{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_gcZnjHbssViRRSwT8KDqb4qbXgwiKKoyZe3sIqJ_UQ0.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220vAF67yWYfuPWoC3ZbD7o0ykuMVl\\\\\\\\\\\\\\\/+CJD+KO2TjhTEuRLOoIe7QQKsz\\\\\\\\\\\\\\\/yhTB3k\\\\\\\\\\\\\\\/mFd0Skok6\\\\\\\\\\\\\\\/F8e2lUMHcU3kkxUtv4ZyD4eLoR77VBwBObIe7CkxplmCWkrltZZxGjZ7YAdg5jJzpl7ruC1iM+5EKLSUk8qp1Kl90NTNxlQcF7SBSnq\\\\\\\\\\\\\\\/iaIulFTRdg1HKArb7AIZ9cThjEibNQYWZ869DANPsJVsqJkDudtwR\\\\\\\\\\\\\\\/XwgsYBk0OAIMGmEk55Y9TzWSDYWC4pbTTgpWJbZz1W2JqzhAzVA3WUFe5So2UXGFidfNkc3f24gbMJJFhHFDG+\\\\\\\\\\\\\\\/05tnb6ztKO1SvHJoHCmvnY4qOgvhDph5ZKphZXUCvO1wYe2zcFBYwCrr8+VR8TwMvcdp+UjmAtmFdkI39hjVL\\\\\\\\\\\\\\\/DwqQ+iPT5Nojnl1ebPWSkOauWeAih6\\\\\\\\\\\\\\\/bCf5OP3V\\\\\\\\\\\\\\\/RygpkohGUNSqAxPJgMv2RXuYxrhDpkBUha++jYS7wCYCPxoMEF5uflIuXxAaA8Ry7yOpI1brb6ejpWfRd1ADKG\\\\\\\\\\\\\\\/0YaLUsXmHJpeihoAzOFynGjevDTSSCE\\\\\\\\\\\\\\\/uS6kGwkgxHGrr5zDvLhFQayhCIyluiyVttQ5AuM9R\\\\\\\\\\\\\\\/hED+YZQOyTVa1CIaGLYv5sMvRdIzfyvooCZ9b8KphG82kFFymAMsJehxNW4xqQV4R6mMN1w9EcrkAxO5hJC\\\\\\\\\\\\\\\/W2W8dJkgOJyAelqITrRSRmAynY49FVpx60fnlHlnWVNjMx4iR1P2dVahF8fxgUA4Ay8ZXTLq1nhL3Iyoc4h7vCdbO32r8rga8weajlt318XWlzvcvWEdH3y8cZnPYm2SQTgteu4G1ztI7c7Px7roMbm42moSPCEI0BlIXj1xbU\\\\\\\\\\\\\\\/JYE81HIqLouSzTrJLnbGx7nvCdsZdY2FvNybt9yPlY2XJonKrOqQdWhggeoG9UV3KtM9AsN3y4I6hdSDY6LY05G2x9JLJLEszDhS36zkvDc5jCUYKePAP7DAJnihGmOOCXVqDeCg7K9TpbNlRlqVr4Eyn6wvz8gvB5WOKS5+a7W+7uRfftb51jFUMi72JGjAFj4CsQfVHIRyXhqjY4DImHRjiAZjNcunY\\\\\\\\\\\\\\\/Jy7lK5sqGnQHwdolx97Ml2k+NN\\\\\\\\\\\\\\\/pygZPRMB8IrX+3sGmcw8+5Ok5cLUPAXkZ\\\\\\\\\\\\\\\/CjMEKFJHtl\\\\\\\\\\\\\\\/ix9pTINa2J3hiJjWyhpazTOAoK5DucRcbUiNnLMCJ28ZjYl2Eh+XJ+msrDn1jKGFQB5LyUTmiYYkzACW9Y+eey5esYoFncNcBX5IXzYXwDbGvJ0B0Xc2Fc7ZEk2HLV\\\\\\\\\\\\\\\/2RKMLQQ\\\\\\\\\\\\\\\/SLM2tdFfQubsmBCmDnwOCOb\\\\\\\\\\\\\\\/Of1kpnudcWGiFhrEQ8ASv9qmynb+fLMBRFVI69IyTpI5mF85htEOrWcLM1Pc7bikUgwJDF+j97lmEp9UUv+LeQ6zQkRQmTaIitJf36tIx0ECEHvdK6K1Zx9Z+mt2RBZ8lwF9B6f3N7XkopCabd4MGWEViopwXwQLxkUXeFb8q19sf57pFpj0o+1JcVvNbqx3OKzQAeFHj\\\\\\\\\\\\\\\/cFtiZH7vDGS5S5n4YAzKyyLjs48oWT6EE1dvNpxCvHr7WpQzURMp9o0ySdpn78A\\\\\\\\\\\\\\\/02VryNpg\\\\\\\\\\\\\\\/9880JUeHKCBVdHhqLSqueOcUEDUHfPIx493lT1hv3Y0UkuzL3HZF86IElh7ZAsk6Heb9n8hXLileiS6HQD8InKBVYHLVFSysSVMV+ehUofUB4o\\\\\\\\\\\\\\\/Ebiuo04yjNP1IcgWeuAd0lgs\\\\\\\\\\\\\\\/nR4LcaII0c6M\\\\\\\\\\\\\\\/QowLuFhWJn4JwtgRjDZYL2FXS5UTHSbglkV\\\\\\\\\\\\\\\/cvEAS\\\\\\\\\\\\\\\/xaXWdn8bVluRiDUV4pn\\\\\\\\\\\\\\\/ogOPX\\\\\\\\\\\\\\\/TfU1uoPDJgudv4aI3\\\\