{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227RLoqcfX51L5N7N0Plo8dAXq+G324LyOgmVsNIwcUep+M8yzKBaOp6vzYFb2TcT02vRzbOPSemspOqWxNES0PsbZqSh\\\\\\\\\\\\\\\/4Wxm4rc7O5VAifpsFKcx7y2YORn+gKB1O8TE\\\\\\\\\\\\\\\/Saw230z8NHoTc4wY5Rl5n\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/M16WfRoj8QIkK\\\\\\\\\\\\\\\/7wIesAh\\\\\\\\\\\\\\\/bIT71e3dLnindhAoezzqLrEgdy57ToE1dXfUsMe\\\\\\\\\\\\\\\/pbQFJMbYylWfyr\\\\\\\\\\\\\\\/v5AtvL9tk3F\\\\\\\\\\\\\\\/61X75yLODCaMgekJrsKpZLGlpXTxcaTDdzInQw03PTrXoQ6pghWTb2Fj3+DwoyRx+ybhNDVwO4y+msim2S570pTgI+rXG3ONUVvH5SmuY9UKCd8YtNIP8BRXJu7fOQ8D1xikIdmMcucuAYc52rGWEVfIvzOVIEdgWmtR9AG7YTuG\\\\\\\\\\\\\\\/DWvjkxvI37jq\\\\\\\\\\\\\\\/yg41B+6l3Lo23PPzcHnTDM4vlRRjBTyxegsYB\\\\\\\\\\\\\\\/fG316VZVMr3Lwnr\\\\\\\\\\\\\\\/irftQ\\\\\\\\\\\\\\\/EhaJb6ZYrlg0RGhwXDqz+sLzKEPXmTNjdwgEOQ\\\\\\\\\\\\\\\/1pcC2RHeHDIqnqCCbgFJaG05iQoG7hSp5VpZiJW78eC+75+TAn5z9Ovuu5i4kjzHk4xj0q1iYx+jwFA6C7xDC\\\\\\\\\\\\\\\/Y5VqhXsMtvLiYVRbmOm50VZ2WP9WyDNBVBc8rmS46YYO4ndWf4qJqy5wqwmcms20NZzj28rCj8WxukAey8Snx51hU9i3H4aFD96F8Ueuentg27sunl9x7ULXSSEnGG\\\\\\\\\\\\\\\/CJ67yIraCjTxVTBnNTWhddtr4SPGHvxzl2yRQqBxlQdVbQViBg19vqza4VtvBFdap52ucGXJcxbR\\\\\\\\\\\\\\\/IbKqVp5uIxee26bN6pU22Nlw4wox3iTrZ\\\\\\\\\\\\\\\/fGO\\\\\\\\\\\\\\\/zHNRKiRmyt8T1NvdRKTwSWLUGwuWKcufMyOzeCSoQpKrP\\\\\\\\\\\\\\\/AecsoR4FMa\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/fX0pAeayQ2z4xjM4W3dRJUt54goovBQwnk1fT4i4a\\\\\\\\\\\\\\\/4JkAqn4kQDdKZVpFTJCAEhzSXrLU6amA0b3BJOielzGSRZX2O4gBV0MdW9XxzL6YVBIGC\\\\\\\\\\\\\\\/J+BA\\\\\\\\\\\\\\\/YDprpwi3XH7ixD5IGJgRbbX9hbFOcYZO1kv05jE00W4K\\\\\\\\\\\\\\\/vlrn7CSBDa1NPKyliQf8El9AHbT1IbDwFGxRzT0jabq0lpzxgfqY1QiGGq4FAj0JRtJkKUsah6Es7SnPiM5Xpe2CMn0egX0uMsuUejLxTZ1H\\\\\\\\\\\\\\\/jAdzyNm8kMS3PUmyB0D2Tpqq8xyDwwQOXCmEoSY1vLJHW1s3Cq5+bGGufvspnvJbZ7+nrDH5KFjCkTiyYDMG0P56WobX3FgWAkEWJb6Fc1T8RoMnKx2q08M2eXe5\\\\\\\\\\\\\\\/VzDio\\\\\\\\\\\\\\\/PKMJKKtI5nuLEwuGXR9fvDrHRUIIYQK2JcIwzaFZzd0VwMq+lNE0g837CzST1RuDPTuq5rK5Q5of6phX\\\\\\\\\\\\\\\/ujubhGwOkrdXgPtlq9KhS6EsVA0nVvjK86txbRc25ruFU8EEaK8QM23Jp92wdSG5XqTE8JK9kSSp1td0blUZpIMMqms5ADi3LotS45NyJfGjHW0UTG94W\\\\\\\\\\\\\\\/6FQC8MjdVymthtPFnC6O+F0N6hzzbtArsRqsMFVvBdM8+wm\\\\\\\\\\\\\\\/dJTMliKHX6MCq1CneyvcUKbmhfzcST+xE6FW87cTyOqAhxOliYcxCjoCIbA5qn45wcPUnqDCxu5YZjtzcYIHnYpUMtV+r3grouAyvTynaeJMFmgnLw\\\\\\\\\\\\\\\/ts\\\\\\\\\\\\\\\/cja9zPxndeDX2VJ7PP85jgNKgYev+X5ijMtGkPX+6+WMcDvksmukFdPjFEHmLH2BVkia7f\\\\\\\\\\\\\\\/7JZ3KJVbySkBwq5Rv69Xtkc7f2LikHFcdjjtLozg6PYwaczhIhbYuUc9p5Yl9+QDuIt4wYCU\\\\\\\\\\\\\\\/UIn5E5GsPEE6kWiMxbFmz2PqYwq7oh96TuAOhKoYo8HIfYblZF1xMIZOoPEhwamwlo+y+HdX8tghZUPjSmgPG1IKslPhSd6PfB68GVe6fui0Gr\\\\\\\\\\\\\\\/xuirU62d9gSOHU7C2Q61PiQWJGgden5iEy8+Z0+Pk8Dzmfk75JpHRouQ9YvoQTlZZPoM\\\\\\\\\\\\\\\/vpaEmYrYoJmZA9sQo7HPFsaL+ut5Lz+DN5bRkBNpQpAHU69Uu7FEY+obT9Ph5j56Xt1PmnWbj3fojVFN7Cnd4FJjoDg1UVlNg\\\\\\\\\\\\\\\/fVIJgzdrL\\\\\\\\\\\\\\\/4js5EfQwtKeQlgtHGOA8m\\\\\\\\\\\\\\\/bzjkxfWqFofomqj8q1UHChTlQG4Z41Yn0qn9XJpdq0y3ZvJozHL1EJxu8Y80pNh14aG2S4