{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229jTLbsh+DZZcTeriV7tNXwvrTqjHIEClF0GDak5iBrWwG0K7idNBBS4ArCNIiDAWUKGNeAb\\\\\\\\\\\\\\\/Rwq9WumxEQL\\\\\\\\\\\\\\\/Q72scJ1P\\\\\\\\\\\\\\\/h0wBcjWVAOxS6agT52xQHyE+QMPy2QGpXmBBDxzgz+cNMvr4UFeiFv8c8QuJQjJDKQgXl7mSkE\\\\\\\\\\\\\\\/kPnzEPefdzHj\\\\\\\\\\\\\\\/onM6UBOyAHUNmhioyQMG7FeGlxLhvfdRM8oEFjhW3kjAiX1YPCdFiGXGGYfZuG3FR0OEYnA7tufn\\\\\\\\\\\\\\\/+SubGeeABYdhz\\\\\\\\\\\\\\\/YLnMvWattECv4bPyXhAhe16B4YGLJiURtSTDjYHZYE9tPDTwbkkjGYv1TD7r3OUDn4YDP4JJ\\\\\\\\\\\\\\\/MOg4zTja01+ATJ3UcpmvtmaHbLIU7iOmDbwm80O8q8SMIYUKNC4iIsuZpKD8OMwuQhXZqmVWHwJbLs4zE7qEMHjSeuQY+yYt\\\\\\\\\\\\\\\/NlEgcYBvzbyvp\\\\\\\\\\\\\\\/EqpaQCuEBD2\\\\\\\\\\\\\\\/UFjXSag8\\\\\\\\\\\\\\\/CoYCo3idXzgOgpIqn35vHjFcSWAUkMB6cGqDWGwrjb5+KCoMIf1GeWWpZ5BFHdkngArViZKLTjHW5RQ4wfWXBPouSDQraJjO93r5EHGMGKHgXy22OUBmGP8FYAc0+YcXmm5VHYKxgR4\\\\\\\\\\\\\\\/yIMhgMOEkyfEyhCICgMAwEXpVWU5M2ZQRSWTGfA4Y2BfN6ERw94cAllAEnWgqB\\\\\\\\\\\\\\\/7qlQs+3kgr0qsA+GG+BzOJe+Ex3Z1DQ9fbhMnAEsuhofpsizDoLarXXPjw1aq7AICouSdXwQ6YHzPXzSOTC+JPyi29sOq0s511hBTir6aqPtfV+xPMUqAua9bsNVw+1rICIe14u3A5540Wu\\\\\\\\\\\\\\\/O9xo3VAZS1ytsdVL4TqVqm1wvdQxOvdQYojD+d3HpXbfdNV9lCXN\\\\\\\\\\\\\\\/JCY3ML2+hgCxkD3xZYHAWCaCeq\\\\\\\\\\\\\\\/af87tpRy7rT0WcfyiJ9g1As35N9v9PoV2YrBjOrIwohwPKcNecin2CIxlWuRtJzwrhdTe+BbilDxMJALOXaeRPL6SyTncE2ClUxkST3UufHXMKnlHcHhjqNKQV179GkTXiTUvZtVcIHYAgXzdl4HKaOq42v1tBxK2Z2IdXFOH+PPwkiXN6ehacmCYxVNIWP3RHL9VXT0FftQQLwUgaV9LbLkD0x\\\\\\\\\\\\\\\/Y1wjI7pWbIx8tY\\\\\\\\\\\\\\\/O+paLz5WIGiBrRpnUO3gQeujZbD+Vsk9Cpd8dCEYBd3yEcY\\\\\\\\\\\\\\\/L\\\\\\\\\\\\\\\/ql1XquVP+DR+r2gxp8ylCHpQABNa4xjklfq\\\\\\\\\\\\\\\/gVdzMVvk5T6ehsnG+2zwc9eFUaUihDpbNZeVghF5xBo+9m1oJ\\\\\\\\\\\\\\\/LuYBO8KvALd+iAUFygJY0kTCCJjYkAc8ovBJ4rLj0zlmnoT0rj99WGGazLt6AfVfzyz2ecBz+SsxtujC24J+JO69p7yiAJ4gKhWF7Bae3hjdGdTV4XgrlvUnhwshh71JNuKKHEqe\\\\\\\\\\\\\\\/oO\\\\\\\\\\\\\\\/b0VyBi7GXL9YJmx0EQk21tNQiGM2nU\\\\\\\\\\\\\\\/K32WYMpzdaxIWAkJ177BtTeWulSpIw59\\\\\\\\\\\\\\\/Wbkoc4V4rRAePZqG+\\\\\\\\\\\\\\\/O7S73\\\\\\\\\\\\\\\/kpZJgIzZIEhmVpSAWJiTsS+5ZD+wjSFhLdTuW1WsCXAI467uEx45L8UEGjWV5+EVFRalforBJK3V8dQ70iLtnEcXRzsdIjHGadvK8K7tPWWmC+dfIxNtlxZwK1iWJMtj3YpQ4YTtP\\\\\\\\\\\\\\\/QRN+v+atYZH7iLmlGR1J\\\\\\\\\\\\\\\/zDSFfUE+DK4sepqIDL4iL2\\\\\\\\\\\\\\\/Osk32xwgGK9vj7J6kvpk5+0LMT1SDf79Fz6KP4bwX7slkQcM4ToOztQ\\\\\\\\\\\\\\\/gsnMHDFtm3XoP0DBIZo9roPG2fEm2wB8Y8TfcpuUuYWoSa52yThqHFr\\\\\\\\\\\\\\\/FoIOikNQLTyXNeHFkMKOcwOAOyx18+InWa6zy4rosljAmEQHcWm7FNXnrbmybxE3sMKnrWFZBoeHD8ZNJHnTsAjIscfbh0ifv29IhzTTM99BvgCW1o+0cDw6hHUu1U0wXDV7vB5VxeIOeZ810TGVKqaoqa\\\\\\\\\\\\\\\/LyrOLF7JWiwCyQpmt+1ULEawFBOckXXq8TlV5p7uaP0m3NyVPXEJP4TqlIedrHRiPSG2Xli1XwH7zIgYit0k8UONw\\\\\\\\\\\\\\\/28\\\\\\\\\\\\\\\/4aleFqzc7LE1jTdeEm4X4MmBJkG4XdCvDnLYSKBfyJFUq3lTBIeUSapzVnzcwg6seHtVapo671iLyU76MxoY3MTufQLcOTfO8S\\\\\\\\\\\\\\\/6ZMiBtOk55nGErRoDbbnfkkVmXJ7NRMR51dfFW42FZBIi8PQYhmIeQD9kRlTIbFUKRNvQm5DRcFTNHxmJIz9F81CVXDMxiRv5v0+fnKF7V50TXhS6yygxFXQPeaaLL+foFtVMF8WJlf4PcSD3SfyAxF1uR+WHefrff693iCxwcjTSqCzmrCIXq3CddFp2OJutcO48yN7YiVpTI88Iu7i9FyvayFSfWU6IBn5Lv9swaUtIxWg7zWoc37U5Ov7T+NMIrqW9tJJc+yiZKOg\\\\\\\\\\\\\\\/1G\\\\\\\\\\\\\\\/Ztp6jZqYJxlz4+BjBv5y8twGY5lPHlDTyVms1fWH\\\\\\\\\\\\\\\/THoSDrG94cEdscaS6lvttySqWhJe0YSgIFIow2pLW\\\\\\\\\\\\\\\/ftq1WQRQN0pBCtqqUbAPMvwIa5ov+aa8IMWHJUwVaCR2aINq8rfrsTwsxkS7RriaOPhscfo+7Q+asceYWkYhKcsH4UCj29eVQbmMy34nwxa2ryk4UzA3ao\\\\\\\\\\\\\\\/c3oUe8vpL98Ve41zaOG3qsYMalvlNkmMNQqVHVOzLwN0xPpiDKdV8nWSx\\\\\\\\\\\\\\\/K+e88EwGitT\\\\