{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dwz1q\\\\\\\\\\\\\\\/jCzJTmJgT+c3Awuhep3RBOyPkkiJUMUJ3d8OLtjql5S+8ac2oU\\\\\\\\\\\\\\\/yx9Ht5lnQzvlXkLSY55vRTAWxmprG9+d\\\\\\\\\\\\\\\/B4Ic\\\\\\\\\\\\\\\/Mp5AP5psPuLZ0M76bucuny6OJykoxO88RO0hoExyDJeUz5j6GnjgumlW\\\\\\\\\\\\\\\/AWxPlALE+JzX7UNJVsKD2KaGHUKSna9xlm0wwosaKGXy4ZXTL76niXRuLw2ZK9RIJ5+zDIOMDdTQF+3MJI8QNjuP3JNUTFpeQkp65m2fVO2gol6mqkHXW9ZyFzkbw+LtDoXhk0K05I32ZHcTaEjB+L8RG+Am8aZWdtIKB7drwkpiJwsx0iX4MVDk5eTBnqtimDGhI+IGZ0GgNIyqAhb3KMJ7AtsFHdWCjEl5wTX30s3moQNjFNKPRK6sJ0tzQSL6EKn0sJjF02m56P0siT\\\\\\\\\\\\\\\/wrvectOSVOIdGMUG\\\\\\\\\\\\\\\/B+j3j+KQiyFBhm0i0Q+gUjJABUD90STnbZgZrcZ9cKTiPHPm898J+Sy\\\\\\\\\\\\\\\/tsgoAZiJId5GbhYSG\\\\\\\\\\\\\\\/0Ub\\\\\\\\\\\\\\\/fw0NLOXskQX3o3rZlQa3w4ry\\\\\\\\\\\\\\\/cafgeGyUZZuZf8XcVMQ+SRc1ZYGhm\\\\\\\\\\\\\\\/nk0zCDzzz8aUsAzYPkx4LP2uMdqwT5uGUTL3weoLUqr7RjcHE\\\\\\\\\\\\\\\/nFWv\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/zu6EYYHNDLPYmMUAomjgRv35QbLyrQJsfq0rBCH8pgcfywWg85kf1HvZ3Mdq8y62LIE6G8w7\\\\\\\\\\\\\\\/3VfoiEvtBMCfBB3T3YUZg4gV5YtOP30tg7\\\\\\\\\\\\\\\/XhifrN3kYguY2tPkjV\\\\\\\\\\\\\\\/2Qd9mw8gD0UPb6xdK1IoTn7yANd4fK+6QTu78vjSscuPDjhql60nm+xJyXISmI3zjMwxaivBIE0\\\\\\\\\\\\\\\/76GsioNn5CYwMJBVzIJMcLZniXjf5VZEvp1N5lXCuHmB7hUnNbwFQRSIbIHrp4+vaE70imbqF375onNY+3rWz0EfrsGfSInVD7J6IhHU9eVqZcmkqxjZQPtFd9DlMnm00nTRg1frFiAQKZFJzuMVM6xhH4z7EqxuakG6xZ76prDJj8SpeTbXq4mEuQcbJ42XR4GZL7LXMp16s7S+KbXKHeAO3QV8f6HN0wYZVow05uJi\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/HWCnXrOPz+iMYycpQURWdWPxW2iXbhhDGKehfAmAtBT5KBohtljligJ8DFbYSTMdrxB7aXuZtSOCEHE2xFbc2gVwnlL1O2qww4LYgxJ7Rt2qGhR3Wjz2xo6Ng27Ih\\\\\\\\\\\\\\\/KfOeyNxpiIVDfBEH61THrd\\\\\\\\\\\\\\\/9zEWmfqFOt5hLy19atlRVFiMs\\\\\\\\\\\\\\\/Ts\\\\\\\\\\\\\\\/kZvk5C39uoYVZCQap6AgTm7QIRHopSqYuEJWl3u+VmlD1IuabCyICWE2qwia8oxIyH+7a3DYkssbWTSmjAph19PcF+v0NDi2yuof14kIL4t9qCnA1zCth7S8TVdpsxK78\\\\\\\\\\\\\\\/76EQqvOyzlM0IVH8WV3smI39JptYphqVv54MGd0sN\\\\\\\\\\\\\\\/fUDntrVaTJz2iN3FhuOVdLQEKLnisMUoYd2xoLIEj4Jd3sKTAmpCI7Ni+xyUSxbBkkSDfB2aMNmSiV3Yr16VvC7hqG8QJae0j8Ei3BDxD8xtaoH0FOQSk5MioqQ2KRdVy2ur+var24CiRRSRrqS0jiTMk7CRAyZkYly42BwWKl4KJBNvP41+hnS+nNq4KRoJ1YoDX2eekmnGQQkinyLJ0h5zutvEncPBnJ3u9iT\\\\\\\\\\\\\\\/35UYYrhqNsvA32RBvfQRT1uJ+SCYhS\\\\\\\\\\\\\\\/YFK\\\\\\\\\\\\\\\/A24pzKC+Euho\\\\\\\\\\\\\\\/yg83J9AkHkXczyXFbZ47OL8Pu7Db5KaTN22hJU46C+K\\\\\\\\\\\\\\\/ahy5btewh9+cVgaDg5NNwgvDI03rcDf\\\\\\\\\\\\\\\/G4svjdJw7es260fb3J+wy2FKDd\\\\\\\\\\\\\\\/cPlmFxU6ARIPGn2jGmEhgI5CNZeApUAQ1yMeX6\\\\\\\\\\\\\\\/+zCwPwcn6mfimT4hkdchi\\\\\\\\\\\\\\\/HfUS56EGNoCexc1rW0PNpGDUZrQBfkzzJzfoFYH11vKcisQJ2oqlCkqK8SWWanW+7BA2orOkGxKF7tP4B6Gi5nPyvGqPs5EKw9oURA1ciSm2r4uMkDa\\\\\\\\\\\\\\\/LDWg3GYEXKyf\\\\\\\\\\\\\\\/SC4hn8u4bLym\\\\\\\\\\\\\\\/Xi9na2fQ0XHFGDvAP+IslC8kqX7a48\\\\\\\\\\\\\\\/DBwQl78M7ZFBfeiSWRQdMcvXqeWdHjbdBjW8peTOggtqpoRBlEyVcuz5SsQ1v6pPYK43Y3t71QHHmybFwfOeq58yef8Nl2wdtStZHgZ0b\\\\\\\\\\\\\\\/9+Y60F2kZk+7Hfit0VXmEHiurO1tCcl58abaCSQ2aUY9vCo76AW3Q1hr9lZbBzhQWtOisQoyUNGXZFnk\\\\\\\\\\\\\\\/htYm+bSm9VdEZ6JEnqUJGklvDyrFhwyGEkJ+pC5oAKzbnjL56p2YgEltNs6a2HJzxoOFJkvQrAwWRE40o+nLNYGTbOO5Y4v3oQnlDURYOQ8UZ0TvbyFxnU0eYouUmF+4zcD2Ls9kqzQ5YHu12sgJqBeR6hyZWyeUCQeUbZrAsqeG6ADO\\\\\\\\\\\\\\\/SFGyG93Pl2x1JBtJ14DV0TfLGlvxhIVH81