{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221VBeUomK5NDrSYDbA40V983Ffc8A5mG1dkbTKtOSg4FGgbRGo2DAY7SK\\\\\\\\\\\\\\\/i+rXc6PujJb5Ves9PPmXt0dbeY4CkqGyrvVnR1pr3z7ypNTCupvDt6QF2ENFKwe1zLwZgzdp1zmNDQGBFsuCfBEh1o4Bl9\\\\\\\\\\\\\\\/bLJzyw12TXudHCifbuQfmhJY6Qvr5nWa8MG56dzRBe4Ztv0pnfnTnnEyp7LFD225bvTRB0OKP9sqAtl443wt9NjaXV47jL1oTQx5jNGZLoXfm5YOoWPswi8RVPqMeplj7xhag2gCztHD+SQRwEw+6lGUP99vEpVCBWcDbRTS5BR5XDFldb2KPiIygtOuJgP7kq0RNoq\\\\\\\\\\\\\\\/i60Ka031QjsO7pcbfkothE8OTb4zBNaGHYwZkYeUf3Axh\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/leKx7IBItYM2C5hgy\\\\\\\\\\\\\\\/MkVO9teEotHGmwnDc5BIoAqwiFHNUuqSvTg5SKL3uvYWYKBoX+FAroRIclDFd7MRjeH6FujKxU9JAe+5\\\\\\\\\\\\\\\/X6mZqCsXtyIni8HxKT\\\\\\\\\\\\\\\/3Ahn5+ybRL3eCaREWA6NkjcXVEtY7CMk4uVNPyS9ipXiyKSr6jqIgX7fY02WJdYGEyXD6C5JEUgkZrV9w6YQb6hYFfo7yn33TOgBBfe0VgrelFTEOyXe\\\\\\\\\\\\\\\/EmTLg7rFlqOhIQ2IaMtWAXSNyv1sRtPF56ZTtz6opXDmwHh3+hRvOuCxykI7qxNnmeRf0UGbokAbi8cNQ6cA04LGTk+uT7IXg\\\\\\\\\\\\\\\/dGfjkefI3SzXGgEwUobqgEY7jW\\\\\\\\\\\\\\\/q+KcgGQgEk37osN1BatNyBRnblTjMxZQnwyVD+n2h3kutLrYmOZ7oTHeibkFNG3H64xG8JESCPHVaLooiajosGSVvNNTZDw1FY4urm9Gnikz9iNNh0DrBFcDD9txD+5ZqzyBFhsGAhP5YHkm6nfs7iEjUUYDawiktX\\\\\\\\\\\\\\\/qNTZ2ZunbzNmb2DRVFJECvV3CO9VDPBpR+USA5KJYVr1EeoUnoxb5XhrWRYiNCKHUOI+TEfnn\\\\\\\\\\\\\\\/oMUb\\\\\\\\\\\\\\\/dLr\\\\\\\\\\\\\\\/JyThUi+MUbYuqZvoyhIXJ\\\\\\\\\\\\\\\/RTmXyBDPpgVPQjYJL8OMNPeqpibayMhc6fzVPHIujcRUjna6idVLpXd5aXPIAOmEgU2pL+VyFXaTjp4\\\\\\\\\\\\\\\/EGwnphHJUcjuX4gyv\\\\\\\\\\\\\\\/N3KjT3a9Ten2dVu7+tbFsw50d4SUaPMED9cydeS3Ps5JeawPyL7X9l3hHPX10I+rzsm5uaOQ5oczhdX3JRo5M7WaknZE3\\\\\\\\\\\\\\\/cS\\\\\\\\\\\\\\\/KKHEQmsW9aPGiUBrx2FHaNP\\\\\\\\\\\\\\\/118U+JP\\\\\\\\\\\\\\\/Pj2ZrEh0+bWgeU0x5eoXeUCLZqnw1OvF9xF8vg3+gUe6vXBvcxzP4WX3SbZX69Ncm2OiaR+evBz2FDogigVZdcuD2fAuJRwV0v3g6nU3uISIvq8XEzP2OtTz3ENf4iu8kIjDWpbk67eCwaEqyStUesPbrOwveAwyta00uyfGDDS+24SMmJ4ASPmxMtozt8SUGHb3RWfz+5dLIj+4gsDnJQUu4HRbiSewi3jn+OEdYLlD82uUss1V50oINL1RqdMoNW13tME++d+8cJVyfdLcCxZ5Ag\\\\\\\\\\\\\\\/ubgHfYnh66S2ONSr5pUhkGCFtYc67CGUxPNDXpYAE12Vruet\\\\\\\\\\\\\\\/cSxUwSFjUO9ovTmH2ufmOnjUfs59pGG3+iQ8MX4YCZ+k5OBDlZb5kHxxggsPxyypxKO7pd6H621kxAHrOZG8awrAmokzZpaMGZjxdzuvtUJoOEcQXC9icRvyFO3F2m++6IE+TjfpYjLTHVdg88OTtqErzAH7Xl\\\\\\\\\\\\\\\/D8qmd0nhfXnZbN6t57qg5CgO+zocsya6Tgo+7pJmX3RtM4LX4lziSUAkU2hQ3uGwj3IEhqToBUcf7vjaz+oum48yta2hul6FchgordqvBafhguLomLIa3K0ZIPbZEPBwX1RQt+gz\\\\\\\\\\\\\\\/18eN813gSRseTcPJpJjQufWcmCYlSAvd5GpaVeZBgItSPq9tAKgmAIpkm6I60kXow4vrr46zdbmZXU4j2dcNFChCh0iqXC\\\\\\\\\\\\\\\/1qiNXF+ybOtI5LBPeMzCtugH1ubk966ie4Sv45wxeV+C5YUWqd2ZiNPBoUs3w6Irro\\\\\\\\\\\\\\\/59fFqHhAZ0AvJHamMXdqBjscF20woCKiWjuP1TQ0j59h\\\\\\\\\\\\\\\/RpJnxjHLXVG9oWabU2LotZFteeeOxlNWJuBB316ON2umJxvDvCLSTjtUNrUliARdSwQ+MwgywlK0yPSh6WzcQ8IRX20yMhMhai4ibwC+iiAyH3OrOJzCtBM6bqnM4gKmk+2e8amVHPFMq9lzmCjbU1aA6RfxlOIs5xXa66u8iW\\\\\\\\\\\\\\\/OSDzKySlZBs1ZyH9bOScY02XVALjSx\\\\\\\\\\\\\\\/rpzASFWI3EHucRMMNFPu\\\\\\\\\\\\\\\/vvh6pavpddk7jAipN\\\\\\\\\\\\\\\/r0EhyWKW8tnPTQUz1s2jyRkZH1mpfkvA8Fk\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/bvNDSRVye9bcNjMlUq4rpQUf1iRk1ShN3IrKO8\\\\\\\\\\\\\\\/hie17NxW3zF68iOmlUQqJ5CyYLcws75aEAvuuvd\\\\\\\\\\\\\\\/cTqrVE98TFPeJBi0i4+4AprLCk0rFXVIF6Z22dqzBBkt7p+qm0rg9IkF+iG\\\\\\\\\\\\\\\/bX2eiq6\\\\\\\\\\\\\\\/KT+3k0U1vjET10+Xe8dA3wRsdnHZWfAuvMRcQte4vHhlunFGrLpZgmcRYYB9gt0RsuB6bRnv0QCm+4PSdWazXL9W\\\\\\\\\\\\\\\/FUK2eF7ymlZBT0QKlW7KqLtBIofpp6R166aJrB8YZ1ukTbmqH11Vy1ih\\\\\\\\\\\\\\\/4V2wePbDClZ4wwUaITPbsePbe3scfzURJz83Snk9gzqHOS9IiQ68imqpg1cTb9oZF\\\\\\\\\\\\\\\/hE21zhT5bmjOQE5ldDmoqCeCJ5KAZaJR0R2Zzdk\\\\\\\\\\\\\\\/nt7XB9sJ97R4fimJuAC50PAByv4wbwwYpfu02PS6l\\\\\\\\\\\\\\\/rdUSThrSH7Az2n0igYTLDKTEcO8cll0e99fjzm8eQb1pvkhilVYCMK9ZR8YhBXINTfo6Yxg8vEElG7\\\\\\\\\\\\\\\/9iEaFVavNhq+Ew==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Tn\\\\\\\\\\\\\\\/BVkjxdDIsvEhhEGvyTQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022be05379b62fe603405b7a8a97c7abd1ce41dd57d7d5a49c55c6e18f1d873a14d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002551.