{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tHDv+zHgeNmsrrD9y3IQffs711D9rb1BlEVqQlEfO\\\\\\\\\\\\\\\/nKLbMPVyZtx2lopK4PdxYaQEO+h\\\\\\\\\\\\\\\/ZOl4vEU9pbB3J93Y9FcV01SFdjgjjPOE1i2GNYBQYt2IbnXjNNhiHLkt\\\\\\\\\\\\\\\/hcHI57FJGWZQkVZO6wBNodFvP0KoLQ3\\\\\\\\\\\\\\\/j50TECQtP6tePdiSaAoectqVn90D\\\\\\\\\\\\\\\/EXxPG8viOVbXyTIx6nN5ynCWnC3bVI4kTkp6PxQC+vBbAZLCBtfBD9ZNEJjBsChbRnkc8+bnZfnyJcV1HpHQvZvpbgOh9mPXMEENtHCD4q8veJHrJT9oJNMO+L3+VJWd2nNk6vpAQHW9e+M4L2VnemMiQMzBVGN9khGITC7NJPfNVMEZ3EiwsYeGVwvFPcRqWX3SBIl2piicKF6vSWiSSQhS5B+cZoF3NAzM3N38+gyP9PXuRYHRRH8WhdopX0\\\\\\\\\\\\\\\/0Qk3AzvtZOBrO7k4o+KWF1y0mUVSw2bOlqG1sQd2dGq7SnMhx5I9jWxlNvWDFimwuG69RGn2Z+wQshO+UsA\\\\\\\\\\\\\\\/YYmi4Ury4DfjXE5p1wqtccrRxObHU3GGgUACRM4KPiRDDumF\\\\\\\\\\\\\\\/icWDRUeQeMFFWrdZbBTI\\\\\\\\\\\\\\\/ZSENL\\\\\\\\\\\\\\\/2BZhx9tjePcA8oPRwQkd6iejcGby5JLS0XyEzXwOkq8YHziw\\\\\\\\\\\\\\\/pAngXAX88MPlEfQvNFGhJVch1SpBVTMsujPDQ\\\\\\\\\\\\\\\/S9R\\\\\\\\\\\\\\\/TG0Rnk1dskeEmGpJG+QiWDsL\\\\\\\\\\\\\\\/Q+Tn7T9SuZWO\\\\\\\\\\\\\\\/9oNA23WR77lm1NbwwR+udWK3427XhtrYNnydSdPcEqGaDwL6hbcokl4Dcla9aqJDlOOGmornOGv+mLY5yv7VuZwuJMNBKws4rdfPv2losPHt\\\\\\\\\\\\\\\/DRTSxKzeYf2rsq471OTk+mMKmQ7gpDN4k289dMoUnm1piitkj+GjL\\\\\\\\\\\\\\\/AiNt1nHAyBaPWcsq0o8xU0l9gao2tsy9sGJvP5g2HURiDoShQewOlZ1BkOsTBTaHyxxhswypD20zoyDaNrjtkDQz2hsmNyZPAqLlZVkduD6OeddzhEI7Ojo\\\\\\\\\\\\\\\/HwDLKS2fTjDI2bQEv5ifOeBbo+\\\\\\\\\\\\\\\/1idfEBu9dy+AdZ3oZ+ef9WzNQmW6qNSbN8BM2H3qN1bSGcAwNBiAGokzzlAomI\\\\\\\\\\\\\\\/rmohmKh0G36vp\\\\\\\\\\\\\\\/bxFEskaMKsjb9RxZNsn0MX+M+EY3osFQGfzRmU\\\\\\\\\\\\\\\/69tehVGS9Qk3ri7Tr2wb1Twel6+LqrI9ii5KV2G0WFsmYrbJdFwbyuI7\\\\\\\\\\\\\\\/NsAiLYqxJhBH3g1Sd0AYCk\\\\\\\\\\\\\\\/8bJC2rhT\\\\\\\\\\\\\\\/0gh3fegfTY6yZ2T9c+5c\\\\\\\\\\\\\\\/vkCaK04OxOQgFqPyyTeIjOtR6tCb6douq+eUkKUmeSbbQzyGig8X7urKfYCFEcwFtyYwdet0A\\\\\\\\\\\\\\\/SGT6GzBZaDLnmUQX2SCA1DiSXWB90ligYSr3+HTDUGdjSkk6AckqmunNaoEYIxXIewlvxJue2lLtG47EB77JZmstSt5WHVY43tMNxx4rZxfDE\\\\\\\\\\\\\\\/Lxe6WXtOVULHCDrYsb4IeMXFhSLrW2EnZoutW9Kigg8sYI8CsP\\\\\\\\\\\\\\\/cS5mC5asmPQ8dPcVLXdvAzBHD9R6rgKAvRMn5MHYHWUqnRUx9cE4yQ8NnRq2dLtpPgYhTfhuD\\\\\\\\\\\\\\\/uLtu2QcRknHBvi0Xjn\\\\\\\\\\\\\\\/xLCLgu9L7PIQ8eeHhBn4YvO3a5\\\\\\\\\\\\\\\/u+qvGycLX1y2bZYpKUE2KRX4Zl1SJTG5IW5BMC2aylPVXk1ielTLqw7tL9EJICUYkGPyvyHtcqeL1sUcUFbSKNjpQTXL7huciTuvJoxJxpPmyZL5Chvz2fSOBn7Sok\\\\\\\\\\\\\\\/etZ9CUUVBAktmgkYm7nOBcr8Cio7aOZff1cTYgMgnPptgkFeV\\\\\\\\\\\\\\\/3MdIZUWrSKam5OUfEpnJ1SpNNqh9eI7xn6DrEk0o+hANvtGrTQqA2MZ+n7gmMxveMJAhpHExftJcJFpQ8bK7ohlWz3KoHmOB1\\\\\\\\\\\\\\\/tu4xXQH7M1u5MoGFexynk7SDmlqLT47Wyne12yD7lijQOsycv+qz5f3QstuYpMVoYRWnfvRJoEt4Jb2DnfK90\\\\\\\\\\\\\\\/U3pHbhp45l07HQquLu1ASia3oCAY5Sf6gt5Hwue\\\\\\\\\\\\\\\/K0yjnUH+2qb6ypho0c4LRqj6Zzd9wwonEgYaf01RsAxsun8NEnIT+PDgzyeGeVYgJuyY+GwEQnvLffITkp+YcOfp84inP4YIp+Yv0KGtpqPlRNKGP8MQe8nZiCQSWSedCr2B6hAK2LxGUZeYwAgN1JmNi4Gvn8ptwCaVJmTceI6zv8k3oWKQx\\\\\\\\\\\\\\\/V1kQEiuD4cvCC5nu2tY8tPQ7w3dQwsA2VNhCofTkbCZfPHIK4Egqn1+nRWc2QAM044m555Ihmnpe7Ru88P8r07eeR\\\\\\\\\\\\\\\/XBvptHaLjlAwSpSKUpbvKN1Gscl0YiiR4K8JjuV25BaOeIuLpa2Nab5Ow0+MfoazQaIdOj3RJ8gpzDZwRW8uMQqZyW5roXacCJOBsQSed2ClYp8dFi4Q+S0mwGmN\\\\\\\\\\\\\\\/cf8xhmlkOzZHpGvLeK0yK+JbEfoV8VTnGaHwTMcG0YVdm28B7rknT4cTRbSxucwW0\\\\\\\\\\\\\\\/gJu8sk2HgnQt1kxPcYpb7h1O1t8QdZg9\\\\\\\\\\\\\\\/g7dRQ94cTv9hPclM3cWsMJDMYabxKams7nt4xHzD4ym0rvlC9uHwIUWK6Pxk1Fng4Ww5G2JnPj481Fot18nzF4WTnSfuuQ1tT\\\\\\\\\\\\\\\/T25PSeWqb7eY2bi54T0tRa7D5E8v7I\\\\\\\\\\\\\\\/G22NvCiC5n2MgwbxPt0x0SdLT55asuY0+FA9THBE9ANbEMiB\\\\\\\\\\\\\\\/GUN18OCYYyPykLZzmrAG84+sHs7zdV6lP51dU+o0w6um5lGBWUCbggJrtrOkTSZAptRqlrzPv7Rkr8KwLI4LcpGHn0Q04XH1pJsidSHO7avWHng7t8LDtPjdm42V88qwiym6231RNz13XQl9cgFxbYp5qJSX\\\\\\\\\\\\\\\/1b1MnX4ycDOtW3ts2b4najad5YMQKBdGQI0f0oEOg\\\\\\\\\\\\\\\/CTliA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022FIJt3DyQY2IYqSavFxKPig==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