{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nIqlej6ldSwUXiGRK4OlNXIVXgyW3fb3IABZqJi\\\\\\\\\\\\\\\/lPI+EHjaq3BjyN7i8Nem7lC\\\\\\\\\\\\\\\/H89pQr\\\\\\\\\\\\\\\/xpauaQ5kTaqnU\\\\\\\\\\\\\\\/E7iYf1hKs\\\\\\\\\\\\\\\/oy6q9ee7ZpMH+6yX36SZs+PUTFlh7ySp6Px0YSdk3oKR0lyFGgbKwFcFbAXWffyhH7IMdYoutPk1k14E2cvsQY8E9KQ+nQOhIh+hqn+LkakHQXpX\\\\\\\\\\\\\\\/B4K3C7vhMlDbwd4sswkoveNnNmvQ+EBwE9qcjc7uNESCPiSGCsRYNdpzwa07efuRwyH4a5wYUIeaEhIhNB\\\\\\\\\\\\\\\/8ORx6Kr5wRQz77gp+3HZF0qV8BtdRCZOz8rXObHl0V6jIbU57dsZ\\\\\\\\\\\\\\\/by00uXxNviQ8+zJqh80PKDxXcYmYSrLXWp91L\\\\\\\\\\\\\\\/q4AXeuJIcqJDnyEZx6ur5BGt\\\\\\\\\\\\\\\/yAbl4XWldN\\\\\\\\\\\\\\\/YhvgojvNxQD7DKHIOhOQubrXR3sYKdbTZFQw3DRRxVuDeG\\\\\\\\\\\\\\\/pUhvohFn2ayqt3o3bQ2XL5H32dky9GExoKiyq\\\\\\\\\\\\\\\/9e6TPmZHBSogBNOtRPMx8pf0Hdt3GseLVuDApDM\\\\\\\\\\\\\\\/HivdnZaJmcnjgcHpNkxOC9R2XCS69PibKoEWhVXqCIw8Bor+JGnApsQe5JVDGYENM+p3n4I5TQUgz1U9p\\\\\\\\\\\\\\\/wLvHG2XvUAntftwq4UqiEtlLwy7exGWxfPXAl2Pm2SGU2agZRW4q4W6LihP8K5diDJQ4XCzWa3mUQaT\\\\\\\\\\\\\\\/+SzSvFUSPINhWDgtv6XNy9y20qWSPSNf5gnTWZRDHSbL3geySU8vkTFRMO0cgAAKetIGbW8T1YfAXEKFa9\\\\\\\\\\\\\\\/Fg8uOOUasz73aAoW8Ezh+r2\\\\\\\\\\\\\\\/NkZk8CDIx67c1gO13fl044GaWtmlXrF7N2um9zTEB7tIn3DwnCHXICfAYKSDPOF8E2IBr5SgDzZr0nH7Ec3daW7HeP+XaX9mfaa3N2MUigTU9O5lmDM\\\\\\\\\\\\\\\/lv1A\\\\\\\\\\\\\\\/bUVZQHhAmRqf7wlM1xeiFXmCArHzjj+zYlwfXgT9ryUULamuBQFJtA0OqKP9wg5s3TylsuYsWKSH3HVV8o3asWk9CCXUzRojV5GQPMrpPJR+6z89Pgf7Bl05Bsxz9u7H2MzdZ7sINGMZDBuW3gkvf6ifvRhxJ0SrcEAgX6Uhalmy89I012mTC1QDvMLbCIwxM4J7uW4z5jLKmwQb+j8d8tZ6y1Uus2HPz6q1jYuf+Fd1Q7sE4Xbv7SgiqdDbqEWGLzKaMTkH3OfbDAdO1gPt1UJPPd9isGKpzfW56sOah4vQR4cB7463pzEq3WNjQ8dmMs2r1YAZKMmt9nfmmZuCAh3D\\\\\\\\\\\\\\\/C4yOHOTzR4viID6BAQK5W1Zfxkzz7Vg0rc2i4q+\\\\\\\\\\\\\\\/5K3n\\\\\\\\\\\\\\\/7ULCWhDhfrPvcryrxFTtj0H+ZzTtrDA9s\\\\\\\\\\\\\\\/LQWXUkqx5S\\\\\\\\\\\\\\\/cnuW9RLxSsW3xpY44MOqZCrVEGIMw7BQBIqir2sVLkTTfaKukvRbTAvXzFUh3DhH+OR3bFXrEvZHVW\\\\\\\\\\\\\\\/S\\\\\\\\\\\\\\\/G2Ryf90NzbjY60DTA28D+ZNmwVX6bIS3K8FpsFonUNJjslkBTnasdvsrl8QmyOoNzuMQwBbm3rkdy+mr4oj6tUdiSFct9xYCgy+vgUZKaArT8+kyjirrn+y9KaacOEthrnMwBEmVdaheNanpusAb4s19Y3biOf4kJGfvfSAdReGYdyJApDb6V6iWT58hlx8mnGLySY4cfXI042xkIRBkW7m5fSkQxL6NHvtjp\\\\\\\\\\\\\\\/ASKaN1lrJlYgsZG+mgx9YopyRUa4iwzHJwhH3+aIYnL\\\\\\\\\\\\\\\/bxc0lTFKTmw+Hi2xt+rKdBmxweoKpijcO8HYuczaa3yowOu\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/R7\\\\\\\\\\\\\\\/YHblKfNv4btM6KVRNNZdy8kV1RJZ06dUK\\\\\\\\\\\\\\\/kl01qdWbRx2oRbl1MozncZHDk2ex2T75\\\\\\\\\\\\\\\/VYP\\\\\\\\\\\\\\\/jNMZF\\\\\\\\\\\\\\\/mKO4exINpIHr6dgLluj0Ewt2i5aWPfmfu8Tl+mhiLmQzVK+u5wqGdhGRgVLvD1bIvqut2Z2prId4g6PfBrIDkrCdbFJvd6J6GNcYqqrzw8j3aospLJDk+LiZfJjXV\\\\\\\\\\\\\\\/3XXa5VxG2WLeGiC3LyONOEf5USsqDGsWvBwhvIcnH27M8w\\\\\\\\\\\\\\\/SxjsoaUrekpYwbRa3fABDI+LBZjuAtiMCuYPtIgLv9CtLsZga88rFn0OQWXij6Vh2UplFLS8ji3czePK8Nfh6w3tVv2uBQ11XvRrVPfqJtCqleKm8616bMZqOCMjix9TL4ss8pvZ7WERWdE+zPWu\\\\\\\\\\\\\\\/QqnH0clGUPwLcI6co7QgG73zUwRRxIZNLOsQ6VWC5S2a+Ngu9KWU790nQY6HF5NwtJZqPdhqpn+UPun4E+ydf\\\\\\\\\\\\\\\/2GGRyrjsHobZnfOR4GA7tJJUuqjbhv2IHnwzlHIUtjG\\\\\\\\\\\\\\\/0wucvLx5zrUBDpnVjzV+UfHWlOtW+fQGaX7DVfteCspvAUf1mwPWWt4qn7tVrbI2+1M5uoSYLSv0IMG1Od4zoZm7N9wk3HpWO75pyDaQpcvg4deiGIgbAU8OLu\\\\\\\\\\\\\\\/fQtl2FNcIPrc7usOlAcjPXER+R7i4nouTp0T3gFu30vJItEIM0PjKfqiJ\\\\\\\\\\\\\\\/d6QhNUafj4LqZUqLmlOiaDVzHFbCbHXlo79Ck4rwTjINO11N\\\\\\\\\\\\\\\/nPe8OZCMKcAn\\\\\\\\\\\\\\\/c8JFvlNu8gi1J2V6cMBSAWaEzWGB3QNonWgxHgggqG3DZQKZh8Flf7zTOLU\\\\\\\\\\\\\\\/wFvCRmvPGzJlA7b7f6dZZdLzlpIZ+EnSZTnRl331g\\\\\\\\\\\\\\\/G3hfP3A1078HHwm97ctsRWuAH3EGz7rIor5pMN5Vs0PvHWyNCOHsyUG6PLYrW4\\\\\\\\\\\\\\\/wCab+ZdN1cCIqVCGjayXJKqT9NdZqzrt8eB28kOjyZbQaOv2nk6Hld\\\\\\\\\\\\\\\/zvlpkLvj0MwO+3htM0zPYbk9tQfvQZx0dU8ffBOQUxBjTX6+RLhTQ6pSnDqC03uEkDNR\\\\\\\\\\\\\\\/YrT1aX\\\\\\\\\\\\\\\/JZ8fzvTAAlSRFUwSS53U86K8ERgr5SmmPExrKXNMRpJXcsf8zFL\\\\\\\\\\\\\\\/ccKlw2g==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ZeQ6AmacHnHovSy7xdzCQg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226e4fb9cbca9263e30fb2286f87ae7aa7df530c48cb52934235f917af448db00f\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERamez\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPhilips\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nVanderbilt University Medical