{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223Uy+PfM+TF\\\\\\\\\\\\\\\/BhFQr5dgjxIDkrt29NIaA6ivfjUvGJRQpPGBGQH6NlPvU1R+PIw\\\\\\\\\\\\\\\/7+XUsIl2MUJmtuZjAVIMQEzL96ing8GR6mnoFYsqY733dyrnCic62OTIuzAPiKYx5xuuuKtEpQWWIDQqaHVqxuMSVUveYWiKCizG96tICsh19zyZ62wGk8rzQE0N\\\\\\\\\\\\\\\/mdbmJHaMYuhUTeZPYW0EhQ0u3RnsR8v4nC6RwBvCxYzLxtOUli2LCVnigVhemCn7bzNCKmVxkI1EDxfOEIEGBr1GQ9u8jlAriqwMmeSir0H9X\\\\\\\\\\\\\\\/QwhwVdCB7hrmILJb+T+pLtt4k4NaAFVLU7llE+fIunRSlcB9V6z4GDuskVrPHNXutosENKVzndR2Si2Vb54dy\\\\\\\\\\\\\\\/QWTwS1D0zf4TkRyLbFPfUpP6DdiEob0qTPurIdW4qwFGnUTXQuUl9qjaBlD8KGRIUUu3k9a2v8fd4iftncLD0iO9OipQdOpx5JO1yiAQ+RNKg51yHK\\\\\\\\\\\\\\\/89Q2pXXjtzeHRqCPa5bhFQzUt4EvFYFMPtXUBV0yV2NWEgOFSHkVE0IWV\\\\\\\\\\\\\\\/KNawuKj50gyJFWn1FQwX8F1SqVYLuusQVxidUEYd0pxPqO1EoRhdgPeS7ZdUUrt+Crk9nAvdEmC30YLUBEnuXYTAyW6AIxPaVT4x\\\\\\\\\\\\\\\/cy\\\\\\\\\\\\\\\/sgYMBoJ+MgUuVRL3aEDL4Qc04CezyXmssnoi9s56WFbtP0aZS8Yc8PunRgkYYoXTsWgEIEWLWVLsNY8qiWkcIm86WM\\\\\\\\\\\\\\\/l361GwOuN9fQ9EKkTnd9oSAqjMdSrmm0zdClA2CaAgA9DqWPzyxrlwDyzmMeXUPFE98\\\\\\\\\\\\\\\/uE9E2kxZLHMcIyceXwGfWJoaWhf+XdNMO26Oh4R8LYtQv8xM0k6Eecp1bv9aJB4I5zANn\\\\\\\\\\\\\\\/VA6cjUGpl3kmr8O6zj60PfSBHR\\\\\\\\\\\\\\\/MoI0JFFGMUYDNwXe+15TfJRc5kq4aTxVVNYmpp3OPiTpHUhIUn40p3D+MlNU0kDzUsIBb5SACMOkcuQ2tMLfYNCbz5heZX8fnjCtC4TS0edlautaIWedeTZJZfsiY8p5t+F82LSGAXgW7EQRh1thgXtQhp+HVeu\\\\\\\\\\\\\\\/xWXVBiyEFm5gzUGfEmMUC6AvFwgmRBYe3AUI4HCa6LM+PjOuDahKvSJyv3\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+KURd0TYIWS2qjTGVFXsIZ1v5mI66oCFscRQP\\\\\\\\\\\\\\\/1oQnyKIQVSwYNXnVkF+mlHQmdcDwcKdOz5ktFXFb6UA4WSapj35xfuK4dy+erHBRQ+EMd70spmb6iL2OsmKxtVHunknwl8Fo7Q4LTopqaXDTdRbjHC5SSMkji8s7fiu+fc6zmyc+x+BHG99Iur+EpW5mUAV2UPIW5H9OtV6GlQFWTqLgEDKeDBa3Clv69n4Zsay+ht1F4nQKqch7amggAFfjiZ8I0\\\\\\\\\\\\\\\/QXB9nnMD4tenfIdsElId508A2jBIPC2ngHDbTFSu0LYxTZaDuRoSj1Ir0wzAo01hq+zzjZ2R010LcZmDMX62uHD39Y0fNqobfNx3Xaj3pmMUeeTdk1WOuEksz\\\\\\\\\\\\\\\/MxWveXI4x2j\\\\\\\\\\\\\\\/JMrREqCP+Lhjq7nWAUP55yHbJC+8XiQH5HDuJiHLHkf5uemx2j4lj\\\\\\\\\\\\\\\/YaURNkeDIkCKUfyVhFydfEGgvd2Cn4DRZYd2VKM1HFZtVGa3msORVS\\\\\\\\\\\\\\\/WNLJdqbw2O0KeVErWBK3ikXoZTjahKLXNb5VWtv0OtgKiz8QK3vFO7aBdWAHkBmz0AD3J\\\\\\\\\\\\\\\/+SA8D3PN+RUV9jLyk+5wNZbiq0dxXRx6ga1KDQoWqGgdcK\\\\\\\\\\\\\\\/LghaBqNTSpzPIkW5iO+m1V+sj38y9Drp4rZkl7XPz6gkmcZcJHISbDfX94+nXqnXxDo+Wt8M7FkP+is60vchCMIGSttfYVG2xaHZ8nz78IY1K7RoFctm\\\\\\\\\\\\\\\/qr5lwVlVTJRHBp\\\\\\\\\\\\\\\/zDeLRGwmRcRbisKzT+9cCVBXT2PNUCXlSwkUh5JXePJssS+RCZQ1Jck9WbRrkmmG9EUUnM+j3xKonlvtLnuc\\\\\\\\\\\\\\\/OMo2zlI\\\\\\\\\\\\\\\/uV4Wndo50LqF31jupsbhlAjBNFgkIGEUeTdkrlPmnc2RsKVYIhD7sK6rDr8L8vvJ2Nzn3r\\\\\\\\\\\\\\\/VlPuQL\\\\\\\\\\\\\\\/u8ctHYZvNXHvj5A8N2whimxz\\\\\\\\\\\\\\\/xuQDQv\\\\\\\\\\\\\\\/ROcJLV40qNStuXUvyK49Q8C2e5IC4jSuL9wwRTCfVRTJwb3n8q+rEViOan4a7IssMlYnBbKvceFw4xHFyEi+zarqvDQ+TyRVZDgDD9GigymMDYssx1mRJBQJrXxXS+CvwZxmbDw4pg+DIgg+IY5zkhaWcn7vqjWG4fCjvnCOdKfUjI+W\\\\\\\\\\\\\\\/l2RO5BC7E+qFttxG7Q9qC0CcqjCz3+KJ\\\\\\\\\\\\\\\/5abqZdMQlf9cH3drZ8TU598kz2jdANKZY2ZOaF8JGMZBvgoMNFyypGo9rIB+QF7YKDTuZIQLfOBupoYJZbIy15gv9NubtWJWApA8qkW7WDD08F3cfoNFP2NYCRG7ot+HYLpT4v0EfWLuQHz+SGooVfueDnSXEGlfqKJmzUruG0w7lolG+t2FePsFlm9X8O44ryB\\\\\\\\\\\\\\\/q7I2CaflLFzUJdpZduuXfyJe9hJ36jg8ym5HK\\\\\\\\\\\\\\\/vSQqT5lkvDTFRG3\\\\\\\\\\\\\\\/nxSP3DqrzQlr3I28AaDSFhTsWORNYx4Kk5Xk4pSpgIDIuZVk77qXBFwUd0l2O5z0hSuYhVc0452XP7GKKWeUC9g34VaSdzUwZdqBFkiH0ar9jztCdgr9BKgFTpqGM3tWrJYoQYSmw5pfbziercU5afPHh7hjBTJNOGAojPPPqV9jIJjme6S\\\\\\\\\\\\\\\/y1HhuLaRk58MdtiunwMxDZ0D+pBZIMXUSHwOj86OhLJDRtwEp2RUXairVcdfyaDSRl0ounK87\\\\\\\\\\\\\\\/EoiJlkBEF1Sj4sFe0SXldwmkxSHWEAMIIrf66wPFuW9Am3scfMHvou+QicQ1WZSkj5+KYUlUUspjh21o\\\\\\\\\\\\\\\/PqLOkDrpGS8j+MA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SUmwE957ixFd\\\\\\\\\\\\\\\/b8Fq4cpLg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227c2c5c81e0f411a991b9f165db7fa3cfb9f18865be789a1a7159bab84b66903e\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESiddharth\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESubham\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUniversity of Kansas Medical Center, Kansas City, KS, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Subham%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASiddharth%20Subham%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJohn\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJeppson\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUniversity of Kansas Medical Center, Kansas City, KS, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Jeppson%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJohn%20Jeppson%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EChristine\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBrown\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nCity of Hope, Duarte, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Brown%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AChristine%20Brown%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDavid\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAkhavan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUniversity of Kansas Medical Center, Kansas City, KS, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Akhavan%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADavid%20Akhavan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48569\u0022 data-node-nid=\u002248569\u0022 id=\u0022node-48569--2452281992\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A352\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0309\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A352.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESubham\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EJeppson\u003C\/span\u003E J\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EBrown\u003C\/span\u003E C\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E309\u0026acirc;\u0026#128;\u0026#133;Protein Kinase C is an upstream regulator of IL13Ra2 and small molecular activator enhances CAR T mediated killing\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0309 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}