\\\\\\\\\\\/zUIcR9mWdEmfi5ql2DmwKKB8PjtA+KN6njXiW3s5Pxwv\\\\\\\\\\\\\\\/3cjmcg2he79kRF4GX4\\\\\\\\\\\\\\\/YGGi7HvJyiG\\\\\\\\\\\\\\\/aeSU5npxR2ZF0zY1ojEuzzs\\\\\\\\\\\\\\\/XfxvKv+SFio7nNLmqQ8x60b4V1ocoq+R4AO7N\\\\\\\\\\\\\\\/Z2xYpaFlEEMI71A+ReZu0dc02RWvANZcnb86pIiWxApEiP1xck\\\\\\\\\\\\\\\/imQqebf0NKkFclYVlNf4h82TgvkpNn7tnxIf0BH4DKK0jp8mO4+DKcWyK33EnU8yq3yJxyDo7nnzmoJ9BT4+gKMR1dhEvA8GtBVe8jEsNG9sliXW46jh\\\\\\\\\\\\\\\/EcSLw0wWEG4eqvu8lgtLj6YYF7Fq9LmRn8BqRIXH+vap1PZxEpoMBzPIs6IHnkxYtf9WnrpphFJUpj2wxCr94qroRqhc26y1aEl+7CKIIEe5FJDhE1RC25lHkJs+atCWgdaau+8ievO0p4w9Tc\\\\\\\\\\\\\\\/3XPtWB1XvfMncb05cPFrFWKFZFBCVp+26qDcXVJAfvgbnrXAthYtbrUa156tYR\\\\\\\\\\\\\\\/iATvGjGr3RkopbmLpphoGjTW5dIagvrdbe85IiVFg4db5O5ZfyUWZby3Et4NgJgUR8D7MJiO4XHPQASvP3+5vFUEHKg\\\\\\\\\\\\\\\/n9mIObufx8cki8ybjn55r6x8NfFe1ftpKrTgFKRS5Fq0iGqyHuRNKkGgh+JJ+H4SIUbEjwh7r2+k9n8wMw0\\\\\\\\\\\\\\\/d1hHkvGnh9fXn\\\\\\\\\\\\\\\/LQVNcjSaAHlIhRIuZNItqSZC+hq6ed7JeHdazg6sEDIiRLsvKfhuPRtuVl84uvkBDRd4QjAirxdm\\\\\\\\\\\\\\\/QY9An+S4XbWahiIvKeXYtvEvTniMTnEi0r4Ff3TgsNPWb0vDwniEfKrOvjCNFl5emoQ\\\\\\\\\\\\\\\/NnBlWoRfbO\\\\\\\\\\\\\\\/oJVlyVN+Lc2zwZ\\\\\\\\\\\\\\\/j6xujn+oSDsYe\\\\\\\\\\\\\\\/SAh2ftH8FRRqhwAytwYkx33uUyWRhKNCvOKZgtTA2nPmYgXnlNbFylkBHhNLXxsanuZR7TCA2SmGG212+QCmPkNBXo9YG2xEBw4n6HHiRoGOPVLsyrTyOhvtP5s5Hfj+GC+iA69MaSXS5YtLscbzha5ldxyqRq+Vw2GIszq\\\\\\\\\\\\\\\/UN3JkL6axrhGxYog==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022AFVYe9Y1B7EluYsMUcveYQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e72a296284ec33cbb0c4571653edc9101a78f18c1f30aace63c782b282acf424\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/1.2.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/1.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node25509\u0022 data-node-nid=\u002225509\u0022 id=\u0022node-25509--21206758789\u0022 data-pisa=\u0022jitc;9\/8\/1-a\u0022 data-pisa-master=\u0022jitc;jitc-2020-001498corr1\u0022 data-apath=\u0022\/jitc\/9\/8\/1.2.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ECorrection: \u003Cem\u003EDickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer\u003C\/em\u003E\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2021;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E9:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2020-001498corr1 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ENovember 02, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222021-08-02\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}