{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022gSN6ZWCOxFUqtOdiJG24sppstwrtNIH5GFdx\\\\\\\\\\\\\\\/ZDODqaTepNv5WTmgiCCCw94uXv0RsenWWUDz\\\\\\\\\\\\\\\/wV\\\\\\\\\\\\\\\/R96EZjhR2WCA3BMnpJwBm88WAK8FAsIYw4IKBFzw38c0KSZoALgwExSQt\\\\\\\\\\\\\\\/j8jkTCbRrcPVC25s9Ft4x3gmtr08De2VaqFHnx+nC\\\\\\\\\\\\\\\/OJ8w1vyp9o06Ja92fXVLHiXrOH0NX3t\\\\\\\\\\\\\\\/ZpissXoxSs5IgqiKXo5oDBBO40ocpcyvGgAHaBGqXXeVwNNQrc2vpBM8Ck\\\\\\\\\\\\\\\/DAPnpwUAhvxdxOyLePYPg0iECio\\\\\\\\\\\\\\\/ZpEXv2Zl2bObvsxa8GUnZH5vWtFOOACs2rX3\\\\\\\\\\\\\\\/Y2UkeFtgW1ixptWLjjzUdL6U9hHWGMY4UGkDcMpvZO+j0YggSWbOSG6rSnMt932vByoDkbrS4wZoGfbzo7YLOQFXMmTCUvLr24ZFXsyLbMYNRGYWEVkFix9+nFTN5ahtHGAIJQ1f+pplXamx\\\\\\\\\\\\\\\/B8mf94boXOYQbqyCgv4xONg1hUQ6SL8ram7k0rm439g2LyIpVk2hTVPakEGyPT0E6OFDtqjmbGmdYQnicpiSSI\\\\\\\\\\\\\\\/4elwUNbaJi0SIdVh+GZPZUrugAP8dxI+XXLZY1+tJsxo0NFvcyhV8yMdD0IVeGiJXw85FAQ18y5vVqvRGOJQDQuTQ262WU6PVHqRo4uj9FYnCN85ULvwqXuvkfqxefqbW1UPSiBVE3aildbFVS3X50X\\\\\\\\\\\\\\\/VoytoEJ05sMZ8qMTAz\\\\\\\\\\\\\\\/n01t\\\\\\\\\\\\\\\/wDaN6h2RLb9FvpRjS\\\\\\\\\\\\\\\/zMqI15S56z886clCBpDfm+xwSoxlS1I4CHFcHlgtKswgmlDd8NCfcWjtjOMU5pvHpduEDb6LTzcndowzo5HvYUuewSzSwxwlNpw3+Y2MG11EwjJqr2yq+hSIPwN03eKXawNISW7XKX\\\\\\\\\\\\\\\/k\\\\\\\\\\\\\\\/xBy+1kLgrd8lsT7VIVe6NIte+IJfin3OmzBgdmyDqpQ3cprzXwB4H4vn4UwDAsL59aS0VODmhvd+SPpUdoWtNIbRgt4\\\\\\\\\\\\\\\/WRW1DpA3wKAfSb5VQr0\\\\\\\\\\\\\\\/1a2YrIyCyzmqo2zc5rZgWM3uWLZfc9gWDq2oR4eA8AUNibrE17WOv4ip4IZnElc4Ki\\\\\\\\\\\\\\\/66g0h7UiP+1ceCITj1H0azQSqmFdkUEtd2Mgkj\\\\\\\\\\\\\\\/LDjQdt7sE1OoKwI4ayNLtIofbxR5pA5iVauCPBif2LYZcXqUjDR3TY\\\\\\\\\\\\\\\/9MpDtQKXbNRf5sEiPZhg8867+iXTjtB+Wl8IThP6+AoNvjIQ0GPIikXnciisUUNmXjZe\\\\\\\\\\\\\\\/ThE0Rijcc4+egWRh0hWeU9sr+0WrDiJv3zCAIqw7BcBqeA0bVJ28PATDLKxiax7w043wzp0EA7Nrg9fadMxpg7EqK2+f6kqTqgC6tGPtzBVihPhO5NplWSlKUeW3tyZPcVvRHEyv7ZspjZFu2IlVbFlUd5NwsJkFkscS05IGXTP94KhyG43gqqXON5jVo04nVaNLc3Z6RG5gxhjHLwgm9Xs0JszrzgQoGCVtyv3PuuoW4B+HCQueGngDFT14N\\\\\\\\\\\\\\\/ApAqgGrEVATSfyJC3iInXS3cLC3KTWxXmHYSoCfoJ0\\\\\\\\\\\\\\\/R+\\\\\\\\\\\\\\\/+vvh4VQNsY3Znyah59M5u4HUxNeUW4kctQlBd+hvVYOOcTRq3qR1ImGv1QO5jexOZGNc38ZHZVG9hb9dgb\\\\\\\\\\\\\\\/2CGvBT8BpCL3syhAOgqtQwBbokA4yIZWegmraoxCLSBCUhYc8QtTexJ7Q0MpokK\\\\\\\\\\\\\\\/ubh24OMAjl8VKNW9amLCgKJgWgfFzLSjjRMIRfHaDcGEPFL\\\\\\\\\\\\\\\/zRTSS9fu\\\\\\\\\\\\\\\/HXhF4SimDsnC2eTykvsP2\\\\\\\\\\\\\\\/ejhB2+gdqYYD0ADgmtVUQon0cUdkITU8WnqimZfhCtnFalkmUuazcuAXibfiIG9f7+XRbLU2klrE9ZDEIHrtMI6DUvTGCDggoBA06GP+BjwO0dZZnnyHD0\\\\\\\\\\\\\\\/Obvwl6sJ5FgYjtL1Ccu8pNgh7\\\\\\\\\\\\\\\/x0CmTbioBlZCVnAQOguB\\\\\\\\\\\\\\\/q+J9KOj8KXuF8ZifHcVZWph4COuVy3VCgPCrAeewnHCcYg72JCsH6EyrVAUMFI0Z9suoDqb9tFFqcsTJU93eL8Fiti\\\\\\\\\\\\\\\/SYnpzZQhyppuUv7yL8hPkC4Adl0z5zcU2BNfXwtcSw3ReHyDkNnYecOSrNSPbYjSvxbJG6QEjnlgGGjG7h+agIwWrqCRrlkNfSHI2D8o2EV7pjjzIXdPutKoxzv30mDuNgnXG2PFZGbuLZDS3E\\\\\\\\\\\\\\\/Ak2WyNII2c0l3HNeN6C3HWJQExzJU8\\\\\\\\\\\\\\\/wb\\\\\\\\\\\\\\\/OHfOy1vByf+weUzgvSo9rNqyJRw\\\\\\\\\\\\\\\/5sUt5MiTG7He2dwMia7BG31fiZ+FjUi7sjpSunHBFC5XwVjGU0YO8+lNnqhUxdgp5JFRpxzfHSgkLMKxLGRaRSBG7VAADSCB0jlaq5E8hnLr\\\\\\\\\\\\\\\/Aw1bHF+Q+7V1\\\\\\\\\\\\\\\/yTbLLEJsf2\\\\\\\\\\\\\\\/lSDUhZ+qIRhek9sp6xclYWLUKfkzcXggGDUGCPpgrbN1N2dM9Mfm4j2Y94nFtc6HPqBdGJI7KLML6RjncewsgvfM5kwPWKKZXiokESw6cmoocnWwKJF3lm5IboK9HJoAa\\\\\\\\\\\\\\\/az4tm2ya1lsuBHtWuIJ0XfP16tXm7Jsm4XC55+gYzpFtYHWRoGMsZX3fsPegkQeeEYnhcWC\\\\\\\\\\\\\\\/UmdSY2N7bZ7tJoLAPCyd+9JK8YK4czUrGbW+dXnN2V\\\\\\\\\\\\\\\/UZZ6a7AnoSYrXQ8f5Pgfg\\\\\\\\\\\\\\\/gtx8OoFQCvQFaezwJUPLWo8mq7CTgfJJEMCvfWp8zTl63KLBjStq0qrB089nNCvyEb5S261XYhbqrlQC4Ccoud\\\\\\\\\\\\\\\/vW7pOTNIxfTtpxo3QWRU8SCZBwwT+XiwpLvxDKdpnGDAGlWLIZq+gDS9p239R9ujJ1wsulU55SRwPsdO3z0mB4cSISdRzg8RQQs3JqsLsAuWC6isLvAAT1VWpchyxJBZELlwrPCdbcVAHJRDj1nSyyupNGY5cJmXcDkrr+XCUWuynPFxImPzA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022n1jzxob4p2qucPculbcY0w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223cabf28ec9795c64b3f22ce33b735bd09b35ea2fc7f8106cf57564bbd8b292e5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e002976.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e002976.