{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224T2lxcOu87CoUNohuOhK5Ex7XwMPlR8IXQ9+xOAIkYW74Y+m0wzu3CHPz6sWLx9HXkaRJjIGTvYVSoD95vvg1NgDI8y7J5uYht4BMgOvOO2tStHGy8LWqtyUgr6ej9Wpn7f\\\\\\\\\\\\\\\/PmuMQVfCsnr9R49T33\\\\\\\\\\\\\\\/NkOoxYxTKhOl6zvBmb5PHmrWIaKwj+E8mHxKEzNAGv8PPmSrLt9b\\\\\\\\\\\\\\\/l\\\\\\\\\\\\\\\/sP9QaccKBJmVoCIealDO4MTfu36SvEWz\\\\\\\\\\\\\\\/MYaZ62nBRgHIKMr+spIPe0jcw1EGZcxuC9TuG0DXtYPrNKPw5OC4fF0\\\\\\\\\\\\\\\/ueZvx+re8j968j5QmIy\\\\\\\\\\\\\\\/hg1f+rmelohtgiXpDsbhP0n92jvZnS+rhXx60TuJUDdEbwFCGufsKErkpGJgrC2YeHreskjxg9jQ0V72hJCKwhUMeT5Fx5pkQrHYMHTYZYgsfv7y3GWGKmrV0CvB0pztsUnoxAMyWf1Cxa8BCWzYCEVVQk7E99VrTMGL0VsKw1KlRnBWplqOg6FHhI7YYobfwRQPBuWBe4jcXxdWNgxvAJJ8\\\\\\\\\\\\\\\/EEshvrKlg8mqJ0UeJYKCWJ6ojRLsoEZBLetuhuXUHot5s4YZRDoQPqP+Jr7xMaEUdiqxxfcRJ8ILLCf5Z46sM5\\\\\\\\\\\\\\\/plrPd3oo1cLaro6CNM8q5uSIdVkGzgLlSyPFLfXm3AZYQ+1OxBv4aNF6dc3BGbtF7N1MS3AmtZ9hCFGhUP+5IKJVHiAxurCN8+1MAZCWes5y1ISpjYuKKRc7uMw\\\\\\\\\\\\\\\/iHb3kX7Ie0bTBZ45LxkM8r7Wy\\\\\\\\\\\\\\\/l7x9U1s8ZACPUagRm\\\\\\\\\\\\\\\/tHb8p6UCBUtcUp4wkrnHg27t31RKPqe2lxUW7X8gjkFhKViFkWwQzX+xmW7popJevM22VyxYRVxeoUHsDJNNZqGL1m5JWs6cphU+tpSCs5jRyXGwZvwiMNtyPEbN07V4PC4WjIJBY4WUEucyYJHVWSMMBiooodDoQLdKZWjmgcOZYrTnBHCDDw4hj3X4uR\\\\\\\\\\\\\\\/RcbLIxZbMHAIj8QSXUd+Mg5\\\\\\\\\\\\\\\/DPjOZAXwS98gLvN7OUGtY0TUpzMMotsPUxWGlhpJZA2aybDwxRywsQgr\\\\\\\\\\\\\\\/5bl5pX3QKpHEfBD3lzpczeFVGR4Ub\\\\\\\\\\\\\\\/DPDwt+VqYXfTsNd8+WKV3r1V2XuxZhoFSgEOoTkqNq7ZWc2FOI\\\\\\\\\\\\\\\/uSQAWK1CmpU9Pz0wbE5hAb0wV\\\\\\\\\\\\\\\/wZKnuFsAV75oBjgW+WYIK99NkRbl3Kyotrnh+qIXLD9MSd5wn+95W4WI\\\\\\\\\\\\\\\/Lzd7Gsy9lVlcXtVAE7UUxaZd64gLzhJuY9c4sy39L3wFQSrtIJhj5NggEXYeY6581ysxBCgrPElwDAPPxKj3RpGpNOz44K6UkesNqRmmUQ1gdEC4nXFYKKTi2GwIR\\\\\\\\\\\\\\\/dCjjbYgqCeoNgHZMC+zWsmjMbvCdf6lJOGZHD0XCOXiVtXQR6mf5Qr97kdQ0SaVpbrEWogjiTexcIEt5B119s9lz7lwmvZkyECdZJc2vYOj8HzK0T4HTnt9gbVHgOT6mJYCnIq4xZX\\\\\\\\\\\\\\\/6wA0axZwXVoS5MM1w1sMeEGDV+GyTn7rwy9WIKzJm8+H+3GIYCrR8sTmjlZ\\\\\\\\\\\\\\\/B7SfowrAvk5O8IVcpmAH1+\\\\\\\\\\\\\\\/u6KR7VGXn1qeQ2xDHajRf8KUvcQQ2Uz0y7LQlE67bAVFOCf9EJB94jWFJzvmKG8E1wgSI5+X66MGBxwBdhJArJQRv7vtmF7DF1dZu99m5x994rztOHsmXKxUrsdnMP1FNXRU\\\\\\\\\\\\\\\/0NY6+1yPmDPdOdYBxXfFm8Zkeoxh0dczKMDDOUKRcNroWIe7xmu+OLRxc6JBhQ6bLQ0VF6oMD73zEnkDey70WuH\\\\\\\\\\\\\\\/OmrKcyTXE+L2NZWnya3YzyTaX3mJkOnH+0btzj5B7Rc\\\\\\\\\\\\\\\/q4YHTmVYqQxhOToiA3hB2pFxb3MABV+NHGH+00uF06nw9B9MYeTQYuUCkbk1yL0hfyyvSm0gCZ2cYiHEQ\\\\\\\\\\\\\\\/PfgPZwuWUpDMhUNH\\\\\\\\\\\\\\\/vvTpBoAiwlOT5HuQ36NlsmsEAMMyaOiVd5tYsTMAvpKXiRxnJEshOIScL7dgF9gxuecxmgct49S6wkhkAej4b3DKkBuiE8SFyed9VAJIzr9mww0p1w7epJvBpgKxGGkXEJnIdP9aRjTWciZjbqv3KFXzm10Abu628ly8qiqX+oqpqwjp7hGDBkoAxcnbY+YjyqBS0ilQF3gIV2cH4ZojJzwu2XadERUpG1qxVOAM9KvgZ3D56RTeuoZSgaAEx3ioUyTjJBLpS+PGAmh6K6j97kSk3eYTTwjkIFhInsx7PQlSngITPSguGdhtqAFYyqpW0cHFK9vNc7p28q67bIPP94JU0wFPJOjOhCf+KvAUFCoMquM3Fxulwjyp3DXT3CHJ+ulQu\\\\\\\\\\\\\\\/AKFYKRMqb0P5FsWFYh4AmqcV9qYng1bSXea\\\\\\\\\\\\\\\/nQ7CTHPPcg6IBBOxEgX+dV75YN7NcqUdZNGbaBxaLYA9Z27ZWgLcaQhvRjB1+a5PMrdTfaV2ysMXBFYhtKQEorvE4qjtovT9RqLoNyxzjnzrj5Dp1QA\\\\\\\\\\\\\\\/U+hHVOF6l7GWeb6jpsy0CdeNg6VTAPbKlW7AGkqTb\\\\\\\\\\\\\\\/b1f5xKedaV+gIe0LMN9PxmAy\\\\\\\\\\\\\\\/o38bfoby6KfO7WISTGLtZV2JvIQcwCTbuJ4dg4WWTwtnFCm5Feby7OhSXb3KmAk\\\\\\\\\\\\\\\/JqSj0\\\\\\\\\\\\\\\/aN0XWGZMEF4kC4iwoEUq4iGyJGM1mLVX6+dUeX+PiJyTFUNrMmSBdvDrPgluVhBKGkjSUSpu2ikVPDAUv5qc90YJYEAKz+\\\\\\\\\\\\\\\/mQDFfBaJZ7h5h1HiIwQ1jrILcvBmqN+DOJa9fHKWV+7FWJINdZnDP5fMzxBpsUZtCvUthU2Q3hjYp38F4OSsuwABFT8Ot2iL28DjNwjxzUh6JV0lIieS1ukKnThfAogS1gPHV4buqBGAub01Zp1gK1+znHQ8qXX724NaDAHTZ+n9vuFSE9AbdHvy3X+It7nBQ==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022HtJHYkjWj6ltdsSABXIFbA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221c514ace30518839a733d814789fdadf186cf8b8a3dd5f4030c1f593540b76f5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/5\\\/e006483.