{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/sx5MVPly9Jchl7ifdkReh4GYoJW++vXGBIRFBXjgbdMUXiJoxV91mrP+WMXbp+0ImMzryaZoaa+tThnU0XyQUkjZ7vqNmKvKCDTc\\\\\\\\\\\\\\\/gVPqFTLcXvfOvlx2ZMUfOtfkZkEk2g5ncDOt+VOyyiImmdONX0TM7Kn26cyfP1PqCtg2sTXZw6BCEkrYviQ4G4hVNbuyiicub79ETfA1opYXgtsidnl3iVI7XXuOyDSWLGWFCiVlQf7H1AEmfebZh\\\\\\\\\\\\\\\/S3Tv\\\\\\\\\\\\\\\/by2f3gWANZL2JSudUQtNscMBnFUcW1lT557tlOxZb50dpPDci8bBHQ8oqwLKAceQ8DOcd+MtCpZJvdVuppELYpVxUZbRPpni7rD9f+j\\\\\\\\\\\\\\\/WveqiYfRiRZBV5sprBBnM9AVd4fZ68b07WUh7rG19MytEXK8nVYWnlOW+RegM+Vmtw1eu3l7VBatTQT\\\\\\\\\\\\\\\/dI4MYynZQpx4CNqEsUBLjX4ktweS9f9OpKMJetKmJrSi7UIrB4l5s9UPZdRmieYYkJhTMpFwp4PvQLjy3cD831sd6Sm9Wrpfbu1yDjeX5fepsjkasdQgmxQHn4uFbSTvW5cak5o+pJFKVwrM72NIjuhN9OBNHEVsfNs3D8+8M5QyLnRRc4utvtuFHwtTwoasOtb6n39Bp9ECnv34bFJqT2ItE9rBFwxsS+7qNaxz30cGw3flnqY3u47KPrilIeqaXDj90+tPPF9eIvJK1P5kdUH5bramoGSFAaHZ6xRWQrodGIgv\\\\\\\\\\\\\\\/oOcCtnGv7ButwMq2A4M+1uGl0+g1azVfm\\\\\\\\\\\\\\\/LNHXz4X3ywKPOykUE62T+YFwvyrxlkyl0z2m0TzBrgw2XFxmvJVrNUuOwOnB1nS5OhPaWdTRIQkAVxaacIT4snJngrW9uVcNZHlta+FrgKWk9AAbirfz9T7ZgomAqSkvFIXoiu4SAX0M4kpDSMYcxnFuGgjB8T4QXPNPI2Ox5G60L9CVp+ji6RUxJ4HSmSbArcc7l+5LjHQEA\\\\\\\\\\\\\\\/tvT2YwCW8dZ1cjvROVKxji502sJcT80HDRT6byWz94UFbh5ACkUSvd4aaZmSTKMae6CeHues04tKGEh8Wv1OlBpF7jERAfrx46gUftrTe\\\\\\\\\\\\\\\/Ck3YBc3c8jUuSQ931glLwUbJDjsqAYyZqnMYtvQLnvHp4wfgS9w6n+PYUIZ4s+yxLJLWBeHFiXkaOw6v2dlcj4PfsuAa38v7QkV7njoqfUP06DEBNdnlZHSY5wpMsRwQQqR6MdGA005NSZNP8lMApEpgkvYEAKa0nsO3budVpDlQcyefoOioX+uxYfNUr9U7iSZy3UlwVQquewp9nkUeVethOqZiUxm5tq25t5Und2ehXTnCTGkX1w21ORDyvE0yTmVQQSjWyhERFDyZTRLlKg2j7ECe7J8z5eFpXWSN8z4ggWxf2+AV9tK2cKhD0xcMtSKYGH3MVm4OCrHmEt3+wXwNU8tU3eRKc\\\\\\\\\\\\\\\/nvYLC73d8WILwkFTRb3ozLpfmX2DGmWJk1nbJxfrOH2ZxdvtCZtPA1XYmQZCrrpgHKNaVc62qcjpwKgaQMpeKcg\\\\\\\\\\\\\\\/jKEXjV58CTvBkrcGsMLu7uUFLfKO2Ldv96Efy1jwPYhjGy7ULBab9r0iYWFuGkxQIZTNqFtS4kT\\\\\\\\\\\\\\\/vCTYLxXqnfDS7CB3wYgot7R8eStYvLrhd25mAuWgvvQy87kacwzHGnUg95zSwXCQ1dm\\\\\\\\\\\\\\\/pT0EFioxr53ZjAD3B\\\\\\\\\\\\\\\/VkgZ4dh17cneqvDkm6rPdR9OnBmDwy8edNr1NWcOPX4SdwjUbnADkrSOhaEaNPLia3NqRDC\\\\\\\\\\\\\\\/EZgz3TkjPrHp2oDZ3wwkpncuCYZzmMD+\\\\\\\\\\\\\\\/9RCb\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/SigK1YZRfDhTvXwrWxc4kJqxgt3XFsUwn7EgQEW5qV4uFldfKOjgtXPdWaAqvxZvSEotFylMwG4EJjIv8s6YERTSyOghUTQCOagi8pWKHH1nNfa4XFrpjBKL7U098PI3WOUf3GJq2zVi0HlN0Z8am9TE8cEYHuCweSm0gln6ALQgam42MfeBlnJgkkBU08gUZ2CP2L\\\\\\\\\\\\\\\/Jq2ywRUxlv6smzvRt\\\\\\\\\\\\\\\/rV6Gn\\\\\\\\\\\\\\\/beFDF9pzmSScTjdX0+R4m2PP2L6Pb7izTuHDveF0uks3sLM\\\\\\\\\\\\\\\/kQIp2jVKIeSTanB\\\\\\\\\\\\\\\/deTDdygefKXJfSzgGVHx4Fa0tjpEcXIhY5fFhawFBX8+uCOyGQ9xNVT5wyVAm3mZ2+icgW0er5\\\\\\\\\\\\\\\/9d8cpaUuYbbCMrvq5uIH5BhuOzsYsz3h7ufa23ORfNvPAF+TC2\\\\\\\\\\\\\\\/kCqAoXkI\\\\\\\\\\\\\\\/ToHKvMonRw+KRMg3nBF1Z4zLPMLy7pMSM8CsR0LPno1XP1+StVUPjCPfvCcRjwEnW9e3DvPcoHR+Aa3lP4CA+OZFv6WUFxr82N57sJRCEZ0TS6Cgdi9CZIhBN9kPPRHTDQXMeW+3Ozkw1QkixkBb0pG1\\\\\\\\\\\\\\\/aER0\\\\\\\\\\\\\\\/I8RXkDDgi8Hl7ZZKVqAieZiu\\\\\\\\\\\\\\\/KUYLMyu+K8OTYgyzO1ipzhGAUw14UdT\\\\\\\\\\\\\\\/cS+8WooZTeqHZrM85xI6eRbGkTvbceZZ0g+HXdCMSGlcPXX4FXjj\\\\\\\\\\\\\\\/8+DlZXYDSpTZVUXXvay1lWatcBHCPka8aQtEmI9SFA7Gp1pN76I4JFyHrJonfik02gxEogHOUpUlhdzdBl1C1a\\\\\\\\\\\\\\\/3AG+V7Tvx\\\\\\\\\\\\\\\/34dKRlbq7zQ2Bz0Saei1faTQRm12wds\\\\\\\\\\\\\\\/4aMGsQEEh+VXPt6FHlv2GOle8\\\\\\\\\\\\\\\/HI9SdnCes37T9YkmKjHFjz8lXrVsvwWU99ivzyhu2HEO1vat\\\\\\\\\\\\\\\/ll+haoTs+hqcl0XIsf07d3B\\\\\\\\\\\\\\\/LrFi8zScPM8IGXTem9dn5xEA2zbFymNOoxX8IAMDaEGHqyq4Gw4vofr5FIN+JRBioIbdnFkkMFcnXcAdKa9EKUTXpeKpM6zXq+fz5PbEFjXxsolaGNXi8ZogYUf9VzHnINZIRehko17HfjihebGd+qBNjpnmY9gZbpsOVIfo9hOrnh\\\\\\\\\\\\\\\/A==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wjx5l+l4zC2LuywdyXEG3w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221fda51eac0ef403fc0b4859068be4213738f30f6774033b983a420589293d650\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESupriya K\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJoshi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EUniversity of Pittsburgh, Pittsburgh, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Joshi%20SK\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASupriya%20K%20Joshi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKonstantinos\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELontos\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EUniversity of Pittsburgh, Pittsburgh, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lontos%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKonstantinos%20Lontos%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGreg\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDelgoffe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EUniversity of Pittsburgh, Pittsburgh, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Delgoffe%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGreg%20Delgoffe%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49613\u0022 data-node-nid=\u002249613\u0022 id=\u0022node-49613--21223847080\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A313\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0273\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A313.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EJoshi\u003C\/span\u003E SK\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELontos\u003C\/span\u003E K\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EDelgoffe\u003C\/span\u003E G\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E273\u0026acirc;\u0026#128;\u0026#133;Hypermetabolic expansion conditions imprint lasting dysfunction on adoptive cell therapies\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0273 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}