{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022WO+Grhx29zhS2\\\\\\\\\\\\\\\/D5MFXGQyrwlO3kNQkMX\\\\\\\\\\\\\\\/J\\\\\\\\\\\\\\\/OtLAf+dPCAS0aEOQYiuzQiqlShPh4Byojx1tydlfB4SDJkI6azJEfkuIDRs5WU7Dc+jsYZ3Vvy+rvrqbVOjSrmBwXDAdDWs98uV0LV\\\\\\\\\\\\\\\/FR9rDxfkWqufTL4U0mqr7b29OHzvjht\\\\\\\\\\\\\\\/NzxwGTAwyTRbmvaZRt7krfgwkQCNgGC4CoGNGmK8aHuxcoz78fKv+6yf+tOkozzirqm6fmchAMCuhj1rQIhzhPcwiGEfnvJqRKG13GekRMCOWFv38VXlOS9z06+Y2LX0gRiWECvBMJylDTVO22Yuad9olcVzB9lhbifqaWUDHlaVGrGeZ++uMla42V0ALvNO9Pmh0USCJKDRAHs826KhQWTwzbjP9xy\\\\\\\\\\\\\\\/rVCX4zWohxwroZeCp4cxTvpBhIW84p9HSuehSgLP4N0+\\\\\\\\\\\\\\\/n0hzXySyyAyRl9KXzEQzoGLGwqt9yfL6XhH5gHd10tuMzk8oHykT5OcGL2aMewD\\\\\\\\\\\\\\\/Kvi4vmh6ez\\\\\\\\\\\\\\\/XhM1lBumtX16e4tFAZZ7ukTVp3aDKR\\\\\\\\\\\\\\\/hDPaP27a63FoS8iFqpiMSP9AR17e1mRY34Mlt8XLaEA47+XOr4FAA0J8VeZ56DfMaJ0qSvnzEpGeRR2SRM3HTPzoHToR00jnIXvR3TUTY2HxIOdcxxMQDczR0lNKOFr3T7VHIGzhRxSKBgkuNapfgLzlCuBvZg67J1lap20EIRLkAFSugttTezOOCLRdg350A7oF1FE07w2r3s+PrKYHo\\\\\\\\\\\\\\\/eTBoXhPCOuQP85OSIqqFipLR2xhxmeWtYKSFdOPGeoghP97gzSjoP9VivEdqQdvxRxA9lsPuKOL2T9iPZiCZDnjrfEHRFZaq0l4AJTZQXpu7KFf9U8po6qilZTqmHHpWubn5QKZeGSdK9fX+2Wklauur6i1MIL7bxiPqjfK5KDsNZdmbB7IiSZz9Ndi3INiHPJs9ltgK1kvZskZ\\\\\\\\\\\\\\\/WfvPCQCF\\\\\\\\\\\\\\\/sy1HFmToHP5ectF8FsR4nADHFxhjD5X0ifcRRpyLwHJNLsUYDUwGg9WLPQUJ5PJj0oTybyf\\\\\\\\\\\\\\\/HMsnK59P6sU+Rk\\\\\\\\\\\\\\\/QEw2\\\\\\\\\\\\\\\/+2QzmMYrk2\\\\\\\\\\\\\\\/tqzMX\\\\\\\\\\\\\\\/Sv+UWORSisuPeYexegLXGYUP\\\\\\\\\\\\\\\/iTNtoj8aVuP\\\\\\\\\\\\\\\/HyTBGCaCyDXa9t3OMC7LhGe39w5DdsET0jVlr7n9j5kBubgpH74STv4X5iFEeWWo8n0SQPP5FJyKjI2iB1HptjTT1l8PVESnx7E55AUY0kGBOGHxk4CsrtCm4OVfjY5eEIn0s56Ksa4Dz9MsNA44DwxYeDWYD4FoT\\\\\\\\\\\\\\\/STPkGH7Q90s0z9LsTimhGXRS+dVr2J9JjBnN7zsnVnAsyd8WR5JmKcBv6MpL8wkshtHMCAclq8x7ynuVG18DfCfQ2MAr+M2VkHg6s9TWuQ0mbTnfmYL6C+Ege86tB239U0ZUfp+3rfKtdDvLfNDmURdt3DmDKZ5H2F2UeDHU1OWUtQ8Dm3d\\\\\\\\\\\\\\\/p102UB2OaQgySGJDyCO2v7XzJ3TvKZVVG9mI\\\\\\\\\\\\\\\/MzS79t9jJ2DRyYjltla99IbNk9b3aUfy1isaKzWv+uYJEbtMCJXt8AuffqU\\\\\\\\\\\\\\\/2uy4pMZ0ZLKzal7KBE4gWkDlwsk9bz71e5xC2R8iTohzCXRP+CNUQJs54z7kaZSrUsdUFwK0c\\\\\\\\\\\\\\\/tybEpUGs8dUqzldDHZAngmx3goyYKJy7LW5LrgxLtVKboEnJnIzAv7BO67aZUIltR9UsTmn66ONCVFORUqDY2CNpohcxHu6XrirQyR+2Ge0fhfz3k3DPoBUyyCyio22l+4L9lhVIKz4Zi860B6zAwJl6EvbVLrOzEODiGuBY\\\\\\\\\\\\\\\/Ob+6\\\\\\\\\\\\\\\/QxggAVQwxscoC9r8YKYTtVDR4qa\\\\\\\\\\\\\\\/1genjIwn1ij2PQuiFV2IQyvudqQIlI9KBapilb7B2VJ8LRtjjyw\\\\\\\\\\\\\\\/mwyacH6Xpi9rJujqHzhfJHrV8DTQUUBKntVCWgjm2Syrz0EOdzD4MeL4gRuSaVtYbuQ1wdj0QJxm3C5V9M\\\\\\\\\\\\\\\/g2OHbPHZuqCO24Z4iYeQ\\\\\\\\\\\\\\\/gQgPfWFn+dTQsFd72nQddbCm9410UIcCNvtsW5cWZEFmu5LHcd3LvxjJ7dICn0QrZXSckjjVIuHTDlhvYUdA3nxZSW0DpBgrVhN1ffjboEhXx5V6tJMOTVbdNegSqUNsXgzrQp3PBXwHTosUB7mni5FQ8VUlWBidZNaERzR7PfpbGzcbG0gF8r7VJ1crwkG1FL0J\\\\\\\\\\\\\\\/XcMMgkw+25SyZG5hpZofqk+LHv5e4t92gH+nvRYYzivfdPfjbo2D\\\\\\\\\\\\\\\/b54\\\\\\\\\\\\\\\/1cqTg3E3RBdCzg95WUQyN1k0QkVRZTzQEeL1ZmloKdL2kdJrX5Ow5dfyIJ3LkVAHl7MlehPnwg\\\\\\\\\\\\\\\/HM3uzRLi64lkRQ9X29E9X72DDoiIilsPqApU9TRC\\\\\\\\\\\\\\\/z+3Q9NsLdzf2X6YAPiwjKp6ojXvhZo6hurcqrG88wGBit2T0cMjSjCJQ7w9HOPUuu13dnTn3cJH6AgATjuS1PR92HeAE1\\\\\\\\\\\\\\\/yNcVzlVXu9647cbrtJOx4dpqMy7oNNwroL\\\\\\\\\\\\\\\/lNIkLfKidguegIdd4PAYsOrurnFV4el0ECAWhFDMiX+CS8\\\\\\\\\\\\\\\/9UKAwiwZTGrOhxMEaK+B5OPSGyAcBiYFE7lpOX3UjpFezpn\\\\\\\\\\\\\\\/NgeAJRSvYdUfrrT6YdxyMEzZ8SkuzX2fN4Xy6jsfiCq+CDXfPp5+8dChCV\\\\\\\\\\\\\\\/QDc7BJ8gpj3xB73ll1UDESCU6\\\\\\\\\\\\\\\/SmlCn2AHBxDVbzfR91lzBoZF8\\\\\\\\\\\\\\\/9uVm7uRe+E4ljvvhqf+tvhoLbLQP8uKBYvW5FW9DZnLdrZ\\\\\\\\\\\\\\\/1f1V\\\\\\\\\\\\\\\/d+uEssck\\\\\\\\\\\\\\\/qpQmeskN+o4I28lm7xA8GsNeDaJBuUKCHLaJe\\\\\\\\\\\\\\\/MNRubPraai3lsj3S8FH3HzF+KOCDbiiy+T4X7mGb0rK2UvAqxc3uWq0PAy0DnVJC14vfXeQOuP4rb31BmzYg9WCitYrb+ktzkoPqHmFg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221WkIpsnY0Mzg9us0YkyPNQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221990b928a6ce187ca6c0e3d3a9e3d361db43ec13e2b46ead201065b26a0b9142\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EX\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EShirley