{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229ktrkS8gHl4YymeTzpBviglxOKavh+hJWICCk30cjqo1fwoe1bwQQWx9ZrwNKzIe0gx7SuhtMJTbbNEtnrkt1txNaG4sfpsCH3YSSKdObcmCQJRZbsd+ykrPvAZGR8BiYprYr2rlIYN2DmtAkTif6JHBladn4EIuzQNbpbV0qHNoSILbzf9Od2YFks56drCmW1soNFjNDOlZC1A8NNF4DR1dbe+z25rEnfqnFd2jPy7C4KFCkjkoUs7\\\\\\\\\\\\\\\/m77jB30Ms+dJy+RI44S0B22awSYxGodUYmbYhCVtW3VunJCk8ck\\\\\\\\\\\\\\\/t9l10tNJw\\\\\\\\\\\\\\\/OZWH8N20lOoyuig1IEIC3EAJYO28Vz+Juqr5I7sfee4dKtanaS2RZsgExUgaRFEtZu1RqH8bfDP5kDDYKSCvQKfAgp++fuji8ndDhvwPNqDK4pAN7PF59cfRZcxOLeqxHLaA+xzPfegoyG0lFDGQqEUDelmWM6d5hoosgrIVQ\\\\\\\\\\\\\\\/cjzWMjd691bW556IWie1Cv4HejwVJq9V1hPg4KbLQJ3fwwm6FGlJwiBF2shF2KrnWvJaN2NN4wxq+jxDllXIlCsefyjHcnZEkuEKYliyBL08ymYM4sH5olWdad6efgshyoqXZ2bSB3Bxw0SGYx+VJ8QDk8C5e8JdLn6sXLUtgZHRlTjJAB8P5yWPEG8hMWz\\\\\\\\\\\\\\\/qpIuxA+7nDVQaxVD2Nr+Ul5QwMtsfELzRZGaebj7\\\\\\\\\\\\\\\/pqFRw0P8c+Axo\\\\\\\\\\\\\\\/rTu48Z2Pw8cvNSojqXFEZVyuExIQ1kIBkufxNqasRGMaIvxXMYHOWnZ3GuigcRKkJDVJ8gqvvGTqu\\\\\\\\\\\\\\\/MtqD1cY+PF\\\\\\\\\\\\\\\/3EjRrZRp3WVIgKrREiss8UkdnFkjZK1kfYHMHmYQKb\\\\\\\\\\\\\\\/KOiECxgDnYkvjqYexUyy0NHzaqB2xrbAUZ2+qHEOMBpLi3i+mjN1IVIb7V3kcBfSC3KMyqI6bvL\\\\\\\\\\\\\\\/44DP0VYvYlh7FcPrpJJWzI05PBItyc2945gHionNjiU6fqId6FNj4eVGQOh3qlxLDLVq9JmkieenyztC6w\\\\\\\\\\\\\\\/NLQev9YTR0ie3BcMdff6Jjlhm6nVUakHWfsiVZqtMPzVGluGCuC9rynmFRzujo4i+hGTY2eTTvRF5r+8lcNNKvrOCqyoj0dRDTVXomnxpfBJiN6zlEhabQvchWRxP2NZyhyeWxAKUxGgKt3bvgeVSOjeDVTTF+eRFUkdIu0jKkONdgo5K0VL6bicy5eUHIJUbLsIzOEg0KYV6rGCsqtVtJG22GLsDL4\\\\\\\\\\\\\\\/zXDfWqZ7M\\\\\\\\\\\\\\\/yMHeTyxbrhJLeghkK6GJu4X7f7UXlHrk4qafpKkPFWOLS0oS24mDuv+9snb4jBdcmTTx+amJZOGJ+o2lohESABngSYFmzNobYClvEMrwO2IuxHqNeOaX5uKD44f9EBpdUXdOtF6lAhenqS6h\\\\\\\\\\\\\\\/R1SAMk0MKjM5\\\\\\\\\\\\\\\/XyBXjSQHJBPGJa+PbhwZwrpNHiWXLdyq6vOP4NornWf2XSejFrKlJjhni0kRSjSoVLCDvKtudct\\\\\\\\\\\\\\\/35SB1sjWsenJ4GZaWE\\\\\\\\\\\\\\\/bmv1+Kn0wCKg0epDqq0Ef0S\\\\\\\\\\\\\\\/pzEv9vzt+AYBIQ3cgUxTGYLjVxe1sndPiOrBkLamQjnOjSwr\\\\\\\\\\\\\\\/uCEAfHpsPK5GAgWzs0dXa2R7j3kABoGt9Qsayd4qfC5OqGvWflqvsquRhDeSEW48jtEvBXsRtcNwW9mibXrZY4+b9OQ8MWbO804\\\\\\\\\\\\\\\/MeYixb\\\\\\\\\\\\\\\/sP\\\\\\\\\\\\\\\/dPiQKTj+qCoG7ve2WJn3LhKi+n+BbcYtJtBKY7vw7VNjlgM8On120OqnyP1TchRbn1fanvWwYyDNG+lj1qMN7gOZD9HRjjV4E7Qn3wPAGltnYbuYnOPGJLRsjdXvE7Wi5b5PpTZOLU3AAKHDQ6LgS8brGhtUy+xQL8s7twWYn0SLUF+1Zf06EeLVQdaUBW7TWxccVE9QgaMejD2RZ3WTNrW2PXRA+i8Eucn2zzCMTPOjHtr6uw1ZPQgU4HEnpR8EMmZUAA57C1Wm0KiZ00JWbJUm2puQVX8FxU6ec1ycKwlLnnSFugX8\\\\\\\\\\\\\\\/yuuEqYi\\\\\\\\\\\\\\\/cde0riAR6susZ2Up2cGXlj3pcLrl9T09yhgdtv3EAQ6J+STJ\\\\\\\\\\\\\\\/NlfwhH1fzPAy8gA6EDDNugNMUoosF3hQcg4swwPx6VPId3fp2PwLeULx+Va6W+aWZgNbtZ3mFqfhHP455qkpo+CWiN7xCBysgDFpD1mmPKss\\\\\\\\\\\\\\\/DlX6RbDVe7pOYWouWjn5Ru6rYgYaCT0aiR7c4HBOH1B+bHnjwrOV1FNySVu05kUhuJhiSgivJITrV0MaffYl03\\\\\\\\\\\\\\\/jGpyzsoCh+sTqoLEw9lYMVQopj6x6nwO6ojU0NhycHWVzc01+uhoB770\\\\\\\\\\\\\\\/49ki7NmYytBldS+PN8qPk5d16sIMGsO6BKs\\\\\\\\\\\\\\\/3u\\\\\\\\\\\\\\\/LwOojmrXglo8AUL6G0Ls4PdhcUKJsOYBQJbjPUApd6Qz4hNR1F6uMkoEO0O8SNCAFSo0W8gdEHcSskevFR7DXOI\\\\\\\\\\\\\\\/qc1sG3CVlIT2detz5wuLFwtaiBQbh4JVSh9pecmv+ooyLtPcrgqLxnKciQI9lTrxSqBPQw\\\\\\\\\\\\\\\/oGh95MIJr3EUMCS9MkeleVe+Pr\\\\\\\\\\\\\\\/TT6PYvINTg8xf8YQULLzbnD539Jgk\\\\\\\\\\\\\\\/qfjYzs+VUWcW5XxcvKEOhqvt1mmywcwtVZqz79v2uBvtmqhVEJ6CtXvz3FScFDa3NQUhobgjcwoM8oIxpoPffV2SszwplwoTb840TbnYFh0lnCUChLCzd305i8ciMxei8+2rFDWBt+9niJmZiS23wjH0jplDIgORuXHCIvNnNUOWqZtYmK0g7xcISo79QoooUMHnenRTocLFyxaWVSUZE7xAlQJ7zCZPmVg\\\\\\\\\\\\\\\/eh0HMENTdfZSgzS5aYH0HyepnXXzInQyWBwKgZ9j7sa+pRU05nzv4lfotwyTu0mYJK5JQbcbKUbb3QsZiguaie6ncogvyS3OI5cIo80Y3BuNsDhA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229twbaZSCkfPx8fl1F4GrVA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022074799dd02176e8d049f243967798695a1ce511c53cd38dfcbfdc2b5e461cbd4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/29.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/29.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EIlan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKirsch\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-1\u0022\u003EAdaptive Biotechnologies\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWA\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kirsch%20I\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AIlan%20Kirsch%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node4109\u0022 data-node-nid=\u00224109\u0022 id=\u0022node-4109--22109382293\u0022 data-pisa=\u0022jitc;3\/1\/29\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-015-0076-y\u0022 data-apath=\u0022\/jitc\/3\/1\/29.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EKirsch\u003C\/span\u003E I\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EImmune monitoring technology primer: immunosequencing\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2015;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E3:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E29. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-015-0076-y \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 16, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2015\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}