{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022N2Jeo89umdE6QGvDPA+qy2XCcWzjBesaC0LVMceERseTEoNtYgch8Li1ImBEWySwHU0loBFoR4I9UCKw+uYoJLgFIPwlzJ1U5pEWXQH9D4HDYOYiYdz\\\\\\\\\\\\\\\/eIliAMzFp6pM8PYEZJAp76jQOzwAbzCNLwznxKh8ad+EzxyZ4h\\\\\\\\\\\\\\\/x4c5RgXh5bWa4dgMiFNHWUX1kShsaurnwc9Zw+cdBr8MLh0UBG9JCODmgdtnMLeEPRRI86ZZZzbBlTNkCRUheiUERMDXbhLzp5RucgE7N9KQVBovLOWXDT0aJYjM7vLsb\\\\\\\\\\\\\\\/MGv+Fer9ams\\\\\\\\\\\\\\\/5Sq9mzE6XzEtQ1WCpEU0jIfG4yP0sOe\\\\\\\\\\\\\\\/eM\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/TORgjj3+6AG9qUReDfKY\\\\\\\\\\\\\\\/yaRShcq51rxhJsnV8ZECnrn3k5MfTl1ru5M9sBqjqEYUJAxN7cHl6lUxrA1lwvnlUboj1pZhkybGdmrvWOSgzDXCsTaepjWvyhD6ccjLFlU6U1Srq5NFFCERUgWS9+TfO9UizC3vIkhxz\\\\\\\\\\\\\\\/Ux9R\\\\\\\\\\\\\\\/sIkKxXp8vtHHO1Gkj4APu9g9JhtlKGPRAx43WZkPCctJRp5dGyrjHYIZoR5\\\\\\\\\\\\\\\/0V16pVzQ\\\\\\\\\\\\\\\/ao2FJqLEj0wo0mKrSnbQQYDrnqW48MwKCVuzrQyP\\\\\\\\\\\\\\\/spqoaIYNN6BH+uYEygixeBcGj\\\\\\\\\\\\\\\/vqY0fGkMN4olBOtWW7xA\\\\\\\\\\\\\\\/ztZkr+yy45j+sUhezhT5KD5kWtfq3p+i\\\\\\\\\\\\\\\/1zjjSy4As8qLpGAGC0j10U6seMY792GRt0woQR73Ubi+7\\\\\\\\\\\\\\\/4j9rG0CnHvaIxzI38bA8HvBXsPrMVxRwyKYFZ8kSXNAZ5XNYOrB87qW08o8t\\\\\\\\\\\\\\\/UVxAXbkDj5C4TivNlnCtJZm78TaOKRuahXAEVuZ5007\\\\\\\\\\\\\\\/dWqFklJvDnS7MB18\\\\\\\\\\\\\\\/OJQdjjNUYJD\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/oKawG3585aYtePoIq7c0OmdwCQxYaGSanR0kHUFxxtYIYE4i\\\\\\\\\\\\\\\/dzRqhfU+mrep3qM+W315zLCsxWvMpCLCoXoHLDutHGK06P9B6v9R74Dlf7BtIIkKs0VnuYhmljt18rlty7a0tJIqN9r1HL304wc53nHJwvy2gYg3ZYfDeVZj\\\\\\\\\\\\\\\/dd3fJfbVmvKUlxfmJGiHN2AY29JfiE+xD1L6bcVzdNLCVJMyTQawDw4EzYczZku2hde2fyUllngqVkNxkd8HceqzYabBt1Wibj\\\\\\\\\\\\\\\/ZoMhqlvw8Vfg+hzOHUr5b\\\\\\\\\\\\\\\/2T3y3k3+hdc4FKyW89XCdKfQubGE6fHkQAEjsUurJqNsrBcVMtN4TpF3ZcuB9xcvcwApcpBFkTjKGjmKht+2ehVd0o8Wfrnh3sN9JRFd83Oa+wv7rz29Iq0DQ5eoum37mkyhz2oLgbSaQdrczJZvu\\\\\\\\\\\\\\\/NX+uL9JJyF5teBSZoceHsepZl88YGdkSX98qJ\\\\\\\\\\\\\\\/NtOyhTgRtzGgD+qtMZatERnwMtXhI2V2\\\\\\\\\\\\\\\/zABSbeVI91dYez1yAeVMvrnyjHGZ5QjFgEu1ciDsDeZV8iCWEKHSdMWzJaJ2ZcXcys5LVviz9oUVPHG70pQacZBR6IPKSHAiP\\\\\\\\\\\\\\\/L3nyQtVPOa+YTqnizQlYmReqlKZXQkaZ1+NLg6Top7RZZiV1LmCKFeQaq7iWacypANz6fl24DTnQk14mjSGQ7tAfEAjuhQapcLvMN5KAUgxdcuyw1FTEj4ZoWvUc042DLc456JAfEd2TdnYsj4rLuezQcRuKR63gGc4NGdhohlGbJPXbLcqhc1Hze+jGGx9DP899Av3AoKw4GTgTI0+jKriU+FgQJseyd3APrlpF3DV7y03HEDfuvoVaUvwRu6Vdi1YuZi50P2waKDH8EVzlMQvEW71xt9c\\\\\\\\\\\\\\\/AdTPr6utcaWRAHMZnXmQZm5yWcUacgA3NyILbpqAFjqtjtMnuevx9Z1TAEOKCob6snU8RSi7klpE19bqoWaedlrLN+GMIA2Mlg0S6oORh19sTYaDrNoo87m3EzhfHt1qwG1zsGhQiCvPlsW72LfE+i6tnHQiJGStRZy3xujPnpVJcuwd2L8rfcmEXQm9XWeh2dRhb8aLpGUEcKDOZDm1VewhTn35RhJQ5juXX6PKMQrjfoz5IE4ultqUf37ajGj1Dk3TtKfktsslrPDxWrIX8hCFgq7C1yzf\\\\\\\\\\\\\\\/wMK2iOWO237G3qUyjQ+xTPjy155qwT+4bzsEvxsz+ucFAm5ltzqbGFtxgTeNnuPXhMb4xPSw7W9s4L32ytU4teAkTBDCvSGmg8eVguzG+FufuUJYX3VBb4NZXiJO+jUWwFlndpqKzQ22YNR32jzYYcZtN+rWcQko\\\\\\\\\\\\\\\/qT6pkXCuAgThJOA7H82zBXWuqG5hwm3zmeSkh8vST0VyjoEa1d\\\\\\\\\\\\\\\/p7G4i\\\\\\\\\\\\\\\/hDvTcE4+cpEcmoGU9gK4hCm8qFZpnxvhioZB3+VW7OlR\\\\\\\\\\\\\\\/UT5k0xN+3ezLvIQ6EBhQWj6iaUOA\\\\\\\\\\\\\\\/mkbCRAAkTtTZEkl5bNRcm7BTTJ2m2dOdqyHx4QTVb+94ThcXq6pf1HuakOujElWdZ8awVGoN7vkgaKIbOgJ1+bAlQ72Y7\\\\\\\\\\\\\\\/UEgGpYQPiSaXk4tFe9J0i4Q6ARBdpQ5yGreVLr93dZtwD8Xt2TnE9vYWmKK6X667MOii2hjyDysBGqL0S2IXOwHIe4SDIWdbGcFklZBMRrnR\\\\\\\\\\\\\\\/mL1Q0RU2W+otxY2K7y12NxsnoubasHRkvBPZcogpbioUnB7WlMXq0CbIXdEfCxHimyDhyCnYCT3UvvSpFgCgojc5Yx2RbENT1c3zUr42OncASrnrBqcnuk+CCEOREWOeYcwVii9xkHMwkQA46TsgQd63XKr\\\\\\\\\\\\\\\/57tCyZTbBvwndnCoS1OYEQ7lsqSazgQFaBPt3lBQqi4HC5kxNv1Qy+pUfUchnK9DcKsBn0GK4dAgqlexe347EGJ3HlI5V3AmN\\\\\\\\\\\\\\\/mJGDVhWpIcFNDvUOyeXFLcvDH331DYXnIZGC9ENSTd16hClXwSs6RDEPNj7MspIgWbR+CPTcZbVbnM+iFQ==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022C3LJDrEkHPbtrgpN5tgsAA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f718a258ab2d46a96bb2c0441b730cd446a8c14e04ed688d39996e3483df898b\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMiljenka\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EVuko\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Vuko%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMiljenka%20Vuko%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFelix\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESegerer\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Segerer%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFelix%20Segerer%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMingchao\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXie\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Waltham, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xie%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMingchao%20Xie%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMonica