{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tiOfNilXx2Mmq9AmuxG\\\\\\\\\\\\\\\/kfGgE+D5025WiSS1C+lW+n4muqHwCaHz2ephd88Qx10g2S5X97yoUvbmMHMDq7d1NQqPzQzAioo3u\\\\\\\\\\\\\\\/u47Yq9\\\\\\\\\\\\\\\/mmi0Oyi0Rb4T\\\\\\\\\\\\\\\/xFk51lZNbrTZZhbkmC2MlHKy0QSAlboy+jnQgXGN\\\\\\\\\\\\\\\/N+h\\\\\\\\\\\\\\\/AAxbUqjRJJuvPoAT9gzwsBR5WkiXsfAsrCCe0leGYzBrNxIaZAls\\\\\\\\\\\\\\\/dNfzmVfy+T0w\\\\\\\\\\\\\\\/vA89r4meLrUbCPlFMzWYlLIt8jRz22v8i6dEGMHCbzlulSrg1oSd1+GLXoNIQaZgUs3PSaj5jOH+4zhw7FEKKwQ5cdfXldlYbTB3ItYPlScW8mFDCs4D64nxWVmiVy+yKl8xzetLusl9ykl\\\\\\\\\\\\\\\/p3EG9SOqHfSHazL\\\\\\\\\\\\\\\/TohJifjS+p3zZrR9y6Vr8IqcPcc1fyQcIavhKwG5rUOIdSKYhdKQLqhbS6HdaDpSyCH4Pkl+dR7WPrOV3NP8nhpXHF0O2t7o42\\\\\\\\\\\\\\\/5KY1cPTOyQ5rgFVYzI1wCCgRdsLgOYAUE+XIcioO7eLn51OGEqd+7nlEpeT+WIZzM9xOC5U0zr\\\\\\\\\\\\\\\/d3SKIJqk5AXXNqfrUQG+kOk3kXj33BZAr\\\\\\\\\\\\\\\/9X6XfTLhJeZ\\\\\\\\\\\\\\\/X4pRj2a42qqMTpdMP6HmBapLrTv3\\\\\\\\\\\\\\\/KUapnJeMvVm4PTAOOoOaHvG9o13VD+F+ibjOHgZHZX6oLbdMDQrB8Dd4fPPWN06VGfyRXRh\\\\\\\\\\\\\\\/JY5l8pDWwskZmtfGdaw0KMCNWcyq5NtFWUP2kSKSJcbqY7+yp2CCVn9Cr8ue57vYcQKrlm0NgaYtyz0iRD1abI8AE5FLSdPncF+d7b5UEGFvv9JLSI\\\\\\\\\\\\\\\/JuV2yhP81M\\\\\\\\\\\\\\\/mZW1En3BosEC44zgBi2opz\\\\\\\\\\\\\\\/vS2my43lZY0oHY45ELhbICw851qoymKAl519cMosfo+tbF7aQDX7o0CfiIoh8HNANZJ3vMBTzoT\\\\\\\\\\\\\\\/ur3FkvGh19wM\\\\\\\\\\\\\\\/isGKKF4Trfax3SAPkvqqSUhQ3qZxkrmKdACMfP6TMVwGyqXp3+iNg5T7x9Qo94nK\\\\\\\\\\\\\\\/OpHizFaCyUemksohitbSOuu5NXMoXljZR8tQlPqt81HDZDb2UgUOo6VDfTNbKDZnkJ\\\\\\\\\\\\\\\/tMpl9jIQ4MLf0fYE4RUg8p58nxYcB2YKozHzRC13n105a7CsgkdXgHzPZDdNNp8Jes7gXYZYmrTAxFbnpvpGpi0fYAl1x2bs0w+jlC\\\\\\\\\\\\\\\/mbv8lyWwOPbPQ5pqKOrsJLeUa0R7h2Pvhlz0H07L7sRfUlVdyGCQVH\\\\\\\\\\\\\\\/9WiTI+tY6CrjybzZIXUjX+GHjEsDkq6aL0fk8HOynI6NrUsyeLS9eE5n1QNMXtsjULrZHtm3wTY7jwVy7T\\\\\\\\\\\\\\\/j4cPeBsdq2nds9Gs6Xv8oxS9f\\\\\\\\\\\\\\\/Tps+YXLZMeAUCcavqZQ3j0mZDu8I+vuDrnG8Yniw1k8NahMs9+WAntVeMwpBdtm8Ij3Xr11PFU5nHhUqW3tK3Cssc43jHjtplXLx+up5EafpQXYHGw4KBbNmajCZSJXrH6FRYgid9iK\\\\\\\\\\\\\\\/qw354ZKF\\\\\\\\\\\\\\\/4s3PnXEdPAlkFxFOtNe00DRTVKqZYUFs0Iz8zhkSJwxp\\\\\\\\\\\\\\\/8H9vEruD7B3MMglZVeU6\\\\\\\\\\\\\\\/B5C3rnSakN7ceQzjVOJq5ijOvuW2n7fz3yc2e8zL0txHLVVQxfYR1QEvEGLnMf8OBALXkdOFtPjp6HrlBbkqBAjL6lEajTrRbDY9yFrDV2kbEkBy51moUT35+or8ww2FdinCOT4Kqjg8bIzQKPtNArXZOK432nBi5Jv7AtT34sy+u2Y8NPXyhv5rq29pbZQZSHZ7FmDEHGhzJVluBq3c7tE6YSN73BpPIhoZBnWYx7HnZemiRcF8tJWF9R4xj2VxQ3RVbdtMtaMd69P1G3acoKEKd9xfS2HxAYeayMIRZpJ+R5Hroyd8UHIYqtobPRQqRw\\\\\\\\\\\\\\\/U6OYIyVtW2y0eNkZPHj613\\\\\\\\\\\\\\\/74SK+ylHYbhCGLMtAxrTF\\\\\\\\\\\\\\\/vNMGLQurakc7sHykqrWSGl09XritL4H3ZDpcVBAGcqhwn4r8NYscWysKFgS+M81dcxpHQlJ7TJlhpEukYvVl+A2kifVRT1M6laQt7AuFbDQ9fsdyAPemkTUGvotk6Upgh4CahH2OtPZ3nVhWY\\\\\\\\\\\\\\\/5Jz6BaEtMjBmloSMl+BR3tT93hsi8ZzEvjQY2mIWHr+Q83DAeNB4fj2geSd477\\\\\\\\\\\\\\\/rYLQDC9dGL8W\\\\\\\\\\\\\\\/zMMKL+LM+jUjQDMc48cD9tXF3YAsKMJ\\\\\\\\\\\\\\\/sl3ADvfv9c9XMPRdFwgmDbGcIDuWJXc5E8nH4rWHNws3uUpiYz3ObyYNmAaXgpJPQ+PJ9RFHhB3RUtoTu7iWBJwhkWTzjcImzrE+ZPgB7pyBdHpe+wPbeLjltLzORh8DWp1HwzVwy6HYo1DizFrOhbuC7UmUzlncC1k6sWEc3bCxdmij0uBmUs8L0pW\\\\\\\\\\\\\\\/JKnsyRMNnk7f8FH4F25HjnWCdhGIMLWQezPxwfDASIjniMq3Pdczm3yUfIZetWgcyxoGKepQZiC1HLBTMNW\\\\\\\\\\\\\\\/06jTrW+FVguGtCcURnWrcdMFbZxiM\\\\\\\\\\\\\\\/V6\\\\\\\\\\\\\\\/VsSVcu0SS0GbZTlKwMCJxA7f5jMX3cX7Ly0DeOJ7OHHOzwF\\\\\\\\\\\\\\\/SU0PWJdIqg7xOxSp8P7UUW7MvENMVpf256vMMgdJx8FFJJUXwKNk17C8IhXzj41uxyJtKOtBXZ+r59rVgr9SnatVfQ6iv1smhZ+X645BKWMGRbQBffNJRZ\\\\\\\\\\\\\\\/lobujNy99lnzHc9Z7bmj0ioLPkAes\\\\\\\\\\\\\\\/82llIjboDPghgqSp8cdHetH+BlEUkl6M4r19vyOGtZupp0ecn8AXtdOuyGR63fZqNPT6cy5nKbFqHzXpNVvwvvPNLlCFifbjSk+9Xg5tpsD6WejPFGdf3a9WtoULEasTW6WR6MpyS+jDn3HQ1GS3dCGylDV8XtYMRtHjqtL\\\\\\\\\\\\\\\/uCVcCQzK80ZAA1dQP16uwGuoc4rAbUhMGYDfgXi0lWg4eQLA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UnBwAzH84ZQP1AhvRXE0gQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227ff23706b4a49b8df812c25e310f32d50975df7539494caf7fbdaf27c253fa5e\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMiya\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHugaboom\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nYale School of Medicine, New Haven, CT, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hugaboom%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMiya%20Hugaboom%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKelly\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EStreet\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nKeck School of Medicine of USC, Los Angeles, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Street%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKelly%20Street%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENeil\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERuthen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ruthen%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANeil%20Ruthen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELena\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWirth\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nYale