{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qbHTfa8vjw6XgNf50M5xuzceNi+OfBIsiI3mORMRkDDwufdg158J3spCti2GW21pB\\\\\\\\\\\\\\\/aXD\\\\\\\\\\\\\\\/jR5KnQpSxAmAccABS\\\\\\\\\\\\\\\/FLs2an+5pgge18G+mliARy9Bq+TH\\\\\\\\\\\\\\\/jr3Laa84G4lmOn1ClqBHGFG4Jr2bLr6wH7iSs\\\\\\\\\\\\\\\/rYb0DAJqcvnDhRou9Y9vp8xc+uWQCpOpZMvx2Qq8Pvs6Zk6TFWzOdDvkNKWvvRyxS3g1K425m83x81ws6NfVoY\\\\\\\\\\\\\\\/c0VgsCIOPJPxqvhTFs7TGcaFEAHVGyzlN9obBJ+n5D\\\\\\\\\\\\\\\/Fh6sKSTp60fFJDcrrQ+CvuIXDjr7d8lLheajr998fQ2vRvYaDOcwnzC2SZZkBGi3Z2KqXEPWYlnV+jXi\\\\\\\\\\\\\\\/XTnAjIU\\\\\\\\\\\\\\\/VhQOJDzlK1Pjf3II5F93bx8a4WMMRsZAq7N3c+0xQQgqacCVGAxSqkmNjCZoXL9LH6xv\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/IZfwcSRB4KbufyK7TORLiSEYO8gZylyq6mtCyLABTG98lgsVEzcIbCOA7eJVs+RJHdL7AV9Coa0jnRHFUqfkbxeHKsnwoHbvbRdK6Y9r9pFAg9HIzZy9bOG68TpIO3j6QvwP\\\\\\\\\\\\\\\/sfMDWHr5Ub3RoblHTRF3lQrQg7XK9Omoq9v2trvle7a5rGMB1NAezckEX+aQhynoEOCtY8IOJ\\\\\\\\\\\\\\\/TpKHhR0izR2ZNXUe7TZ3Wc6f0zpmJR16mrW6zbPArpMaAvGz4+oi\\\\\\\\\\\\\\\/KwnpM2u9zbFaSiu\\\\\\\\\\\\\\\/R0HMJbQTJ3qAGcBMHazAGZZ3FGs6n+VoPmhE+Vt8cHYpqV2IQnLOsb+eyT51o1AH+x1f7pbTJwyR0U7B9bTqTqvUv\\\\\\\\\\\\\\\/L3Qkwk+NgRZ8wmd1CZmSjOvVsr0fylykPflyev6MVeTMso3oMS5ocwPyAAudcijCUyBq6\\\\\\\\\\\\\\\/OG5ZsHRk\\\\\\\\\\\\\\\/Kla2G6tz7H9cOcj6p2DfsTNYRhp1mGDwxfz+J4juj0nNBhp3QSAVqQW0hht6iAPTJYZvg8FPyJogNPi7KhTZXD3Vsyf6VF+aBbt\\\\\\\\\\\\\\\/sYnFpfHeIjHoAoBRPtoM+TcXdUa6opYNMuRoug33AsoosZb51iKmQOAkqzueM\\\\\\\\\\\\\\\/RyklvnoWrIYhdCNiM3hxhof6fLnsJjL92tqizKGQQIeB9wi9YajWeXob1+3iUGl6ntMY5W3OGvrz4UchcYTzEcvAo5PX6u72WJdhjzZZXbkKa\\\\\\\\\\\\\\\/hK6kodM+UbcmmpgJALmFVYxaz0srmveeO8C5OeOqXaU+RzCIGCfJsPura1Nyk9NeRqjrwfYVMBZgVANPyqRozCKv0qIqtxMymoLgo2ZzSjFbwzOUAe+4JXdbs3Xj4iFBIWA53958W7UCJ5aVyINAQQPRdWuCCGV0opxH1ZriAxa4JFCvZJ42UV5b0HyD0MbGBxZTZ2yCg5K1c4sC0OAf8D+7Vx7uWpPBchfn+Nxi5h6RWnJoXX93CuFZoWI7Op5jKOuupvMwYsrACmahkXkUwoLklw9h78ZHSV4CWKrHm\\\\\\\\\\\\\\\/J+okj437mHW4aEz9pZ1iltRFSOrJYlC8BxLHjVQVZlIIIX3D3h8lMtMU70ciV590ojNg+wA+a3kX6ZXlYR0DvBMakoAeEhCObEsyoGi+UlFTwf1ZR\\\\\\\\\\\\\\\/LlLRbo9dz4Wye4YeOkJjB5ztxK4N2qAkwfLgaaVOsXjzmkt7zAECY0OyyG2Eax7CBWVYfAmMc5vhgiWi0Oael7i58ntRZTH31iEzTpQZUvlt5vRkT71rNdGUZvSNGBv5PcNMFhPDiMsNyQhwvJX4XILc7ChdYwfcxPJ0XowDMCnR3RmG8686QVe+f0Yzl+V8SlfSvt9BBE+AELnpCbIPEEO7Tva8VNyFNyq2jqHKgvO4sp0lvhJbOrWPzXf9v8SkJZrV\\\\\\\\\\\\\\\/r49WBTMaMToublPDRihDlmVKkM2bUwPUMeuA6ylmHP85FS\\\\\\\\\\\\\\\/c2uTh\\\\\\\\\\\\\\\/+PWdEmDaghC\\\\\\\\\\\\\\\/G9wmecyeRTYds5g+BhAnn5SXHWoLwrLiWB4Wsc1r1zmMdWNmbCa\\\\\\\\\\\\\\\/rEvMzCLDRFg2QB9rH3pnPEztX\\\\\\\\\\\\\\\/DC7D5dXoQP2YDcvOkEqBfnTZnZ9L9lt40f\\\\\\\\\\\\\\\/alfiZoV8roPeVYtk6bNHDB64lOImizx7bH5KXjm42urRw8mmjwGRjb93PaLGYEj8Qgq92cBuFipQhQg1DoFN4PNTVW1v04y\\\\\\\\\\\\\\\/+qiu8OTB3YAwvzg5oltgU6Lv3pbfmPOUBoM2HH2Xg2UOwCBv7NefQJJO\\\\\\\\\\\\\\\/WumcQG8O5Jqz+QShxkwNZIOljZLMXe8XnuIwJ46IkQGp2hjiiAsTrIWuUSp+H8HEM0s+dJsM5jIEebGxG1q\\\\\\\\\\\\\\\/kJ\\\\\\\\\\\\\\\/bYpSWE0hJYuJCAqi4NlQJSZ26eVkfoTLIdzbh9oLZjzcldqDH\\\\\\\\\\\\\\\/eymk68Hs5J2eukSjEixKdKr4t831BSbi5UldT44lVvn15wVxvApERD840tD20PYn\\\\\\\\\\\\\\