{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ME1J8GPsdDoUB09DZ4vlTkAuZV1irSyxAJU51Y2o7sBw6oCb6+g29taKI2sYDm2KtChTv05hu4fjOjvzn3uY87fkkoYu9B0KMMA6ol6AMf1YDToOLFTrDlubThLeGP4Z8cnKM7X1h7\\\\\\\\\\\\\\\/xkx2Egza8u5rWpPItjQJ4bDurW7W\\\\\\\\\\\\\\\/U3ycceFEPDfn5vwCGh67r4gsUAoNSfbY\\\\\\\\\\\\\\\/D5mcboBw1vTu2+2YtdVyejvjZm8Yn0gYay6wmAFhMr3Cv+SaGSntsvqnBwelDdXtKgl52cn9+yEzAznA5UHDnDclEVsajKilTr0AqkxeoUXFEBLaD8gRF5cM\\\\\\\\\\\\\\\/uihhvbrxwZBdm924RdBgW1ayeGuqPAkNOF1JP2pn0IDQGOCi542k+Gvt1yK3oOHKEHJnYZSWd+mi7EHRjs20\\\\\\\\\\\\\\\/4l8l2qihY1ecs\\\\\\\\\\\\\\\/ibfU+G6KZ9QQpyUjUT\\\\\\\\\\\\\\\/XBVhsx5gCRKoDwrpTPhzSSYpZJQHBaocgFcJEbqklhCnrM3m5GMh36qzm+trYBRjGkQaJEz6kEbPk36iJ1G8\\\\\\\\\\\\\\\/ZZ4UdYva+ULPosD1Qnk1yQYMJBrlMgQCFt+QLwLZJCm8QnOLp8AYID8HroM9tUcPnEvnGIh2AUHlsAnZxobUZECINKC1cDzXQLW9fXDZTPpy3C8sqZQe9tfVVpf7+H7fh4XrNkb3H5IJPZ9tjmqU1LAH4cTWBY0oaSiZwZt468ZY7q631jirlPBhgJxYQPU9yhmVmnEJuLvryYfUqiy1\\\\\\\\\\\\\\\/TJZhs2Y+cbGA4yo\\\\\\\\\\\\\\\/+QeQV3qqmkcjihF00gdC6qkWuqACxIznpTzGoixVtAwcJafa\\\\\\\\\\\\\\\/kSt0wSHxI+xJsU7udU1t1epaxH8ZC7L3NC88b22qK877Z5tg1sZPieIWzRfs9M3Yt7dYiZodzSOZJ6x0Ug\\\\\\\\\\\\\\\/gXo1lkmG6eauuozDxpeSrL6OTNJoz4C6TCwevGSi\\\\\\\\\\\\\\\/y1d\\\\\\\\\\\\\\\/QgItn2boHqBJrQw+1jrNgK6bgeY9bntoG6vde9ASD9DCEIwosZ4U7iWQ3N5wh+jE2DWCUpD9bCSwxBA0shuRDP5bQuq01LcgGhMo3JvSWI8aQvrSiHPUTqtRxoZE+qw3+ATRoyIQp+8MxyjBsP9ZPJQVleS4Xx1i1oXGme73XsMekiigmAEwqj9NxbYmG6JlS0wFka8u7sZC3MxzVnYaZbCJYuTfiht32x26xfCdiFW8aqyReh\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/iVfeJWwDKUAvXtXxC+TCpU+VCXh7tUxXkbv3Wcvv4s0wrxraYEzwJk1LP7HmAgTl9ivWBpTgfCHRLebQqfhN9zKtyGckZ\\\\\\\\\\\\\\\/7lVjAGkbVMg51JstOX8cJ7Ys3FaCd3ccFSjUreEjvOLKBHqCzuIhxhD3jJDTWcQpe2xz3zMqCb6jWwxCYY7qY9M0C6uyC1oedZucffUBFFz7WzPixg\\\\\\\\\\\\\\\/l6qeApyDEEa3u1DMN1nJTXAnE41H6qlicGMEvQRh9CRC70hLvm3HKkVVSFpT913RHGZy8ppAlIdyMPRcgRe7VwK3G3PTqer97ZBYpHD+Y3L2I8veNA1k9eQd+ImxtR\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9q\\\\\\\\\\\\\\\/LQoTK6EUd7ZIxFMHUPEW4gs1E77etn9RAMyjt9AvzDGC6dOYpW6UPxevMp3Ke83ng4kau3sUx34+JcIWUL4iLI3pw5h+Jr\\\\\\\\\\\\\\\/nLDkkUXQngIUFZwMFBoB6mhVtMGvgEdl8aAyyB+XooW2Gr1CrPlkDmaauunXvawartfFAkuTrVDIP4veYtjg5fpYgZN+9zDVPmihyqVxhD8ZtwokDdH\\\\\\\\\\\\\\\/3Ztq5sV6O5Nx1udgLu4sYicM8WJsE5Qeu3aUWxndembD56NZnqin2gw6x0CnWrjvupoCTFi\\\\\\\\\\\\\\\/gIuM2dmHicybt\\\\\\\\\\\\\\\/kFMkj+YeuvmY8PX4NellGd3no4\\\\\\\\\\\\\\\/fKfwyNfsgGlv6OopCT\\\\\\\\\\\\\\\/PhW6QzoeS2OfuZla+hjFaJPuJqXRLcf9nFgLLMujRLALrZAsEeEQP998qkgeMIAt+oA6ftlyrCCs7ZKZk06aovm3jvjIZDzxDP\\\\\\\\\\\\\\\/2AIVytHGSOciX\\\\\\\\\\\\\\\/jpU5C0jncC4BByXLjVbSFCJnFt7zwTMUzfAM1M3c2uoiok5svnqlQ+KoACxAiy55AqgZ0XRZACpWekUDhQ8hNYQeTy62aKrfqFEUjhyWORaqeE7PHCgFamMPULPlDxzdIcBT\\\\\\\\\\\\\\\/GJkOfnYZgFU8RpPj0lavp00\\\\\\\\\\\\\\\/X+FldmSZICBnXrH36Cx906XeHPr+p7CaHv2yUZt+I7azCMR902J\\\\\\\\\\\\\\\/IPF7E3KbjpxkkbhZ0dSg1KUeCNCCLCTQATuLBFbxCysG5zfLOrriYQ9+FXG0+ajUsAb7cRatGCoSUA0UUPUREko0VrtgzAokqSUMUYjZdYymeoFylnVGp56S9TV7mtTUB\\\\\\\\\\\\\\\/ZTOP\\\\\\\\\\\\\\\/uyclEOUfDJ24hb89mp1UDTT6To2gRdfGJt40vmU7pTeijmTC+jjoZpwCWDlyxtUIM2iQZzCRx\\\\\\\\\\\\\\\/ZPTpOH8DFfY9UesQ\\\\\\\\\\\\\\\/8XVlUbOfwbueRPW\\\\\\\\\\\\\\\/fW9fBuP04p8\\\\\\\\\\\\\\\/pLkzZJ8I8VU64yAn405zL8ineE4Wkp\\\\\\\\\\\\\\\/hSnigMm72jgJNwM+Wdj1Lt9B5I23JF9uXacodY7gnWRbYYGwhjzh6jb26Ic41CsVO4+j2fknFPkOtyfSfxaSrhzXgQa2bIve8BuiNUPT3ldQ1+snk8QBkOi6wUh\\\\\\\\\\\\\\\/F+\\\\\\\\\\\\\\\/I1NBVpdDXqupi90Oo\\\\\\\\\\\\\\\/P6+ou5ZJj6SqEe3EgWRhX0JuvQf1xyvnC1XBeAIwPpkmsRNTu+h7yJTf4eiJ+b+muodWNkFBHzprrzzQy64o5j2PxHxoAN+ZIPyw\\\\\\\\\\\\\\\/FGEhx\\\\\\\\\\\\\\\/iELOT3HmLTP2bIL1va1ARE51pfJ8duMLTFovZwobIomswKhTErlf67NNDeJqR4uqd6mJj1RUx85HWAfnCwSdAI2BSYg5NXgL1tWAXuli9bMQWjfD1AXpQH13YBfkgCd+6s\\\\\\\\\\\\\\\/Bmiwd0kZlmloI\\\\\\\\\\\\\\\/rSkETqOrPUEW6\\\\\\\\\\\\\\\/oYUR+sUtZygzloNz00T4r+9pw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022b9sbSlaxGeM5GDrUh9gnAg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ae74762684eedfb3892f67f4d0530834a18a430f4d686d1d074cfe85a3c50b7d\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERudy\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChristmas\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Christmas%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARudy%20Christmas%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJieni\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xu%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJieni%20Xu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMark\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKrimmer\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Krimmer%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMark%20Krimmer%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYulia\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERybakova\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Rybakova%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYulia%20Rybakova%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENicole\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELessard\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lessard%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANicole%20Lessard%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ETom\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAddison\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Addison%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ATom%20Addison%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EIsaak\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMueller\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mueller%20I\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AIsaak%20Mueller%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELeona\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELee\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lee%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALeona%20Lee%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECafer\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EOzdemir\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ozdemir%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACafer%20Ozdemir%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBurak\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYilmaz\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yilmaz%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABurak%20Yilmaz%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYusuf\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EErkul\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Erkul%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYusuf%20Erkul%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EManfred\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKraus\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kraus%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AManfred%20Kraus%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAniela\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJakubowski\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003EKernal Biologics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Jakubowski%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAniela%20Jakubowski%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48800\u0022 data-node-nid=\u002248800\u0022 id=\u0022node-48800--21490236557\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1493\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1339\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1493.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EChristmas\u003C\/span\u003E R\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EXu\u003C\/span\u003E J\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EKrimmer\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1339\u0026acirc;\u0026#128;\u0026#133;Systemically administered onco-selective mRNA LNP achieves tumor regression and improves overall survival, as monotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1339 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}