f61c95734311da33c2e2199820d3fb44f61d24ba55ff42bebd2cbdfa4183554f\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGuiyun\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tu%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGuiyun%20Tu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EWuzhong\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EShen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Shen%20W\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AWuzhong%20Shen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZheng\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yang%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZheng%20Yang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShengjie\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXue\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xue%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShengjie%20Xue%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYing\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tan%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYing%20Tan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBingbin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXie\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xie%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABingbin%20Xie%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKe\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wang%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKe%20Wang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZhejin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZhejin%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=He%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASu%20He%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZuowen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDuan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Duan%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZuowen%20Duan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELinsen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGao\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Gao%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALinsen%20Gao%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXie\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xie%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABin%20Xie%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHanyang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chen%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHanyang%20Chen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXiaoqiang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EITaMed Ltd., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yan%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXiaoqiang%20Yan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node49353\u0022 data-node-nid=\u002249353\u0022 id=\u0022node-49353--21578208907\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1308\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1188\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1308.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ETu\u003C\/span\u003E G\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EShen\u003C\/span\u003E W\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EYang\u003C\/span\u003E Z\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1188\u0026acirc;\u0026#128;\u0026#133;\u003Cem\u003EIn vitro\u003C\/em\u003E and \u003Cem\u003Ein vivo\u003C\/em\u003E characterization of CD8\u003Csup\u003E+\u003C\/sup\u003E T cell engagers (TCEs) for cancer immunotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1188 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}