{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022s6caIJCjFTWRfhvdfTkLZgPfN1WWdBbq8YkAXkVjCFi1esMf9SgtYHSlvRHfTgTwdtUQGt9vloDeNfZdX1WRK5yA5MD4MbaBywiwWMz36\\\\\\\\\\\\\\\/6GelgzPOYsCnoR0Yg++qKvUJWIBIMITLU\\\\\\\\\\\\\\\/9zXcjWbfecXTQUg4lnX\\\\\\\\\\\\\\\/xOXJFo6d1YlRZX7gLgXq2gMrz+SHJBGmZZWWXejkB689CSXWLv1lI9fPkmAZ9PSk6j3rZ0Pv1TqQE8HSwl0lByOMzGtGaAel0GemHz8C9HmoBsCQTiTEaoZflI1OYwxBau5tCQuAm07CccGeYrWFV2gCrlWc5nxyp1Zflb3TJSRHu6IACj3bjLKEouf5nmdBlmvU\\\\\\\\\\\\\\\/LH3pUxNr6synhuqjEXm1tPfJ+EcMSCdZCrLkW8Yla3NjpzG2bWN7bbY3b8h8Tag4f99NK9KdJA+xyww5UVTX+eUyPsZTaQ4KwyO1MXstDBckQLt0V4NvwfrMkJP2hkYYIrRUbrym36NAnNtXtrC8Z5WT+L6JquAPrG7BB\\\\\\\\\\\\\\\/54h6cyOIVDrngOvWwLlOjRN+0jnYQNZhtCbwEjY3Z2tMJI5EkHKeoXi1hSWC2mcNNtkxfRePCDJkgbHB7ovIqlLLNcqSd1T9e\\\\\\\\\\\\\\\/ov1ExCwI7Hn1eXFIa+TMUYeALEwgdKn9ODodX+h+pP5wF7glYOPSE1LAlDTPUti1SNaKZI5+WWgSqovRAm4rMhu+mVa4Mxsc5vXZ4eBHEStcRv8m0U7SV1CpsdCfbclwNFJ4ExRHdPYrfXpyTrOW+MyCj4tU\\\\\\\\\\\\\\\/YAevnnW83fPLanzRqkSHiJ7xWFR+t\\\\\\\\\\\\\\\/zT\\\\\\\\\\\\\\\/A3nkKwxOdi6fTbZdMX\\\\\\\\\\\\\\\/5EVUFBIsqgwkbsp4gFOkd0ujeCfxTP0D1Bi4nnw5WBgz+dtqls\\\\\\\\\\\\\\\/ZgCzM9ift4nEIgREMveIsSrzEiV0ZXKigJtxznhcuSr1Lc1TsS3dL3jQeP9iQsOikA3RWlVfxscCAK4NuNyZMEZYlwDVEkRrExS\\\\\\\\\\\\\\\/y+GxsWcmBiT09UcyV1BBV3d5e3ujLU94F74WJD4JP740FmkrCXhhCiSRhA6tVMkVPLtvyzJUD44uSQeJ429o2Jbyr+dlmPqWv4I5iWvpIf9GakJM5lUWpfoMyNZ9Kx8C6SwkYCKnTG4wtEChGETGT3lsn5\\\\\\\\\\\\\\\/ix+L\\\\\\\\\\\\\\\/YGR9VA7NdqypG+sqU3Q6f7Xrmzcoa2lI0SjDaJEoOxXWbfU9S112Nn+K0MON1R28dOaD1aEWaSPg6n+qMONWHWmin8wAqqCOtz5n0qBfmBhpgOW9l5YBCc6VcIDXgsOboXxgYkIDeKjiCkC78lP7LqeUFL2KL4yqee7eN1Xo2tettpCg0B8oRBWMomkwrstjlvsQOQXdoWznIpWO\\\\\\\\\\\\\\\/aTYqmhPJKECI80Cmzsb4SNFVUeh5ifSiXIc9sAgWbmj3ZEpm9\\\\\\\\\\\\\\\/8Rp7NCC6hpIMdYjre9RxJSFgSePYGz7fYHMcAr5xueZYordDdqsItqTmxkySVICiM07jcJ+JApnjVVB1mYjYN1wnrpwtOjYt7H\\\\\\\\\\\\\\\/vKwjGHA5XNIGZ2\\\\\\\\\\\\\\\/JJyr4hxV3FsAEyiYxKV79J7l0vo6xHW0PDci8xwStU\\\\\\\\\\\\\\\/YJ5SvrDT7enmroR0flDmsNZIJ6ZEz30Z8az2YMl+fRdLv\\\\\\\\\\\\\\\/HIBC+4ug2mYi3cn2ik8vr8SaWp63aUcSSKdrSpqmG613dBfZ5AiB1QPxAL4JIZHneWo2p+ytAn\\\\\\\\\\\\\\\/vsTT75elFZnQb+vuE9u23k7Exe3C0nFBIHquiJwg44d+HXFkqAS0HMXB4YPNnUmvRbpiO9AiCsu5ewn+nq+UhZ5bF1BLkjPygbMI\\\\\\\\\\\\\\\/Ojyif\\\\\\\\\\\\\\\/dK7NuVFa1CmW+h0i6iKg9zYkqRMKauIRZZIZFUE0+YlP+La2aExluXvfUpvZ0PgooxuXz6SCeYDAEsEK57skNTp06IoVmJcKAx1aLYNYa+toN4W19XrKwXohOtcTuYsXlMvxaySxT\\\\\\\\\\\\\\\/IgPbcCiLgjWlR0DE8lZhwJApgRYY1Fs7dgOMYUmlhy0vpEjZesqe6aXhSMq8pYdI\\\\\\\\\\\\\\\/2RDN14nJK1iJtH62yKtBlultKfWpbDgt4L9WKqRcKzR6cQMCkDwktRESgY1OXtfkd6D6bHyz5SdxPwc9P0pqGTJXTYBs83NYjRYFFt+XkPEF9kViXp52VfJ6SWMdzEmgOh3Z8VEQ8BrlJr4hi1JHYXGVSXJyFWeDgdmUpHuzHg\\\\\\\\\\\\\\\/amY5ia+t+eR+4yrISxyxrtt47rL2LCBjV\\\\\\\\\\\\\\\/c91Pz2UGDGAxExCtej6wp+zTxPW+8MiBJ6UWtI82LUEA\\\\\\\\\\\\\\\/cv\\\\\\\\\\\\\\\/6CRiBSSUXrGSraWh8KER2YfnxlNlnZXqP2Kw2Ak45Q4l2q36viIkSW\\\\\\\\\\\\\\\/A1B2ICort5+DU4OcFH7jcKGUqFinA1M55YzcKQtrqdagv53aoE0HXX6yMu6DCbwvjbaaSmDK1mfIeF2OnXzI7X74wOvKagGUICGODMperdnf8+UQ+BH57nwX4qFflLkhmSZwM3kuIWOEcAi2Q2xey9wWHfhfg80i2H7mHTMoojzdcFXhngLFfjNXDZn2SoGejONPuTbL4icIj1IPfEr9+Xn8inZM7bVAkv+5DP5ptbM4KUe\\\\\\\\\\\\\\\/Ai+Q7XtjLJVlnCrqmAW5qNws9gl2iPBRYyxWeek5m61rvZ4f7lok+TPw3Lyt8LzgqrIvUKWZulzEfK+KgX5mkNPopVwwwaUko71njA8+ifr1br4Dp\\\\\\\\\\\\\\\/BEGeUxBeFqFgZU9p+rS+c1EckJOB3lQQTKBtP7WZ3CrMDb2BZ9JWkVqq0qhcj69uLUmNfXslRkD3hOD6ofJnEwS2GSO6BRF\\\\\\\\\\\\\\\/cXoDV4CRh\\\\\\\\\\\\\\\/w6LWd4YuSbNNfulDmJM+SCJxmEwJNl8+AzwUrO+LmmKzg8FEKXQKBdxa41G6Je\\\\\\\\\\\\\\\/WNc7V\\\\\\\\\\\\\\\/kOTckto1aUiDpCMCTS+5ccGGGq9u+5o7J0FzUwQiKTRSLMLjq6J\\\\\\\\\\\\\\\/pw+ybI+RCwEaJJoKFhzoayaLg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022e3FvnQRMMMjb2zFMs8tprA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002205f5bceb432c891db32c7460ca5865572b447d406c81e5ffa3c9cc9ab56ba721\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e005082.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e005082.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list double-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPaolo A\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAscierto\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational Cancer Institute IRCCS Pascale Foundation\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENapoli\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-8322-475X\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Ascierto%20PA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APaolo%20A%20Ascierto%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EDirk\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchadendorf\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EDepartment for Dermatology, Venerology and Allergology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversity Hospital Essen \u0026amp; German Cancer Consortium, Partner Site Essen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EEssen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EGermany\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schadendorf%20D\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ADirk%20Schadendorf%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node39511\u0022 data-node-nid=\u002239511\u0022 id=\u0022node-39511--22057593062\u0022 data-pisa=\u0022jitc;10\/12\/e005082\u0022 data-pisa-master=\u0022jitc;jitc-2022-005082\u0022 data-apath=\u0022\/jitc\/10\/12\/e005082.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EAscierto\u003C\/span\u003E PA\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESchadendorf\u003C\/span\u003E D\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EUpdate in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2022;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E10:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee005082. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2022-005082 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EOctober 18, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222022-12-01\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}