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJanjira\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESoh\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ECentre for Healthy Longevity\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational University Health System (NUHS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EHealthy Longevity Translational Research Programme\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Biochemistry\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-6\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0003-4400-6861\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Soh%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJanjira%20Soh%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EZi Xiang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELim\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ECentre for Healthy Longevity\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational University Health System (NUHS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EHealthy Longevity Translational Research Programme\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Biochemistry\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-6\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-0562-9321\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Lim%20ZX\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AZi%20Xiang%20Lim%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EElaine Hsuen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELim\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDivision of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003ENational Cancer Centre Singapore (NCCS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lim%20EH\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AElaine%20Hsuen%20Lim%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBrian K\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKennedy\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ECentre for Healthy Longevity\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational University Health System (NUHS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EHealthy Longevity Translational Research Programme\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Biochemistry\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-6\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-9\u0022\u003EDepartment of Physiology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-10\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-11\u0022\u003ESingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology \u0026amp; Research (A*STAR)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kennedy%20BK\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABrian%20K%20Kennedy%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJorming\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGoh\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ECentre for Healthy Longevity\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENational University Health System (NUHS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EHealthy Longevity Translational Research Programme\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EDivision of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003ENational Cancer Centre Singapore (NCCS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-9\u0022\u003EDepartment of Physiology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-10\u0022\u003EYong Loo Lin School of Medicine, National University of Singapore (NUS)\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ESingapore\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Goh%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJorming%20Goh%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node36676\u0022 data-node-nid=\u002236676\u0022 id=\u0022node-36676--2807581136\u0022 data-pisa=\u0022jitc;10\/9\/e002976\u0022 data-pisa-master=\u0022jitc;jitc-2021-002976\u0022 data-apath=\u0022\/jitc\/10\/9\/e002976.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ESoh\u003C\/span\u003E J\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELim\u003C\/span\u003E ZX\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELim\u003C\/span\u003E EH\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EIroning out exercise on immuno-oncological outcomes\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2022;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E10:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee002976. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2021-002976 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ESeptember 30, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222022-09-30\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-2\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}