{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022+KVGMdPF+YHO60jyPY4v4yhOeP0273IpELj\\\\\\\\\\\\\\\/s9GlgNo5KfOdEpHVrCWTWR2uOphwvN8M4Pck5n4ZLAVeoaF3ACUV4YghA2G1701N+QN54rLTpYkTR1Z4lbjBz0jPwxhZaowwvnAgzbRWbclQ2noNfMOzMf9MHD9it4GR7KOUd1YUsODxy5vWHej9msTEq950TNdDVXtu9BHm42Nz9BPMqJBo7o+C5sDw5YjVT+21WMTNvL2T76qNA5P4Pj6TWmupBHzx11rLFkfWciNKw4eV8LzgNVYzsDlQrLwqzQG\\\\\\\\\\\\\\\/aGWQnmg5eIqDTil4p7D9j5fDRMTt4EmAy44PW+lNhZQqIT4ZrbsDpxxLC3PH3TcqIpF1736Q3ni5Jro86NDPvypkKWvsoTdm\\\\\\\\\\\\\\\/sN5To7Xewk2+3cueCVqlrVEhwaJDyea1Twhxek3MP9njvejSkyhJQWcCg95dWySCWekl0uTc7A8+4h74NGA24UR4+FadGNwfgngeVj1LZE5d0zPsiv6Fz3UrsxzR7GbU2pk+vrVAoUgzZABq1R\\\\\\\\\\\\\\\/iWaC1pozwhAm5zb9S1ezrDoLv7Y4EBc7zjWO7irPUefs1tH0yE3IXzOOT565ftCT0VO8\\\\\\\\\\\\\\\/h5b6L\\\\\\\\\\\\\\\/LtMo1rERnd9YxDWT4D7BXu8Cw9rURKTjNz9qKmYpIn5bvKrYbGheSdbdfu2qIRarJlgoSk2agsK9wYsYCQXVjSvT9WSN0d3qAYU6bjD7\\\\\\\\\\\\\\\/EkHPUaq4IaWWw1C0CV5MdYtwSDpl1OJTqQvLXVoqJq00g0HcGC5N\\\\\\\\\\\\\\\/lSvgfX9mn4gxBvwF91BzPwfWm\\\\\\\\\\\\\\\/S4ixnOIfnS53ZujopYII742X\\\\\\\\\\\\\\\/8lyQjMRIogXgaQPIJj3y6n+5S5qk+p54VtiPTzYSirf6afidx43FUJyRF9pRcYdccsKNx1ZVbDQm5ZLIIKSzLO76Ha66nGfudvvxd8ietsjUc98DGFkN2QAAD1Kd3FcpsQfWUxCqswO2d9WIhgFzXTdNxfFHDunmpP4ZKS\\\\\\\\\\\\\\\/qH9W0CV3iUkByUp51bBb7nuzxAxNppbc5x6cTEGOP7G8q1Mtz0FjH02i6UZoFhuU\\\\\\\\\\\\\\\/pi0FDh3EuPC97V3Wq9CglKWleJLcln36v5qGVJILFdRVqrViREd2MYJ8gfLX8C9zagMjaiQJZfy6xyZqBcM8Fxum9KE929s9IegtHrb7+N5OXcnN8TpGHcXk8+bKp+zAEDV2pu1Wqkfggp12ykDnSoJW\\\\\\\\\\\\\\\/ozGdEPX5aY7lERUfUIQ5vmDIAnmDHI8ickrYad79RgaGfLt4L8uo76ykyiyaPMwczrXKuzEbAe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/mfC6Hi4ZJsZqMBiTKJvtbrMm25ppO\\\\\\\\\\\\\\\/xK9+cpBjYs\\\\\\\\\\\\\\\/J+B5eXe\\\\\\\\\\\\\\\/PhI90YH63a8ZH0nRVORS+lYoSy53bYw1UddwtlwHjmnIY4Dsge1KYmbdbSqWomSq\\\\\\\\\\\\\\\/h39FWUnNZeo+NJl3vDFFt7POIRmxhZrYMCQhusTNFuoUv0AkW14WUaRaJqYU2bQiB9bYMypBXlgDZ3jUHpxcnayDRZFoZMn\\\\\\\\\\\\\\\/5QSIp6DbP7LZ6cGmP6bdeYdDSSs+y8m1LHuubtT6KufENZ8hYkk7Abkq7PsX9wnB+wyMwLO5kISbVIXdW9Z9m4uNc6uPg3TCy+Zh+j8nrREtAMzhbAsAXJjMQaClIi5DJLg\\\\\\\\\\\\\\\/nGsZmHoQzYbKKLcFtERo1iQQ1GHBaz+s+zbaVe+repV7DQLWTZAwiFru1ZZvWjH9w+rGR7nghQh3q2ba8hS1FGKREGjkoG70L29lV9BbKwV8djYOofQxct3Z8Ha2GHByLp77Hql5SvobPfdqIU1UES6BfJJPiCbl7olNIQ9arAFZatGyS34k+MxuD4cKojaOOeyQKk728Yic7q0pC2L2wkbFsT2MLEmGJAVygo6t9XdQfCkpWYo9IRc0uwEEVvbJ92WY3RrC2moCuiupNVDNFQeBnaiJ50sPVeMp17DAatg+K4hEeg61HNWqIQGgKR\\\\\\\\\\\\\\\/JQjhZbjbLlkwWepsCxBjXQmwyLPWMQo88amdfQAxHUKskXgX8262K\\\\\\\\\\\\\\\/7nvwGqRKXLrDTiND6quJdtdX44JdBAVVt7sh+YYs5erRmA8C\\\\\\\\\\\\\\\/amppl9SEzna4GoRM8lWTvPQosesDS5PNU9KchcuCjT+R2besrCckAUIEz6fVL9pBzDLJSX2YWfawF8MxbZaRW21uIKhSo3hWZKpicCjdo7fg+8OZJpzbA5uKx34y+v0bJU3MfpRCLcic0BqvDFVNspMLgz2BjznAgXHc2Nhxr+TZJlyY5pwzo4BFupa1gZIyp1ubEPC62NLJpeRi+q8pnBGy6Bk60Xh1p3DhXgPDv5V98qtUgvHk+IfnkfSjnyi6hFCHHCStRT7u8XxrDBCQPhMOzzZRPt6wm8i02hYoVgYjIZ3W0xO+UK47ONjOG1cyTMalzZO0k53xn9lz2PH+tlPvHN6Kh5b\\\\\\\\\\\\\\\/FjgM64wH27k\\\\\\\\\\\\\\\/kAG4Jd1Q4pa7rpNg2c0c8UeUUQd1xLXZPSnvoS90n+I8OGhLfnoBvRlwYmbTD7aakZ2rKXwgMZqtsWs2tf04HaM3TVdFxloEvBLd7Xbx5h0hM9EmD8MXslIrhNx90JhNZP6t1\\\\\\\\\\\\\\\/XdJDB5hPQjFf+mt3Rj\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+pWN8Nh0ya5nh1NFYmGSp8hzNlX1EmNpY5cpSJWAcZrzjqBBFLffJDSHZkjLyVOtHnhdsbb4k\\\\\\\\\\\\\\\/Bp2E8tJhYUmH9+svnRopXOVysGmcznm7XfqFnGQODZbseKFEV28qe8OqZzax2qgnVI1X7rUjlJqDc50I3FvFMhOIiNJBRJHHxnJjfPm2AKGke94rVw2t9b+vsGjuT88yr302VBkVxxGOb8BoBC1rbMg9as6j3eafcAJLMECkNCoHKjE3p3TibhNlACA74nknSk9KreD\\\\\\\\\\\\\\\/z8MSm8bME2a5\\\\\\\\\\\\\\\/zthhLZNIX9pZeNM7u48d2gleVpb3BIVJh2rAFbUW+KfC4q0Q==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dTYonX5mnwNQvol4EoKMSw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227b609ee0351cc4dd754663effe28f7c35f30fcf5f96f5792550093f442905923\\u0022}\u0022},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGuolan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nStanford University, Stanford, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lu%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGuolan%20Lu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGarry\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENolan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nStanford University, Stanford, CA, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Nolan%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGarry%20Nolan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEben\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERosenthal\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\nVanderbilt University, Nashville, TN, USA\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Rosenthal%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEben%20Rosenthal%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node45904\u0022 data-node-nid=\u002245904\u0022 id=\u0022node-45904--2176925979\u0022 data-pisa=\u0022jitc;11\/Suppl_1\/118\u0022 data-pisa-master=\u0022jitc;jitc-2023-SITC2023.0104\u0022 data-apath=\u0022\/jitc\/11\/Suppl_1\/118.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELu\u003C\/span\u003E G\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ENolan\u003C\/span\u003E G\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ERosenthal\u003C\/span\u003E E\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003E104\u0026acirc;\u0026#128;\u0026#133;A spatial pharmacology approach to decipher drug-target-microenvironment interactions in situ\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2023-SITC2023.0104 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EDecember 20, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-10-21\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-2\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}