{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_emoFzfXbbTdflMmmME0VF2KnfND30HvkST4A1XKeKus.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221RLHoTCBJfeAD4RVvebVgmx9KK+ajAGhrl6h3mbYO7DkaPG5aW6C8qD72KD3Yi68bjuGB+FoJfRoVpa5heuCIZ4K+18LCArsSoZkzwzZ7abtNDPtPsKymYxQQQflO4Jrto1kddaqylyVEEgaVbpdav1h9RGQL9qh1EyQGSXWUEoxTTJORtBJgWqezTBumqQknpEAWoooA\\\\\\\\\\\\\\\/tjy\\\\\\\\\\\\\\\/oq0E1VSHMt4EEibjTMooOZCNNiS8xl3t4UubpWmuBW2BJ6AfhrR2SAmCQLED1\\\\\\\\\\\\\\\/vV92bSSS0TfZwW+AaMWYUeExWYSkodCNAgPHvM6qQ9eAIaDC0kP2Frewp+6ak9nQbjClWlIhRK9PZ0UyXTwcbCoS1OcpmEgBHnbAuivFeUTqFTvWbiGdfzUOhAVB8BlRntDg5DnjwtVpv6cHZPEOQRUpqXnxvJbCOLMQ6bMTHuHbNJpbMNX0DP8FrRYM8HTSGBYFW1KAY\\\\\\\\\\\\\\\/YoIpLY3v7ypImoC14796bnbAoibtyNDhxE5av2B28RO6K\\\\\\\\\\\\\\\/OQu5kjmNn7OlI14GFmMaI\\\\\\\\\\\\\\\/2+wReUf8Amp2euXgDuNypT1Ggc4SvrrnGK4CWwWr1NuFNg0EPINSXmg+vjJqajW15G+KLe+X+3y0F71Z4wjZlJU8Xvq4VfMh96KRDAjn0KDyFcnr1arpnyonM5efHFSIdvSlth04G1W2jLZhsQRJfNFODdhBHsuCOyQVRlSpocaFbof7Fls0d8ZrfGrUXEq13addg3L20Th0QwodWJNEihMPKivEya4tE\\\\\\\\\\\\\\\/pcjF+DBJo9LrAduIGwHbkII4SbsJUUPe9e0nvwtnwD5+TS3IaNZQYI4wvAfHM+Hp2YQ90cuq+Gdwp5lHyjW7TebfookEHhmShQ82wb0YBFUtIHXsgyRVcOW\\\\\\\\\\\\\\\/hcO4XJxQ8yC4crK7YR5v1YykaLkQjm+IEY2nRtBc+HFDwALDmB4vijdWQEjSOnfOaEYI76QGCbWo+G1zFR6ltiOOjSZNXw8I8fN5k4\\\\\\\\\\\\\\\/YzQmxvsN7RCDey9tCFpM2osnmR1u7d4Zt78egQ3yfzVYbuIdHTzvI9L\\\\\\\\\\\\\\\/vKnexp42FMGVM\\\\\\\\\\\\\\\/jkM4WUs8P02ZRofcorfeTKXB9q\\\\\\\\\\\\\\\/HFFh\\\\\\\\\\\\\\\/RqlR5JD+2TRaj6o7TMj6ZAUvVxSlfIHl51ZciQlCM2ExYPfQoZ4N0LyeZCrX7YpTjk+2SwEcsLiQj1DqByH9HgHH4Hb6QdtmkaBvDTIQabCoxLdqOpxTlwLXBmj2tgUYJBVZ5SVXYuKn1hDM7gznWio2ZeIcrqqAkwyhT4KWwjxOPBOCLVcfuZD+d+wnihuSFbfiwKKcv02Z+V+Juo3f5UD5I\\\\\\\\\\\\\\\/geJRACpELI47Tyhei0OXQs8I8Ib2nfkZR\\\\\\\\\\\\\\\/HlSFQI\\\\\\\\\\\\\\\/8j3AFXa2a98KWqlXHCQJKfgdMfaQnjcyGXU+WjjS2vmpzHpOkoCLue53ZqkgV8p3cm2PsLcCs6ELtxUSdECN3pW20jjdrn16YDEotDIF45L8HcAe1Jotqtua2kVekuW0iCIiNK66\\\\\\\\\\\\\\\/32e8PItcl54tuXwqFsHAWcXm3Ml6Fxq4\\\\\\\\\\\\\\\/RT4y6mGBElw+p\\\\\\\\\\\\\\\/SnVN+5RvWikcfkqt+j0pE8PTcOgjk+k+rYJIMDmYtlPvfp8q8IN+cFPcB9U4iVhhMP1iVLsgkXgBH4RpdM8yKiYtunF4i3mgKL6DPC8E3bhvNF1Itz2srVucQP\\\\\\\\\\\\\\\/npbt\\\\\\\\\\\\\\\/sRmtUST2eDufIass86c0oxTafgO5WezlVgrIbheB2xm13qnik5vQXaiznaEvnEeCe8XWy71XdrRb1M4n3zO2L4BbdihJHv2xY+fl3JEtbzdKMd0AFE9ePCrPXFHoS19pur1gAL3dM\\\\\\\\\\\\\\\/we\\\\\\\\\\\\\\\/Gw7bgN1+88bL474Hsgy+NL6uN8eat1Zv84kIZpKA7HXGCcmAHTFSAAbJdNnd2gzIYDW2oBXXH6qZi7luSS8ZbRiZIFvZeSZQOHCWiNt3yk6GwhAZh7CItt22qt5Q7IE5ycdPWoj4ICwYPWrEDa97IzB\\\\\\\\\\\\\\\/GEwLQyrvql\\\\\\\\\\\\\\\/CE69IK\\\\\\\\\\\\\\\/zTtzsD0U4HKjaMuNOdogcpMCai+naXhAsBdKOQCJSvg91lamlizHXCBO3LEWfabv14r0ZukgxNCsyFhtfaktAAi4qZlV6cC5YTM++iUpY76LUTLRYWYaWAt1ughyNko4IFXpkWAXZ6KR4EPQxNU+SYChbOZk7EfyIax\\\\\\\\\\\\\\\/P5tDFof8aiGwlSBjGAiTEAJGvEldwsdt+KO3kCfMMhI+bKRKGS1snYP7YtjRc5h47v1T\\\\\\\\\\\\\\\/pl5207mimn+PlBZnEJQCsh5mGSxHPzgoI\\\\\\\\\\\\\\\/IvklreZamFa6thKPkloV++0dLD05Bkhg80hHYURaKwZIGLnA6HLxJRd5BoBluOjzIe2abDO8tXl6GxZjf6TmYaBlT2pC+RCmjjRBRl9rYWs3mnA1EFGMaDAnPWISwMoPrGM39zLVE1eT2lXhr2+pXTQ3CwOCIpTTqskqLwjc7teMtuKibZEheEO8U7ztH7KTz2uw0+I0DMx\\\\\\\\\\\\\\\/8VZA5X+SpxhgRUcrjA7N43ld4O8qiF0rWLa7OqV8iONHBGp\\\\\\\\\\\\\\\/l5QUiitjQXufUC8tWWpfjFh2T9kGAg0STWszChbO51oE\\\\\\\\\\\\\\\/QLj\\\\\\\\\\\\\\\/UC6wkoW65pEtCapaHsTBLBUYJmkLlhRutGAEQs6ig34YskVmQTZDEkT\\\\\\\\\\\\\\\/O33AT8dvEI8hquwkO9r2RHk13AcbsIoxb29gtnbX75+XILeC4Hfo2DuHPK1aotUiCWYj+YSnZYgeiOuSl4hYIogQ1a\\\\\\\\\\\\\\\/nWghsf98b\\\\\\\\\\\\\\\/Aqx6FtwmNlKrPOkqTej5+Kov2IS81RDabRosAIpQh\\\\\\\\\\\\\\\/tmwzGvymf5aRLHQLV+OM6Mh4HdqYBtkdQ91ox5C6lZ85G6xgtosJ+1LzJLwt1Jt7jSvDd9oiVm11JUUNaSQqNIYRX055LGjYhcHV0kge+NYQzMgFJUjdHNv7xeGpixK012abuUfIto95eYr1bDZSNO+ulLadWPZY0n9A==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kYxiWEs6CbJ5CM7ef2OaaQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223fc72b19a4a1a1b3611a7e470c2a12c25608a85ea327e7f36f406b0d1ea8955b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003087.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003087.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list single-contrib\u0022\u003E\u003Cli class=\u0022first last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMing\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZheng\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EInstitute of Military Cognition and Brain Sciences\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EAcademy of Military Medical Sciences\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBeijing\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-3\u0022\u003EBeijing Institute of Basic Medical Sciences\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBeijing\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-3651-7701\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Zheng%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMing%20Zheng%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node31725\u0022 data-node-nid=\u002231725\u0022 id=\u0022node-31725--2983896630\u0022 data-pisa=\u0022jitc;10\/1\/e003087\u0022 data-pisa-master=\u0022jitc;jitc-2021-003087\u0022 data-apath=\u0022\/jitc\/10\/1\/e003087.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZheng\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ETumor mutation burden for predicting immune checkpoint blockade response: the more, the better\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2022;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E10:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee003087. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2021-003087 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EOctober 18, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222022-01-31\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}