Liu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Shirley%20Liu%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AX%20Shirley%20Liu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYulong\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Li%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYulong%20Li%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXiangyang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Wu%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXiangyang%20Wu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHailing\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELiu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Liu%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHailing%20Liu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXiao\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xiao%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXi%20Xiao%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHuizhu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELiu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Liu%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHuizhu%20Liu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EQingyang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDing\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ding%20Q\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AQingyang%20Ding%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXie\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xie%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABin%20Xie%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECaibin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESheng\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sheng%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACaibin%20Sheng%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERongbin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZheng\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zheng%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARongbin%20Zheng%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EQuan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yu%20Q\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AQuan%20Yu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKarim A\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBenhadji\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Benhadji%20KA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKarim%20A%20Benhadji%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXihao\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Cambridge, MA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hu%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXihao%20Hu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ETengfei\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EXiao\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nGV20 Therapeutics, Shanghai, China\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Xiao%20T\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ATengfei%20Xiao%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48568\u0022 data-node-nid=\u002248568\u0022 id=\u0022node-48568--2638407161\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A568\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0505\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A568.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EShirley Liu\u003C\/span\u003E X\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELi\u003C\/span\u003E Y\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EWu\u003C\/span\u003E X\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E505\u0026acirc;\u0026#128;\u0026#133;IGSF8 is a novel innate immune checkpoint and cancer immunotherapy target\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0505 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}