{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221ZscwNIqL6CwaLsXG2YEiWa9RtQSLqe8NVyedcIDB9oPyHV4FzLVdHmReXU7WD0BeGXcD7q7PFr\\\\\\\\\\\\\\\/JCqIyi6EUJmZLPTmRSkD2yt9is2Ia+KXX8t+rGaCxS5EwCdrE73h3pHF0xFDsuF0BCYqgFVez2N8HmMedbypfJdJwzGaoytkBcW7mSzBL6HXLDAKNAqGM4wZZNy9O6jEizolnbUgP8gpQwmU4ipDOvCA1VF+ifMB8IGU6\\\\\\\\\\\\\\\/6RpVnpvOw\\\\\\\\\\\\\\\/nXxRZM7evvBzYHyT0\\\\\\\\\\\\\\\/vwT4mbAt0PBDxTquZCZD+N\\\\\\\\\\\\\\\/opAkvQyfk5+tQdGZ+EDLGBpEvJN+I8y8LnZW5E21L4FTmQJX6G6AItlIhSD1zsrmhDg8sNlAkPnlhcDfwDnPqh5Duhn7mm1O0hn1nqTAPthWcLWYTkZemkljE\\\\\\\\\\\\\\\/+Q8P8iqKHYjLKQbHOX8oc3W3eO\\\\\\\\\\\\\\\/gh1KvhKaSDeD2fT6HxOnA\\\\\\\\\\\\\\\/6ghlJZjCxnHIFkS+NkgHJM2gs0xKvP4LgisY\\\\\\\\\\\\\\\/Od2eqoLw\\\\\\\\\\\\\\\/5\\\\\\\\\\\\\\\/LOpS\\\\\\\\\\\\\\\/vWYJcNNDvcSF6y++wxmLZwcuhbVBjG8ayngYe3EGQnJZ0WadIam98DYYy+grusfuTZ9nAukCSIt1mNFqpYC626bJeFwq3RdSRhKx2iKMo7K86GF+4mM098rbZS1nb3tGA6JY\\\\\\\\\\\\\\\/IYjL\\\\\\\\\\\\\\\/lBXyokgOn0Z8LpZuDrvw4MhyB4BlmmbxbMb8m3Jc9pdZcj5Lg8hZI8iCB9HmZvAYbf8veED7kMJF2JYZZ1Hk513SIDuFRwvVGM436uibnyrKyD7OinSvSxnybJTw3ShC1BXPEXUYIyCZJlfs+6yudfdNeYU+aZLudmw+vzkyzIgcVI1AcDS8hMoM7wbSCL7MIW2\\\\\\\\\\\\\\\/SVIWIqMXyqRymmi9YwqCEm3I2WIrM4Esh5l+gAb866XFM4vfs9WQ\\\\\\\\\\\\\\\/6cuzsGJ5vsEAyiNxzLRODJwfeE+WUuabFI4389o9haY6kyGAMoRX0F2Dtv7vKi\\\\\\\\\\\\\\\/sk9p4\\\\\\\\\\\\\\\/AdMpTwDt0eaofvsHTKcJqFOTLsqhoVDFcZN0fFyuf5VssqMLsvuT3a2+JCeLfGMWFe7UOQzUJ9MXvnKIA0Ifu6eiqi8S8\\\\\\\\\\\\\\\/6SgSgGExr0mCpG\\\\\\\\\\\\\\\/fo\\\\\\\\\\\\\\\/CyWDKhdCbsnFJX0LWuM8wcjoix7bzOxHseh\\\\\\\\\\\\\\\/Z6XlpayOObXP2BIc+VXjWjuhh4vUQzJXqnbd6wzAQKiLyFohXWZvPEGa9DS05sgJSBYJuAaxpbXLSTjTptcrKeXDUI+jBGupKfw9bs2EehcLhaphu609UyYcrQ4xFjETz5sQepG2DawFP+3D5NICYybhI8sIbSmsuanbvk1SMujOgW0XbUcdgdcaiEzhwqrJaHk4wYlvNLp8jSnvNUEVfObcxsa36Gc4qu+aGb7gB7pRZSHuhq8NSNpFzU0E48Mu1AB51z3kXMEgko6YeZa49cLwuQ2z0CoilxMUDMayldXr1enjmDg+CGPiphRG1lOPy6pU\\\\\\\\\\\\\\\/597NEiAfvCHREX+TsVnX7zCmd8EmX2HFm4l68L5qURxfNB1q\\\\\\\\\\\\\\\/IMdqCXvnoYu5\\\\\\\\\\\\\\\/rB8LMuMn0WOQDh6CclHXRmvnpegpBzSN5TX0XZDgc5aC+BMfI3+tMeDW6uOLWPV\\\\\\\\\\\\\\\/l8gbA6Xs1Ox8NZeDLQAq6eU0ZPDdXFafqe31JK3+fUnZxDPSTkj6L\\\\\\\\\\\\\\\/eeeSD6m1hx54ztGir9F8A\\\\\\\\\\\\\\\/RLVx2qV3UsK85TQ8AURoiE+ofdjYcLU4sRSqkj0GFGtUut5UUZ44UDDtvc4ZwsVDKjO3n0pK6FDxbgVEvnJzJkAM1pBtJ81SvoAonEq7614J8JDpjyRsjzFtgti\\\\\\\\\\\\\\\/UuhhErm4vzURRA1C34kw0EzEgJU\\\\\\\\\\\\\\\/RUHwVgGlNqwf5C54p6uK09AI2Bw4PkfaBO9Ot9cOeVAmerw7UZCcA+aM1GsNpPy6neKD2ma4uL0so5aegoCc2\\\\\\\\\\\\\\\/QEjbUXzUE34KHhL\\\\\\\\\\\\\\\/+YTe1Sj+JMJZdZwFDMBnKR85V7ihbPjP7WTBCh4ORMm6xwpXmDuZama45dtuDsRf3BYyVT0ed3AdCAhQEDG\\\\\\\\\\\\\\\/PuDBhWG8TccD+Jbu043Xz2R6l\\\\\\\\\\\\\\\/enlXsN24l\\\\\\\\\\\\\\\/ZCpbpbLD9NvViSfckfwN\\\\\\\\\\\\\\\/xn9YASuXXzN3XiA5wu6Hqscaa4yOT5Y5SUGc5sojUXmOv99Tjls6RO12zh3y8fkKrKojQaKDJJchs95E07Z6aU0k5TWzGPhXOJCxJSq43AsY2DDCKFchjLEczF6t0sKYJU8cxIOXVY2wodZ\\\\\\\\\\\\\\\/PUDj5TicgxwC4jqSnxaLT+LBm67xpp9T73t3bd9fN2Q4rZn9eRztvMaK\\\\\\\\\\\\\\\/lGXSkZQLYzXMuAXCLWhf6FGpeO9L9z1n0kYJy\\\\\\\\\\\\\\\/9NzjwLZMc4QJXB2HMbqnUgfz17Qx45iVazb8ATMjlNbEFFroxNPjU+10Lxgh7bxbc7s+7uec1GNOIeABa+seHx+3D3mtOG7\\\\\\\\\\\\\\\/wE6EMGq6Yt7E2gmnXJAiRUSh4ojtZfZw\\\\\\\\\\\\\\\/BbukOuLGSNFc69dQehEWaDrP1XTY3ogmJr+Kazdq7PKjCuYI2LDmA0n+kvERPeHfqvAPS\\\\\\\\\\\\\\\/MmDZ01kLGaY57F+KJALhW7r1baIw5bBsT6X+Zv+A1VAj4mb7mlbqhXBPei8tnARQZBhwTS\\\\\\\\\\\\\\\/lEPna17N69zSxvSUKcnfzCtfo\\\\\\\\\\\\\\\/tymwSc9SGIjOWT2RaF2CaiCFUxYmVNGk8HBGQ4V0ofzkC7xmFRQJZMK80GwN8GrKWvCJBx5HpOJibucOLK8zwdIws0d6PdyF5nbtjORjlNv8l3bQ1\\\\\\\\\\\\\\\/AuFqsJu7xLQMcdf94umEsWxaReOwOS9tpQmxPaCjdzxWJH6xiUNxvobScPyIYd\\\\\\\\\\\\\\\/460+xpu+yhm\\\\\\\\\\\\\\\/LIb\\\\\\\\\\\\\\\/rUNs97QpraZFpcdkNc1UjyHC+Pqfg1H37FJRpNLOsP5ciUSG8s9LE\\\\\\\\\\\\\\\/KQGJzHFr44mtTqwYu8ZF4nHRXzTXDmIIMiJ7l6pLRr0Uz0cgR1b5JaHBpQZQT7fk47synX63wKMdA==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GbSc3+RJleUmV5QjJjOqgw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c8162bf4cf23493d1225706d99dd0443c62b73366e92edcc3f3d2b136dc86315\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003525.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003525.