMwh0sp2RNjBJKXGoP2PPL6s0A6ymLojKhV4QsjADGlWO\\\\\\\\\\\\\\\/vZkfQutTnn9RCXAmkftghmueGTk1+vskUJdRB2Jos+WF9KACu8xFF9XVo6XceB3vLtIdRogw\\\\\\\\\\\\\\\/iLh6pmlolUSC9MTMfht5if5m+\\\\\\\\\\\\\\\/Pnr2AId4Dd9AWoV+kiLspW+IgdmjgyQYfmj\\\\\\\\\\\\\\\/Q9JkAZS3Lhjrw4l6ssJsYvTC8EYB2nJ2oYroUsMPliMk5qtW\\\\\\\\\\\\\\\/MWjDPt3UBJ+6sx8w2zqvuLJhDWaHeFnpW2U4DsrIBe2SdUbnKsfyrWXKtneOXOvQpPUMJgtV3qUoj7QeySoScBudN7\\\\\\\\\\\\\\\/sjbHk9RRwfTKT\\\\\\\\\\\\\\\/tIRtrCAKTRUJDJQaV8LpmVElQ+n\\\\\\\\\\\\\\\/os0ALK9jKoW8irkmd5Nmu48EyljkI4CyJQHw0wKdDKg3vHpjij56+qxC9FYnfoA3WoxokMHYUkiZ7PvyogmpqINrZswJnfCn5DiFjJpnWHs6wKiL4B8k0doq+E6StYhsCgqrBCtMFrXWwRPTwr17MXFMNCxVmuiQrWFZDUilVR1qKOJ8iqg3n9weoZ\\\\\\\\\\\\\\\/4w0rVkyd9zjA4p824FydqDZ\\\\\\\\\\\\\\\/S7bjY+EqMghcnCWS77ZUEeVDF5WA2Oz2xCxhExrJnsbf26ZdGMmkdgY80JDTUt\\\\\\\\\\\\\\\/3LV\\\\\\\\\\\\\\\/bet+NFafs9x6Ms1\\\\\\\\\\\\\\\/IxWEu5Itx6nSap0VfM2wz9DHl8stiNHPdv7plXZ7EX\\\\\\\\\\\\\\\/wkUPH+neZ8BaDY+lux9kmMXrsGU3\\\\\\\\\\\\\\\/STTUh61ZTQEgVqyNO0U6yyRkl11xqcfgy\\\\\\\\\\\\\\\/WxnHOK5tePLe+Z0Wqm7siHfm9i9C4\\\\\\\\\\\\\\\/EE2qeph9991CITK7ORRKFp+3dnNkahAWqUaszapphZd0KuF\\\\\\\\\\\\\\\/JYP+W6flIjVOhoqyoK4ThvzzG6KOETKymmzgsnv3ujzMRKYnoCAa8B+WRYuGxRA8Lsga5iENrXDSmHSjOPebRGfvII+8jQk\\\\\\\\\\\\\\\/EyjaYt5u0w\\\\\\\\\\\\\\\/+JYyEUK2eHNE+4G\\\\\\\\\\\\\\\/0MReyxSqIAPNeGn9Lzn1R8vIR1Vn0BxNxvrYFGnYVSOEovD+1RALNE28DBHfqlLjVsr\\\\\\\\\\\\\\\/yOS2U6GLBSDXH9oPDs9nqMIx7s9b7q7HzYxKshwzyv6k6zQq8o8t3ApQgsUQlVWHW3AwM5OwRnajjQaFCj4drtRqh4SsFGUCgo2cNgjA543z4joHcm1CQQPIztU38+Ismw3zlE7g\\\\\\\\\\\\\\\/63wWNBCDD9KR\\\\\\\\\\\\\\\/G1ZClzuCZBCYNWWavpGd1DIaflIcHfT7yYW3IpQ+WYDHBS3W8F39OSqchQD5mhEBGElAqjxKGO6sFs5S+PKxzu3S6bRZzXrJ0nfLSxJSHi9bZHvyIGjA0hiGbKnCoidSkbkTkTMKWwJA342e4acPgcHfKpxbSw3vNPerD\\\\\\\\\\\\\\\/Rmr0CnDtgo\\\\\\\\\\\\\\\/ptUKcCwrxdfA9rv6OgoyT1i6L2ywvC0M8DlqETcSk\\\\\\\\\\\\\\\/mrnq+gUlnnny2rISfAdBbvVoS7IiHO8dPvu\\\\\\\\\\\\\\\/OcEQG67SxF7RXarlpwVj6pU6JUugUjXHmGo\\\\\\\\\\\\\\\/PlGSS4Z9YXGX6wrQZ9i+\\\\\\\\\\\\\\\/O2ZG9t5MfiEyg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022gr7rVDReRrwiiA\\\\\\\\\\\\\\\/kpVViSQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221dd87801a5c5908476ca8ff90c804a08a1864733a608adea5b27bd98a85a87bc\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EQiang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Qiang%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALi%20Qiang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMegan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHoffman\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hoffman%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMegan%20Hoffman%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELestat\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAli\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ali%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALestat%20Ali%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJaime Ivan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECastillo Silva\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Castillo%20Silva%20JI\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJaime%20Ivan%20Castillo%20Silva%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAyantu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETemesgen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nMassachusetts General Hospital, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Temesgen%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAyantu%20Temesgen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPatrick\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELenehan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lenehan%20P\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APatrick%20Lenehan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELauren\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKageler\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nHarvard Medical School, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kageler%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALauren%20Kageler%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJennifer\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wang%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJennifer%20Wang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EElisa\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBello\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bello%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AElisa%20Bello%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVictoire\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECardot-Ruffino\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cardot-Ruffino%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVictoire%20Cardot-Ruffino%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGiselle\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EUribe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Uribe%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGiselle%20Uribe%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAnnan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yang%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAnnan%20Yang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMichael\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDougan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nMassachusetts General Hospital, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dougan%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMichael%20Dougan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAndrew J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAguirre\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Aguirre%20AJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAndrew%20J%20Aguirre%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESrivatsan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERaghavan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Raghavan%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASrivatsan%20Raghavan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMarc\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPelletier\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nNovartis Institute for Biomedical Research, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Pelletier%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMarc%20Pelletier%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EViviana\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECremasco\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nNovartis Institutes of BioMedical Resear, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cremasco%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AViviana%20Cremasco%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EStephanie\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDougan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dougan%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AStephanie%20Dougan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49799\u0022 data-node-nid=\u002249799\u0022 id=\u0022node-49799--21710787158\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A896\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0798\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A896.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EQiang\u003C\/span\u003E L\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHoffman\u003C\/span\u003E M\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EAli\u003C\/span\u003E L\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E798\u0026acirc;\u0026#128;\u0026#133;TGF\u0026Icirc;\u0026sup2; blockade in pancreatic cancer enhances sensitivity to combination chemotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0798 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}