{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022YKzTaone7WeQnCel+3bRy5saFYTVmRtnnJOYrWLEKxJ3Rptmq3o8ENc0vJ5vBE3T\\\\\\\\\\\\\\\/ePB2r+fdI2aadAhuQbhD8Be8ry4QiicRnOtXvgqatrboEHo2JYk8sC6t+N2NozOaJZoionvrblgvPv\\\\\\\\\\\\\\\/STDM1yCeVEegsUQ6seikEmxaV1\\\\\\\\\\\\\\\/jMQH9R779E23oquGwq1PfBhwCwZLaQk2fyteyijP1gzcgginV9Feq8hGOeaHTGAS58tYI\\\\\\\\\\\\\\\/tAXPMO85b2Ww3Q9VGZ3yryhFeARJ7YSUYyyEIXKB6SZGBA1BsCYeP\\\\\\\\\\\\\\\/I7FXdbJPGV94SbiHwtpk+CQQ6PCHn75UHmRq1M7IASlutizYD\\\\\\\\\\\\\\\/QmpcXQuy\\\\\\\\\\\\\\\/szHq\\\\\\\\\\\\\\\/RaBaLApwGYpIsBAN8cJ4+v+HeHWK\\\\\\\\\\\\\\\/ZAY\\\\\\\\\\\\\\\/14uthhOsN59aFQ9Fz2WVct4o7zG0tpX3jSOpZdgE\\\\\\\\\\\\\\\/FezHPgjCUooT2Pf8q7cwEVGDtVFKWYDYX2qXRPsgs+qE9RWe16gs919GcAdZvGWdMXIieoqpjttkxfk7IkQFsPmGBjs1j\\\\\\\\\\\\\\\/lZy\\\\\\\\\\\\\\\/6TpBKqzERxfdGgRcAZ9mxJQhcapktT0NE+FtPpNQM4utIKBRYse+fZ64fA4xgtQkPv88T2lJSJ3CsVTC0RXD0ArUiw4cSArrJHRFT9TxJKTy8dPBmYIL2aXSLiIdTXYPUIBDbirmnI4GfRiFDFGUQt8mKP2xNn+D2doP5R2WjoA6ARKyofNXorVu9edUEEcUQaVPEnr\\\\\\\\\\\\\\\/NBRqpjNpqPLwQZggdDlb\\\\\\\\\\\\\\\/OgTQ2OqmIowXyahPW\\\\\\\\\\\\\\\/W38+bREEUC9ux7rJtNP6IXHh7BLV25iIljRiEI7VknYeCaJjiGUZuiWFdD0OPpPG5C29wRx7qTGOYWecds1L3NAq4srRSKPesnHaekyt8O6XQcXyy1KujVP9SQeqQFGQ75hkM2pZJadtUUxtpMTGrFlDIcgzod+btyv36iDZuzqrlm2Os7p9aNvJPbmSS9X\\\\\\\\\\\\\\\/MtRKF7M1+G56cFJHPoJu9xbGIG28mPO7ToCYsXOR5TCsYaJoYA3Qz1NejHg2c6k1WeNAEB73aHfvvw\\\\\\\\\\\\\\\/UXueK7T3ExCuddTnmaswERR\\\\\\\\\\\\\\\/sZ96slkBhWbQabVFR6U6dHKEgrjGoPpgPVYJyqBwDZyJcKv1OYb3y+n91h5eGkTEXlZs0p3zPV0yJ4OATb38s4lQ8rEAEsZf4UPwyKSDouqFWGGoIb09QYGKy0hEwvmmo0sYmB6idEpkt0A0PSidLCKWr05uD8We\\\\\\\\\\\\\\\/adhHdMelXkqrhGOWTex2aEWMYBAfjfQ+jDQAudLzfufd\\\\\\\\\\\\\\\/EX\\\\\\\\\\\\\\\/Fq4d6RjziwWKRGkxtYKJwbrY94829pTNNv7BxfUCRk4y3W7Si\\\\\\\\\\\\\\\/un4ddxEFKHo9vS+jGrlQureknp8zo5CCbZe0U9og\\\\\\\\\\\\\\\/HPJnt8ZKE3fD0EpH6vVb3Na1GriB02OikURomaAxB\\\\\\\\\\\\\\\/rdtZ43viO4WMinEDThPnUIt2BR\\\\\\\\\\\\\\\/rDSx9no34SmWUCLGxeEAMpuARlZ9KeLkIHZr4Q3o\\\\\\\\\\\\\\\/Hy9Xq8Qvd5NXLla2BUXXgaWRrel4zfIoMAMFczv+RVkGcA0NJSSwzXOm48dWHO3haWBemJe0E8Ondsf0I8ol1z+rtRuQ1VXgE1q\\\\\\\\\\\\\\\/gSTU4Sk6air6+w2au4EojFgqNRUjTmh8McNsH3jDjop01Koe4BVR4GClwhD0o67dR\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/RXBVeoEI\\\\\\\\\\\\\\\/zureunhqZLwQrWcV0rG2++zV9vQ9TqcLoLKwVaSz5IeKFyfDmGqfOxKukw7IyFCWN6DwDEYpsrBE4y\\\\\\\\\\\\\\\/1hlAvdZKmDLcij5u26bFzn8coDq2qM2zeH0+Apt\\\\\\\\\\\\\\\/g3lnwcx42o9XFv0mkP0ibtVzWT2vwE23WlvWDoQskNA0xmPTPg8r01NKT\\\\\\\\\\\\\\\/XnjXsdwSNLXyYfLDlSj8Fld2SB7xEM8h+jHffcWCOaqIjFZUbHrtDvISLrSYaATRZ6rRFUqZCf4xU1r3Y2SWow1nS+bOBfHe6epiuhf\\\\\\\\\\\\\\\/jVQBPVrW01VBgT5rJ8PbpEzk9q4DzAx86koCr88xXyZeUVWfYptvfy9FTiMQB8fc8qGyNcz22IGWxkrGnmCSsqqx4JWSus463Xiv4xqMU85SPB2lr6CcUq5erHIrwayKvvNfpzuWPsKa3tAgvCEsWp3jGCEXxJ9w4W0v2P0wc1x6GJLj2zPhPUcp3Pon6cG4i+yGZeopfiqRGg17R77\\\\\\\\\\\\\\\/F5odjbMyCezriMtEcmyOcU5GK1XaNCj1G5APvKOQtEppDKu17BeZYzWHXqjxa0kA5v8nvXs6usIdP+Ex4ueaoV650OxI+cFMqHEYq3HeJRpH86xhM9o2Ni6Tby7aOFenRrL6tE7H2yUiHlJKvJBpW94Pol4AJIavCsXMIcuT0zWo\\\\\\\\\\\\\\\/ItZTf7nUNxz+A1nuyRAlpLKFDfCUx8cY1LPLD0XNF2nWci+LtnIUs4\\\\\\\\\\\\\\\/Ofq8KS9LAB1BoTEds2x\\\\\\\\\\\\\\\/eGHdU6at1wl9OPKL4nuMgqCDy09DfFWsDHrdH\\\\\\\\\\\\\\\/FurmBsPKBRUFmRMfhwT7+U6pU89nzh+Pj2Czv3kjiP8ZwouzthSmpU4PqEfVjctM1chU2gjCL+UvrXiKLQBlNRp\\\\\\\\\\\\\\\/eg0Ni4PrM5tg\\\\\\\\\\\\\\\/eH8n9NE47VdlIDu0A+EQETVlwuKplGs6bU02r8uJtWlU5ugVEKmqjfn8HFlDqMPDV5n2zg4KHIVHT\\\\\\\\\\\\\\\/mD5920DwQ+bJ69SwGUdRto8Npr\\\\\\\\\\\\\\\/WZPE8JPfi3BdKXuM\\\\\\\\\\\\\\\/0bd1VNPa56Nskvbnta\\\\\\\\\\\\\\\/wWZFy9WyjPB5QTaXbzXV8LLm3zNQXCv1QFDF0GVDhJE6HqgA\\\\\\\\\\\\\\\/Hls8BkRJUgpUWb\\\\\\\\\\\\\\\/F16UP51BADy4YSg2z67vGZ2y0bBtoCwK9kl4eqC5oE\\\\\\\\\\\\\\\/eM0Z2qeb\\\\\\\\\\\\\\\/CtBVoLlTOdXX+bZuYF8o3Q2MR+mocn5ALSUCJ2rM9VXsBkeOoMIwovGTo4k\\\\\\\\\\\\\\\/oxqniE1FQaT2TseVQdZV\\\\\\\\\\\\\\\/U9QF6ZXZcUt6ILZ8pfCbFs\\\\\\\\\\\\\\\/4xvAFiRQQ==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DIsnu9x0FSk\\\\\\\\\\\\\\\/OIDkf2PmFA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022660a60cb14f775354aa768a059e6cd12a9888e0c65f1649b9ccfe171a1988ff1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/9.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/9.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGuo\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Biochemistry and Molecular Biology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECancer Immunology, Inflammation \u0026amp; Tolerance Program, Georgia Regents University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E30912\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EAugusta\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EGA\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Guo%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGang%20Guo%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECui\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution-wrap\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-division\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Biochemistry and Molecular Biology\u003C\/span\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022org-name\u0022 data-hwp-id=\u0022institution-2\u0022\u003ECancer Immunology, Inflammation \u0026amp; Tolerance Program, Georgia Regents University Cancer Center\u003C\/span\u003E\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022postcode\u0022\u003E30912\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EAugusta\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EGA\u003C\/span\u003E\n\u003Cspan class=\u0022nlm-country\u0022 data-country=\u0022US\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cui%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYan%20Cui%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node4103\u0022 data-node-nid=\u00224103\u0022 id=\u0022node-4103--22078566990\u0022 data-pisa=\u0022jitc;3\/1\/9\u0022 data-pisa-master=\u0022jitc;10.1186\/s40425-015-0053-5\u0022 data-apath=\u0022\/jitc\/3\/1\/9.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EGuo\u003C\/span\u003E G\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ECui\u003C\/span\u003E Y\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ENew perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2015;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E3:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003E9. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1186\/s40425-015-0053-5 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EFebruary 16, 2021\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Atilde;\u0026#130;\u0026Acirc;\u0026copy; The Author(s). 2015\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (\u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022 data-hwp-id=\u0022ext-link-2\u0022 href=\u0022http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\u003C\/a\u003E) applies to the data made available in this article, unless otherwise stated.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}