{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022kVdh2ZP2FnFHtNiyxdg2NW3Gr+Mt75Q3KQIu1G22T1jroMGRF5TSgJzhUgRszEk9uptKU7kvdb67ly2B736KQ+H4ub3eKVZVROY5PJYlaU7pdf0UxPmmbOtqE8BAYyboCNyTqNVdPEbzrvkw66a6ARhTS3Zu92Ab4mSa78OsP0qL5XvubdrQQEzeCtL9PlGkacb1rQfyd+6JK5ExB0jT\\\\\\\\\\\\\\\/1ei+FnnZ7GtRNpJ1rpXG\\\\\\\\\\\\\\\/e+J42LPTcNEmKgyeRvrMOlFIPgkWJJyWQ3Y3TfeJ7rlw2BX8ZAGzq6AX1buXb4huDRmsp9\\\\\\\\\\\\\\\/Wd5lX5hORWLiUAY4XEB+qQPFN97RSEsqa8Ea5aaG9un4HS\\\\\\\\\\\\\\\/mmvyNQF2hYXaty8nJlKLk9Bq252agNsyj7y9AhVgEsuHi1FaruRcUljsZUq6NVfdTCaxZPWJxx35hrRRpECTKGUKuZxQPo0nJ8FJgpR1qtqqRDCGnGnEtBYQizhZ75hTKibJAAhuArYW4f9uzHySu6EcRbtJRIlY0sOg6q+prpybHsGGnPR1KEtqRtus6ZybBqr81txrBgejsg3Ts6Osa2EWqJfwxIIdDtuVWyHoHrpIc8zhL51M3fkk57rgzot4\\\\\\\\\\\\\\\/Z2NMcoVQsq1o0KmSu2i9dMz7Ii6aAtndaOlqXrQeKwo9WN3\\\\\\\\\\\\\\\/jEZ5B8BvqYkg\\\\\\\\\\\\\\\/Nn7s\\\\\\\\\\\\\\\/pG12taGyl2RlZymwxPS8qPDdjRCsNoaXyErb1iUs5\\\\\\\\\\\\\\\/sK9Ya\\\\\\\\\\\\\\\/nClYcss7oov1kPIDKODJqGwCNBPxOx04eJknJ1nIsd21FrDAChcNIDrwenJ8IOLlNkbGOUkuqqBiedOFhYZSWVaStBkgq70jPtHFcDU5rmCVcTAjtsz7vCN2\\\\\\\\\\\\\\\/FyflpgJkFHeVQX97U7xOmCoa8CqmKydT+tgE6kpF8FhW5W4x5p+AdxyvDtjltwGm4ly9ORnbsYMKIvVEc1E6BtXRoTcJtfEQ0AvnzVmWAmOBXTWsUNbY8QJSVXXboU3HgjtYYKlm0IYvB0jCdm5oX\\\\\\\\\\\\\\\/BPjHD\\\\\\\\\\\\\\\/sLhF0AQ5wk1j+WXsRTDUj2Xk\\\\\\\\\\\\\\\/AgSUlI6dCeSWanWstZl7Qwyc+RK4w4v+EcxompxU\\\\\\\\\\\\\\\/lMKuFyHnlJPxwBcR7HW\\\\\\\\\\\\\\\/6aS2m80e9lF6PsjgxmMVXkODa6mu5ojz9hvKVUDCXA+60irF1mCuLgRnD18pkzli6+LNf1TerIUkGzQU5aoDAEuSxWwE2lIC33ie7KJijsm6b0ajfBCWKxW99XCn0tPzwE47ux+mFHbjgd0eXuZJueEdCTsr3uKPNw7GTfqlUROCa4+BLVVVwK8URbfTGBdk3eez11u+yUG\\\\\\\\\\\\\\\/pNGTCBtyx4aYf0zbgkSCGfvQGWt6al2r21E1mWvAkdozBxsGbt8rJSQWZgHqKWMgZKQ2Z4jhVI1NEjfA1AryzTl5KPcIjJy0Ak0lNL5J2KfBUgzg9+TOMQv+4KFQY32RJP8fRYlunJPhYxBVb77kk3cx0Q1VETvILpPlfFAXKA+ntcWTExW4rh9JMWFUH55DPElaySAZW+I9ntVN2K22rC5ZEtYiAHLYLFMfX9L+SXtdWpgBk55\\\\\\\\\\\\\\\/n2qAv6lABImQRKigbikvE0Ma10xKU1GTIgp\\\\\\\\\\\\\\\/Vqtqxja5UlWatz4TIaqKbB+Opj7pAyzOtfmf44pHS5wpn5EgHFZwzGL1E3Enc7tuY3Vd09pjJz25HFGl\\\\\\\\\\\\\\\/7SwitdF7zBdIITc11z5Fmd0o3QeMpz+FcskMb7yJ8nqidxMK7vK8RcECM4CrS6I4X1djdotfcxtoIFq18V\\\\\\\\\\\\\\\/e8Tp9dAyhKWaF1+taeBTBmDg5Akk4YbrulXDwMfvJxJ9RWKBnr+55+hRIwPsDfwU0Eks\\\\\\\\\\\\\\\/aJlwfM5njCWwQ\\\\\\\\\\\\\\\/nBZHzRURlmcbXLWNyP3OpW3G8FEHOyml1PWW5wcSX3hAeQ2dKgQqSWDmJP1Whw9qc4UhkN7jmNBCd3ifMvLH186lbPSSgGwfoYX83GaeAkQyqkgbz\\\\\\\\\\\\\\\/Bi0QrzWcyLKtKn6+2as7Ph5RNnVWNBem3EWYHlxg\\\\\\\\\\\\\\