\\\\\\\\\\\/trsCuDr+kYdrFE0FLOWaClm6PsdhHJql1rDOOBC+9o6c2sezyb6lN\\\\\\\\\\\\\\\/Agtzd5DFMOjt4ly8CmiCSNBivmLv9kUOIZpG\\\\\\\\\\\\\\\/81txjs6iAH5AlYDQZvKDUGD\\\\\\\\\\\\\\\/2yuz8TDTvdTp2GMvqO2b1lH+hN8EkiZDH+s3qv9+ZBnhZlTQ4rB5p+z+QsZ\\\\\\\\\\\\\\\/a0iNsno0z5kGZg4k91R1zm+KEwzmrueKN\\\\\\\\\\\\\\\/g==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225yMLEs3xO8szxqBVZ+p\\\\\\\\\\\\\\\/Sg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f02ee85c6bd5da62db9433fa087999774a01b158764242fd5af47bfdc36dc4c2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/9\\\/e003218.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/9\\\/e003218.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJames\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMcAuliffe\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=McAuliffe%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJames%20McAuliffe%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EHok Fung\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chan%20HF\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AHok%20Fung%20Chan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELaurine\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENoblecourt\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Noblecourt%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALaurine%20Noblecourt%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERamiro Andrei\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERamirez-Valdez\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Ramirez-Valdez%20RA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARamiro%20Andrei%20Ramirez-Valdez%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVinnycius\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPereira-Almeida\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003ED\u0026Atilde;\u0026copy;partement Biologie\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversit\u0026Atilde;\u0026copy; Claude Bernard Lyon 1\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EVilleurbanne\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EAuvergne-Rh\u0026Atilde;\u0026acute;ne-Alpes\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EFrance\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Pereira-Almeida%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVinnycius%20Pereira-Almeida%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYaxuan\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZhou\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDepartment of Gastroenterology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-6\u0022\u003EPeking Union Medical College Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBeijing\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EChina\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Zhou%20Y\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYaxuan%20Zhou%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEmily\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EPollock\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EThe Jenner Institute, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003EUniversity of oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Pollock%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEmily%20Pollock%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFederica\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ECappuccini\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EThe