Azqueta\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGavaldon\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Gavaldon%20MA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMonica%20Azqueta%20Gavaldon%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAndreas\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESpitzm\u0026Atilde;\u0026frac14;ller\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Spitzm%C3%BCller%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAndreas%20Spitzm%C3%BCller%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHarald\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHessel\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hessel%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHarald%20Hessel%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlma\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAndoni\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Andoni%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlma%20Andoni%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMarco\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETestori\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Testori%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMarco%20Testori%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMichael\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESurace\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Gaithersburg, MD, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Surace%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMichael%20Surace%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMari\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHeininen-Brown\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Heininen-Brown%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMari%20Heininen-Brown%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJaime Rodriguez\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECanales\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Gaithersburg, MD, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Canales%20JR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJaime%20Rodriguez%20Canales%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShashank\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESaran\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Cambridge, UK\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Saran%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShashank%20Saran%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHelen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAngell\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Cambridge, UK\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Angell%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHelen%20Angell%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGuenter\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchmidt\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca Computational Pathology GmbH, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schmidt%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGuenter%20Schmidt%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENicolas\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBrieu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Brieu%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANicolas%20Brieu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHadassah\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESade\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sade%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHadassah%20Sade%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJ\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECarl Barrett\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Waltham, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Carl%20Barrett%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJ%20Carl%20Barrett%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMarkus\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchick\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Munich, Bavaria, Germany\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schick%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMarkus%20Schick%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGiulia\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFabbri\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAstraZeneca, Waltham, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Fabbri%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGiulia%20Fabbri%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49583\u0022 data-node-nid=\u002249583\u0022 id=\u0022node-49583--21648315109\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1669\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1505\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1669.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EVuko\u003C\/span\u003E M\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESegerer\u003C\/span\u003E F\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EXie\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1505\u0026acirc;\u0026#128;\u0026#133;Spatial profiling of the SCLC tumor microenvironment defined by high MHC-I expression reveals association with functionally relevant antigen presentation\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1505 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}