{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022n8lHWBDcZ5qP7Us4rQjgGLi1Ah+8XNMTTvTducWE3EUgR6iqF4L\\\\\\\\\\\\\\\/BNDtuyDNPWxrjPpKQ4TJ3P7YWQQpN8efjVmfj9HQGraiAhPljHhue2Fq\\\\\\\\\\\\\\\/UYA6NGZZOGw3Bw3iz0AEsWP3bh6KscdutTUJ\\\\\\\\\\\\\\\/jXm6GaL+MjYdAbqJa3b9UshCEdckPpKd0qBkGm2AApIVQpIjG2omUk4P5SSlvGRl\\\\\\\\\\\\\\\/DQeC\\\\\\\\\\\\\\\/bb8m\\\\\\\\\\\\\\\/J3JUZqCEQGGt20iVq4YRSi2EThNaX9r79MWF2JSU90D0sRd8gZ+wOWkiBbE8WTiuBdXdPzV0vzMZHQ003+rOYyBeydAKk+BZfYPRwUal0eA4vP\\\\\\\\\\\\\\\/DJXSBABb4LmK6zB0TAUiBEhyxIsLMGxVPGrvTTD6WtuRygKpj2tvf9gSGx27AUfeoveGi4R21kJQKbmMqulubMaJF76Feg9sJJCBQR47MNnwI8v+5PWb0xsW6BPRXx\\\\\\\\\\\\\\\/0kItJBoxhORfyAuk+FPIwGeglIfRcyjcNrXrC0Sr16NYz3zPxWARGUgZb2uG56jXir\\\\\\\\\\\\\\\/bgwgNOdMfNMC6V4bGyUebXvmmJbmue7dWfIfx1b4HHuv0B\\\\\\\\\\\\\\\/84gCax0ZvvZrURkjRKco1xDs29kADbPtV04uY\\\\\\\\\\\\\\\/SB\\\\\\\\\\\\\\\/LjbwKVNVYuRw2IWfLlDJDTvhDdc5BuDno3mv+uOldeb6d+zFmzVJULSD0Ao3kSOcR3PwDcKrF2Rdqx5cw1Z6+4UK3h3+T6WIR\\\\\\\\\\\\\\\/0irX8XEBfn+EqiCE3sKHH7ZkVKTy3GrwPYR9OvXxXmHAeyIAjYqUYjgP6Ck9ZEvIxv7EdtETzRco80U0\\\\\\\\\\\\\\\/Y2\\\\\\\\\\\\\\\/WLed8JnqrzDlLZWN3kNiPYeX8GUPQRgGfHDRCoPVbCpbv7xtcSmrZi5oAv22cgx3yWgmtPSY99DzVEkryNfLcRHp1gpHIXXdV9Ga+\\\\\\\\\\\\\\\/aHr7ootBcviDXD+FuIGkcxEfNcbNEDXLs+GE5C7vLwoIU90xenFhbDSOg2YNBa\\\\\\\\\\\\\\\/zL7ynGeG4eUE7FtmTePtqMKkh0W5C3KkrJW1cCaP3J1Ry3Kg67Br8G7ZHYFz9D7iXLhDt060OD\\\\\\\\\\\\\\\/tlQjEHGsOlCoChbhuYujBEJtcZD3jfR+ouHklX0luW\\\\\\\\\\\\\\\/zsBhkKtpJI3+hktiIimbHgv5OPohSJQMko\\\\\\\\\\\\\\\/JkzsgJs\\\\\\\\\\\\\\\/JevhMG2+2yTg4mFppWpXqAwA5wHzgiP9C3SmPx+bQGndCGRAYPgiGsF8d0zXgqy7mpbSXg\\\\\\\\\\\\\\\/7jkl3Lqs5iDNAqV8a1ME5MbEu\\\\\\\\\\\\\\\/IqZiDmYonSwewbvpiWLv5QNlh9Vkq4jYaWjksTA4qJS8CyzOeM7RKjhVBH4NBqlWgfmhfLqF3IQQJqhGoyLfB56UwlPEdZyBaPJ9VeOmxqzjaItJR5TsRnbwl+HKyFUCGBUMutXNMpKqusfssh1IcEpw7FDabrH\\\\\\\\\\\\\\\/JXvTAD0jaqzGqcBS9+EJZBHwmgysNOy9pfo0qXkYJsJFw88XwaNCjEt2oiIwiel8I4rPBTt9dL7l5JaCEYNlk1ulEetlhxG4f5xE6NFxMs0JyKHyjutUZmXFbHyEHK16zzr2ya3\\\\\\\\\\\\\\\/jBhSc6Ytxnfq51UB1+L2EpmLrVIgmnscP7Uv\\\\\\\\\\\\\\\/Af44y5pjpM61TjDzauspSPHTywQdDYAqOOqf76TbkbNm85LqYCGrCtz3UQdoaW33xJcK+CWBV08AMNu7Q3nUHwnaE0XFdb1eaNJCTwh5i2t8vxwn6FxjG52+ptmjFxE46e6xBNA6Lk4WOHo0lVUWcl7Ts+JDlS3amIlM9MRKc0H31+rz39saWH057Pb1zxWdduNYQ6B+KqAk1ycp9lYYn440IyKq9S7Kes\\\\\\\\\\\\\\\/jFNWOydqOwsFbly2ZG4wzlEmYu1Uz8pz0Q6vRd\\\\\\\\\\\\\\\/gg6pk7BDxmjSaVikpBy1vQF1lCWNZRMvGRjp6be4x1iN+AsKFwZ845VVRG9ON5tn9TwQ+zkyddqV9atYoHAr6N1sWzbGKV7xXpEFz0G4X\\\\\\\\\\\\\\\/sQC+dCP4vUtCKt0pJF6xBXtN5\\\\\\\\\\\\\\\/8LzzfNIZxlpQvHT2avdkZ8XQUVz20jnw2Q0mdlJaconENBw85gN9qES79s95PGmAVqPAqFiDb45MUbN9\\\\\\\\\\\\\\\/kPo3oweH8OAt1R+f94UtjHE7qdMkfd0CzLbyp4wkCfgG7NAtQLUVWDOLtAaDjU6esYw4shJdBdRM27IdS\\\\\\\\\\\\\\\/fVrAKY0b\\\\\\\\\\\\\\\/NOoCqt+YHhaPUMVZAFXWD8foIbiSuBZlPsFr7J2\\\\\\\\\\\\\\\/XzjbaCRm0yZZ0LHf9NVXIjPX2tFpu6AjGiBM43ZtvwsvfDc74VfE7vz1Po+0rFNOM4liT0TWHaZoJLcbL19jVoiQ8NW65m9qE44mYgpl16DWVDA5Yvx4nHo59vtJR3k7R3eDUnusfKMqSYkDokuKH7J5K+O5J9S2vz07c4BmSOaHbWocrbQ7QFRINapAtuvf1+7ZN5Dmeye36dU4rDFq09V4a0gdV7u5dLDNtWpWSo5kD\\\\\\\\\\\\\\\/MuZAXhulO53\\\\\\\\\\\\\\\/MyjITP+UOxlBd0xyWg7NXWk9oqZcQZq2YCuiQxBXv55quo\\\\\\\\\\\\\\\/LuR5HktgzjvfhJ9rlXijHqkjXeKb7\\\\\\\\\\\\\\\/HUGiQBH6236\\\\\\\\\\\\\\\/Ngq2aN\\\\\\\\\\\\\\\/zjgMXgOwpby23\\\\\\\\\\\\\\\/iiYwpIpLhzVob8U3W8IvP6fx4LZbXT8WaZccDiXO0ZjJgmjBFcO4dvFGWBuRz3pY6C2NY0Ztcr3uNg1md6Hp87TVvm33JXCVI5PXo2X4oWfmKBRE+2Lx9avMddMtGAgnK8OgmNhgdUn83HA3bjfAs2S+K\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/XN6uNoX+x6Q1jRCDfDTyjpSI4puuXgDWeHX6q9XiGMZ2ZPTdWziDcCGxGJQ8nPjM7SdHaBg2TJRh71sce0zTpWnYUkSNXdEWK6i\\\\\\\\\\\\\\\/G2GBsbeh0Z7GPct2zboNEzhyLI2JfnBaSlW4r1+rJJLdNgUymrAb1iEc3um6+PYnyq1MlWDR\\\\\\\\\\\\\\\/dE7vtRWIU2fU0rUNqRE9\\\\\\\\\\\\\\\/BlQd7kZl8YNzsizT6FVwO1bxkfpDDg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224RG5Y9OCTfb1mjBIO\\\\\\\\\\\\\\\/m0UQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224726742d425f398b791702d40f68c1e8a17ef2e54d56c162031d23c40f8672eb\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlex\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENisthal\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Nisthal%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlex%20Nisthal%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESung-Hyung\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELee\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lee%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASung-Hyung%20Lee%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EChristine\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBonzon\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bonzon%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AChristine%20Bonzon%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERuschelle\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELove\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Love%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARuschelle%20Love%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKendra N\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAvery\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Avery%20KN\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKendra%20N%20Avery%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERumana\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERashid\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Rashid%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARumana%20Rashid%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPanida\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELertkiatmongkol\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lertkiatmongkol%20P\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APanida%20Lertkiatmongkol%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENicole\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERodriguez\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Rodriguez%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANicole%20Rodriguez%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EIrene\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELeung\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Leung%20I\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AIrene%20Leung%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESher\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKarki\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Karki%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASher%20Karki%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENorman J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBarlow\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Barlow%20NJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANorman%20J%20Barlow%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESeung Y\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chu%20SY\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASeung%20Y%20Chu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGregory L\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMoore\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Moore%20GL\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGregory%20L%20Moore%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJohn R\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDesjarlais\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EXencor, Inc., Pasadena, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Desjarlais%20JR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJohn%20R%20Desjarlais%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49522\u0022 data-node-nid=\u002249522\u0022 id=\u0022node-49522--21533846483\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1167\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1060\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1167.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ENisthal\u003C\/span\u003E A\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELee\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EBonzon\u003C\/span\u003E C\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1060\u0026acirc;\u0026#128;\u0026#133;Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1060 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}