{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022zn6pP2+Cj9IyW5fqkSuFBfK5JHaqXkwtPBb5B5HftmjFw7ZyysprHrRoBw4zBCJMg34WnLYXduAw6EiWsbx2vAwJaLX70z0p8rojmyFH8rSVOJ1fe5OUJu4v8vHQY0\\\\\\\\\\\\\\\/fGvAzbEA2xJ5K5pVeb5M\\\\\\\\\\\\\\\/KHSvFLGEflOjhfNf3RD8fV8F9UCHIIx8Put3uGEq5HtPHnP5jHjH8WtYmS6UWJWTNyQTjwQoSRS\\\\\\\\\\\\\\\/WG2BNN4Qi5fJkBh5DWc4BAgyBwsVT10mfQ+kPEIhJW\\\\\\\\\\\\\\\/AQ4ne5xeBlgD862Jgg737kPGSXEHqJ1bDMMYSo1Qi2NfOlczsPG2hXofExM4c5OMvhH\\\\\\\\\\\\\\\/zC+p90EDUue6DD2rSKtsMEa\\\\\\\\\\\\\\\/Qw1tdEosRqWT6T1B+VTQHbVZADMO9WYea4oGv96GUnxb4ngFpGsp9tOppXHAeMvCuVaPEzoO1jRkS42h1vM8Wx7z53pzryhHzORCYEmSpFS5VWohcpfM21lavx1hwocis6\\\\\\\\\\\\\\\/P+uJsyGlkr3oH9WUHnlYxieARUF+rAZK9WkCVKSV5XKKuJ9hFAnWF57iYRLd+dWFRSb4oCQksfSXBPLDSto5sy6+MCPwOWWItSXuhzNan8QZZkkqu4nukOo7bByxoeVOslHuTxdf1betzxoxk1P+CU0oTaD3SlVIyQy8QQyewaqYKycp2Y32SqfeLxXo9JRScJeFzBHaV0XqJVVTYfJLWi85hf6ZffhFd0iS2LVTywO05Ev\\\\\\\\\\\\\\\/KHj5S6i3iOOWUUw8gt6em7VWwdCCuEDcMWxj\\\\\\\\\\\\\\\/ZM98iRx4NU\\\\\\\\\\\\\\\/RmUDToR06ush1TmCyrgnDzYexBI4CQ\\\\\\\\\\\\\\\/wKxyFpvDQXwnXxHuW7MA\\\\\\\\\\\\\\\/5ukQwp+JCb0Qw7yEPWX59xrEjMA82EL8hy6nD4Co1RHwSFycYPfpNamWpTUs5YEci\\\\\\\\\\\\\\\/BcJrJzFVMeir87QMtXMz6hHidrFUOfRhpI4X0pt\\\\\\\\\\\\\\\/I8aRyMnW0pmq0yUTE+8dujDcxqiPXAsp\\\\\\\\\\\\\\\/VAQmFblW4arQUYJzg3bVDyqjG6nGwt2DA+I6EcrZfPbMEbb47pNEJuHOZSncpbWTnL0lD+R4LVXW5FreW6DN53JES+KYFGabeUzZ2FDM2qma80OG3A5Hk3nTzv5knmDXKKo4eau97vNIww2QLaEK0BsogG+xxH0+M6rjSW4RLYWHz\\\\\\\\\\\\\\\/WJ8M4uJNPd28T2\\\\\\\\\\\\\\\/OKeGw2VD8pIuKIJQf9LMMN4wTQbUv7Lhe7C2zS6xfCK9cOxW2CZsEF8sPYdOSJmaipJ\\\\\\\\\\\\\\\/rnwMbamJSaZuIzcvTX2gg\\\\\\\\\\\\\\\/5vT01Sm6YsIETx9uuDN78OWjF1Pju1yxu+n+EXOXQDh+BldXYrTGM+kmsmo8D9KllvP29Unxbj2l0F2r5kT8ZEbi8o\\\\\\\\\\\\\\\/97LdKdXVZyyeiU3J6dsLCvSRlHH1ktp98U9IXlQW386eZV7M+9aEwgymNlHPr\\\\\\\\\\\\\\\/eM9KW5RI7OjzmuOu31nte\\\\\\\\\\\\\\\/+CHtyjt4EYi\\\\\\\\\\\\\\\/oyALIv1KIzsr85x74myMuMW\\\\\\\\\\\\\\\/wS3Z4x5fEdiQQImjmdlCZtb3v6zVLmbW1JSOZoifatX2U4JBl3aDYUZeBl1a0N4yn63GvcnhTdkupJz\\\\\\\\\\\\\\\/iqFWgg3rUMK3sNo8KFiFx34xr37oKbey7j3xd9HxQN\\\\\\\\\\\\\\\/ugiTo\\\\\\\\\\\\\\\/qq7HLbZt17QZUmooYV+RkliMfNLlWfO4vLCsKMXQQye9EvT0rfLJmcwWVpv1YgpGimbjOIfBtz379A67udKqvqks4XpxGEOGCKJFSMhgMkw3OFzcWg5ln9qmmQZBczoqbKGYS\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/z2feHt04ZpeiafrOsYIz6RWqmvRwCuXUHExs9fYQ8MBP519\\\\\\\\\\\\\\\/jEhKyptCDwv9waqaqzKkfPZRJQbhi0yLXzkugAM1e3H3HHidfQh5Nd+8l0X45\\\\\\\\\\\\\\\/kIUN7ndBS4sIoY8er4ocb89Ph+jK7VEZviJBG5FqAwU9RdbN1ThFUdxOhlYbnGbwZ7LhMc8ALx8R6pQFtQDXjit8oBkq77c7UWTAbcuQ8xyeq5lo3p1V1DgEqdhYsvOqg8F++5sPsiiruYcjVw5RnXg5ei2hz9\\\\\\\\\\\\\\\/ffYSgoH5aqbGe5+w+AAFTSGImrIXl2m8x0upDY2h91NOe6W7JqbeC93A0DBEa0IQb3F2\\\\\\\\\\\\\\\/MhF7NfiGhc01fCJduqHQVOdUEccA+S6T3BppWtnZpIY\\\\\\\\\\\\\\\/sjbVWXwaZ5QnetzfBNkV5xx4k+XeuRttWPpSkl8Yq+Nje+hbhUyyBDOf9gqWiYBXYrZQ04FzyM4DzckeBI5+DtCEAnb8SS3bNjo77X4Nkvyc7qlXEh3q4a\\\\\\\\\\\\\\\/BXHXE5yAka82\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OmmuNy3VRuVLbrSmxo31yB+daPLqwkd9MxFTWQuBBIjZFqDAdtqpXJ\\\\\\\\\\\\\\\/aHhnCDOwn7qv3w4GpKpyYcI4UQQmIgWa4SzyGjQuPeG3m0DbkqJ3YayCDR1FH6MnuiiHfKdpXNXoQFxYy+xnQWKAp2eAWDweBF\\\\\\\\\\\