{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224qYFf1SawYlRxMq3IHnUOk+iQDMJGa5RGuMUV5RGtUTxZeKs\\\\\\\\\\\\\\\/+AIcs7XkGkCNpl6FYteH+vk5biZetoxcZErRgTrpZg860x9WFgjXXdzYa41HU3hPbBJKvejlTE2o1ZvYnbEvD5Xy6YGCUe5dRLoNZsT7TcOr9Ij\\\\\\\\\\\\\\\/VzhUjSZ4I5hORAobIQeRCRPlvutLD81gKnGqW8CTChyc5yQwxea2\\\\\\\\\\\\\\\/9JRe6xP3XxYjMw2kLMM9BX\\\\\\\\\\\\\\\/5WtxS9A2NNKlf6vzL1i5AlJ8gd+Mz8K5mwKHilMKsVYbtbyFuBcDGpDHE2U4xBvD2ksLxfWk+cQRUaAAzLG0rOf2zXprYv\\\\\\\\\\\\\\\/hoDalN8QK4JZi7C7dBwHR70Q5qRpHKtYj3B0M54EuNsw3KIhD5+Z\\\\\\\\\\\\\\\/E9Lx9QoEyK9TtCyOmNqLxuJQeNLTt07k2aWkyxh6gm3Pg3P1qs2SdmTLn\\\\\\\\\\\\\\\/39gZz3\\\\\\\\\\\\\\\/bNE\\\\\\\\\\\\\\\/S52oF8x7brAAsNTicRzv97arcMH3P6diURM4xQAeGJ+50G+vXX1JiczmWkOViNCu2f6xTgkw32MtCL15B9EzS3fuMldbGb\\\\\\\\\\\\\\\/+Hq10qZuS4wMVu\\\\\\\\\\\\\\\/OY9Uw7+NZO1SHfKLPTu3hX74W2bjXyITMLaU7W3\\\\\\\\\\\\\\\/xwaZXhPhURbTVpuwfQcU2iVvvdDd\\\\\\\\\\\\\\\/XUoFjtWHBOCHH5KvugBvhYKSQL2oSh+kNSA8AoSQtOU4VjP3QptMe+29pvuoOSlqhUmS+Uvogvt8TR\\\\\\\\\\\\\\\/UCfve1csXiTQ\\\\\\\\\\\\\\\/lxzOI2qDmSal1Ehyc8tXw0ovDUXrovXiKHsWTYCfxfZnR5Wo3LageYz3wp3qg6toQ8hQ+D+NdGH5jxRGIyD5SHVLbFJNp+3xV7QSOVG3CjuMrX3Hev9GIpWVcoBhkVjd4AtovaBxNSTHDIhPvpmFaxo6HXEFLp\\\\\\\\\\\\\\\/0SYmN+CsGei2TPOT6MDrqm458Ht9MgcN12fpCurrGoWaZgUKSdrQIyVzbUnctdkh7oSUOwVMKfNXiW41dkvEZzZ3qqHxagyylvAve84+ATWnGXLA1AE2lVr\\\\\\\\\\\\\\\/al9pOcAbiYHXJFWwvxSfHpQFtPWzS7TUUEdCE5DMHG\\\\\\\\\\\\\\\/Ar4amLEFNxp1mFOyZa47GsegpiKfonyZEr3MZz5LY6jFdKP5dudhPCp0oXvOT\\\\\\\\\\\\\\\/rR0RVGMEIpkEWkO49A3Efb\\\\\\\\\\\\\\\/0qqYonaRrQIJO7n3apARLhjtrf+8G1k1qgiQRXxsoMradn+Sm\\\\\\\\\\\\\\\/tF4bqos7wrWrPDJTc53dmDhF\\\\\\\\\\\\\\\/rtt1j\\\\\\\\\\\\\\\/IlkNwyy2C48r9ZiGGXHRpmVhsR43VTxInJrEYbodpDKGKk1zVr4t5wmXsA75zxLejojZZ4lOBPiT4\\\\\\\\\\\\\\\/XRIEyLV4f5duvq4XOeHRgkvFK42P2t8bZY1AXqjK36kbUUO6ayLaxXk5i0yNdu1kMHQBnElUQfKdgOARWJmYdcY\\\\\\\\\\\\\\\/pFkRpE4qPVPg4BFvNa8pGF89lpQ6\\\\\\\\\\\\\\\/9y3qMAUXKYPHNTXgSPUvRhIrEem5E+i04jowvV\\\\\\\\\\\\\\\/BA2xYiWmIU9DkB5gfqeN6bfSV+MNzJlCsMQUsO7JsxyC4U9gEC1KiT0pzdqSN48sYKz23VI3F3PdVlUrA0GWsqWAbjcmQVdxNS3mI7OpI11LdGEW6BhUti3wYr4vWKuPFVXmTcXk5+jBnQ6pdM1HN4lGdYQ\\\\\\\\\\\\\\\/krcS+hVxjq5TEyny8SytUlki2jW\\\\\\\\\\\\\\\/9ktnaPUkjIicdRf+cyhKn6L8UnCPo7Q5\\\\\\\\\\\\\\\/UKCsJMcNIdyrLtEQGKmPLh2oRYxmC7CKrJv88c9XiTJeGTDZ+9Nx5RjFsHcMCoHajphZWX0w7LJv9MbM7NF7VPTINYTli2hL3VvqZ96LgZJCzgbsmpEQs0tkfLkrPnG7GHBjHfb3twzFTAYlk9iPGKxfV8XCZtPuRpE6BuVAhbPYkYzZ5Yw+aqfO9tG\\\\\\\\\\\\\\\/RgF18Ni8mN8EezetcYjb91ADQWNNoAN8pSjNDDiVCROUZiFVSso8IOlF4kJHA+as3vPUZrShnVzQGG9gvpebTtTquTpbL0FAnfZNx8CihatI4XYstBBbhXqVlx\\\\\\\\\\\\\\\/uD2F7SkOSULEzufLwMgt3eZPd2yEWSGZ9u+8RIshTW8qbKoZ52cX0UTr42VQ6ZSd0IxUcik4k+5QqZFkzP5ByuMEVeN6hLBxVwi\\\\\\\\\\\\\\\/V9JRSAUukn55xV3bOxrJLwxzTPijuET+06geEAJFBP2fb4\\\\\\\\\\\\\\\/bSSbH1dmj8XZxqqzJToVyoNkMKuEP+lHN2WA4CUqFfS7u0+T44eH7u\\\\\\\\\\\\\\\/EE4NyChcQTDZl44TvSy4I+SwjrzJyKNxpj+wyfLfG\\\\\\\\\\\\\\\/OUU80Pq8coA1SgAqvlhB+s\\\\\\\\\\\\\\\/YHA4LSI4vtf13pjeizjU2oVD1sKXnSIE5l1Q1lgmfNlJbPTvtkrN8vXF8TEVfkfxY2u3mRUoWPYXAZoX6PTMpG88jcuTQMZY4kxqDO6KmVfrUpBlLxVWTMS6VK4JAB8yTMb64cWy7f\\\\\\\\\\\\\\\/CtdtfSusjCTgaGHAYqy2thI\\\\\\\\\\\\\\\/yRnhh9WYUjnYWzxRNOnusg0r9uHid0EM3xObS2w1FNMpfl7a+eJBIQSCuWJFo0mdHMW6AHyYLa5AiycOw9+iSWFYWIdSEIgOtr6rYWcXESzY8zO78K8NR6uKg8IPAXr0GPdvd4Vaat+pUqq0A0NuBS0lJfuESjzAHBplhkRjiU4HF14SB4\\\\\\\\\\\\\\\/SX3qA8pkqVk8fo96xGHtM7zcZP7AV9d\\\\\\\\\\\\\\\/MEg+iljpFZXVbk07mTmHCSpEkGdU+YqM0k1H9NOcHF5h9GRhOLFb+AVP7UhAaRD7NGG9\\\\\\\\\\\\\\\/XAKuJId8UVIjRPIBfhV9598IBmdib4ZLvTI9YITopjQGRvoG4y\\\\\\\\\\\\\\\/q3Mg+4sVISd+25FeHRlh6TQBEu1onIba637ykIytanskVDAl06u932y99HOLY4rDqIl2liEW1bvvPQJquWaYxCMy9qOg2SWDC9nUaLuEEjJ24Mkvxg6gCoFhT4kljtFsxnkhX50lJbGVkWC165qeLwpkV4Lj17oGDIQ9GQ==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022KVx8XbgnT+92fRbvMaXg0w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022da8ce7cd4fa7f6e74fd7c2c14f0b5aa735e8dde8bc7a77da624bff85169aa91f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000860.