\/0cWAL\\\\\\\\\\\\\\\/UMTEx6iTzd1Sgr+nrE8bTwT4Oqd0P71ntR8WQ4RN8u3Ai\\\\\\\\\\\\\\\/nq+LLQN4fXy71nhQFs8O+E8Z3WvsfY4Z2AtJhXes+ZOTABWIX6lvZoErCw39Dad6CF4Rgf60uqIVEC0EgjMuM+w6rfdxZEihnF+I29twfnfWGuUqNSZ9sNPprHn23k\\\\\\\\\\\\\\\/2Gw6wUaGvZ0FBMP\\\\\\\\\\\\\\\/FwoaB2YJkv6o0oxUUd8+\\\\\\\\\\\\\\\/vjhsM86nTIJIr0rJ1NnapC3UDtnw8v94vji9cZgtrXzC1uGQkW0cAUNDcGYYZFEyn\\\\\\\\\\\\\\\/lE1OLoEJ8jEHSCQBEkT+Srk3u0aejmYhfnEVQZROuPP9wffab5nDdyajqgiq1ffoX3U7fU44WcAfwvdaI5ilrafBzYw+M2rkLFBRlZezXkYyP\\\\\\\\\\\\\\\/UjorkHUrq\\\\\\\\\\\\\\\/U0xtk\\\\\\\\\\\\\\\/vKKWudkc2gja0oggIawC++kAw4Uhi5k3+IYoRaCKs40oXBv76AEFGmTMJwhuh\\\\\\\\\\\\\\\/gNNdEkuz+ljOUIGUiILwemPSG44Ou0OoGdi9pzsVAXfKSQWXpgnn3F9s+uCk8Ne15+NOqVhRaCxwYE73cqbIfg8BBlqsAIH6HtoiCSGdlNQ\\\\\\\\\\\\\\\/pR6A6HLR2XfEdRW+1lILpIzApyDoJ\\\\\\\\\\\\\\\/vMSidCNSDkNqXLRHqAU1\\\\\\\\\\\\\\\/oTg58WGdE+xVzuAaMk1QeUmTkYpbKbB+9wM4z9OslSmtg6c9U8CvzJ5SxHDQsYiIB5rPxC8PWyV4atCdFqiDew8UXH2+WBzlKKFwhHyVbaEG7ORa0v0E\\\\\\\\\\\\\\\/wRwpOBY+hvxgmP1bz1I3757ObgUxcCXBoRwRheS1gJpgLPblQQvjIpWmRYwb7xkulCZlUT1Al4vu6MRmcG3doM9\\\\\\\\\\\\\\\/NEUlfSEzXjJkF\\\\\\\\\\\\\\\/FLupmHL+q1FOzUo8AZOeO05s0ppDp5k7b44fGRQ4F7IM+Xm3953R1fz9a+tjgR57oZwTl3xb5x6+3XTrPw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224VcxGZvIuEE4\\\\\\\\\\\\\\\/ItKIUWQ+A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224162baad8871c0abb1d7e3bfa50a2e259ad5626074a64233c8753149eeea911c\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJun\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EIshihara\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EImperial College London, London, UK\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ishihara%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJun%20Ishihara%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48857\u0022 data-node-nid=\u002248857\u0022 id=\u0022node-48857--22060527593\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1337\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1213\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1337.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EIshihara\u003C\/span\u003E J\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1213\u0026acirc;\u0026#128;\u0026#133;Tumor-ECM targeted IL-12: improved safety and efficacy in clinically relevant settings\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1213 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}