\\\\/Jf9OYgH6gGWfmiBzZT1+\\\\\\\\\\\\\\\/X5fbElp8997KOhZiYVpAIBDhUZGYec+X4dYa0soKcOcO8gNUQAsCweVUMo67N3xEQaQHtzXHGjtsfUKIW4wus8OUNoJmm2EhuiDvlVEwD2Sq6R3fz4GzhfvVnHKalfD9QeABg2JTHxCWV3RRXRe3uVaVHSfGuFOQIuWv48zekca7AKjoZBtGNUtyBHUzG6jLqWs2d5wgF+ts6+Q6EUopEy27hv2jk0fQunbMkg6T9vWM+Wn\\\\\\\\\\\\\\\/4wirSlRPnsb+fIWGpq5o3dCKmJiyy\\\\\\\\\\\\\\\/476cPjalvFq1KwnTNz69tvRw59+zgUHt14BvlNTPzPg4mGIUnwDnkSBcVq5bxlxH34f7rW\\\\\\\\\\\\\\\/ufrrq6cSnVVONfw+0AvMTz4l7\\\\\\\\\\\\\\\/Z7aQ+k0y\\\\\\\\\\\\\\\/wKQM7lcT\\\\\\\\\\\\\\\/Gft7L1YHR0n36YipLuPNtjFAuKWQIWwVSAHcFnRyfTGqRrBbWD\\\\\\\\\\\\\\\/wLO5ETSy8eaDNtqlw8ISGzH6mUrItoDRKlwxFPj47Pd2wtSRnLcOA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mRKTYjOwT4RdtblhlsXVPg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ec4de1e9f8a29e30d51711d30c746db8aa2bb69629dbc3a2d809185771028317\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShawn\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EIadonato\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKineta Inc., Seattle, WA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Iadonato%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShawn%20Iadonato%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYulia\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EOvechkina\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKineta Inc., Seattle, WA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ovechkina%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYulia%20Ovechkina%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKurt\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELustig\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKineta Inc., Seattle, WA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lustig%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKurt%20Lustig%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EThierry\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGuillaudeux\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKineta Inc., Seattle, WA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Guillaudeux%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AThierry%20Guillaudeux%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48925\u0022 data-node-nid=\u002248925\u0022 id=\u0022node-48925--2109589509\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1511\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1357\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1511.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EIadonato\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EOvechkina\u003C\/span\u003E Y\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELustig\u003C\/span\u003E K\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1357\u0026acirc;\u0026#128;\u0026#133;CD27 is a new promising T cell co-stimulatory target for the cancer immunotherapy \u0026acirc;\u0026#128;\u0026#147; development and selection of a lead anti-CD27 agonist antibody\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1357 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}