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/5\\\/e006483.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGanggang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12474\u0022 data-hwp-id=\u0022institution-2\u0022\u003EShanghai Jiao Tong University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-9490-9925\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGanggang%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EFujian Provincial Key Laboratory of Tumor Biotherapy, Clinical Oncology School of Fujian Medical University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_66552\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFujian Cancer Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EFuzhou\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EFujian\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lan%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABin%20Lan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EXin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12474\u0022 data-hwp-id=\u0022institution-2\u0022\u003EShanghai Jiao Tong University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhang%20X\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AXin%20Zhang%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMengyao\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELin\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12474\u0022 data-hwp-id=\u0022institution-2\u0022\u003EShanghai Jiao Tong University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lin%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMengyao%20Lin%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYi\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELiu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Radiation Oncology, Zhongshan Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12478\u0022 data-hwp-id=\u0022institution-6\u0022\u003EFudan University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Liu%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYi%20Liu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJunsong\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChen\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12474\u0022 data-hwp-id=\u0022institution-2\u0022\u003EShanghai Jiao Tong University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chen%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJunsong%20Chen%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGuo\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-specific-use=\u0022Ringgold_12474\u0022 data-hwp-id=\u0022institution-2\u0022\u003EShanghai Jiao Tong University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EShanghai\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Guo%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFang%20Guo%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node42843\u0022 data-node-nid=\u002242843\u0022 id=\u0022node-42843--21064896037\u0022 data-pisa=\u0022jitc;11\/5\/e006483\u0022 data-pisa-master=\u0022jitc;jitc-2022-006483\u0022 data-apath=\u0022\/jitc\/11\/5\/e006483.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E G\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELan\u003C\/span\u003E B\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZhang\u003C\/span\u003E X\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EAR-A014418 regulates intronic polyadenylation and transcription of PD-L1 through inhibiting CDK12 and CDK13 in tumor cells\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee006483. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2022-006483 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EMay 10, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-05-10\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}