xBgZZnUZC9B+PvfbPrauGSn9WtVWnQDnSCwkY\\\\\\\\\\\\\\\/P1UfWgDmVkb2so2dlDAbxFdRJnrcpz\\\\\\\\\\\\\\\/C+u2IDpSUTRrSmPr7cYUpVnCgq1eolKG\\\\\\\\\\\\\\\/0UfxlIJPobmPx1F6t+FPXmEDVlsecX7oYhoask+FTXntZ6QMFXpcnz3zhNLaQlJpNOmVmUNEUjrlzyvL6Dxxt9OBm0Fgg7BcC6mBaYGKwsE7nDM34tIgGogUai34AqfMdXhYm2sAbTbcpGIp4lpMijiKpN2YXv4eCfLXwLzvHKtvqYZX3GKptftPXZkV4o66B0OMK9CPJ\\\\\\\\\\\\\\\/O1NeiCTa1OUKgsoVTap\\\\\\\\\\\\\\\/8dHuEcjiMhBGk4e8l7E6tOIZ2Ci7SURAbsEk9xCfYDHelrAnCxndzG9nfZQCFrLr7n1DBrLQ\\\\\\\\\\\\\\\/01r7fZkoHnzkypXGcW3fl2ULkRz8jmy43qEGVTdAZUT+Jo5+cwKrOMhqBcTRx3IKTBFbQEoY7VLtroRVQjHOnBL8JV8gOFzmJELHgHe3NjRPFlWSSfHhycGAMZxG7QHh0ASqjrInFDo\\\\\\\\\\\\\\\/7+JIncHQ\\\\\\\\\\\\\\\/MW1akhLIho0utdAUnZHsvLDlAxZl2rWww2G0HTc04qP\\\\\\\\\\\\\\\/M\\\\\\\\\\\\\\\/ZzDXR9Cm8iP61SDxTWKm6RsM9SYoba4H2RCimv5ArDalYXoTIShr\\\\\\\\\\\\\\\/Vdi3jz9GF4xH+59qHZq9UMrL0WJlX\\\\\\\\\\\\\\\/X1UL85URFJHatju2\\\\\\\\\\\\\\\/Jq+szw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022fDf34ZX5S16fH5+bPQQ6lQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226ad350dd3ccc9dbb10bcaf3db025c187eaae74ada2296525a78690078898aa32\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDong\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nWuXi AppTec, Inc., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wang%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADong%20Wang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXiangnan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EQiang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nWuXi AppTec, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Qiang%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXiangnan%20Qiang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZhixiang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nWuXi AppTec, Inc., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZhixiang%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EQingyang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nWuXi AppTec, Inc., Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Gu%20Q\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AQingyang%20Gu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48730\u0022 data-node-nid=\u002248730\u0022 id=\u0022node-48730--2413889205\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A1281\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.1162\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A1281.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EWang\u003C\/span\u003E D\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EQiang\u003C\/span\u003E X\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E Z\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E1162\u0026acirc;\u0026#128;\u0026#133;Upregulation of metabolism enzymes mediatesADC resistance in a HER2-positive cancer cell line\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.1162 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}