{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jFpm2mfLTxTvuR5RuI+Babb+SRlrOcVVm8oZHZkvWI0y\\\\\\\\\\\\\\\/ZOfIxpvLSvRp\\\\\\\\\\\\\\\/tFP5SQuyJ9XZ8BhTNqO5dqjXJHFFRkK41xzHHZBdk+Ov2kaEf4vKWbcRujHxVZg7Lou3dIoll3U7GhRtkSutry4ZJghyrBUk93J6\\\\\\\\\\\\\\\/eTqJf8RV3V7w451HwM8xo5t+8kZoKegM8hr4nh8ZIl8ElgMl7M2kvLuT9Y1yW95TgQP9pZLYBmMr2tbucJZDSdxqMN0caRo9KlgpxQENGUj16uht8a\\\\\\\\\\\\\\\/8XRWXP9Mt5OAt16yS50WH+vWtQdZi\\\\\\\\\\\\\\\/Zdq7h5\\\\\\\\\\\\\\\/ld+HgR+fvCgGiYpLRsexWb+85jSaSUcAL\\\\\\\\\\\\\\\/MOq\\\\\\\\\\\\\\\/x4k7A\\\\\\\\\\\\\\\/vnH9VXqzWWaVds74yvFAF0UlhWkFtJEGQRtuAImCvImMygi\\\\\\\\\\\\\\\/ugoYbYv3M+EWkbxqdlpMbB5Mo7CUM36ghlisFXMj8gpu2s4zWLvY2eS9JEcB3iJ5ktAEX2Q7B0EmXjFWbr\\\\\\\\\\\\\\\/nkqnprOHmCvVUMq6tT7ziih41iBHS0k3rUG4Vj3ik7wM5UdLi9rlooApGwkmv1Ym4TE8BJbQyHLtMIeBR3LKc0c1zXDrCIlRrPyLL6C1r+XKJwz5aoSA6BYjPyHb6q3z3uRP\\\\\\\\\\\\\\\/V+korINjAoEWOxPGS2jPUTZ7jrPmtBOPwu5d4wmIiFcEMJIvVIDURTnJdSKiESoOPCrSMCF8FJVHhE6TVpM5RKkM6NB67KiVYdwZvUrN1wbMsjcLaC\\\\\\\\\\\\\\\/D8sdtI9utkDqs1xS1rfna0iFia08Hnp4QfT3HbqwXdPD\\\\\\\\\\\\\\\/E8XPOW++aK2SqPNgG\\\\\\\\\\\\\\\/VJqmE52GySxzpfYyCc4xy\\\\\\\\\\\\\\\/66dv5W+8D2aTNBZteEqqMXY09Eh0zT7aO06URLJkG21Vh41DZ9qM2FCC\\\\\\\\\\\\\\\/tqGLTP7JiZvyo0\\\\\\\\\\\\\\\/Wi2x3Enszu2gfUstjk4Yb6HlmJ7pF2CWqhoBW2GYsYhJ5jnYlSqTvMzPYnxRl9u15W8TOjeTLFSVyvLcmSOvB77rdI6rTaCvW+EYwzuMcxc5j4FTLk\\\\\\\\\\\\\\\/GDz0ZIvzmbcHmVbVTemYni9CTh8HeJVtbPdwtnXNnzr7BjFb\\\\\\\\\\\\\\\/EOKuxZfd5ARz9oHMqO3XJ6MFVnnR1VhzNO4IQbQkY3uxLysVg5ZYxL7C0\\\\\\\\\\\\\\\/+mAYQxwditZLZ3h9+W\\\\\\\\\\\\\\\/EeGAwJ6Khbhz5VEHud9nf6WfZkCQCXRR1\\\\\\\\\\\\\\\/9FbfBbNAGUPn7lE53JnBFoH4ielK92LYBWfgAxHmF9oH5IptSF9PibXQhfH\\\\\\\\\\\\\\\/dnIQshVoDkk7Z2xr42EfIqEssEeQekwu2ahfJWo0Sr94EcIhUoojggaRPyKJESA6ti7VD65hONkDQmGGTbIHkKTC5LxoF3jv6hTp\\\\\\\\\\\\\\\/Hkp1wA2tgW69LA3wYTduMiSKT4Mf0nXGPgNucNwDyKEiTNsEZ4CQWYUQwArQL9uGaijKrj6i\\\\\\\\\\\\\\\/HtuqwTzNnGhu+aydnmaZKYJWR3B\\\\\\\\\\\\\\\/TwQCLE2un\\\\\\\\\\\\\\\/ExhNgnznHFPGdqs5Kv3+NrtEuAObysRN\\\\\\\\\\\\\\\/u8vYnO9qcJnXOigv31SWUUK5NXgOc10w+BigLh2V1BdvAX+DktAuf99f0O0rpNR0\\\\\\\\\\\\\\\/4ucIdk9imkzOV3yNKEJYBzTcIGSQxjjQzo6QqNgLge1O3Dpwd0wTgBrOOPbjiYGNkV11X7IfrBjxhqgG45MADAduly6n+Ar4Bm2TQHEWE3EWAnw7XgABQK\\\\\\\\\\\\\\\/ORxL20yz1Ol\\\\\\\\\\\\\\\/ynwMNBMsNlWk27iLxKPFmmaHDJ5xqyLhUIBXV8zBaZoFWD7mU0AoDE3mljd+ywFSghM8Vd9ncBLA45+Y7rKGet7j+gzwcO7VPhV6dnLzKNtEJ0ouZJID9tkoJhi1HRTykC6nc0krgwqo1UdXglj9jd1WiFO9jzdJo0lAeC23joJm6x2pfx4PS2U32M+8fdr3lkZ0Krjbu\\\\\\\\\\\\\\\/u8VHaddlSPpzJqmOSmLn1uLf6yDnhmATS1JBPOEorVLlS9d9lkQTS9Kobhh83O2+lOF8LSz9aMzoouSGmwozuK6GGQVzF8ch152FKethW5GqysaX0k\\\\\\\\\\\\\\\/e7LoTjCoY0Sxz4FegsjRPaEVUEJJpsXv+OBJxyI9kNmo+p2\\\\\\\\\\\\\\\/ThD6FpsZWNw\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/Hpz3D1DxPmJXwVZew92gudIcdArwPpJamK69JI8cRQWU0TyAc4g6qGTBi+aWdD6Lp481J+4ujDa8caI80+bvlbNZhjutq5GTwpFEuENoLQYlsoTEOjE7sSrUCn2bmeEwG5t\\\\\\\\\\\\\\\/u+YxL3gHGFfLNDxJsDNk2AMIUYm4SJyl\\\\\\\\\\\\\\\/3Wjo2E3NlsLlYj88Ihar1wdkOHSXeU0NJPbGywUOCL5TOWvb5wOyRE1qBPvj7DACuqY+T+Qop8qUteBOkmNose7Uje0Yp1e0Kt3QTISDg0unrKbNnDnFTdRY6mYz9FUP5WEOabk4uIRDZPbtD8AMfpmMcil9HleDiShRgGPOpbSJWmpibKXEbX\\\\\\\\\\\\\\\/FPx0BlbXsju9bvNDPpSKNaYSwNosRSf5xvh4ee1O6OtdD3acFpOTqy0pdwbnq1DC0AQkJyblQqQtPtnD7X40pGwSIr1HW9k29s\\\\\\\\\\\\\\\/8nSp\\\\\\\\\\\\\\\/bM\\\\\\\\\\\\\\\/VEFmkcQHtoF7yMyvCZSP3eACqfvBBvR08MhUeMSAXxVxL4FW5Rhas5Vpoptg+0TT7FGNyndQ24+2hoYPBTjJ3aiVPqWLv2rYZnwkmEcnqYyq\\\\\\\\\\\\\\\/JQWCR8RR83RnrCoIpwPEsszDCVDb3VYfzs1g5EBrCBtWmI77TwscR2GstGa0NJI2bFdoSLMEUjXcGMmrrPCZPuQH8\\\\\\\\\\\\\\\/ZNPYbPuM93V3OsVS+55u7k4aQ\\\\\\\\\\\\\\\/CnxURtViIJ8Tz8RhoTYTh0xr86CiRQ4bpXfiR4V6coQb+1ufDVO4gxE7GmfDmS3iiFgC4fMnIPq4m\\\\\\\\\\\\\\\/CA0G5xtJ4RJkWPOh4Drnb21F3lz9LhB6zsY+h6pLbCaK+QSuuSW7m+m6pvdBdtASCReYWwS5W\\\\\\\\\\\\\\\/A3\\\\\\\\\\\\\\\/peP9YWFzCGSGcDWYNQrQg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225YRO7OcyDurPob+aMWXtlQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222d9bdb4dc8c547c83be110b1af5e0629998f319c83c5a17316d33f06f7c2b592\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e006346.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e006346.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMario\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESznol\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EYale Cancer Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EYale University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENew Haven\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EConnecticut\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0003-4137-9662\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Sznol%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMario%20Sznol%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENaiyer\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERizvi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-3\u0022\u003ESynthekine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMenlo Park\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ECalifornia\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Rizvi%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANaiyer%20Rizvi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node40708\u0022 data-node-nid=\u002240708\u0022 id=\u0022node-40708--21387236259\u0022 data-pisa=\u0022jitc;11\/1\/e006346\u0022 data-pisa-master=\u0022jitc;jitc-2022-006346\u0022 data-apath=\u0022\/jitc\/11\/1\/e006346.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESznol\u003C\/span\u003E M\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ERizvi\u003C\/span\u003E N\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ETeaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2023;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E11:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee006346. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2022-006346 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EDecember 07, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222023-01-06\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}