{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223taHNE\\\\\\\\\\\\\\\/EN2TXv5WzSEcqX14HprrxLemkiU2oV94Lk9pgH8VBKaG3AMETXptayJL7NKNVHBZqwsTizDDtfolD\\\\\\\\\\\\\\\/gEtN+w82hJirYlfIKjV8ZoP+qmGQY+sKyPUR+YrmQr0V2AeYPI\\\\\\\\\\\\\\\/Mv7VWQMZGcMUbKD3+BHVJ9GN1pZ1V+bou1vvntj0SDfHDmgfkXFHC2ekF1mWrkKfVLGxES8sNlt1Za84o9aUGqz1MoXTFQl3H7xHYhngmq8PXifCuX9gypHyEL1I4r8KrRhjYPInFO6n\\\\\\\\\\\\\\\/ve\\\\\\\\\\\\\\\/rsmMGzcb39mI+dusjc5h+Ec4qRZ+uf9J6EmOieM6HScyqQWBNaNK+zbgT24DlQOr26SNmd+Q9gs9RRLsMwzt8GJjPYz0BjQHsSqbjstz1lfHP1iXjSoXHD6IotECtRr2kFjp+aWLexhf\\\\\\\\\\\\\\\/1PFAa4rRtWwj\\\\\\\\\\\\\\\/h8N21geg+A0bftjtbgCtqjyZONmSFFJq\\\\\\\\\\\\\\\/nfGEjUOS4WaOMfNIHnTZZ8lNLfvuU9XmqvrK7gD81wD4anlyA+\\\\\\\\\\\\\\\/0pghlfBw5NRAb+qqDChIezEQTFy82GxLQhZAf5Z8KzZwfS9tOs\\\\\\\\\\\\\\\/n+NYSmTSENXm3oQ2vPOLkWspq3IPjX2HF6Xe4kzFiJ+0VTMJCgh54SDN3WmVcVyur0YIfHZp4zJCmihCliYQwgF2jUF9zN1MP50Eo2so2XEz+RDfw9KstJmMAkucmhCFr31KpoqNX\\\\\\\\\\\\\\\/XvReHF6q+pUO9Xt1GlajwGNPcxnRAvsxrDeRGp7bSfvSchuxL77WXHikaR1wKKG7DZbi8LSu\\\\\\\\\\\\\\\/YLunspRIVd8PzHIxyuSauf0EZY0b7ob\\\\\\\\\\\\\\\/fAoMVG5ZT548z4qd3l92A3HIVXJmuIxjZMAzI6zGgxQcQZffv9B3iLkMdjJGGGVY3uf+Y6tqRlYF3zmY2+YWWF\\\\\\\\\\\\\\\/zMPRhBrhTrlevAISJMa01uXaxKkbqMIyjCxY9yDzNsbfoIKdcUxTfegPhrX1EFvBR9yXHp8ZM5wQuSKEVQA2HLBxWZpR3iS7oqM7Wu+B6ypfRccgF0uRt1gEprKMVj9iq3L\\\\\\\\\\\\\\\/XWldh0uquj0KPih275QwdEBhYlR1im2UqRp86toLfuMEFUwjlMPAwap\\\\\\\\\\\\\\\/OQTAaiVkdprk9vbXPXSPMsg+lk0nAFppBoNgYyrsP47z0XUOv\\\\\\\\\\\\\\\/bwlEQ6XjM2ABLHcyViCrldr3cAfb5bC5BZiZML6P8VmLscyNmiH+A9eE5ZOJA4VUN9KS0vqF5SyfiebT27UjqdH3KYh1U3NfSVhqKYomoOAbmP38Bi68YtEUJKX2FpfLaV7pPLUFBVJVVBjUKGaZj5aZ\\\\\\\\\\\\\\\/npGpxt+Yc4dn8E+UWi5FSSQUqesCwGxU+zuKqPsMYj3knHKVvxS8pFHHLPIhwxZByg5Sw19Sjc7dHiSHC2SQgQOTolNjh7ZZ0CycBBbO6b\\\\\\\\\\\\\\\/1qur\\\\\\\\\\\\\\\/KQmG12liMttD6+ZODzLb1y35hQz3HGQ\\\\\\\\\\\\\\\/QHq39LXrrlzkTNoIKXNvVkf37lwxnN7OvzNVrKybvHZM5pue+OBNoyBpBUqsv4uOQjfuy1Heg3\\\\\\\\\\\\\\\/c6zG9rIegs5Zr3HPiiEvhOw3ykNLSepTx46jfBbeTK6Y0goF20yHWewI8jjznnbgDOt4HikqmLMe1JFeeivph5n\\\\\\\\\\\\\\\/fo7MIVOTI6Y6A+lihsf8CUTOdav6VxC2ZASqH+Y4\\\\\\\\\\\\\\\/YZy\\\\\\\\\\\\\\\/Ky+dyq9yQN1I5f9Ofp8XIy6EB4F62Om\\\\\\\\\\\\\\\/d6UfjzrESj3FjN0i\\\\\\\\\\\\\\\/Y99supPx\\\\\\\\\\\\\\\/AO93hDrCy8V7YVazl8dyPA3Gsg1M9ruxzLL3espBXxxSqAAVnF40qHnbzbSSi+wBgK+I+jmjksMh8c5sOPVzh4JrG4nTGIZxxrLAckL5zw2VydMsVJQaEwr1hoZScvH\\\\\\\\\\\\\\\/sGGc6rdk1r09y+y4PVXRVRnYeUA39LFOna+3reO5RZRp4\\\\\\\\\\\\\\\/omo+FeymOwaqg+k8SS\\\\\\\\\\\\\\\/d80xh+\\\\\\\\\\\\\\\/72HeojPhlCOfwZBmVpdwI\\\\\\\\\\\\\\\/aPXzfEXM32TnoHpSLTbKmhBvHjzoxOv3eNBgAOSBSXDdZbdBSv1F6lIZkpXOngkuSE1sASdcljTi+6CxCKyraIu5Ix7Aq\\\\\\\\\\\\\\\/+CFip2qCV3aJbDI0hpHotmIklEe1IWShgYXIfQ7xmtmUGI\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/Oli3yosi+pcTJEx4sco+bSTnAo45XWkijk+p856NMoFflvzyrHDJ8GIUia5dIJ+D+CZ+EXHaIjPMGUBuFX4bgXeQuaJpsyU8KMAz\\\\\\\\\\\\\\\/uogsX2+Fs\\\\\\\\\\\\\\\/dVyRM6YLnlxZEquN6p68h+llu9npOi\\\\\\\\\\\\\\\/mxTx0qw\\\\\\\\\\\\\\\/Dog1StYJGj3vTOcvQIKh0U76XtpMQCxa2AQdpjHLRq4ULHGlrvDaRruSZgpdHxVyuoZ6yo7u9ZqituwSsQ5bIp7Es1uGpIqEgUNIpBkXZ34SPuHOkznzkteP5bUodmgx0OpWmN\\\\\\\\\\\\\\\/m4sU\\\\\\\\\\\\\\\/RDA59+gnPOf27oEmESLTQkecsYrXGtrzYEJzd1Tpf7ziYfvF4deo+jlZjjZTJ4f\\\\\\\\\\\\\\\/AkGa8zrIz8fzhrqz9yiiLk65AGNOl46QQWwBZR+fYQO7KxOGGN2v7AvIFfVYhVmP65fMpI7LxRATI6OkClbKCn0HFrB0IpGWMvJiys+sdmrcpjYid2l\\\\\\\\\\\\\\\/1zR7ES6oNsxUS61rYTiyZJzLQruzm8vJhiKR1qklKHhRgs8gHiqATgNAvnXrXOfIqE9bv80hKONY+bzDewBxN4fC3xX50+lBcCHVs71T2GrbwJU83wtHuHHgaGDt7+48BiLZQVaxMsdQnu6wOuHfoTlYg\\\\\\\\\\\\\\\/QixNJOu5BGKJLazziLg0y7bCgOrST+CIGGEYsZUed+\\\\\\\\\\\\\\\/XOeCqJp6iNgrrbDCijQYmg9sk7LmabdRkp2auF4ZUZslfJjbdJyi2gCXi+xk4oFiqz7R4VJdlGHtNiAkS8swkaIfgKZ6gPIbW5DLE7sYanetZ11Df\\\\\\\\\\\\\\\/megXeLAjJTbl4wkMTJLeirsY0wONsatVTCryrmYHDWg+Ee9Cg\\\\\\\\\\\\\\\/IIbxvw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225rTaJniqiUiwLtr4g6qx4g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a4fa6c25498af975e5badc3fa1ad71710a24f16f31c97473ab6b68a60ce36e27\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESaya\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJacob\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUCSF, San Francisco, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Jacob%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASaya%20Jacob%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMarkee\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMicu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUCSF, San Francisco, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Micu%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMarkee%20Micu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZoe\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EQuandt\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUCSF, San Francisco, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Quandt%20Z\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZoe%20Quandt%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKaty K\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETsai\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUniversity of California, San Francisco, San Francisco, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tsai%20KK\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKaty%20K%20Tsai%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShahriar\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYaghoubi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nXencor, Inc., Beverly Hills, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yaghoubi%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShahriar%20Yaghoubi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAdil\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDaud\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nUniversity of California, San Francisco, San Francisco, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Daud%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAdil%20Daud%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48389\u0022 data-node-nid=\u002248389\u0022 id=\u0022node-48389--21218491830\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/A872\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0775\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/A872.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EJacob\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EMicu\u003C\/span\u003E M\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EQuandt\u003C\/span\u003E Z\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E775\u0026acirc;\u0026#128;\u0026#133;Phase Ib\/II Study of XmAb23104 (PD1 X ICOS) and XmAb22841 (CTLA-4 X LAG3) combination in metastatic melanoma refractory to prior immune checkpoint Inhibitor therapy with and without CNS disease\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0775 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}