Jenner Institute, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003EUniversity of oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Cappuccini%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFederica%20Cappuccini%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EIrina\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ERedchenko\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EThe Jenner Institute, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003EUniversity of oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Redchenko%20I\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AIrina%20Redchenko%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EAdrian VS\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHill\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-7\u0022\u003EThe Jenner Institute, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-8\u0022\u003EUniversity of oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hill%20AV\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AAdrian%20VS%20Hill%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECarol Sze Ki\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELeung\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-1545-7228\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Leung%20CS\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACarol%20Sze%20Ki%20Leung%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBenoit J\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EVan den Eynde\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003ELudwig Institute for Cancer Research, Nuffield Department of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Oxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EOxford\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-9\u0022\u003ELudwig Institute for Cancer Research, WELBIO, de Duve Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-10\u0022\u003EUCLouvain\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBrussels\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EBelgium\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-4995-3270\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Van%20den%20Eynde%20BJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABenoit%20J%20Van%20den%20Eynde%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node26109\u0022 data-node-nid=\u002226109\u0022 id=\u0022node-26109--291421359\u0022 data-pisa=\u0022jitc;9\/9\/e003218\u0022 data-pisa-master=\u0022jitc;jitc-2021-003218\u0022 data-apath=\u0022\/jitc\/9\/9\/e003218.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EMcAuliffe\u003C\/span\u003E J\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EChan\u003C\/span\u003E HF\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ENoblecourt\u003C\/span\u003E L\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EHeterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2021;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E9:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee003218. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2021-003218 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EOctober 18, 2023\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222021-09-03\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}