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EIngunn M\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EStromnes\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Microbiology \u0026amp; Immunology, Center for Immunology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Minnesota Medical Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMinneapolis\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMinnesota\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-8120-4547\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Stromnes%20IM\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AIngunn%20M%20Stromnes%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAyaka\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHulbert\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hulbert%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAyaka%20Hulbert%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMeagan R\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERollins\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Microbiology \u0026amp; Immunology, Center for Immunology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Minnesota Medical Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMinneapolis\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMinnesota\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-9459-6890\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Rollins%20MR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMeagan%20R%20Rollins%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERyan S\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBasom\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-6137-1807\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Basom%20RS\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARyan%20S%20Basom%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJeffrey\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDelrow\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Delrow%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJeffrey%20Delrow%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPatrick\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBonson\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bonson%20P\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APatrick%20Bonson%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAdam L\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBurrack\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Microbiology \u0026amp; Immunology, Center for Immunology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Minnesota Medical Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMinneapolis\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMinnesota\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-4001-7849\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Burrack%20AL\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAdam%20L%20Burrack%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESunil R\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHingorani\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-5\u0022\u003EUniversity of Washington School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-3869-8729\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Hingorani%20SR\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASunil%20R%20Hingorani%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPhilip D\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGreenberg\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EClinical Research Division\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EFred Hutchinson Cancer Research Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-5\u0022\u003EUniversity of Washington School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ESeattle\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EWashington\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Greenberg%20PD\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APhilip%20D%20Greenberg%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node32268\u0022 data-node-nid=\u002232268\u0022 id=\u0022node-32268--21563972721\u0022 data-pisa=\u0022jitc;10\/2\/e003525\u0022 data-pisa-master=\u0022jitc;jitc-2021-003525\u0022 data-apath=\u0022\/jitc\/10\/2\/e003525.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EStromnes\u003C\/span\u003E IM\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHulbert\u003C\/span\u003E A\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ERollins\u003C\/span\u003E MR\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EInsufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2022;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E10:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee003525. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2021-003525 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EOctober 18, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222022-02-23\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}