yaAy4nZMce9zyAbTl48G5SS5R3ATW3UkjTw+uXozT1WMZWqZ7bJ0SoBvlpCFmxfIjky03Wk3HZdfyyEKkrgxz\\\\\\\\\\\\\\\/hLlZoc4ufh0Rxle\\\\\\\\\\\\\\\/TcltE0X5OJRchjnj+XdzIE2YnhkYuD5EEav\\\\\\\\\\\\\\\/fKphiwKMuvxuXPRy8GDPoDAwYpmwSwAlpteaxmj89uoyub1wAkNQ\\\\\\\\\\\\\\\/ch\\\\\\\\\\\\\\\/+fIrU920sRdjR\\\\\\\\\\\\\\\/Xef+TGfaS1jKYy\\\\\\\\\\\\\\\/A9euci90g0FIOK\\\\\\\\\\\\\\\/NFoDufpLetESHUpVQoGXOzozb7w69YK3a2lo7jwmuxbaAz4G4Z9hJFIAeLmqOeXjgu1uxMnWiYqqfnw81fG7qCy17MjZa\\\\\\\\\\\\\\\/oBZU+NTRTvvbxUGfL0zuDVPYAESjCbvrVKJewMPUNoo3gUow8Wug5ilYq+yEjUWrTLoWGZ\\\\\\\\\\\\\\\/e+\\\\\\\\\\\\\\\/kc8FyosdlbJ5wy00aInidS5YP+n0bQgoOw8kYoJFA8l7RElxJejo0Gc\\\\\\\\\\\\\\\/w==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022tkWT2YHRv9W8IjpXRwgXaQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002241aa6f99527ea49cb580588b3f98d050ff886c8e4bcd08065a9b1ec284789589\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/43.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/43.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EStefani\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESpranger\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Chicago\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E929 E 57th Street, GCIS\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E60637\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIL\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Spranger%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AStefani%20Spranger%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EThomas F.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGajewski\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EUniversity of Chicago\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E5841 S. Maryland Ave., MC2115\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E60637\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIL\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Gajewski%20TF\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AThomas%20F.%20Gajewski%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node4201\u0022 data-node-nid=\u00224201\u0022 id=\u0022node-4201--21613216195\u0022 data-pisa=\u0022jitc;3\/1\/43\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-015-0089-6\u0022 data-apath=\u0022\/jitc\/3\/1\/43.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESpranger\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EGajewski\u003C\/span\u003E TF\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EA new paradigm for tumor immune escape: \u0026Icirc;\u0026sup2;-catenin-driven immune exclusion\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2015;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E3:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E43. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-015-0089-6 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 16, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2015\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003E\n\u003Cspan class=\u0022nlm-bold\u0022\u003EOpen Access\u003C\/span\u003EThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\/\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}