{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220aPe2Sr8qQv\\\\\\\\\\\\\\\/t8\\\\\\\\\\\\\\\/8iqbjMHE4e\\\\\\\\\\\\\\\/Uny3GzICCHuN3KQJQ+y\\\\\\\\\\\\\\\/Qc4wlRNNbqlT4gQvaefB81PAvJV2kFaMBjwRg+Q\\\\\\\\\\\\\\\/PKEW4QjIHUGWGHypuE4r5L\\\\\\\\\\\\\\\/47J0txvGY1aMbcKch84\\\\\\\\\\\\\\\/YqcYKnjc\\\\\\\\\\\\\\\/nz\\\\\\\\\\\\\\\/Bi0X796WGetuuBMszPYqjWzOPX3ryA3BcRaQ1iXsi2Closvt7CGWFDr+8Mp6zPjKSyzOZMvmIuHGYVGECqsRCa5L71893AJilav09orN9YaJUY9HvS2lLcedi\\\\\\\\\\\\\\\/hF2lDCW4I0JCFidrNBOgnnCUGYaFXEFWlorYnu2GFCfS7DIOZ3VjU4HAK5QyDbaJsbR84AO3KleS46RrgXAUM1bToGcCBzeLfRFllLbSY6oSUCm2Q7vVh450a50eB03Yj+ElvaeCtl6stk0wsn7p9ruQn9ucJVnf8uVxpyY2oiMtnPxwiuwHC6ohMh016QzG7tyFaQdvVW6stzI22F5GnZ7o\\\\\\\\\\\\\\\/NojcQVdWoXQYSu\\\\\\\\\\\\\\\/rR1OnVIaLoiUdmjU11YYmWVfWLbt9kr+A2e\\\\\\\\\\\\\\\/LmfG6yPWKJoLLWq7tHKPn93cAnilIpHIP\\\\\\\\\\\\\\\/SIxr3kDL0aK5ERJ1zEuvtjm3d1dSyD2lIhulNOhlXUxkXsxvVYwCbt06UAeFfzK39ORkGssA1SZuBgy7+gDJIlOfs\\\\\\\\\\\\\\\/Pc6U2XgCgFn3aDKB8AizGGls5PmM1oc87EebutL9J\\\\\\\\\\\\\\\/5TjKU1f6t4Ycc22jao0mlMPM0lcanlQvFw\\\\\\\\\\\\\\\/cA2kifXF9Rg4ow3fr7VpjCVIHhKdq\\\\\\\\\\\\\\\/knuxDfDxAU8wR5KcDMHAzJVxobQgV7lVgHf7HwB\\\\\\\\\\\\\\\/1Hi230BoXk7lkir1oy0XGYIM1g4fsCWp7AZKwk0NX4s4CnCC2oNrUVVbSM+9cH1WCvOdOTZVA573KdoMFCjpQh4Tn3\\\\\\\\\\\\\\\/CmYzEo7Mm2EJKK+\\\\\\\\\\\\\\\/Mg4Wnei7XjVDl0+\\\\\\\\\\\\\\\/CP5xhS+xGvHLaBxTDKnSf0di\\\\\\\\\\\\\\\/iAr+fbEez7OPU\\\\\\\\\\\\\\\/tnhRiQRiichNNWlNm2NZvAjPhwWV0Ahp8f5KqIfHG5ZxAg1wLn+3DUPjDf5FvLCTPtue0\\\\\\\\\\\\\\\/gtW2VN1CS5ZesDVhScV99\\\\\\\\\\\\\\\/Ze8NzF3IS3JlcZJ2sWXlfk0boOvNer4uSuOkflkxeexan45rnzGd5jcmOf\\\\\\\\\\\\\\\/7wdffRZGi1XQ2fdWq7XpfK0qnKTruGz3OPpR6fyCKDIa+I8wz8ot6I1mzhQ1azJbWbQgr9XV88hz90gVAjLBLe1MjeIQkXfHOkxaKNMNRsXZGKCLa11982zSjeIvwWCo9INhHdfQ8DGQpWphzAV1UrRlBnzfjXFpWNGgGeLf8dZY+qRgi7Cq4RzMc6vLSVkVkxyB6dJWzMxNrhZckZswXc3pGu0ws+RbCTAdoPN+feY60aoTfGJQOW7+xP3XpwLGP2sX3N5\\\\\\\\\\\\\\\/zhcdEWD9MyujDk5djgnIDhv9A1k\\\\\\\\\\\\\\\/6TYxpkIFspznlkAvcrxeUJA\\\\\\\\\\\\\\\/6PGlwrhn1Yc0ISwVaOV0\\\\\\\\\\\\\\\/plMEkjVnXT5v+wHQsmX42d+Zvz+dz6VOKwFBnQCgJfJXmMUpFJjFdCfdc7hK2+Lx5NMIN3kiiPSg3bu1jFKScChJcyk3ptFJ0ZB688e9B8LTxlYNpZFEuxo\\\\\\\\\\\\\\\/Bjjvz576pJLgIutyQOCW2AUjSyW8jQfilxat79DZRJPAhC\\\\\\\\\\\\\\\/UsuG\\\\\\\\\\\\\\\/0FjLkoYx70Htk\\\\\\\\\\\\\\\/88pOp71yHIAN66QYite0e5kU8tFNPOD95N7Qi9QHGF92wzileLRILPVbpbiXI\\\\\\\\\\\\\\\/nXQcf+iaY4STSGOPRo4+dTMkfYi1lyrI\\\\\\\\\\\\\\\/WevVfXCMcyOhfQJn\\\\\\\\\\\\\\\/fVrOn0TyMDZ9HyxkbAiWVFqAA34u\\\\\\\\\\\\\\\/YxoxSVnjbGhUr6Ua0GdQkRBn5PXgROWAjpfs1UWIQumcYi0nokT9nrM83re2xglM7QtYwwomIgKgjK8YpJ0jiJcBFfOdZp4UJa5R8y1405F0Vmdf2WxH2h+NXhDPZZHDfLQwoHAU3XbSDrjXPtnAdAxI6Sq6\\\\\\\\\\\\\\\/GZrMEu1QlFsbYQHopUtVYMUR2qXtvgPeyUDEsPhdH789NDpGaXwbzlFAnXjCOloYMRpvjLsWxl1k6rJSipQGPNb3yfbFVSEM7oRDnpgndsy20cnH0Ogya85hRy2LEbC\\\\\\\\\\\\\\\/YweMK98i836slnTB626hIy3XTHFHdJFKIdAse1t9bWWRErFAdAlwTgOs6mAEBsImozXLAPZM45vNxdmE4\\\\\\\\\\\\\\\/GgyDNuvV+d1oWq6zLc1RdAQYBzPgI\\\\\\\\\\\\\\\/uYzpPygVQ5FTtm40eFSe7Y9juYY8gRmdAGzDMnP4hOKY9QW5IFVpK21Uwjpp314ZOsp4Pdwy88WvhmF04h0ctQHbGBEybgXStQDMpUvV\\\\\\\\\\\\\\\/Od7LA12dPjCAIljGE9