{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022guxMVePEc3eS7ZOXIZDNRNJeMsUQmRylB3gy5GbQFEVjaXb8uJFjpuvdVq2PI82dN4C3upKHqmEP4kC6rdGRw\\\\\\\\\\\\\\\/rsf7nh+QCYcxOW\\\\\\\\\\\\\\\/m+W8pwwZtA73jqftmb\\\\\\\\\\\\\\\/xH2RxrfK6L0RD+p2y7IGY1N62iy5Lo\\\\\\\\\\\\\\\/Xn3pNOM1JfuU+KCz0dZzPooM3xakSmqbf2sjXqd++4849\\\\\\\\\\\\\\\/M6zosQ0OB07+8DvT+yBhdLcfmb1DhWy9imlR1uhpyIXzfoIjOgY\\\\\\\\\\\\\\\/xOTd37So13j0aB0GTyYI8sqTRTrqvjiOGvbslX9d3N8M5BCipa257pvgVbBHLLU3tmsFGuyW4n7cyCMUc7EvEqd4Ml+kpX9KbxXBVnM0xWh0TkKDYkKKQa96wBQok5xslSwqgvY\\\\\\\\\\\\\\\/x8qCdhbxkvAd6Yfp7OzaubvS43jcghy\\\\\\\\\\\\\\\/Rzmf84d8Mx4qa8ydeLXWmlZiX3wCLaH4liHr98zP7h9nE+8O+IFTB74EnXX+2lixGEHzQxYe8bHEPGd5qSs+\\\\\\\\\\\\\\\/Bazh3qMIjQR2cGiDOfislMf7i4741jwgeXhLNIOgMyb9jlQHTu5L\\\\\\\\\\\\\\\/W1ojnp5d55iXK+hqHcN5jbQYiwxpuUjF59WQXLL+367yDOIZlGQiVr1t\\\\\\\\\\\\\\\/SM7x5vRaFoCOd4DQHpCGo9eBhYH37Gs1WkTdTue4QsZmgpJzEaCW27fBvQt+AhbqnSZSdF9zDOa+bcaeeUeWNhMs08388Uc6\\\\\\\\\\\\\\\/08EtEt12QPaomxRjIu8VD+0BQ5qlrKc2gNo6VkUuR4hdU\\\\\\\\\\\\\\\/BVBIrVuy4eXC28GBfGqby78LFiWrPH1Wk61j\\\\\\\\\\\\\\\/YSnz5dqn9CLsu2Nom9AEyvGQ2NCWyCpypkvNbkH3EJ1e3Si78zIDp9YDaR\\\\\\\\\\\\\\\/dhXuwTrELGtioCnXtxFh0QiPxRDkSZ6ErUPwRbzttifQ8wqkhIUT0T\\\\\\\\\\\\\\\/CB2dGAvHZCP4HWmHzi9JtNbH3t63UdnTYSVy8Hiv3cv6oC1KBeqo8YS25LS2T8Bz7BupO6i2Ry21S50wXtCo+CNy08bd22EEy3jGqS5Y+47+ICq+3tp\\\\\\\\\\\\\\\/W+p88i2Y8exSzuPT93mTgfbfQOafg3GrdJHIfzhsS+PdsGu03JcxWSLAeuOM6d\\\\\\\\\\\\\\\/SZ7pgQLt\\\\\\\\\\\\\\\/Jx8SEnDmdnCwkxTZbugyzVnRdlg3X4zYp46n6plBEi7FiA4QkOh\\\\\\\\\\\\\\\/UnKL2CvYbf53kvxPVAK2naTErza87d+K5jRntD9mWOnI0a4X\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/8ZZRSCx0UW0\\\\\\\\\\\\\\\/w68162WDrbBB7ysXJ6+jr\\\\\\\\\\\\\\\/kBg+0lWz1MjwtOAD+VzTn6JKPazon7+jvZLtRcQH7bWjhxzabiPFMhocJNguVTAxi8RVYNFiA\\\\\\\\\\\\\\\/75PpV8fw17xJBDXQEQqfMQWoJD\\\\\\\\\\\\\\\/eh\\\\\\\\\\\\\\\/t6W4AUEyJ420t12KG8\\\\\\\\\\\\\\\/7+zQLcY6C4tZq9DRWVBidnUAVWUZ9TuJyJ62a\\\\\\\\\\\\\\\/8WfsbYR4D49FYhmqq5ucpk5fA3WLefBPobrxbU5r1lawhoqSYkPYzsy0oc0SrVONBdw5zZ+KObov70DJ7Whwm9IyuE5EcrtBcb02YX5fTJiLRtpukvBxQRLJWqoPZbr0cFTOsRwRiwEC\\\\\\\\\\\\\\\/6PcB4wCYjlNlD24yt7Uic85FhSStHcLpaML5fsw\\\\\\\\\\\\\\\/zIQCbm+vhYMzi7ECxCR0NGH6Iha31S7MgXzoZrwWEOUPfuWd9Sh4kfRagd9oa5FA1ie+Fzy7FQf\\\\\\\\\\\\\\\/Ha\\\\\\\\\\\\\\\/0ZidQ1+uvcAPPlvdWaylUt1rErk1MIvf11WlPeO6qnGt9vbpqol585qYf6d9422USvT\\\\\\\\\\\\\\\/17aOiCc8hqPuhbpSIrdQSJMlTB0+OzdAi5Pe1UIuVzbHeNT6W5ykcbK97JcOvbA5Z8bGz\\\\\\\\\\\\\\\/zI8THmUU44qkXyfnDrtNxJ1MIxYaZEPrm8PaoniEMGVCIdrqrGmcSSnMbqYpmrNXEcI0gNQGbY7ZTzNzRKm6+Z3tV1htw6jWRXvWgrbSNAWD9c9CgF0F1ajCkNhfAzZHlLcW+2i9nlbeMWXVg6\\\\\\\\\\\\\\\/DhKOwPAi5gqYEA9\\\\\\\\\\\\\\\/eNR0Qs\\\\\\\\\\\\\\\/hBVyoQssn3thkgqIycr4XcToCMrvYub4s\\\\\\\\\\\\\\\/TLqTS4UXgaEvAZ\\\\\\\\\\\\\\\/b7\\\\\\\\\\\\\\\/NWPIPMJLInBmi+pMfkkDCntPKqg89ipBTotDfFh3nKvf5oHeihC2PQ+2KYQmXhgFb5tz4OlawZvPsGUGQl2oMfDMmGeL3GVYjcHChfQL0Q6WGPr+HDcB8dC5GnJZFQtEWbj2FNBn2pUJ8NkXjpykkLmLvK6fuokI\\\\\\\\\\\\\\\/BDuRH9TwTtqRFlnLEkRWocrrC756s\\\\\\\\\\\\\\\/y74AdvoCCsWBf7envqZR91eUTaZ12SPNPsCQHwSxjzAf9cTaSkU2y4J75wJp+yTT9ilOIxyXR1AU1UB7RELw6DJqKTJJIaRw1moZT33qqBqeD+QToYmwkc9pz8aeyuEpvEN6RuJfzN2eH3zGUFJykmfwZgvwJduW+S+KhH1tBsIImeXc18g3lmr0YUbpCRdB0FjLb5y8r9DfvAg9qyx7mOXQisSw\\\\\\\\\\\\\\\/azQlhm83kqddJ4hz42jRtqfYDthWVMMszS37zqZunm6X7ZcEQldYK6RugagF3dI4B4amFGxAilZDkI\\\\\\\\\\\\\\\/W078BhpIqCEeE96ZLLI67HsE0+IhYSMh1\\\\\\\\\\\\\\\/JZehny7kBZzpEAzj38H6eRhz6KS3J49mvFjUD\\\\\\\\\\\\\\\/78aQAb9Iw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/3FD0dIFFaTA6XDNr7PZqsS+IcONPX9lxRrOP5194gQ5gG97\\\\\\\\\\\\\\\/JQkxMcZ6sPkJBSgn6gt1D00FkQD8JHGf2FlNZ2CXRH5Jp1+QpPKsB4U9PsOnV8C63wqUb3yYnyudt3MsGM74IuwWhjXVz4ixicmYf25vSkZw5QokQJZc0T7JLuYukJPPRcEeTV1DLGGGeM2NmHGhO1OsluruUfon8H\\\\\\\\\\\\\\\/1Lh7RdvSkS0rqtVUHmVPrchhRl\\\\\\\\\\\\\\\/ggM0kkhdx11ms0bgduaYglzZEpgj85RP0dBdxmhJrySJ\\\\\\\\\\\\\\\/CV\\\\\\\\\\\\\\\/sOh2zaUZfIJzCWG4UF7A90MCx3iS3Ng==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dlL3NfgvwQjQd+gKaKJFPA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223297479becae67cdc4f7814c85c9089294c6557166bad2421156d3e50dcad1ea\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/34.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/34.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERachael E.\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHawtin\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENodality\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022street\u0022\u003E170 Harbor Way\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E94080\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESouth San Francisco\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ECA\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hawtin%20RE\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARachael%20E.%20Hawtin%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAlessandra\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECesano\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003EAC Consulting\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E94065\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ERedwood Shores\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ECA\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cesano%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAlessandra%20Cesano%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node4125\u0022 data-node-nid=\u00224125\u0022 id=\u0022node-4125--2293899715\u0022 data-pisa=\u0022jitc;3\/1\/34\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-015-0075-z\u0022 data-apath=\u0022\/jitc\/3\/1\/34.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHawtin\u003C\/span\u003E RE\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ECesano\u003C\/span\u003E A\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EImmune monitoring technology primer: Single Cell Network Profiling (SCNP)\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2015;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E3:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E34. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-015-0075-z \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 16, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2015\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}