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000860.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFrancesca\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EZammarchi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EADC Therapeutics (UK) Limited\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0001-9457-2170\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Zammarchi%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFrancesca%20Zammarchi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EKarin\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHavenith\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EADC Therapeutics (UK) Limited\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Havenith%20K\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AKarin%20Havenith%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EFrancois\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBertelli\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EAstraZeneca\/Spirogen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Bertelli%20F\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AFrancois%20Bertelli%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EBalakumar\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EVijayakrishnan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EAstraZeneca\/Spirogen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Vijayakrishnan%20B\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ABalakumar%20Vijayakrishnan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESimon\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EChivers\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EADC Therapeutics (UK) Limited\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Chivers%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASimon%20Chivers%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPatrick H\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003Evan Berkel\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EADC Therapeutics (UK) Limited\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EQMB Innovation Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ELondon\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=van%20Berkel%20PH\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APatrick%20H%20van%20Berkel%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node15567\u0022 data-node-nid=\u002215567\u0022 id=\u0022node-15567--2689940220\u0022 data-pisa=\u0022jitc;8\/2\/e000860\u0022 data-pisa-master=\u0022jitc;jitc-2020-000860\u0022 data-apath=\u0022\/jitc\/8\/2\/e000860.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EZammarchi\u003C\/span\u003E F\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EHavenith\u003C\/span\u003E K\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EBertelli\u003C\/span\u003E F\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ECD25-targeted antibody\u0026acirc;\u0026#128;\u0026#147;drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2020;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E8:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee000860. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2020-000860 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003ESeptember 10, 2020\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222020-09-07\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}