YXrf2cKNHwbaeeDUcD0ksXYfz5tvqdIMcpzO\\\\\\\\\\\\\\\/ppkua46imsM13vqLqT+gGxrqQi32NLwgOrdsh11nM0XxSBWf2r+4\\\\\\\\\\\\\\\/WdYYXjd9ISEyYOhL77M9L+dapr7oyQM4YQCrFZqzmDm1LegxbcxS+4x4ROWy9sTJ34dBET4wjSU7tTpbCDNCEa70Avui08sOiENk3yKqtUB\\\\\\\\\\\\\\\/686IzLppfmpA0i6qlT9ogET+VP6csnxWLMPLocxbQtGLgH7MOTgLA\\\\\\\\\\\\\\\/4kbh4RUG6WZIDFUVu7wJU3D4P+wPKLPhKzleUXHW7LaFLEEZ4Ses6yWlmWmDyuG9rCRsQ+vrl\\\\\\\\\\\\\\\/B70LfrEm8EAXoR0Q89v83lVI9Fm3nCDeDLaIxLG8BZhAraSr9svh0BqgzhrjkLGyct\\\\\\\\\\\\\\\/FRN6d5AlbadvqyjG6msLd6mFJl52m9YbcV9rTC43pBlgb9PtRR+AAMB3EHLK9wROMXoAUA6otS\\\\\\\\\\\\\\\/jswm\\\\\\\\\\\\\\\/IbmhutfjKgwdfKpOobcUR6c75vtTuJneSL+cJfk92TU4wCHN36Bpw8uPg9ylnkIAaxp999zzRsjbE0uHsvhdrQRlPiSbueWx21SYglThYqbB8+wr0jiLVf8aQqdifth+kw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/164wuMwOc11xQenjvTg\\\\\\\\\\\\\\\/w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022cc3e4f3d2c5e466f7e7400829b8b83e69bf59f61af4bbad3ff6f80e11a15895d\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEric\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nStanford University, Stanford, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wu%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEric%20Wu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAaron\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMayer\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nEnable Medicine, Menlo Park, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mayer%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAaron%20Mayer%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlexandro E\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETrevino\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nEnable Medicine, Menlo Park, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Trevino%20AE\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlexandro%20E%20Trevino%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJames\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZou\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nStanford University, Stanford, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zou%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJames%20Zou%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49359\u0022 data-node-nid=\u002249359\u0022 id=\u0022node-49359--21032956230\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1463\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1314\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1463.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EWu\u003C\/span\u003E E\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EMayer\u003C\/span\u003E A\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ETrevino\u003C\/span\u003E AE\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1314\u0026acirc;\u0026#128;\u0026#133;Polarity measurements from multiplex imaging suggest immune cell activation\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1314 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}