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002551.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EStanislav\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFridland\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-7200-7154\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Fridland%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AStanislav%20Fridland%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJaeyoun\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChoi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Choi%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJaeyoun%20Choi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EMyungwoo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENam\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Nam%20M\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AMyungwoo%20Nam%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESamuel Joseph\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESchellenberg\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Schellenberg%20SJ\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASamuel%20Joseph%20Schellenberg%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEugene\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKim\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kim%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEugene%20Kim%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGrace\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELee\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENorthwestern University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EEvanston\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lee%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGrace%20Lee%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ENathaniel\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EYoon\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003ENorthwestern University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EEvanston\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Yoon%20N\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ANathaniel%20Yoon%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EYoung Kwang\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChae\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-1\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003ERobert H. Lurie Comprehensive Cancer Center of Northwestern University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003ENorthwestern University Feinberg School of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EChicago\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EIllinois\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chae%20YK\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AYoung%20Kwang%20Chae%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node26050\u0022 data-node-nid=\u002226050\u0022 id=\u0022node-26050--21289273093\u0022 data-pisa=\u0022jitc;9\/8\/e002551\u0022 data-pisa-master=\u0022jitc;jitc-2021-002551\u0022 data-apath=\u0022\/jitc\/9\/8\/e002551.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EFridland\u003C\/span\u003E S\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EChoi\u003C\/span\u003E J\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ENam\u003C\/span\u003E M\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EAssessing tumor heterogeneity: integrating tissue and circulating tumor DNA (ctDNA) analysis in the era of immuno-oncology - blood TMB is not the same as tissue TMB\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2021;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E9:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee002551. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2021-002551 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222021-08-30\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}