Center, Nasvhille, TN, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Philips%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARamez%20Philips%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAngela\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAlnemri\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Alnemri%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAngela%20Alnemri%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESruti\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETekumalla\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tekumalla%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASruti%20Tekumalla%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDerek\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMann\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mann%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADerek%20Mann%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHushan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yang%20H\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHushan%20Yang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlban\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELinnenbach\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Linnenbach%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlban%20Linnenbach%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDiana\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMenezes\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Menezes%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADiana%20Menezes%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMadalina\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ETuluc\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Tuluc%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMadalina%20Tuluc%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVoichita\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBar-Ad\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bar-Ad%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVoichita%20Bar-Ad%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAdam J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELuginbuhl\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Luginbuhl%20AJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAdam%20J%20Luginbuhl%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDavid\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECognetti\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cognetti%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADavid%20Cognetti%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EUbaldo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMartinez-Outschoorn\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Martinez-Outschoorn%20U\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AUbaldo%20Martinez-Outschoorn%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJennifer\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EJohnson\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Johnson%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJennifer%20Johnson%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAthanassios\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EArgiris\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Argiris%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAthanassios%20Argiris%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERamakrishna\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMitra\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Mitra%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARamakrishna%20Mitra%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJoseph M\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECurry\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nThomas Jefferson University Hospitals, Philadelphia, PA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Curry%20JM\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJoseph%20M%20Curry%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node48071\u0022 data-node-nid=\u002248071\u0022 id=\u0022node-48071--2587482050\u0022 data-pisa=\u0022jitc;11\/Suppl_2\/A1807\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0629-B\u0022 data-apath=\u0022\/jitc\/11\/Suppl_2\/A1807.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EPhilips\u003C\/span\u003E R\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EAlnemri\u003C\/span\u003E A\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ETekumalla\u003C\/span\u003E S\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E629-B\u0026acirc;\u0026#128;\u0026#133;Window of opportunity for durvalumab plus metformin trial in head \u0026amp; neck squamous cell carcinoma (HNSCC)\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0629-B \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EOctober 31, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-24\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}