\/vwvT9hq5NpyFn8ZIVL9FHnwpCzPje3LYvuMhAi21+ZxFXeMg0Cxg95E9ynTa5F6JpCey9R+clnIkLzLcwhi0ybv6pYtgx3CbrMvJlwgOHKhB8mevHKoVVw33XybUDH6nawj301PI5OCwBr5dUyDdhWIGwrQsV5LxnjbKAYFdeqA+Z4olQQ5bFkjk0AGy6P5TG66iD4zf19kckKtnF+X6Vz9ZuzHZCm8yZKGQKtZCUZR8lOGgD3CAd2lcpYkkpNJ4GVrDCOj7LzAhMK76xhF9xISELUut7ljru\\\\\\\\\\\\\\\/F8EVVga7XkI7vNO4K8Qi4LRTtJBrIKTB4fh5zxz\\\\\\\\\\\\\\\/NHLicCDjcM+9rpCPWrk8y7QuXZ7Qww6i\\\\\\\\\\\\\\\/sVDdePir2eeWM8rULizRJu4P2jb8SP3wk5\\\\\\\\\\\\\\\/ru96lePN6gZ0+S7HDRNIcJ4\\\\\\\\\\\\\\\/EEOmkxk3+VeoTMcXXqOAWg\\\\\\\\\\\\\\\/tY9UtnBDFoPyVmVZ58TMysyBI+2hGNkoWiiWmv3WO6p2mm6AsoZYmG65jZqGZGGXPZpK8pWvENKoU8cjgtN4\\\\\\\\\\\\\\\/ZAOA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00222gJpgAlMcTW9c6MXz0CfPw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002232ac149e04b9d021532fbfe4ccc8d926fec13d9c4e483f4a9ba37cd6cf1461c8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e006397.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e006397.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECharu\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAggarwal\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDivision of Hematology-Oncology, Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Pennsylvania\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EPhiladelphia\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EPennsylvania\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Aggarwal%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACharu%20Aggarwal%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENatasha B\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELeighl\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-3\u0022\u003EPrincess Margaret Hosp Div\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EToronto\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EOntario\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ECanada\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-3249-4602\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Leighl%20NB\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANatasha%20B%20Leighl%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node40924\u0022 data-node-nid=\u002240924\u0022 id=\u0022node-40924--2654212353\u0022 data-pisa=\u0022jitc;11\/1\/e006397\u0022 data-pisa-master=\u0022jitc;jitc-2022-006397\u0022 data-apath=\u0022\/jitc\/11\/1\/e006397.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EAggarwal\u003C\/span\u003E C\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELeighl\u003C\/span\u003E NB\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ENext-generation ctDNA-driven clinical trials in precision immuno-oncology\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee006397. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2022-006397 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EDecember 07, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-01-19\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}