School of Medicine, New Haven, CT, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wirth%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALena%20Wirth%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EOpeyemi A\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJegede\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Jegede%20OA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AOpeyemi%20A%20Jegede%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENicholas\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchindler\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nYale School of Medicine, New Haven, CT, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schindler%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANicholas%20Schindler%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDavid F\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMcDermott\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nBeth Israel Deaconess Medical Center, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=McDermott%20DF\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADavid%20F%20McDermott%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EElizabeth\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPlimack\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nFox Chase Cancer Center, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Plimack%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AElizabeth%20Plimack%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJeffrey\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESosman\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nNorthwestern University, Chicago, IL, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sosman%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJeffrey%20Sosman%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENaomi B\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHaas\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Haas%20NB\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANaomi%20B%20Haas%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMichael\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHurwitz\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nYale School of Medicine, New Haven, CT, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hurwitz%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMichael%20Hurwitz%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHans\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHammers\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUT Southwestern, Coppell, TX, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hammers%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHans%20Hammers%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESabina\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESignoretti\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nBrigham and Women\u0026acirc;\u0026#128;\u0026#153;s Hospital, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Signoretti%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASabina%20Signoretti%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMichael B\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAtkins\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGeorgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Atkins%20MB\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMichael%20B%20Atkins%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECatherine J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nDana-Farber Cancer Institute, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wu%20CJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACatherine%20J%20Wu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDavid\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBraun\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nBeth Israel Deaconess Medical Center, Boston, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Braun%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADavid%20Braun%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48794\u0022 data-node-nid=\u002248794\u0022 id=\u0022node-48794--21939393979\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1125\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1017\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1125.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHugaboom\u003C\/span\u003E M\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EStreet\u003C\/span\u003E K\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ERuthen\u003C\/span\u003E N\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1017\u0026acirc;\u0026#128;\u0026#133;SLAMF7+ CD8+ exhausted T cell-specific gene signature is associated with resistance to PD1 blockade in renal cell carcinoma\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1017 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}